A diferença entre estações de trabalho é considerada desprezível em linhas de montagem tradicionais. Por outro lado, linhas de montagem heterogêneas consideram o problema de indústrias nas quais os tempos das tarefas variam de acordo com alguma característica a ser selecionada para a tarefa. No Problema de Balanceamento e Atribuição de Trabalhadores em Linhas de Montagem (do inglês Assembly Line Worker Assignment and Balancing Problem, ALWABP), os trabalhadores são responsáveis por estações de trabalho e de acordo com as suas habilidades, eles executam as tarefas em diferentes quantidades de tempo. Em alguns casos, os trabalhadores podem até ser incapazes de executar algumas tarefas. No Problema de Balanceamento de Linhas de Montagem Robóticas (do inglês Robotic Assembly Line Balancing Problem, RALBP), há diferentes tipos de robôs e o conjunto de tarefas de cada estação deve ser executada por um robô. Robôs do mesmo tipo podem ser usados múltiplas vezes. Nós propomos métodos exatos e heurísticos para a minimização do tempo de ciclo destes dois problemas, para um número fixo de estações. Os problemas têm características similares que são exploradas para produzir limitantes inferiores, métodos inferiores, models de programação inteira mista, e regras de redução e dominância. Para a estratégia de ramificação do método de branch-and-bound, entretanto, as diferenças entre os problemas forçam o uso de dois algoritmos diferentes. Uma estratégia orientada a tarefas tem os melhores resultados para o ALWABP-2, enquanto uma estratégia orientada a estações tem os melhores resultados para o RALBP-2. Nós mostramos que os limitantes inferiores, heurísticas, modelos de programação inteira mista e algoritmos de branch-and-bound para estes dois problemas são competitivos com os métodos do estado da arte da literatura. / The difference among workstations is assumed to be negligible in traditional assembly lines. Heterogeneous assembly lines consider the problem of industries in which the task times vary according to some property to be selected for the task. In the Assembly Line Worker Assignment and Balancing Problem (ALWABP), workers are assigned to workstations and according to their abilities, they execute tasks in different amounts of time. In some cases they can even be incapable of executing some tasks. In the Robotic Assembly Line Balancing Problem (RALBP) there are different types of robots and each station must be executed by a robot. Multiple robots of the same type may be used. We propose exact and heuristic methods for minimizing the cycle time of these two problems, for a fixed number of stations. The problems have similar characteristics that are explored to produce lower bounds, heuristic methods, mixed-integer programming models, and reduction and dominance rules. For the branching strategy of the branch-and-bound method, however, the differences among the problem force the use of two different algorithms. A task-oriented strategy has the best results for the ALWABP-2 while a station-oriented strategy has the best results for the RALBP-2. The lower bounds, heuristics, MIP models and branch-and-bound algorithms for these two problems are shown to be competitive with the state-of-the-art methods in the literature.

L'engouement aujourd'hui pour la manipulation des propriétés électriques des supraconducteurs moléculaires dans le domaine des matériaux, nous a conduit à installer des gyroscopes au sein du cristal, pour que la propriété dynamique puisse moduler l'environnement électrostatique pouvant déboucher vers un nouvel ordre de charge et des structures ferroélectriques. Une machine moléculaire qui possède un rotor, un axe de rotation et des stators tel que le 1,4-diéthynylbicyclo[2,2,2]octane, a été choisie pour sa particularité à interagir avec la lumière, que l'on organise au sein du solide, sous forme de monocristaux appelés moteurs cristallins. La RMN CP/MAS sur poudre cristalline et monocristal a permis de caractériser le mouvement du rotor. Le développement d'une approche cristalline ajouté à la fonctionnalisation des rotors ont permis leur auto-assemblage et leur installation dans des architectures ouvertes organisées autour de cation métalliques (MOF,PCP,), ce qui a permis l'élaboration de matériaux multifonctionnels, dotés de la fonction dynamique, aux propriétés de conductivité ou de transition spin (SCO-MOF). Finalement, l'étude de systèmes cristallins dynamiques de basse dimentionnalité en optique non linéaire a permis de mettre en évidence le phénomène de photo-pilotage des gyroscopes par la lumière au sein du solide. le développement de systèmes plus élaborés permettra de mieux comprendre ce phénomène afin de l'utiliser dans des applications industrielles.

The isolation and identification of the active constituents from an Allium sp. extract possessing antibacterial activity was undertaken. The plant material of interest was extracted, purified and screened for antibacterial activity against a Gram positive bacteria. Multiple trials were performed and the isolation was scaled-up repeatedly, overall three compounds potentially possess the observed activity. One compound was identified to yield the majority of activity, and a refined procedure for its purification was established. Initial characterization studies demonstrated the major isolate of interest is novel compared to other isolates from the Allium genus. A ruthenium-catalyzed homo Diels-Alder [2+2+2] cycloaddition between bicyclo[2.2.1]hepta-2,5-diene and alkynyl phosphonates was also studied. The observed reactivity was found to be dependent on the presence of the phosphonate moiety. The cycloaddition was compatible with a variety of aromatic and aliphatic substituted alkynyl phosphonates providing the corresponding phosphonate substituted deltacyclenes in low to good yields (up to 88%).

Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease with no available pharmacological treatment. AAA formation reduces the structural integrity of the vessel and increases the susceptibility to rupture. The inflammatory response within human aneurysmal tissue is characterized by increased expression of cyclooxygenase-2 (COX-2). Similarly, in a mouse model of the disease induced by chronic Angiotensin II (AngII) infusion, we have shown that COX-2 expression in the abdominal aortic smooth muscle layer increases early in the development of the disease. Furthermore, genetic or pharmacological inactivation of COX-2 prior to disease initiation reduces AAA incidence. The current study utilized nonhyperlipidemic mice to determine the effectiveness of COX-2 inhibition initiated after AAA formation. COX-2 inhibitor treatment was initiated 5 days after beginning the AngII infusion, a time-point where significant aneurysmal pathology is observed. COX-2 inhibition with celecoxib significantly reduced the incidence as well as severity of AAAs as compared to the control group. Celecoxib treatment also protected the mice from aortic rupture and death. AAA development is characterized by degradation of the aortic smooth muscle layer with loss of the contractile phenotype. We found that the effectiveness of celecoxib was associated with significantly increased mRNA expression of alpha-actin, SM22alpha and desmin, all of which are markers of a differentiated smooth muscle cell phenotype. Celecoxib treatment also decreased mRNA expression of a marker of dedifferentiated smooth muscle (hyaluronic acid synthase 2). We also examined the role of altered expression of COX-2 in the increased susceptibility of the abdominal segment to AAA formation. We found a prolonged and greater induction of COX-2 in the abdominal aortic smooth muscle layer in contrast to a transient induction of COX-2 in the other regions of the aorta throughout disease progression. Overall, these findings suggest that COX-2 plays an important role in AAA development in mice, and COX-2 inhibition with celecoxib attenuates progression of aneurysm development by maintaining a differentiated phenotype in abdominal aortic smooth muscle cells.

It is essential for prey species to be able to detect predators to avoid them. The sense of smell is used by a number of prey species for this purpose. The aim of the present study was to assess if one of the odourants that make up a predator odour is sufficient to induce a behavioural response in mice (Mus musculus). Two predator odourants were used, 2,2-dimethylthietane and methyl-2-phenylethyl sulfide, which are both found in the secretions of natural predators of mice. An odourant found in fruits, n-pentyl acetate, was also used. All three odourants were presented at a concentration that was a factor of 100 above the olfactory detection threshold of mice. Ten adult predator-naïve CD-1 mice were individually put in a two-compartment chamber one of which contained an odourant while the other contained a near-odourless solvent (diethyl phthalate). The results indicated that methyl-2-phenylethyl sulfide was actively avoided by the mice. Towards 2,2-dimethylthietane and n-pentyl acetate, in contrast, the mice behaved indifferent. Further, the results suggest a significant correlation between the number of switches between the two compartments of the test chamber and the test sessions when the animals were presented with n-pentyl acetate, but not when they were presented with the predator odourants. The results support the notion of an innate fear response towards the predator odourant methyl-2-phenylethyl sulfide in mice, but further studies with more animals and different concentrations of the odourants are necessary.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.

Thesis (Ph.D.)--University of Alabama at Birmingham, 2008. / Title from first page of PDF file (viewed on June 8, 2009). Includes bibliographical references.

A diferença entre estações de trabalho é considerada desprezível em linhas de montagem tradicionais. Por outro lado, linhas de montagem heterogêneas consideram o problema de indústrias nas quais os tempos das tarefas variam de acordo com alguma característica a ser selecionada para a tarefa. No Problema de Balanceamento e Atribuição de Trabalhadores em Linhas de Montagem (do inglês Assembly Line Worker Assignment and Balancing Problem, ALWABP), os trabalhadores são responsáveis por estações de trabalho e de acordo com as suas habilidades, eles executam as tarefas em diferentes quantidades de tempo. Em alguns casos, os trabalhadores podem até ser incapazes de executar algumas tarefas. No Problema de Balanceamento de Linhas de Montagem Robóticas (do inglês Robotic Assembly Line Balancing Problem, RALBP), há diferentes tipos de robôs e o conjunto de tarefas de cada estação deve ser executada por um robô. Robôs do mesmo tipo podem ser usados múltiplas vezes. Nós propomos métodos exatos e heurísticos para a minimização do tempo de ciclo destes dois problemas, para um número fixo de estações. Os problemas têm características similares que são exploradas para produzir limitantes inferiores, métodos inferiores, models de programação inteira mista, e regras de redução e dominância. Para a estratégia de ramificação do método de branch-and-bound, entretanto, as diferenças entre os problemas forçam o uso de dois algoritmos diferentes. Uma estratégia orientada a tarefas tem os melhores resultados para o ALWABP-2, enquanto uma estratégia orientada a estações tem os melhores resultados para o RALBP-2. Nós mostramos que os limitantes inferiores, heurísticas, modelos de programação inteira mista e algoritmos de branch-and-bound para estes dois problemas são competitivos com os métodos do estado da arte da literatura. / The difference among workstations is assumed to be negligible in traditional assembly lines. Heterogeneous assembly lines consider the problem of industries in which the task times vary according to some property to be selected for the task. In the Assembly Line Worker Assignment and Balancing Problem (ALWABP), workers are assigned to workstations and according to their abilities, they execute tasks in different amounts of time. In some cases they can even be incapable of executing some tasks. In the Robotic Assembly Line Balancing Problem (RALBP) there are different types of robots and each station must be executed by a robot. Multiple robots of the same type may be used. We propose exact and heuristic methods for minimizing the cycle time of these two problems, for a fixed number of stations. The problems have similar characteristics that are explored to produce lower bounds, heuristic methods, mixed-integer programming models, and reduction and dominance rules. For the branching strategy of the branch-and-bound method, however, the differences among the problem force the use of two different algorithms. A task-oriented strategy has the best results for the ALWABP-2 while a station-oriented strategy has the best results for the RALBP-2. The lower bounds, heuristics, MIP models and branch-and-bound algorithms for these two problems are shown to be competitive with the state-of-the-art methods in the literature.

A diferença entre estações de trabalho é considerada desprezível em linhas de montagem tradicionais. Por outro lado, linhas de montagem heterogêneas consideram o problema de indústrias nas quais os tempos das tarefas variam de acordo com alguma característica a ser selecionada para a tarefa. No Problema de Balanceamento e Atribuição de Trabalhadores em Linhas de Montagem (do inglês Assembly Line Worker Assignment and Balancing Problem, ALWABP), os trabalhadores são responsáveis por estações de trabalho e de acordo com as suas habilidades, eles executam as tarefas em diferentes quantidades de tempo. Em alguns casos, os trabalhadores podem até ser incapazes de executar algumas tarefas. No Problema de Balanceamento de Linhas de Montagem Robóticas (do inglês Robotic Assembly Line Balancing Problem, RALBP), há diferentes tipos de robôs e o conjunto de tarefas de cada estação deve ser executada por um robô. Robôs do mesmo tipo podem ser usados múltiplas vezes. Nós propomos métodos exatos e heurísticos para a minimização do tempo de ciclo destes dois problemas, para um número fixo de estações. Os problemas têm características similares que são exploradas para produzir limitantes inferiores, métodos inferiores, models de programação inteira mista, e regras de redução e dominância. Para a estratégia de ramificação do método de branch-and-bound, entretanto, as diferenças entre os problemas forçam o uso de dois algoritmos diferentes. Uma estratégia orientada a tarefas tem os melhores resultados para o ALWABP-2, enquanto uma estratégia orientada a estações tem os melhores resultados para o RALBP-2. Nós mostramos que os limitantes inferiores, heurísticas, modelos de programação inteira mista e algoritmos de branch-and-bound para estes dois problemas são competitivos com os métodos do estado da arte da literatura. / The difference among workstations is assumed to be negligible in traditional assembly lines. Heterogeneous assembly lines consider the problem of industries in which the task times vary according to some property to be selected for the task. In the Assembly Line Worker Assignment and Balancing Problem (ALWABP), workers are assigned to workstations and according to their abilities, they execute tasks in different amounts of time. In some cases they can even be incapable of executing some tasks. In the Robotic Assembly Line Balancing Problem (RALBP) there are different types of robots and each station must be executed by a robot. Multiple robots of the same type may be used. We propose exact and heuristic methods for minimizing the cycle time of these two problems, for a fixed number of stations. The problems have similar characteristics that are explored to produce lower bounds, heuristic methods, mixed-integer programming models, and reduction and dominance rules. For the branching strategy of the branch-and-bound method, however, the differences among the problem force the use of two different algorithms. A task-oriented strategy has the best results for the ALWABP-2 while a station-oriented strategy has the best results for the RALBP-2. The lower bounds, heuristics, MIP models and branch-and-bound algorithms for these two problems are shown to be competitive with the state-of-the-art methods in the literature.

Résumé confidentiel / Résumé confidentiel