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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Effects of aging on regulators of muscle apoptosis in the female F344BN rat

Gadde, Murali K. January 2009 (has links)
Thesis (M.S.)--Marshall University, 2009. / Title from document title page. Includes abstract. Document formatted into pages: contains : 89 p. Includes bibliographical references : p. 44-48.
2

The inhibitor of apoptosis ch-IAP1 is a direct transcriptional target of v-Rel and c-Rel /

Pendleton, Cullen Nelson, January 2000 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2000. / Vita. Includes bibliographical references (leaves 127-155). Available also in a digital version from Dissertation Abstracts.
3

The identification and characterisation of two novel Drosophila caspases, DRONC and DECAY /

Dorstyn, Loretta Esterina. January 2001 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Medicine, 2001. / Includes a list of publications co-authored by the author during the preparation of this thesis. Thesis amendments in back leaf. Includes bibliographical references (leaves 123-168).
4

Relationships among the 26S proteasome, HSP70 and BCL-X[subscript L] in apoptotic cell death /

Robertson, John David, January 1999 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1999. / Vita. Includes bibliographical references (leaves 121-140). Available also in a digital version from Dissertation Abstracts.
5

The structure, function, and regulation of BCL-X[subscript L], a central regulator of programmed cell death /

Minn, Andy J. January 1997 (has links)
Thesis (Ph. D.)--University of Chicago, Committee on Immunology, December 1997. / Includes bibliographical references. Also available on the Internet.
6

An analysis of DRONC function and its regulation of expression during Drosophila development.

Daish, Tasman James January 2004 (has links)
Correct development of multicellular organisms requires the programmed removal of supernumerary, redundant, or damaged cells, a process achieved by apoptosis. Apoptosis, or Programmed Cell Death (PCD) is executed by caspases, a highly conserved family of cysteine proteases. The removal of redundant larval tissues during metamorphosis is controlled by the steroid hormone ecdysone. Ecdysone signalling is mediated by the nuclear receptor heterodimer EcR/Usp, which in turn transcriptionally activates a host of transcription factors which then go on to regulate genes essential for PCD, like caspases. The apical caspase dronc is upregulated in the larval midgut and salivary glands prior to their destruction and is dependent on the BRC and E93 transcription factors. To further understand the role of dronc in development, a dronc mutant fly was generated and a transgenic promoter-reporter strategy was employed to investigate dronc regulation. Larval organs from dronc mutants lack dying cells and, when irradiated, fail to show a radiation-induced PCD response. The midguts from dronc mutants undergo apoptosis and have high caspase activity. These data indicate that a droncindependent caspase activation pathway is active in the midgut. Salivary glands from dronc mutants failed to be removed and have reduced caspase activity. Consequently it is clear that the role of DRONC differs significantly between the midgut and salivary glands. The employment of a transgenic dronc promoter-LacZ reporter system identified promoter regions essential for the correct temporal and spatial expression of dronc. A region of the dronc promoter between 1.1kb and 2.8kb has elements essential for LacZ expression in salivary glands. This region was also dependent on the BR-C and E93 transcription factors for salivary gland expression. A functional ecdysone receptor binding element (EcRBE) was identified in the dronc proximal promoter. The EcR-B1 isoform directly binds this EcRBE and is necessary for correct dronc expression in the larval salivary glands. This work revealed some novel findings regarding the role of DRONC in development and the availability of a specific dronc mutant now makes it possible to explore some of the recently published non- poptotic roles of dronc. This work aids in understanding how nuclear hormones control transcription and shows dronc to be an ideal model gene to explore these molecular and genetic processes. / Thesis (Ph.D.)--Department of Medicine, 2004.
7

Investigating the molecular mechanisms of Bcl-2 and Bax in the regulation of apoptosis

Annis, Matthew G. Andrews, D. W. January 1900 (has links)
Thesis (Ph.D.)--McMaster University, 2004. / Supervisor: David W. Andrews. Includes bibliographical references (leaves 134-148).
8

Isolation of gingerols and shogaols from ginger and evaluation of their chemopreventive activity on prostate cancer cells and anti-inflammatory effect on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear inflammation

Ramji, Divya. January 2007 (has links)
Thesis (Ph. D.)--Rutgers University, 2007. / "Graduate Program in Food Science." Includes bibliographical references (p. 152-175).
9

Bcl-x[subscript] L regulates mitochondrial homeostasis and promotes cell survival /

Vander Heiden, Matthew G. January 2000 (has links)
Thesis (Ph. D.)--University of Chicago, Committee on Immunology, August 2000. / Includes bibliographical references. Also available on the Internet.
10

3' substituted indolones as novel therapeutic candidate drugs for the treatment of neurodegenerative diseases /

Chen, Hsin-Mei, January 2008 (has links)
Thesis (Ph.D.)--University of Texas at Dallas, 2008. / Includes vita. Includes bibliographical references.

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