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Frutos da família Myrtaceae: Caracterização físicoquímica e potencial inibitório da atividade das enzimas digestivas / Fruits from the Myrtaceae family: Physicochemical characterization and inhibitory potencial of digestive enzimes activityPacheco, Simone Muniz 27 March 2015 (has links)
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Previous issue date: 2015-03-27 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / As espécies vegetais Campomanesia xanthocarpa (guabiroba), Eugenia uniflora
(pitanga), Eugenia pyriformis (uvaia), Psidium cattleianum (araçá) e Syzygium cumini
(jambolão) estão presentes na Floresta Atlântica e são utilizadas pela população,
para tratar diversas patologias, especialmente o diabetes melito tipo 2. Entretanto, a
eficácia destes tratamentos e o mecanismo envolvido ainda não foram totalmente
elucidados. Neste contexto, o presente estudo teve como objetivo principal avaliar o
potencial dos compostos naturais destes frutos em inibir as enzimas α-amilase e α-
glicosidase que estão envolvidas no metabolismo de carboidratos. Estes frutos
também foram avaliados físico-quimicamente, realizando-se dentre outras análises a
quantificação dos compostos fenólicos totais e a determinação da atividade
antioxidante (métodos ABTS e DPPH). Os extratos metanólicos de P. cattleianum
(acesso 44), S. cumini e E. pyriformis (acessos 11 e 15) inibiram de forma
significativa a atividade da α-amilase. Os extratos metanólicos de P. cattleianum
(acessos 44 e 87) também inibiram a atividade da α-glicosidase, utilizando-se os
substratos maltose e sacarose. Em virtude da atividade antioxidante, da elevada
quantidade de compostos fenólicos e da capacidade de inibição das enzimas
digestivas do metabolismo de carboidratos, os frutos de P. cattleianum (acessos 44
e 87), S. cumini e E. pyriformis (acessos 11 e 15) podem apresentar potencial uso
no manejo da hiperglicemia pós-prandial. / Campomanesia xanthocarpa (guabiroba), Eugenia uniflora (pitanga), Eugenia
pyriformis (uvaia), Psidium cattleianum (araçá) and Syzygium cumini (jambolão) grow
in the Brazilian Atlantic Forest and their fruits are commonly used as medicine to
treat diseases related to carbohydrate metabolism, such as diabetes. The
effectiveness of these treatments has not been demonstrated neither the biochemical
mechanism involved. Therefore this study was devised to evaluate the potential of
natural compounds of these fruits to inhibit key enzymes α-amylase and α-
glucosidase involved in the carbohydrate metabolism. The fruits were also subjected
to physicochemical characterization, quantification of phenolics compounds and
antioxidant activity (ABTS and DPPH methods). The methanolic extracts of P.
cattleianum (access 44), S. cumini, E. pyriformis (accesses 11 and 15) distinctively
inhibited α-amylase activity. The methanolic extracts of P. cattleianum. (accesses 44
and 87) also inhibited α-glycosidase activity, with either maltose or sucrose as
substrate. By having antioxidant activities, a fairly content of phenolic compounds,
and capacity to inhibit carbohydrate digestive enzymes, P. cattleianum (access 44
and 87), S. cumini and E. pyriformis (accesses 11 and 15) could be good candidates
to be used in the management of postprandial hyperglycemia.
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Evaluation of the antioxidant and anti-diabesity potential of cyclopia maculata using in vitro non-cell based screening modelsMatrose, Albertina Neliswa January 2014 (has links)
Masters of Science / The aim of this study was therefore to evaluate the antioxidant and anti-diabesity potential of a hot water extract of C. maculata in non-cell based assays and correlate the activities with phenolic composition. Total antioxidant capacity (TAC) was assessed in terms of free radical scavenging and iron reducing ability. The DPPH, ABTS, ORAC and FRAP assays were employed. Anti-diabesity potential was assessed in terms of the inhibition of the digestive enzymes, α-glucosidase and pancreatic lipase
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