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Adenovirus vector systems permitting regulated protein expression and their use for in vivo splicing studies /Molin, Magnus, January 1900 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2001. / Härtill 4 uppsatser.
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Modulation of adenovirus E1A activities by the cellular corepressor CtBP /Johansson, Cecilia, January 2006 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2006. / Härtill 3 uppsatser.
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p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors /Fuxe, Jonas, January 2001 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2001. / Härtill 4 uppsatser.
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The quest for new improved adenovirus gene therapy vectors against glioma tumours /Skog, Johan, January 2005 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2005. / Härtill 5 uppsatser.
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Étude biochimique du récepteur cellulaire de l'Adénovirus.Hennache, Bernadette, Unknown Date (has links)
Th. 3e cycle--Biochim.--Lille 1, 1977. N°: 647. / Rés. de la th.
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Helper-dependent adenoviral vectors expressing anti-HBV pri-miR sequences from the liver-specific PEPCK promoterSmit, Duodane January 2017 (has links)
A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree
of
Master of Science in Medicine
Johannesburg, 2017 / Hepatitis B is a global health problem that kills about 600 000 people annually. It is an infectious disease caused by the Hepatitis B Virus (HBV), which infects the liver and leads to liver inflammation and secondary complications such as cirrhosis and Hepatocellular Carcinoma (HCC). The available therapies are only partially effective and are associated with adverse side effects and viral drug resistance. RNA interference (RNAi) pathway is a gene silencing pathway found in diverse living systems including mammals. Harnessing of this pathway to inhibit HBV replication has shown a lot of promise, with highly effective anti-HBV RNAi activator sequences designed. However, the lack of safe and efficient delivery and expression systems for these sequences is one of the obstacles that need to be overcome before RNAi effectors can reach clinical application. For easy assessment of transduction efficiency, Helper Dependent Adenoviral vectors (HDAd) expressing β-galactosidase (encoded by lac Z gene) are commonly used to deliver anti-viral RNAi activators. However, this reporter protein has been blamed for induction of innate immune response and concomitant clearance of the HDAds by the host. For the first time, this study explored the use of lac Z-deficient HDAds to deliver anti-HBV RNAi activators expressed under the control of a liver-specific phosphoenolpyruvate carboxykinase (PEPCK) promoter. HDAd expressing Firefly luciferase resulted in a significant luminescence detected in cell culture lysates and a sustained bioluminescence in mice. HDAds expressing anti-HBV sequences transduced the liver efficiently and did not induce a pronounced inflammatory response or liver toxicity in mice. However, this did not translate into maximal anti-HBV sequence expression and HBV replication inhibition in vitro and in vivo. This suggests that the PEPCK promoter is inadequate for RNAi activator expression. This study highlights the importance of careful RNAi activator regulatory elements selection and presents the therapeutic potential and utility of HDAd vectors for hepatotropic delivery of antiviral sequences with markedly attenuated immune response stimulation and toxicity. For improved anti-HBV RNAi activator expression and HBV knockdown, a different liver specific promoter mouse transthyretin receptor (MTTR) promoter is currently being investigated in our lab. / MT2017
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Adenovirus host-cell interactions : the role of capsid proteins in transduction, immune activation, and gene targeting /Schoggins, John Wesley. January 2007 (has links)
Thesis (Ph. D.)--Cornell University, August, 2007. / Vita. Includes bibliographical references (leaves 152-175).
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Adenovirus species B: receptors, tropism and hematopoietic cells /Segerman, Anna, January 2004 (has links)
Diss. (sammanfattning) Umeå : Univ., 2004. / Härtill 5 uppsatser.
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Construction of adenovirus vectors for studies of protein function and RNA interference /Berenjian, Saideh, January 2006 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2006. / Härtill 4 uppsatser.
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The role of adenovirus fiber and hexon proteins in virus-host interactions /Gall, Jason G. D. January 1998 (has links)
Thesis (Ph. D.)--Cornell University, May, 1998. / Vita. Includes bibliographical references (leaves 132-147).
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