京都大学 / 0048 / 新制・課程博士 / 博士(生命科学) / 甲第20821号 / 生博第390号 / 新制||生||51(附属図書館) / 京都大学大学院生命科学研究科高次生命科学専攻 / (主査)教授 垣塚 彰, 教授 米原 伸, 教授 松田 道行 / 学位規則第4条第1項該当 / Doctor of Philosophy in Life Sciences / Kyoto University / DFAM

It was generally accepted that dopamine receptors D1 (D1R)- and D2 (D2R)-expressing neurons are homogeneously and randomly distributed throughout the striatum. However, in reporter transgenic mice, the specific subregions of the caudal lateral striatum have been reported: the D1R-poor zone, in which D2R-expressing neurons are predominant, and the D2R-poor zone, in which D1R-expressing neurons are predominant. The present study demonstrated the presence of these distinct subregions not only in rodents but also in marmosets using endogenous dopamine receptors. We also showed that direct pathway medium spiny neurons in these distinct subregions preferentially project to parvalbumin-positive GABAergic neurons in the dorsal part of the substantia nigra pars lateralis. / 博士(理学) / Doctor of Philosophy in Science / 同志社大学 / Doshisha University