Xu Liang. / "June 2002." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (p. 74-82). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

潜变量模型作为处理多元数据的一种有效的方法，在行为学、教育学、社会心理学以及医学等各个领域都受到了广泛关注。在分析潜变量模型时，大多数现有的统计方法和软件都是基于响应变量为正态分布的假设。尽管一些最近发展的方法可以处理部分的非正态数据，但在分析高度非正态的数据时依然存在问题。此外，在实际研究中还经常会遇到不完全数据，如缺失数据和删失数据。简单地忽略或错误地处理不完全数据可能会严重扭曲统计结果。在本文中，我们发展了贝叶斯惩罚样条方法，同时采用马尔科夫链蒙特卡洛方法，用以分析存有高度非正态和不完全数据的变换潜变量模型。我们在变换潜变量模型中讨论了不同类型的不完全数据，如完全随机缺失数据、随机缺失数据、不可忽略的缺失数据以及删失数据。我们还利用离差信息准则来选择正确的模型和数据缺失机制。我们通过许多模拟研究论证了我们提出的方法。此方法被应用于关于工作满意度、家庭生活、工作态度的研究，以及香港地区2 型糖尿病患者心血管疾病的研究。 / Latent variable models (LVMs), as useful multivariate techniques, have attracted significant attention from various fields, including the behavioral, educational, social-psychological, and medical sciences. In the analysis of LVMs, most existing statistical methods and software have been developed under the normal assumption of response variables. While some recent developments can partially address the non-normality of data, they are still problematic in dealing with highly non-normal data. Moreover, the presence of incomplete data, such as missing data and censoring data, is a practical issue in substantive research. Simply ignoring incomplete data or wrongly managing incomplete data might seriously distort statistical influence results. In this thesis, we develop a Bayesian P-spline approach, coupled with Markov chain Monte Carlo (MCMC) methods, to analyze transformation LVMs with highly non-normal and incomplete data. Different types of incomplete data, such as missing completely at random data, missing at random data, nonignorable missing data, as well as censored data, are discussed in the context of transformation LVMs. The deviance information criterion is proposed to conduct model comparison and select an appropriate missing mechanism. The empirical performance of the proposed methodologies is examined via many simulation studies. Applications to a study concerning people's job satisfaction, home life, and work attitude, as well as a study on cardiovascular diseases for type 2 diabetic patients in Hong Kong are presented. / Detailed summary in vernacular field only. / Liu, Pengfei. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 115-127). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese. / Abstract --- p.ii / Acknowledgement --- p.v / Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Latent Variable Models --- p.1 / Chapter 1.2 --- Missing Data --- p.4 / Chapter 1.3 --- Censoring Data --- p.5 / Chapter 1.4 --- Penalized B-splines --- p.6 / Chapter 1.5 --- Bayesian Methods --- p.7 / Chapter 1.6 --- Outline of the Thesis --- p.8 / Chapter 2 --- Transformation Structural Equation Models --- p.9 / Chapter 2.1 --- Introduction --- p.9 / Chapter 2.2 --- Model Description --- p.11 / Chapter 2.3 --- Bayesian Estimation --- p.12 / Chapter 2.3.1 --- Bayesian P-splines --- p.12 / Chapter 2.3.2 --- Identifiability Constraints --- p.15 / Chapter 2.3.3 --- Prior Distributions --- p.16 / Chapter 2.3.4 --- Posterior Inference --- p.18 / Chapter 2.4 --- Bayesian Model Selection via DIC --- p.20 / Chapter 2.5 --- Simulation Studies --- p.23 / Chapter 2.5.1 --- Simulation 1 --- p.23 / Chapter 2.5.2 --- Simulation 2 --- p.26 / Chapter 2.5.3 --- Simulation 3 --- p.27 / Chapter 2.6 --- Conclusion --- p.28 / Chapter 3 --- Transformation SEMs with Missing Data that are Missing At Random --- p.43 / Chapter 3.1 --- Introduction --- p.43 / Chapter 3.2 --- Model Description --- p.45 / Chapter 3.3 --- Bayesian Estimation and Model Selection --- p.46 / Chapter 3.3.1 --- Modeling Transformation Functions --- p.46 / Chapter 3.3.2 --- Identifiability Constraints --- p.47 / Chapter 3.3.3 --- Prior Distributions --- p.48 / Chapter 3.3.4 --- Bayesian Estimation --- p.49 / Chapter 3.3.5 --- Model Selection via DIC --- p.52 / Chapter 3.4 --- Simulation Studies --- p.53 / Chapter 3.4.1 --- Simulation 1 --- p.54 / Chapter 3.4.2 --- Simulation 2 --- p.56 / Chapter 3.5 --- Conclusion --- p.57 / Chapter 4 --- Transformation SEMs with Nonignorable Missing Data --- p.65 / Chapter 4.1 --- Introduction --- p.65 / Chapter 4.2 --- Model Description --- p.67 / Chapter 4.3 --- Bayesian Inference --- p.68 / Chapter 4.3.1 --- Model Identification and Prior Distributions --- p.68 / Chapter 4.3.2 --- Posterior Inference --- p.69 / Chapter 4.4 --- Selection of Missing Mechanisms --- p.71 / Chapter 4.5 --- Simulation studies --- p.73 / Chapter 4.5.1 --- Simulation 1 --- p.73 / Chapter 4.5.2 --- Simulation 2 --- p.76 / Chapter 4.6 --- A Real Example --- p.77 / Chapter 4.7 --- Conclusion --- p.79 / Chapter 5 --- Transformation Latent Variable Models with Multivariate Censored Data --- p.86 / Chapter 5.1 --- Introduction --- p.86 / Chapter 5.2 --- Model Description --- p.88 / Chapter 5.3 --- Bayesian Inference --- p.90 / Chapter 5.3.1 --- Model Identification and Bayesian P-splines --- p.90 / Chapter 5.3.2 --- Prior Distributions --- p.91 / Chapter 5.3.3 --- Posterior Inference --- p.93 / Chapter 5.4 --- Simulation Studies --- p.96 / Chapter 5.4.1 --- Simulation 1 --- p.96 / Chapter 5.4.2 --- Simulation 2 --- p.99 / Chapter 5.5 --- A Real Example --- p.100 / Chapter 5.6 --- Conclusion --- p.103 / Chapter 6 --- Conclusion and Further Development --- p.113 / Bibliography --- p.115

Inspired by the TCGA (The Cancer Genome Atlas), we explore multimodal genomic datasets with integrative methods using a joint latent variable approach. We use iCluster+, an existing clustering method for integrative data, to identify potential subtypes within TCGA sarcoma and mesothelioma tumors, and across a large cohort of 33 dierent TCGA cancer datasets. For classication, motivated to improve the prediction of platinum resistance in high grade serous ovarian cancer (HGSOC) treatment, we propose novel integrative methods, iClassify to perform classication using a joint latent variable model. iClassify provides eective data integration and classication while handling heterogeneous data types, while providing a natural framework to incorporate covariate risk factors and examine genomic driver by covariate risk factor interaction. Feature selection is performed through a thresholding parameter that combines both latent variable and feature coecients. We demonstrate increased accuracy in classication over methods that assume homogeneous data type, such as linear discriminant analysis and penalized logistic regression, and improved feature selection. We apply iClassify to a TCGA cohort of HGSOC patients with three types of genomic data and platinum response data. This methodology has broad applications beyond predicting treatment outcomes and disease progression in cancer, including predicting prognosis and diagnosis in other diseases with major public health implications.

The dissertation includes three papers that address some theoretical and technical issues of latent variable models. The first paper extends the uniformly most powerful test approach for testing person parameter in IRT to the two-parameter logistic models. In addition, an efficient branch-and-bound algorithm for computing the exact p-value is proposed. The second paper proposes a reparameterization of the log-linear CDM model. A Gibbs sampler is developed for posterior computation. The third paper proposes an ordered latent class model with infinite classes using a stochastic process prior. Furthermore, a nonparametric IRT application is also discussed.

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (p. 139-145).

<p>Constant technology advances have caused data explosion in recent years. Accord- ingly modern statistical and machine learning methods must be adapted to deal with complex and heterogeneous data types. This phenomenon is particularly true for an- alyzing biological data. For example DNA sequence data can be viewed as categorical variables with each nucleotide taking four different categories. The gene expression data, depending on the quantitative technology, could be continuous numbers or counts. With the advancement of high-throughput technology, the abundance of such data becomes unprecedentedly rich. Therefore efficient statistical approaches are crucial in this big data era.</p><p>Previous statistical methods for big data often aim to find low dimensional struc- tures in the observed data. For example in a factor analysis model a latent Gaussian distributed multivariate vector is assumed. With this assumption a factor model produces a low rank estimation of the covariance of the observed variables. Another example is the latent Dirichlet allocation model for documents. The mixture pro- portions of topics, represented by a Dirichlet distributed variable, is assumed. This dissertation proposes several novel extensions to the previous statistical methods that are developed to address challenges in big data. Those novel methods are applied in multiple real world applications including construction of condition specific gene co-expression networks, estimating shared topics among newsgroups, analysis of pro- moter sequences, analysis of political-economics risk data and estimating population structure from genotype data.</p> / Dissertation

Object recognition is imperfect; often incomplete processing or deprived information yield misperceptions (i.e., misidentification) of objects. While quickly rectified and typically benign, instances of such errors can produce dangerous consequences (e.g., police shootings). Through a series of experiments, this study examined the competitive process of multiple object interpretations (candidates) during the earlier stages of object recognition process using a lexical decision task paradigm. Participants encountered low-pass filtered objects that were previously demonstrated to evoke multiple responses: a highly frequented interpretation (“primary candidates”) and a lesser frequented interpretation (“secondary candidates”). When objects were presented without context, no facilitative effects were observed for primary candidates. However, secondary candidates demonstrated evidence for being actively suppressed. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2017. / FAU Electronic Theses and Dissertations Collection

In medical, behavioral, and social-psychological sciences, latent variable models are useful in handling variables that cannot be directly measured by a single observed variable, but instead are assessed through a number of observed variables. Traditional latent variable models are usually based on parametric assumptions on both relations between outcome and explanatory latent variables, and error distributions. In this thesis, semiparametric models with Bayesian P-splines are developed to relax these rigid assumptions. / In the fourth part of the thesis, the methodology developed in the third part is further extended to a varying coefficient model with latent variables. Varying coefficient model is a class of flexible semiparametric models in which the effects of covariates are modeled dynamically by unspecified smooth functions. A transformation varying coefficient model can handle arbitrarily distributed dynamic data. A simulation study shows that our proposed method performs well in the analysis of this complex model. / In the last part of the thesis, we propose a finite mixture of varying coefficient models to analyze dynamic data with heterogeneity. A simulation study demonstrates that our proposed method can explore possible existence of different groups in a dynamic data, where in each group the dynamic influences of covariates on the response variables have different patterns. The proposed method is applied to a longitudinal study concerning the effectiveness of heroin treatment. Distinct patterns of heroin use and treatment effect in different patient groups are identified. / In the second part of the thesis, a latent variable model is proposed to relax the first assumption, in which unknown additive functions of latent variables in the structural equation are modeled by Bayesian P-splines. The estimation of nonparametric functions is based on powerful Markov chain Monte Carlo (MCMC) algorithm with block update scheme. A simulation study shows that the proposed method can handle much wider situation than traditional models. The proposed semiparametric latent variable model is applied to a study on osteoporosis prevention and control. Some interesting functional relations, which may be overlooked by traditional parametric latent variable models, are revealed. / In the third part of the thesis, a transformation model is developed to relax the second assumption, which usually assumes the normality of observed variables and random errors. In our proposed model, the nonnormal response variables are transformed to normal by unknown functions modeled with Bayesian P-splines. This semiparametric transformation model is shown to be applicable to a wide range of statistical analysis. The model is applied to a study on the intervention treatment of polydrug use in which the traditional model assumption is violated because many observed variables exhibit serious departure from normality. / Lu, Zhaohua. / Adviser: Xin-Yuan Song. / Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 119-130). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.

Bin Lu. / "September 2004." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (p. 118-126) / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Pan, Junhao. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2009. / Includes bibliographical references (leaves 121-135). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.