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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Hur tillförlitligt är det medicinska beslutsstödet vid bedömningav allvarliga tillstånd med akut buksmärta? : En journalgranskning i Uppsala län

Hallberg, Anna January 2013 (has links)
Sedan oktober 2011 sköter Sjukvårdens Larmcentral, SvLC, utalarmeringen av akuta sjukdomsfall som inkommer vid 112-samtal. Samtidigt infördes ett nytt medicinskt beslutsstöd för de sjuksköterskor som tar emot de akuta samtalen. Då orsaken till buksmärta är komplext och svårt att identifiera hos patienterna valdes just detta tillstånd för granskning. Syfte: Att undersöka om det medicinska beslutsstödet för sjuksköterskorna på SvLC i Uppsala län är en tillförlitlig hjälp i identifieringen av patienter med akuta buksmärtor, samt att undersöka om det fanns ålder-eller könsskillnader. Metod: En empirisk kvantitativ studie med en retrospektiv journalgranskning. Sammanlagt 151 patienter som ringt ambulans på grund av buksmärta och som av larmcentralen prioriterats som livshotande (prioritet 1) eller brådskande (prioritet 2) har granskats. Resultat: SvLC´s initiala bedömningar stämde väl överens med de prehospitala bedömningar sjuksköterskan i ambulans gjorde. Hos prio1-gruppen hade 48 % diagnostiserats buksmärta UNS, det vill säga buksmärta utan närmare specifikation, och hos prio 2-gruppen var det 40 % som fått samma diagnos. I denna undersökning kunde inga allvarliga brister identifieras i det nya medicinska beslutssystemet gällande akuta buksmärtor i Uppsala län, och inga signifikanta ålder-eller könsskillnader kunde hittas. Mer studier skulle behövas för att öka träffsäkerheten gällande resultatet i detta ämne och fler patienter skulle behöva involveras för att ”fånga upp” eventuella brister i detta medicinska beslutssystem. / Since October 2011 Sjukvårdens Larmcentral (SvLC) take care of emergency calls. At the same time new decision support tool for nurses that receive the emergency calls was introduced, andit was of interest to find out if there are flaws in the emergency call- system. Since the cause of abdominal pain in patients is a complex and difficult to identify this specific condition was chosen for this study. Aim: To examine whether the new medical decision support for patients with acute abdominal pain after the introduction of the new medical decision- making aid is a reliable working aid. Method: An empirical quantitative study with retrospective review of patients records. Totally 151 patients who called ambulance due to abdominal pain and that the emergency call- center prioritized as life-threatening (priority 1) or urgent (priority 2) has been reviewed. Result: SvLC´s initial evaluation tallied well with the prehospital assessment the nurse in ambulance did. In the prio 1-group 48% diagnosed abdominal pain NOS, that is to say “Not Otherwise Specified”, and in prio 2 group 40% received the same diagnosis. In this investigation, no serious flaws identified in the new medical decision support regarding acute abdominal pain in Uppsala county, and no significant..... More studies would be needed to increase accuracy on the results in this topic and more patients would need to be involved in order to “capture” any deficiencies in this medical decision systems.
22

Diagnostik des chronischen Unterbauchschmerzes

Nagel, Michael, Wehrmann, Ursula, Ringelband, Barbara 19 February 2014 (has links) (PDF)
Der chronische Unterbauchschmerz stellt den behandelnden Arzt vor erhebliche differentialdiagnostische Probleme. Die vorgestellte Studie soll den Wert der Laparoskopie im diagnostischen Konzept aufzeigen. Dazu führten wir zwischen Oktober 1993 und Juni 1998 bei 100 Patienten mit der klinischen Diagnose «chronischer Unterbauchschmerz» eine Laparoskopie durch. Bei 14 Patienten ließ sich ein morphologisches Korrelat unabhängig von der Appendix finden. 86 Patienten wurden appendektomiert, wobei die histologische Untersuchung des Präparats in 82 Fällen (95,3%) einen pathologischen Befund aufwies. 80 Patienten (93%) blieben auch während der Nachuntersuchungen beschwerdefrei. Die Laparoskopie stellt ein sicheres Verfahren zur Diagnostik und Behandlung chronischer Unterbauchschmerzen dar. Bei fehlendem Korrelat für die Beschwerden sollte in gleicher Sitzung die laparoskopische Appendektomie durchgeführt werden. / The differential diagnosis chronic lower abdominal pain can be problematic, and this symptom may lead to several diagnostic procedures. The purpose of this study was to evaluate the usefulness of laparoscopy in the diagnostic concept. From October 1993 to June 1998 we performed 100 laparoscopies in patients with chronic or recurrent lower abdominal pain. In 14 patients we found a substrate for the reported pain, which was independent of the appendix. In 86 patients we performed an appendectomy. In 62 of the specimens (95.3%) the histological study showed pathological findings. 80 patients (93%) reported no further complaints during follow-up. Laparoscopy is a safe procedure for diagnostics and treatment of patients with chronic lower abdominal pain. If no other explanation for the symptoms is found, laparoscopic appendectomy should be performed. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
23

Ūminio pilvo skausmo klinikinių charakteristikų ir veiksnių, lemiančių efektyvų skausmo malšinimą, tyrimas / Study on clinical characteristics of acute abdominal pain and factors influencing effective pain management

Stašaitis, Kęstutis 04 September 2014 (has links)
Skausmo malšinimas yra nenauja ir iki šiol aktuali problema visame pa¬saulyje, o oligoanalgezijos reiškinys, deja, yra taip pat dažnas. Mokslininkai atliko ne viena studiją ir pasiūlė būdus, kaip galima būtų išgyvendinti šį reiškinį, tačiau skausmo gydymo rekomendacijų diegimas neduoda reikiamo efekto. Tikėtina, kad nusi¬stovėjusios vietos tradicijos ar žmonių požiūris gali lemti, tai, kad įrodymais grįstos rekomendacijos yra nepilnai pritaikomos praktikoje. Todėl šiame tyrime ieškoma svarbių ūminio nediferencijuoto pilvo skausmo, klinikinių skausmo charakteristikų ir veiksnių, lemiančių ūminio pilvo skausmo efektyvų gydymą universitetinės ligo¬ninės skubios pagalbos skyriuje. Tyrimo uždaviniai: 1. Ištirti pacientų, patiriančių ūminį nediferencijuotą pilvo skausmą, klinikines skausmo charakteristikas atvykstant ir išvykstant iš universitetinės ligoninės skubios pagalbos skyriaus. 2. Įvertinti ūminio pilvo skausmo malšinimo tendencijas universite¬tinės ligoninės skubios pagalbos skyriuje ir palyginti jas su šalyje galiojančiomis rekomendacijoms. 3. Nustatyti skirtumus tarp paciento subjektyvaus pilvo skausmo stip¬ru¬mo vertinimo ir slaugytojų bei gydytojų paciento patiriamo skaus¬mo stiprumo vertinimo. 4. Ištirti stipriųjų analgetikų (morfino) poveikį neaiškios kilmės ūminio pilvo skausmo malšinimui skubios pagalbos skyriuje ir paly¬ginti jo efektyvumą su nesteroidinių vaistų nuo uždegimo (diklo¬fenako) ar placebo. / The problem of pain is not new, it remains an important global issue, and a phenomenon of oligoanalgesia, unfortunately, is also common. Different researchers conducted studies and suggested different ways to eradi¬cate this phenomenon. However, the question why patients with acute abdominal pain are treated inadequately, even with clear evidence that the treatment will not cause any adverse effects so far remains unanswered. Researchers of this study have hypothesis that the well-established local tradition or people's attitudes can lead to the fact that evidence-based guidelines are not fully applied in practice. This study investigates clinical characteristics of pain in patients with acute undifferentiated abdominal pain and to identify the factors influencing effective management of acute abdominal pain in the ED at university hospital. Objectives of the study 1. To investigate clinical characteristics of pain in patients with acute undifferentiated abdominal pain upon arrival and departure from the ED at university hospital. 2. To evaluate the trends of acute abdominal pain relief in the ED at university hospital and to compare them with current guidelines. 3. To identify differences in subjective pain intensity rating between patients with abdominal pain and assessment of nurses and doctors. 4. To investigate effect of strong analgesic drugs (morphine) for acute abdominal pain management in the ED and compare their efficacy versus NSAIDs (diclofenac) or placebo.
24

Acute Abdominal Pain

Laurell, Helena January 2006 (has links)
The aim was to identify diagnostic difficulties for acute abdominal pain at the emergency department and during hospital stay. A total of 3349 patients admitted to Mora Hospital with acute abdominal pain of up to seven days duration, were registered prospectively for history and clinical signs according to a structured schedule. The preliminary diagnosis from the attending physician at the emergency department, any investigations or surgery and final diagnosis were registered at a follow-up after at least one year. There were no differences in diagnostic performance between physicians with 0.5 to 5 years of medical experience. The information collected and a careful examination of the patient was more important than formal competence. The main differential diagnostic problem was non-specific abdominal pain; this was the same for diagnoses requiring surgery. Patients originally diagnosed as not needing surgery had a median delay before operation of 22 hours (mean 40 hours, with 95% confidence interval of 30-50 hours), compared to 8 hours (mean 15 hours, 95% confidence interval of 12-28 hours) for patients with the same final follow-up diagnosis as the preliminary diagnosis. Constipation was a diagnostic pitfall, as 9% of the patients considered constipated required surgery for potentially life threatening reasons and 8% were later found to have an abdominal malignancy. Both the preliminary diagnosis and the discharge diagnosis were less reliable for elderly patients than for younger patients. Elderly patients often had specific organ disease and arrived at the emergency department after a longer history of abdominal pain. This study confirms that assessment of suspected appendicitis can still be based on clinical judgements combined with laboratory tests. Classical clinical findings indicating localised inflammation, such as isolated pain in the right iliac fossa, rebound tenderness, right-sided rectal tenderness, pain migration to the right iliac fossa, local guarding and aggravation of pain when moving, were reliable for predicting acute appendicitis. A CT scan can be saved for the more equivocal cases of acute abdominal pain. A generous strategy regarding CT scan among elderly patients with acute abdominal pain, even in the absence of pronounced signs of an inflammatory intra-abdominal process, is recommended.
25

Alverin sitrat&simetikon kombinasyonlu gaz giderici ajanın radyolojik incelemeler öncesi kullanılmasının tetkiklerin tanısal kalitesine etkisi /

Güner, Anıl. Oyar, Orhan. January 2006 (has links) (PDF)
Tez (Tıpta Uzmanlık) - Süleyman Demirel Üniversitesi, Tıp Fakültesi, Radyodiagnostik Anabilim Dalı, 2006. / Bibliyografya var.
26

Kronik karın ağrılı çocuklarda helicobacter pylori enfeksiyonu /

Hekimoğlu, Ümran. Örmeci, Ahmet Rıfat. January 2002 (has links) (PDF)
Tez (Tıpta Uzmanlık) - Süleyman Demirel Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, 2002. / Bibliyografya var.
27

Aplicabilidade Clínica do Teste de Sobrecarga de Água em Crianças com Dor Abdominal Crônica e Dispepsia / Clinical applicability of water load test in children with chronic abdominal pain and dyspepsia

Hercos, Gabriela Nascimento 25 July 2018 (has links)
Submitted by GABRIELA NASCIMENTO HERCOS (ghercos@hotmail.com) on 2018-07-30T13:42:48Z No. of bitstreams: 1 WLT DISSERTAÇÃO FINAL PARA REPOSITÓRIO.pdf: 2479083 bytes, checksum: cd2c2572fc69fad4a63148cf6359bebc (MD5) / Approved for entry into archive by Sulamita Selma C Colnago null (sulamita@btu.unesp.br) on 2018-07-31T12:42:04Z (GMT) No. of bitstreams: 1 hercos_gn_me_bot.pdf: 2479083 bytes, checksum: cd2c2572fc69fad4a63148cf6359bebc (MD5) / Made available in DSpace on 2018-07-31T12:42:04Z (GMT). No. of bitstreams: 1 hercos_gn_me_bot.pdf: 2479083 bytes, checksum: cd2c2572fc69fad4a63148cf6359bebc (MD5) Previous issue date: 2018-07-25 / Hercos GN. Aplicabilidade clínica do teste de sobrecarga de água em crianças com dor abdominal crônica e dispepsia. [Dissertação]. Botucatu: Hospital das Clínicas da Faculdade de Medicina de Botucatu:- Universidade Estadual Paulista UNESP, 2018. Introdução. A ingestão está associada a mudanças no controle motor gástrico, como o armazenamento inicial da refeição, através do reflexo da acomodação gástrica, seguido de esvaziamento a uma taxa que corresponde à capacidade de absorção do intestino delgado. Alteração nos receptores sensoriais ou na função da via neural pode resultar em maior sensibilidade visceral, podendo resultar em dor. O Teste de Sobrecarga de Água é proposto para avaliar a acomodação e a sensibilidade visceral. O objetivo do estudo foi: determinar a aplicabilidade do teste de sobrecarga de água como um instrumento na investigação de crianças com Dor Abdominal Crônica, avaliando se seria discriminatório para crianças com dor de origem orgânica ou funcional e com e sem dispepsia. Métodos. Estudo prospectivo, transversal de pacientes com Dor Abdominal Crônica. Critérios de Inclusão: idade de 7 a 15 anos; Dor Abdominal Crônica conforme critérios de Apley; diagnóstico de Dor Abdominal Crônica Funcional segundo Critérios de Roma IV; diagnóstico Dor Abdominal Crônica de etiologia orgânica realizado de acordo com os métodos e critérios padrões utilizados na pratica clínica. Critérios de exclusão foram: doença crônica genética, neurológica, metabólica, renal, hepática, infecciosa, hematológica, cardiovascular, ou doença pulmonar, história de hemorragia gastrintestinal prévia ou cirurgia abdominal. Procedimentos: durante a primeira consulta foram coletados dados clínicos, antropométricos. Na segunda consulta foi realizado o Teste de Sobrecarga de Água e a aplicação de um Escore Clínico de Sintomas Dispépticos durante e após o teste. Todos os dados foram compilados utilizando-se o programa estatístico GraphPad Prism versão 7.00. Os testes estatísticos foram bicaudais e o nível de significância considerado em p <0,05. Resultados: Foram avaliadas 83 crianças com DAC, sendo 55 com DAC Funcional e 28 com DAC Orgânica (44 do subgrupo Dispepsia, dos quais 18 com Dispepsia Funcional e 26 com Dispepsia Orgânica). Não houve diferença estatisticamente significativa quanto as variáveis antropométricas entre os subgrupos de DAC. O Escore Clínico de Sintomas Dispépticos foi significativamente maior no subgrupo DAC Orgânica e no subgrupo Dispepsia. Não houve diferença no Volume Máximo Tolerado entre os diferentes subgrupos de DAC. Crianças maiores de 10 anos e do sexo masculino toleraram volume maior de água. Houve correlação positiva entre Volume Máximo Tolerado e Escore Clínico de Sintomas Dispépticos no subgrupo Não Dispepsia 30 minutos após o teste. Observou- se correlação positiva entre Volume Máximo Tolerado e o peso, estatura e IMC para os diferentes subgrupos. Discussão e conclusão: o teste de Sobrecarga de Água não mostrou poder discriminatório entre os diferentes subtipos de DAC. Provavelmente a não inibição do esvaziamento gástrico com refeição teste com água tenha impedido a retenção adequada para desencadear um defeito na acomodação gástrica. Palavras chave: Teste de Sobrecarga de Água; Dor Abdominal Crônica; Dispepsia; Criança / Introduction. Ingestion is associated with changes in gastric motor control, such as primary storage of the meal through the reflex of gastric accommodation, followed by emptying at a rate that corresponds to the absorption capacity of the small intestine. Alteration in sensory receptors or neural pathway function may result in increased visceral sensitivity and may result in pain. The Water Load Test (WLT) is proposed to assess gastric accommodation and visceral sensitivity. Objective: to determine the applicability of the WLT as an instrument for the investigation children with Chronic Abdominal Pain (CAP), evaluating whether it would be discriminatory for children with the pain of organic or functional origin and with and without dyspepsia. Methods. Prospective, cross-sectional study of patients with CAP. Inclusion Criteria: age between 7-15 years; CAP according to Apley criteria; diagnosis of Functional Abdominal Pain according to Rome IV Criteria; diagnosis of organic CAP performed according to the standard methods and approaches used in clinical practice. Exclusion criteria: chronic genetic, neurological, metabolic, renal, hepatic, infectious, hematological, cardiovascular or pulmonary disease, history of previous gastrointestinal bleeding or abdominal surgery. Procedures: During the first visit, clinical and anthropometric data were collected. During the second visit, the WLT and the Clinical Dyspepsia Symptoms Score were performed during and after the test. All data were compiled using the statistical program GraphPad Prism version 7.00. The statistical tests were two-tailed and the level of significance considered at p <0.05. Results: 83 children with CAP were evaluated, 55 with functional CAP and 28 with organic CAP (44 dyspepsia, of which 18 with functional and 26 with organic dyspepsia). There was no statistical difference in the anthropometric variables between the subgroups of CAP. The Clinical Dyspepsia Symptoms Score was significantly higher in the CAP Organic and Dyspepsia subgroup. There was no difference in Maximum Tolerated Volume (MTV) between the different subgroups of CAP. Children older than ten years and males had more MTV. There was a positive correlation between MTV and Clinical Dyspepsia Symptoms Score in the No Dyspepsia subgroup 30 minutes after the test. There was a positive correlation between MTV and weight, height and BMI for the different subgroups. Discussion and conclusion: WLT did not show discriminatory power between the different subtypes of CAP. Probably not inhibiting gastric emptying with a test meal with water has prevented adequate retention to trigger a defect in gastric accommodation. Keywords: Water Load test; Chronic abdominal pain; Dyspepsia; Children.
28

Aplicabilidade Clínica do Teste de Sobrecarga de Água em Crianças com Dor Abdominal Crônica e Dispepsia

Hercos, Gabriela Nascimento January 2018 (has links)
Orientador: Nilton Carlos Machado / Resumo: Hercos GN. Aplicabilidade clínica do teste de sobrecarga de água em crianças com dor abdominal crônica e dispepsia. [Dissertação]. Botucatu: Hospital das Clínicas da Faculdade de Medicina de Botucatu:- Universidade Estadual Paulista UNESP, 2018. Introdução. A ingestão está associada a mudanças no controle motor gástrico, como o armazenamento inicial da refeição, através do reflexo da acomodação gástrica, seguido de esvaziamento a uma taxa que corresponde à capacidade de absorção do intestino delgado. Alteração nos receptores sensoriais ou na função da via neural pode resultar em maior sensibilidade visceral, podendo resultar em dor. O Teste de Sobrecarga de Água é proposto para avaliar a acomodação e a sensibilidade visceral. O objetivo do estudo foi: determinar a aplicabilidade do teste de sobrecarga de água como um instrumento na investigação de crianças com Dor Abdominal Crônica, avaliando se seria discriminatório para crianças com dor de origem orgânica ou funcional e com e sem dispepsia. Métodos. Estudo prospectivo, transversal de pacientes com Dor Abdominal Crônica. Critérios de Inclusão: idade de 7 a 15 anos; Dor Abdominal Crônica conforme critérios de Apley; diagnóstico de Dor Abdominal Crônica Funcional segundo Critérios de Roma IV; diagnóstico Dor Abdominal Crônica de etiologia orgânica realizado de acordo com os métodos e critérios padrões utilizados na pratica clínica. Critérios de exclusão foram: doença crônica genética, neurológica, metabólica, renal, hepática, ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction. Ingestion is associated with changes in gastric motor control, such as primary storage of the meal through the reflex of gastric accommodation, followed by emptying at a rate that corresponds to the absorption capacity of the small intestine. Alteration in sensory receptors or neural pathway function may result in increased visceral sensitivity and may result in pain. The Water Load Test (WLT) is proposed to assess gastric accommodation and visceral sensitivity. Objective: to determine the applicability of the WLT as an instrument for the investigation children with Chronic Abdominal Pain (CAP), evaluating whether it would be discriminatory for children with the pain of organic or functional origin and with and without dyspepsia. Methods. Prospective, cross-sectional study of patients with CAP. Inclusion Criteria: age between 7-15 years; CAP according to Apley criteria; diagnosis of Functional Abdominal Pain according to Rome IV Criteria; diagnosis of organic CAP performed according to the standard methods and approaches used in clinical practice. Exclusion criteria: chronic genetic, neurological, metabolic, renal, hepatic, infectious, hematological, cardiovascular or pulmonary disease, history of previous gastrointestinal bleeding or abdominal surgery. Procedures: During the first visit, clinical and anthropometric data were collected. During the second visit, the WLT and the Clinical Dyspepsia Symptoms Score were performed during and after the test. All data w... (Complete abstract click electronic access below) / Mestre
29

Dor abdominal crônica, dispepsia não ulcerosa e infecção pelo Helicobacter pylori em crianças e adolescentes

Silva, Renato Guilherme Silveira Corrêa [UNESP] 21 February 2014 (has links) (PDF)
Made available in DSpace on 2015-01-26T13:21:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-21Bitstream added on 2015-01-26T13:30:41Z : No. of bitstreams: 1 000795830.pdf: 1301123 bytes, checksum: dd46c160f8713c2ba8ea458e84fbc405 (MD5) / Objetivo: Investigar através de estudo observacional, se o uso de características clínicas detalhadas de crianças e adolescentes com dor abdominal crônica (DAC) e dispepsia não ulcerosa possa auxiliar na identificação de pacientes infectados pelo Helicobacter pylori (H. pylori). Casuística e Métodos: Foi investigado um total de 721 novos casos consecutivos de crianças e adolescentes com DAC, destes foram incluídos no estudo 240 pacientes com critérios clínicos para dispepsia não ulcerosa e sugestiva de doença orgânica. Os dados foram colhidos utilizando protocolos clínicos, laboratoriais, endoscópicos e histopatológicos padronizados. Resultados: Foram identificadas 123 crianças infectadas pelo H. pylori, sendo 76 com pangastrite (61,7%) e 47 com gastrite antral (38,3%). Crianças com pangastrite apresentaram tempo de evolução da dor maior de 12 meses significantemente mais frequente do que aquelas com gastrite antral (p<0,05). Os sintomas dispépticos não diferiram entre gastrite antral e pangastrite. Foi observada associação positiva entre infecção por H. pylori e náusea (p<0,05). O grupo de pacientes não infectados por H. pylori apresentou dor retroesternal mais frequentemente do que os pacientes infectados por H. pylori (p<0,05). Não houve associação entre as variáveis demográficas e infecção por H. pylori. Conclusões: A prevalência de infecção por H. pylori foi alta entre crianças dispépticas, mas pouco associada a sintomas gastrointestinais específicos / Aims: To investigate if the use of refined clinical characteristics of chronic abdominal pain can identify patients for further investigation of Helicobacter pylori (H. pylori) infection. An observational study on children and adolescents with chronic non-ulcer dyspepsia was performed to investigate the potential association between specific gastrointestinal symptoms and H. pylori infection. The hypothesis was that the use of demographics and clinical data with defined criteria for chronic abdominal pain (CAP) and dyspeptic syndrome, could be of help in identifying patients with H. pylori infection. Methods: A cohort of 721 consecutive new cases of children and adolescents with CAP were investigated. Of them, 240 with clinical criteria for chronic non-ulcer dyspeptic syndrome and suggestive of organic underlying disease were enrolled into the study. Data were collected by using standardized demographic, clinical laboratory, endoscopic and histopathological protocols. Results: H. pylori infection was identified in 123 children (52%), being 76 with pangastritis (61.7%) and 47 with antral gastritis (38.3%). Symptoms duration longer than 12 months was significantly more frequent in children with pangastritis than in those with antral gastritis (p< 0.05). Dyspeptic symptoms did not differ between antral predominant and pangastritis. A significant association was observed between nausea and H. pylori infection (p<0.03). Retrosternal pain was significantly more frequent in the non-infected group (p<0.05) than in patients with H. pylori infection. No association between demographic variables and H. pylori infection was found. Conclusions: The prevalence of H. pylori infection was high among children with dyspepsia, but poorly associated with specific gastrointestinal symptoms
30

Dor abdominal crônica, dispepsia não ulcerosa e infecção pelo Helicobacter pylori em crianças e adolescentes /

Silva, Renato Guilherme Silveira Corrêa. January 2014 (has links)
Orientador: Maria Aparecida Marchesan Rodrigues / Banca: Gisela Alborghetti Nai / Banca: Francisco de Agostinho Júnior / Resumo: Objetivo: Investigar através de estudo observacional, se o uso de características clínicas detalhadas de crianças e adolescentes com dor abdominal crônica (DAC) e dispepsia não ulcerosa possa auxiliar na identificação de pacientes infectados pelo Helicobacter pylori (H. pylori). Casuística e Métodos: Foi investigado um total de 721 novos casos consecutivos de crianças e adolescentes com DAC, destes foram incluídos no estudo 240 pacientes com critérios clínicos para dispepsia não ulcerosa e sugestiva de doença orgânica. Os dados foram colhidos utilizando protocolos clínicos, laboratoriais, endoscópicos e histopatológicos padronizados. Resultados: Foram identificadas 123 crianças infectadas pelo H. pylori, sendo 76 com pangastrite (61,7%) e 47 com gastrite antral (38,3%). Crianças com pangastrite apresentaram tempo de evolução da dor maior de 12 meses significantemente mais frequente do que aquelas com gastrite antral (p<0,05). Os sintomas dispépticos não diferiram entre gastrite antral e pangastrite. Foi observada associação positiva entre infecção por H. pylori e náusea (p<0,05). O grupo de pacientes não infectados por H. pylori apresentou dor retroesternal mais frequentemente do que os pacientes infectados por H. pylori (p<0,05). Não houve associação entre as variáveis demográficas e infecção por H. pylori. Conclusões: A prevalência de infecção por H. pylori foi alta entre crianças dispépticas, mas pouco associada a sintomas gastrointestinais específicos / Abstract: Aims: To investigate if the use of refined clinical characteristics of chronic abdominal pain can identify patients for further investigation of Helicobacter pylori (H. pylori) infection. An observational study on children and adolescents with chronic non-ulcer dyspepsia was performed to investigate the potential association between specific gastrointestinal symptoms and H. pylori infection. The hypothesis was that the use of demographics and clinical data with defined criteria for chronic abdominal pain (CAP) and dyspeptic syndrome, could be of help in identifying patients with H. pylori infection. Methods: A cohort of 721 consecutive new cases of children and adolescents with CAP were investigated. Of them, 240 with clinical criteria for chronic non-ulcer dyspeptic syndrome and suggestive of organic underlying disease were enrolled into the study. Data were collected by using standardized demographic, clinical laboratory, endoscopic and histopathological protocols. Results: H. pylori infection was identified in 123 children (52%), being 76 with pangastritis (61.7%) and 47 with antral gastritis (38.3%). Symptoms duration longer than 12 months was significantly more frequent in children with pangastritis than in those with antral gastritis (p< 0.05). Dyspeptic symptoms did not differ between antral predominant and pangastritis. A significant association was observed between nausea and H. pylori infection (p<0.03). Retrosternal pain was significantly more frequent in the non-infected group (p<0.05) than in patients with H. pylori infection. No association between demographic variables and H. pylori infection was found. Conclusions: The prevalence of H. pylori infection was high among children with dyspepsia, but poorly associated with specific gastrointestinal symptoms / Mestre

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