Misophonia is a condition characterized by a strong physiological, emotional, and behaviouralresponse to specific auditory stimuli, which have a significant negative impact on the wellbeingof affected individuals. The present investigation focuses on emotional dysregulation, which arises due to the triggering of specific auditory stimuli. Individuals with misophoniastruggle to regulate their emotions when exposed to sounds, leading to emotional reactions, including anger, anxiety, disgust, avoidance behaviour, fight or flight, and feeling overwhelmed. These reactions might even lead to violent impulses directed towards the source of the sound. Despite its growing recognition, little is yet known about misophonia, and experts have not established any clear boundaries or criteria for the condition to be considered adisorder. As such, it is not yet included in any classification systems for disorders. The aim of this study is to understand how individuals with misophonia experience emotional dysregulation, how do they describe their experience, what is it like to live with misophonia ona day-to-day basis, and how do individuals understand and cope with emotional dysregulation caused by misophonia? The study utilized a qualitative approach with semi-structured interviews as the data collection method. Thematic analysis was used to identify patterns and themes within the data. Participants stated that misophonia causes significant distress and disruption impacting emotional well-being and daily functioning. Validation of this new condition can be very helpful and make a positive impact in their social circle, and that lack of awareness and effective treatment may hold back seeking professional help.

Our senses are constantly bombarded with information. How does the brain integrate such a variety of inputs to generate appropriate behaviours? Innate defensive behaviours are a good model to address this question. They are essential for animal survival and the brain circuits that control them are highly conserved across species. Moreover, the sensory inputs and behavioural outputs can be well defined and reliably reproduced in the lab. This allows us to study function of the individual components of the circuit controlling these behaviours. Ventromedial hypothalamus (VMH) is a key brain region for controlling responses to predators; it has been shown that inactivating the VMH can reduce defensive behaviours. Interestingly, activating the VMH output neurons (SF1+ cells) can produce a variety of different behaviours, from immobility to escape, depending on the intensity of activation. During my PhD I used a variety of approaches to address the question of the function of the VMH in control of defensive behaviours. At first I hypothesised that the VMH might act as a centre responsible for choosing an appropriate behavioural response according to the stimulus. I set to investigate how different activation levels of SF1+ neurons can produce such different behavioural outputs, and how this activity is modulated in vivo in response to predator stimuli. I began the project by quantifying mouse defensive behaviours in response to olfactory and auditory predator cues, as well as to the optogenetic activation of SF1+ neurons. I then questioned whether there was heterogeneity within the population of SF1+ neurons, which could explain their ability to trigger different behaviours. I performed patch clamp recordings from acute brain slices and conducted a study of the electrophysiological properties of SF1+ neurons. I next investigated how SF1+ neurons integrate excitatory inputs from the medial amygdala, a region which receives olfactory inputs from the accessory olfactory bulb. By combining optogenetics with slice electrophysiology and behavioural assessment, I described the physiology and relevance of this connection. Finally, I investigated in vivo activity in the VMH in response to predator cues by performing calcium imaging of the VMH neurons in freely moving mice. By presenting different sensory stimuli, I addressed the question of heterogeneity of the input pattern to the VMH neurons and the relationship between the VMH activity and the behavioural output. Taken all together, the results of this project have led to a hypothesis whereby the function of the VMH is to facilitate rather than directly control the choice of an appropriate behavioural response.

The Stroop effect is the delay in reaction times due to interference. Since the original experiments of 1935, it has been used primarily in linguistic context. Language is a complex skill unique to humans, which involves a large part of the cerebral cortex and many subcortical regions. It is perceived primarily in auditory form (spoken) and secondarily in visual form (written), but it is also always perceived in representational form (natural sounds, images, smells, etc). Auditory signals are processed much faster than visual signals, and the language processing centres are closer to the primary auditory cortex than the primary visual cortex, but due to the integration of stimuli and the role of the executive functions, we are able to perceive both simultaneously and coherently. However, auditory signals are still processed faster, and this study focused on establishing how auditory and visual, linguistic and representational stimuli interact with each other and affect reaction times in four Stroop tasks with four archetypal mammals (dog, cat, mouse and pig): a written word against an image, a spoken word against an image, a written word against a natural sound and a spoken word against a natural sound. Four hypotheses were tested: in all tasks reaction times would be faster when the stimuli were congruent (Stroop Hypothesis); reaction times would be faster when both stimuli are auditory than when they are visual (Audiovisual Hypothesis); reaction times would be similar in the tasks where one stimulus is auditory and the other visual (Similarity Hypothesis); finally, reaction times would be slower when stimuli come from two sources than when they come from one source (Attention Hypothesis). Twelve native speakers of Swedish between the ages of 22 and 40 participated. The experiment took place in the EEG lab of the Linguistics Department of Stockholm University. The same researcher (the author) and equipment was used for all participants. The results confirmed the Stroop Hypothesis, did not confirm the Audiovisual and Similarity Hypothesis, and the results of the Attention Hypothesis were mixed. The somewhat controversial results were mostly attributed to a false initial assumption, namely that having two different auditory stimuli (one on each ear) was considered one source of stimuli, and possibly the poor quality of some natural sounds. With this additional consideration, the results seemed to be in accord with previous research. Future research could focus on more efficient ways to test the reaction times of Stroop tasks involving auditory and visual stimuli, as well as different populations, especially neurodiverse and bilingual populations.

The purpose of this review of literature is to explore the effects of interventional and environmental auditory stimuli on the adult critical care population. Current research has yet to compare and contrast the effectiveness of various interventional auditory stimuli on stress relief, an oversight this thesis aims to remedy. Modern day critical care settings demand the identification of the most therapeutic interventional auditory stimulus and the most stress-inducing environmental stimuli, so that interventions can be made to optimize patient stress levels and improve outcomes. Suggestions will be made on how to simultaneously reduce harmful or stress inducing auditory stimuli in the critical care setting and implement the optimal stress-relieving interventional auditory stimuli.

Tesis por compendio / En esta tesis, el objetivo principal fue diseñar y desarrollar una nueva tarea que combinara interfaces de usuario naturales (NUI) y dispositivos inteligentes para evaluar la memoria espacial utilizando estímulos auditivos, y su validación tanto en niños como en adultos. La nueva tarea evalúa la capacidad de los participantes para detectar y localizar estímulos auditivos que se emiten en diferentes posiciones del área de trabajo. La tarea reconoce los movimientos de los brazos del usuario, utilizando para ello Kinect. Los dispositivos inteligentes (conejos Karotz) se utilizan para emitir estímulos auditivos y también como señales visuales. Por lo tanto, la tarea combina estímulos auditivos con claves visuales reales para la evaluación de la memoria espacial. La tarea incluye un total de 45 estímulos acústicos, repartidos en 5 niveles y cada nivel consta de 3 ensayos. Nuestra tarea es el primer trabajo que combina NUI y dispositivos inteligentes para la evaluación de la memoria espacial. Del mismo modo, nuestra tarea es el primer trabajo que utiliza estímulos auditivos para evaluar la memoria espacial. Para la validación, se llevaron a cabo 3 estudios. El rendimiento de nuestra tarea se comparó con métodos tradicionales. El primer estudio involucró niños con y sin síntomas de falta de atención. Un total de 34 niños participaron (17 niños con falta de atención). Los resultados demostraron que los niños con falta de atención mostraron un rendimiento estadísticamente peor en la tarea. Estos niños con falta de atención también mostraron un rendimiento estadísticamente peor con el método tradicional para evaluar el aprendizaje de sonidos verbales. No se encontraron diferencias estadísticamente significativas en el tiempo dedicado por cada grupo para completar la tarea. Los resultados sugieren que la tarea es una buena herramienta para distinguir las dificultades de memoria espacial en niños con falta de atención. El segundo estudio comparó el rendimiento en la tarea entre niños mayores y adultos (32 niños y 38 adultos sanos). Los resultados de rendimiento con la tarea fueron significativamente más bajos para los niños mayores. Se encontraron correlaciones entre nuestra tarea y los métodos tradicionales, lo que indica que nuestra tarea ha demostrado ser una herramienta válida para evaluar la memoria espacial mediante el uso de estímulos auditivos tanto para niños mayores como para adultos. A partir del análisis, podemos concluir que la satisfacción con la tarea de los niños mayores fue significativamente mayor que la de los adultos. El tercer estudio incluyó un total de 148 participantes (niños más pequeños, niños mayores y adultos). Los resultados están en línea con el segundo estudio. El rendimiento de la tarea se relacionó significativamente, de forma incremental y directa con el grupo de edad (niños más pequeños <niños mayores <adultos). Los resultados fueron mejores para adultos y niños mayores; resultado que es consistente con la idea de que los adultos pueden almacenar más elementos en la memoria a corto plazo que los niños. Las siguientes conclusiones generales se han extraído del desarrollo y los tres estudios: * Las interfaces de usuario naturales y los dispositivos inteligentes son apropiados para desarrollar tareas para la evaluación de la memoria espacial. * Como juego de ordenador, nuestra tarea facilita el control de la presentación de estímulos y el almacenamiento de las respuestas. * Nuestra tarea y tareas similares podrían usarse para la evaluación y el entrenamiento de la memoria espacial en niños y adultos. * La tarea podría ser una herramienta alternativa para evaluar la memoria espacial en niños con síntomas de falta de atención. * La tarea promueve interés y permite la evaluación de una manera ecológica. * La tarea podría ayudar a identificar alteraciones en la memoria espacial tanto en niños como en adultos. / In this thesis, the main objective was to design and develop a new task that combine Natural User Interfaces (NUI) and smart devices for assessing spatial memory using auditory stimuli, and its validation in both children and adults. The new task tests the ability of participants to detect and localize auditory stimuli that are emitted in different positions of the task area. The task recognizes the movements of the arms of the user using Kinect. Smart devices (Karotz rabbits) are used for emitting auditory stimuli and also as visual cues. Therefore, the task combines auditory stimuli with real visual cues for the assessment of spatial memory. The task includes a total of 45 acoustic stimuli, which should be randomly emitted in different locations. The task is composed of five different levels. Each level consists of 3 trials. The difference between levels lies in the number of sounds to be used in each trial. To our knowledge, our task is the first work that combines NUI and smart devices for the assessment of spatial memory. Similarly, our task is the first work that uses auditory stimuli to assess the spatial memory. For the validation, three studies were carried out to determine the efficacy and utility of our task with regard to the performance outcomes, usability, fun, perception and overall satisfaction. The performance of our task was compared with traditional methods. The first study involved children with and without symptoms of inattention. A total of 34 children participated (17 children with inattention). The results showed that the children with inattention showed statistically worse performance in the task. These children with inattention also showed statistically worse performance in the traditional method for testing the learning of verbal sounds. There were no statistically significant differences in the time spent by each group to complete the task. The results suggest that the task is a good tool for distinguishing spatial memory difficulties in children with inattention. The second study compared the performance in the task between older children and adults. A total of 70 participants were involved in this study. There were 32 healthy children from 9 to 10 years old, and 38 healthy adults from 18 to 28 years old. The performance outcomes with the task were significantly lower for the older children. Correlations were found between our task and traditional methods, indicating that our task has proven to be a valid tool for assessing spatial memory by using auditory stimuli for both older children and adults. From the analysis, we can conclude that the older children were significantly more satisfied with the task than the adults. In the third study, a total of 148 participants were involved. They were distributed in three groups (younger children, older children and adults). A total of 100 children and 48 adults participated in this study. The results are in line with the second study. The task performance was significantly incrementally and directly related to the age group (younger children <older children <adults). The results were better for adults and older children; this is consistent with the idea that adults can store more elements in short-term memory than children. The following general conclusions were extracted from the development and the studies: * Natural user interfaces and smart devices are appropriated for developing tasks for the assessment of spatial memory. * As a computer-based game, our task facilitates the control of the presentation of stimuli and the recording of responses. * Our task and similar tasks could be used for assessment and training of spatial memory in children and adults. * The task could be an alternative tool to assess spatial memory in children with symptoms of inattention. * The task promotes engagement and allows the assessment in an ecological way. * The task could help in the identification of alterations in spatial memory in both children and adults. / En aquesta tesi, l'objectiu principal va ser dissenyar i desenvolupar una nova tasca que combinés NUI i dispositius intel·ligents per a avaluar la memòria espacial utilitzant estímuls auditius, i la seua validació tant en xiquets, com en adults. La nova tasca avalua la capacitat dels participants per a detectar i localitzar estímuls auditius que s'emeten en diferents posicions de l'àrea de treball. La tasca reconeix els moviments dels braços de l'usuari, utilitzant per a açò Kinect. Els dispositius intel·ligents (conills Karotz) s'utilitzen per a emetre estímuls auditius i, també, com a senyals visuals. Per tant, la tasca combina estímuls auditius amb claus visuals reals per a l'avaluació de la memòria espacial. La tasca inclou un total de 45 estímuls acústics, repartits en 5 nivells diferents i cada nivell consta de 3 assajos. La nostra tasca és el primer treball que combina NUI i dispositius intel·ligents per a l'avaluació de la memòria espacial. De la mateixa manera, la nostra tasca és el primer treball que utilitza estímuls auditius per a avaluar la memòria espacial. Per a la validació, es van dur a terme tres estudis. El rendiment de la nostra tasca es va comparar amb mètodes tradicionals. El primer estudi va involucrar 34 xiquets (17 xiquets amb inatenció). Els resultats van demostrar que els xiquets amb inatenció van mostrar un rendiment estadísticament pitjor en la tasca. Aquests xiquets amb inatenció també van mostrar un rendiment estadísticament pitjor amb el mètode tradicional per a avaluar l'aprenentatge de sons verbals. No es van trobar diferències estadísticament significatives en el temps dedicat per cada grup per a completar la tasca. Els resultats suggereixen que la tasca és una bona ferramenta per a distingir les dificultats de memòria espacial en xiquets amb dificultats d'atenció. El segon estudi va comparar el rendiment en la tasca entre xiquets majors i adults. Un total de 70 participants van estar involucrats en aquest estudi. Van participar 32 xiquets i 38 adults sans. Els resultats de rendiment amb la tasca van ser significativament més baixos per als xiquets majors. Es van trobar correlacions entre la nostra tasca i els mètodes tradicionals, la qual cosa indica que la nostra tasca ha demostrat ser una ferramenta vàlida per a avaluar la memòria espacial mitjançant l'ús d'estímuls auditius tant per a xiquets majors, com per a adults. A partir de l'anàlisi, podem concloure que la satisfacció amb la tasca dels xiquets majors va ser significativament major que la dels adults. El tercer estudi va incloure un total de 148 participants (100 xiquets i 48 adults). Es van distribuir en tres grups (xiquets més xicotets, xiquets majors i adults). Els resultats estan en línia amb el segon estudi. El rendiment de la tasca es va relacionar significativament, de forma incremental i directa amb el grup d'edat (xiquets més xicotets <xiquets majors <adults). Els resultats van ser millors per a adults i xiquets majors; resultat que és consistent amb la idea que els adults poden emmagatzemar més elements en la memòria a curt termini que els xiquets. Las següents conclusions generals s'han extret del desenvolupament i els tres estudis: * Les NUI i els dispositius intel·ligents són apropiats per a desenvolupar tasques per a l'avaluació de la memòria espacial. * Com a joc d'ordinador, la nostra tasca facilita el control de la presentació d'estímuls i l'emmagatzematge de les respostes. * La nostra tasca, i tasques similars, podrien usar-se per a l'avaluació i l'entrenament de la memòria espacial en xiquets i adults. * La tasca podria ser una ferramenta alternativa per a avaluar la memòria espacial en xiquets amb problemes de inatenció. * La tasca promou interès i permet l'avaluació d'una manera ecològica. * La tasca podria ajudar a identificar alteracions en la memòria espacial tant en xiquets, com en adults. / Loachamín Valencia, MR. (2018). Natural user interfaces and smart devices for the assessment of spatial memory using auditory stimuli [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/107955 / Compendio

<p>Experiment One: The Effect of Noise on Autonomic Arousal</p><p><br></p><p>In response to the growing demand for research that helps us understand the complex interactions between Autonomic Arousal (AA) on behavior and performance there is an increasing need for robust techniques to efficiently utilize stimuli, such as sound, to vary the level of AA within a study. The goal of this study was to look at the impact of several factors, including sound intensity, order of presentation, and direction of presentation on skin conductance level, a widely utilized technique for approximating levels of AA. To do this we had 34 young adults ages 18- 34 listen to a series of 2-minute blocks of a sound stimuli based off a heating, ventilation, and air conditioning system (HVAC). Blocks included 5 single intensity conditions each block differing in 10 dBA steps ranging from 35-75 dBA. We presented blocks in both rising and falling level of intensity, with half the participants hearing them in a rising order first and half in a falling order first. The evidence found by this study suggests that increasing the sound level plays an important role in increasing AA and habituation is an extremely important factor that must be accounted for as it, in the case of typical young adults, quickly dampens the response to stimuli and subsequent stimuli. These findings suggest that researchers can best efficiently maximize the range of AA they can use while keeping their participants comfortable by starting out with the most intense stimuli and proceeding to the less intense stimuli, working with habitation instead of against it.</p><p> </p><p><br></p><p> Experiment Two: The Effect of Autonomic Arousal on Visual Attention</p><p><br></p><p>The goal of this study was to better understand how various levels of autonomic arousal impact different components of attentional control and if ASD-related traits indexed by Autism Quotient scores (AQ) might relate to alterations in this relationship. This study had 41 young adult participants (23 women, 17 men, 1 prefer not to say), ages ranging from 18 to 38 years old. Participants listened to varying levels of noise to induce changes in AA, which were recorded as changes in skin conductance level (SCL). To evaluate attentional control, participants preformed pro and anti-saccade visual gap–overlap paradigm tasks as measures of attentional control. The findings of this study suggest that increased levels of autonomic arousal are helpful for improving performance on anti-saccade tasks, which are heavily dependent on top-down attentional control. Additionally, increases in AQ scores were related to having less of a benefit from increasing levels of arousal on anti-saccade tasks. Additional interactions were also found and are discussed in this paper.</p>