Thesis (M.S.)--University of Wisconsin--Madison, 1983. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 24-28).

Thesis (M.S.)--University of Wisconsin--Madison, 1981. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 65-69).

Inaug.-Diss.--Zürich. / At head of title: Aus der Universitätsfrauenklinik, Zürich. Curriculum vitae. Bibliography: p. 107-111.

Habilitationsschrift--Universität-Münster Westfalen. English summary.

Thesis (M.S.)--University of Wisconsin--Madison. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 37-41).

Bibliography: pages 195-202. / This study is an investigation of some psycho-social implications in adulthood of being born with a congenital anomaly. The congenital anomalies - oesophageal atresia, Hirschsprung's disease and high anorectal malformations are surgically corrected at birth, but can be associated with residual problems. These problems could put patients at risk for psycho-social maladjustment. The three anomaly groups were seen to represent varying degrees of severity. The oesophageal atresia respondents represented the no to mild disability/residual problems group. Those who had Hirschsprung's disease represented the moderate disability/residual problem group. The high anorectal malformation respondents' represented the severe disability/residual problem group. The research hypothesis is that the severity of residual problems and psycho-social functioning will be directly proportional to each other, i.e. the more severe the handicap, the poorer the psycho-social functioning. A research study was conducted on 38 adult patients whose congenital anomalies were surgically corrected at The Red Cross War Memorial Children's Hospital. The research methods used were a descriptive survey method and a case-study method. The former involved three self-administered questionnaires. Information obtained concerned demographic, socio-economic, family background, medical and psycho-social problem data. An in-depth case-study was conducted with one respondent from each anomaly group. Information was obtained concerning the effect that residual problems had had on various aspects of patients' lives. Data was analysed descriptively. The findings of the study supported the research hypothesis, the medical prognosis and on the whole agreed with the literature. Severity of residual problems was found to be directly related to psycho-social functioning. Patients with severe disability/residual problems were experiencing the most psycho-social problems, those who had moderate disability/residual problems were found to have some psycho-social disability/residual problems, whereas those with mild disability/residual problems were found to have few or no psycho-social problems. Self-esteem, depression, interpersonal relationships and restricted social functioning were the psycho-social aspects found to be most affected by residual problems. The study revealed gaps in both medical and social work services for these patients in terms of ongoing follow-up services. Recommendation to improve these services have been proposed.

Thesis (M.A.)--Carleton University, 1981. / Also available in electronic format on the Internet.

Issued also as thesis, Zurich. / Includes bibliographical references (p. 108).

Thalidomide was discovered to be teratogenic over 50 years ago, but is far from being a historical problem. A new generation of thalidomide survivors have been reported in Brazil, where the drug is used to treat leprosy complications and multiple myeloma. The mechanisms underlying thalidomide teratogenesis are not fully understood. Cereblon (CRBN) protein has been identified as a target of thalidomide. Cereblon is part of an E3 ubiquitin ligase complex with Damaged DNA Binding protein 1 and Cullin-4A. I have analysed the expression patterns of CRBN and its binding partners in wildtype and thalidomide-treated chicken and zebrafish embryos. My results show that CRBN complex genes are weakly expressed in multiple tissues, including those not affected by thalidomide, and do not change following thalidomide exposure. I have also investigated the teratogenic potential of Primodos, a drug claimed to be “the forgotten thalidomide”. This drug was used as a pregnancy test between 1950's and 1970's. Primodos is alleged to be teratogenic but still is not recognised as one. Several epidemiological studies have been conducted, with conflicting results. I have been analysing the teratogenic properties of Primodos in chicken and zebrafish embryos and found that Primodos causes a range of malformations in zebrafish embryos. I have also carried out molecular analyses that show Primodos causes gene expression changes, changes in blood vessel patterning and neurite outgrowth in vivo and in vitro and increase in cell death. Finally, I have investigated the role of blood vessels in limb development and patterning. Using an antiangiogenic analogue of thalidomide, I found that inducing blood vessel loss in different regions of the forelimb bud of developing chicken results in different phenotypes. My results suggest that blood vessels might be involved in limb patterning and progress the understanding of limb defects observed in thalidomide survivors.

published_or_final_version / Nursing Studies / Master / Master of Public Health