591 |
Acute Effects Of Cycling On Sensory And Motor Function In Parkinson's DiseaseJonas, Jay C. 23 August 2018 (has links)
No description available.
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592 |
<i>Caenorhabditis elegans</i> RHGF-2 is Required for Embryonic Elongation and Co-localizes <i>in vivo</i> with the PDZ-domain Containing Scaffold Protein MPZ-1Tran, Thuy L. 09 July 2012 (has links)
No description available.
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593 |
The Effect of Vision Therapy on Adult Symptomatic Convergence Insufficiency Subjects: A Functional Magnetic Resonance Imaging StudyWidmer, Douglas E. 09 August 2016 (has links)
No description available.
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594 |
Generation, Characterization, Standardization and Utility of a Zebrafish Model of Glioblastoma.Welker, Alessandra M., Welker 22 November 2016 (has links)
No description available.
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595 |
Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon RegenerationNiemi, Jon Paul 08 February 2017 (has links)
No description available.
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596 |
Co-transplantation of Endothelial Progenitor Cells and Neural Progenitor Cells for Treating Ischemic Stroke in a Mouse ModelWang, Jinju 22 August 2016 (has links)
No description available.
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597 |
Dynamic Modulation of Acid-Sensing Ion Channels: Critical Factors in Acidotoxic Neuronal DeathSherwood, Thomas Walworth 17 December 2010 (has links)
No description available.
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598 |
Motors Involved in Neurofilament TransportWang, Lina 16 December 2011 (has links)
No description available.
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599 |
CELF Control in the NeuronJones, Devin January 2022 (has links)
CELF4 is a brain-specific member of the CELF RNA binding protein (RBP) family that binds a significant portion of the transcriptome with striking selectivity for the 3’UTR of neuronal and synapse-specific functional targets in the hippocampus. Celf4 knockout and haploinsufficient mice have a complex neurobehavioral phenotype similar to human patient groups identified with CELF4 mutations, specifically CELF4-inclusive deletions and translocations.
We hypothesize that CELF4 operates in multiple aspects of post-transcriptional gene regulation; interacting with RNA molecules from synthesis to decay. Tissue-level ribosome profiling experiments demonstrate that loss of CELF4 results in global ribosome occupancy changes across CELF4 mRNA targets and refined our ability to interrogate the synaptic function of CELF4. Turning intra-cellularly, a snRNA-seq approach implicated the CA3 region of the hippocampus in CELF4-mediated mRNA regulation and identified synaptic targets regulated by CELF4.
By leveraging both ribosome profiling footprinting and snRNA-seq differential gene expression data, we identified synaptic and epilepsy disease genes that contribute to, and drive, neurobehavioral phenotypes. In part two of this work we focus on DEE disease gene DNM1, a known target of CELF4 at the synapse. Using in vitro and in vivo approaches, we validate the regulatory relationship between mouse Dnm1 RNA and CELF4 RBP function. Lastly, we introduce a novel preclinical model of DNM1 DEE that recapitulates the seizure and behavioral phenotypes of patients suffering from dominant negative DNM1 mutations. In characterization of this model, we lay the groundwork for future investigations of cellular etiology of DNM1 pathogenic variants and therapeutic development for patient groups suffering from DEE.
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600 |
The Effects of Satiety-state Neuromodulation on Predatory Hunting Behaviors and CNS Sensorimotor Processing in the Praying Mantis, Tenodera sinensisBertsch, David J. 20 September 2021 (has links)
No description available.
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