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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Linker region of the BRCA2 protein increases chemoresistance to cisplatin: Screen for the characterization of cancer-associated variants

Warren, Curtis R. January 2009 (has links)
Thesis (M.S.)--University of Delaware, 2009. / Principal faculty advisor: . Includes bibliographical references.
2

Risk modelling in BRCA1 and BRCA2 mutation carriers

Mavaddat, Nasim January 2012 (has links)
No description available.
3

Gen-Passagen molekularbiologische und medizinische Praktiken im Umgang mit Brustkrebs-Genen ; Wissen - Technologie - Diagnostik

Palfner, Sonja January 2008 (has links)
Zugl.: Berlin, Freie Univ., Diss., 2008
4

The Effects of 17B-estradiol on Cognition

Au, Sin Tung 20 November 2012 (has links)
A bilateral salpingo oophorectomy (BSO), removal of the ovaries, is recommended for carriers of BRCA1/2 mutations to reduce cancer risks. However, BSO induces surgical menopause, and is associated with an increased risk of dementia (Rocca et al., 2007a) and Parkinsonism (Rocca et al, 2007b). This study investigated the cognitive outcomes of BSO one to ten years post-surgically. The present dataset (n=37) revealed there was a significant difference between the BSO group and their age matched cohort on the Logical Memory task assessing verbal, episodic memory. Levels of E1G (estrogen metabolite) was a significant predictor of the RAVLT primacy subscale indicating higher levels were associated with better recall at the beginning of a list of words. Controlling for age, performance on the RAVLT A1 measuring short-term memory degraded further out from BSO. While limited by the sample size, results are consistent with reports of post-BSO cognitive changes (Vearncomb & Panchana, 2009).
5

The Effects of 17B-estradiol on Cognition

Au, Sin Tung 20 November 2012 (has links)
A bilateral salpingo oophorectomy (BSO), removal of the ovaries, is recommended for carriers of BRCA1/2 mutations to reduce cancer risks. However, BSO induces surgical menopause, and is associated with an increased risk of dementia (Rocca et al., 2007a) and Parkinsonism (Rocca et al, 2007b). This study investigated the cognitive outcomes of BSO one to ten years post-surgically. The present dataset (n=37) revealed there was a significant difference between the BSO group and their age matched cohort on the Logical Memory task assessing verbal, episodic memory. Levels of E1G (estrogen metabolite) was a significant predictor of the RAVLT primacy subscale indicating higher levels were associated with better recall at the beginning of a list of words. Controlling for age, performance on the RAVLT A1 measuring short-term memory degraded further out from BSO. While limited by the sample size, results are consistent with reports of post-BSO cognitive changes (Vearncomb & Panchana, 2009).
6

Risk assessment of contralateral breast cancer in high-risk patients and formulation of clinical guidelines

Basu, Narendra Nath January 2016 (has links)
This thesis assesses the main risk factors contributing to contralateral breast cancer(CBC) amongst high-risk breast cancer patients with a view to formulating clinicallyuseful guidelines. The work has focused on several keys areas; a literature review ofthe various factors contributing to CBC, changing trends towards increasingnumbers of contralateral risk-reducing mastectomies (CRRMs), internationalvariations amongst breast surgeons’ attitudes towards risk-reducing mastectomy(RRM), attitudes towards CRRM amongst UK breast and plastic surgeons,assessment of CBC risk amongst BRCA1/2 mutation carriers and finally theformation of the ‘Manchester Guidelines for CRRM’.Breast cancer patients harbouring mutations in high penetrance genes (i.e. BRCA1/2,TP53, CHEK2, PALB) have the highest risk of developing breast cancer. A positivefamily history also increases the risk of subsequent breast cancer, with not muchevidence to support variation in risk with histological type. Risk reducing strategiesinclude anti-endocrine treatment, risk-reducing bilateral salpingo-oophorectomy(RRBSO) and CRRM with the former likely to account for the global trend ofdecreasing rates of CBC.Over the last decade, rates of CRRM have trebled in the USA – such a clear trendhas not yet been confirmed in Europe. Factors driving this trend include young ageat diagnosis, histological type (lobular carcinoma, lobular carcinoma in situ [LCIS]and ductal carcinoma in situ [DCIS]) and female surgeons. A direct comparison(USA v 4 European countries) found that American surgeons overall had a greaterknowledge of cancer genetics and nearly all (including Dutch and British surgeons)had positive attitudes towards RRM.A proportion of British surgeons were quoting inaccurate levels of CBC risk to theirpatients. Practices in the UK varied regarding CRRM – only 58% of surgeons alwaysdiscussed these cases in the MDT, with less than a third ever seeking apsychological or formal genetic assessment. Surgeons primarily offered thisprocedure to high-risk patients (gene mutation carriers or positive family history)but felt that the main reason patients requested CRRM was to alleviate anxiety. Studying over 1000 breast cancer patients who also had a mutation in either BRCA1or BRCA2 gene revealed that the risk of CBC was approximately 2-3% per year, forat least 2 decades. Young age at first breast cancer development (<40 years) affectedthis risk most. The effect bilateral risk-reducing salpingo-oophorectomy (BRRSO)was initially significant in an unadjusted analysis, but when accounting for delayedentry BRRSO did not appear to affect CBC risk. The use of SNPs was not able tostratify risk of CBC further. By considering the above, the Manchester Guidelines for CRRM have beenformulated. This 5-step protocol allows clinicians to objectively assess the risk ofCBC based on the evidence base and makes suggestions of a multi-disciplinaryapproach to managing requests for CRRM. Several breast units in the UK havealready adopted these guidelines and future studies hope to validate them so thatthey can be used more widely.
7

Paralemmin splice variants and mRNA and protein expression in breast cancers

Turk, Casey M., January 2008 (has links)
Thesis (M.S.)--University of Massachusetts Amherst, 2008. / Includes bibliographical references (p. 77-79).
8

Psychological and behavioral outcomes of genetic testing for BRCA1/2 mutations among Ashkenazi Jewish Women /

Ozakinci, Gozde. January 2004 (has links)
Thesis (Ph. D.)--Rutgers University, 2004. / Includes bibliographical references. Also available on the Internet.
9

Einstellungen und Erwartungen zu prädiktiver genetischer Diagnostik von Brustkrebs /

Schwertz, Sarah. Unknown Date (has links)
Aachen, Techn. Hochsch., Diss., 2007.
10

Models of pancreatic carcinogenesis associated with inactivation of the BRCA2 breast cancer susceptibility gene

Skoulidis, Ferdinandos January 2011 (has links)
No description available.

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