Cette thèse comporte deux parties. Dans un premier temps, nous allons faire un lien entre des solutions stationnaires de problèmes d'évolutions de frontières par courbure moyenne avec des champs extérieurs et l'existence de minimiseur globaux d'un problème de minimisation de périmètre avec une énergie. Ces solutions stationnaires permettent en outre de fournir des bornes pour les solutions non stationnaires du problème. De plus, en modifiant l'énergie, on montre que les résolutions successives des problème de périmètre permettent de calculer l'évolution d'un ensemble par courbure moyenne. Enfin, on présentera un algorithme permettant de calculer les solutions de viscosité d'un problème de Dirichlet portant sur le Laplacien Infini grâce aux équations d'Aronsson.

Cannabinoids have been shown to modulate the immune system in vitro and in animal models. A major area of interest is how cannabinoids impact the brain. A whole variety of neuropathies or brain disorders, such as AIDS dementia, Parkinson’s disease, Multiple Sclerosis and Alzheimer’s disease, are associated with a hyperinflammatory response within the brain. Microglia, the resident macrophages of the brain, are the major cell type responsible for the persistent elicitation of pro-inflammatory cytokines (IL-1a, IL-1b, IL-6, TNFa) and other mediators. In vitro experiments have demonstrated that the partial exogenous cannabinoid agonist delta-9-tetrahydrocannabinol (D9-THC) and the potent synthetic exogenous cannabinoid agonist CP55940 down-regulate the robust production of pro-inflammatory cytokines elicited in response to bacterial lipopolysaccharide (LPS) at the mRNA level. These observations suggest that cannabinoids, devoid of psychotropic properties, have the potential to betherapeutic agents. These highly lipophilic compounds can pass through the blood brain barrier and act through specific cannabinoid receptors, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). CB1 and CB2 are expressed in the brain and the periphery, respectively, and may serve as molecular targets for ablating chronic brain inflammation. Electrophoretic mobility shift assays (EMSA) were used to assess the effects of D9-THC and CP55940 on the LPS-induced binding interactions of the universal transcription factor NFkB to its cognate promoter binding site in BV-2 microglial-like cells. EMSA analyses demonstrated that the D9-THC and CP55940 down-regulated LPS-induced NFkB binding in BV-2 cells in a biphasic manner. Furthermore, reporter activity assays determined that D9-THC and CP55940 attenuated LPS-induced, NFkB transcriptional activity in the same biphasic manner. We then determined the specificity in which cannabinoids inhibit NFkB function. Real-Time RT-PCR analysis demonstrated that BV-2 cells did not express CB1 mRNA, but they do express CB2 mRNA when untreated and stimulated with IFN-g or LPS. We performed specificity studies using CB1 and CB2 selective agonists and antagonists with our reporter activity assays. The CB1-selective agonist ACEA did not affect NFkB transcriptional activity but the CB2-selective agonist O-2137 exerted a significant decrease in activity. Furthermore, the CB1 antagonist SR141716A could not reverse the inhibitory effects of CP55490 but those effects were blocked by the CB2 antagonist SR144528. Lastly, we determined the site of action in which cannabinoids inhibit NFkB function by assessing the effects of D9-THC and CP55940 on NFkB’s inhibitor protein IkBa. IkBa retains NFkB in the cytoplasm until stimulus-induced cell activation. Neither cannabinoid compound was able to inhibit the phosphorylation of IkBa, which initiates its degradation. However both cannabinoids inhibited the complete degradation of IkBa. Western immunoblot analysis also demonstrated that comparable levels of endogenous and phosphorylated p65, the transactivation subunit of the NFkB protein (p65/p50), were detected in the nucleus of LPS-stimulated BV-2 cells pre-treated with or without D9-THC. These results suggest that, in addition to inhibiting the proteolytic degradation of IkBa, there is also a mechanism of action in the nucleus that prevents the proper binding and subsequent transcriptional activity of NFkB. Collectively, these results suggest that cannabinoids suppress pro-inflammatory cytokine gene expression at the transcriptional level, but it is likely that there is more than one signal transduction pathway involved in the cannabinoid-mediated inhibition of NFkB function.

Primary objective of the thesis is proof of the statement that if for ∈ ℕ a ≥ 1 a bilipschitz mapping belongs to +1, loc ∩ ,∞ loc then also its inverse −1 belongs to +1, loc . We prove a similar statement also for spaces loc . For this purpose we construct a new ordering of -th partial derivatives to generalized Jacobian matrix. Thanks to this matrix we are able to differentiate matrices in an applicable way. Generalized Jacobian matrix is projected so that there still holds the Chain rule and, in some way, also rules for matrices product differentiation. 1

Jürgen Moltmann suggests that where liberal market welfare policies are introduced people with learning disabilities are disadvantaged, whereas Christian communities provide a more favourable environment. This hypothesis is investigated by assessing the social capital available to two groups of people with a learning disability. The members of one group are being supported to live independent lives as ‘citizen consumers.’ The second group are members of a Roman Catholic parish community supported by their families. The results suggest that both groups have few resources of bridging or linking capital. The second group have larger and richer resources of bonding capital which comes largely through family networks. They also had significant resources of spiritual capital but not religious capital. In the light of the results, a theological critique is undertaken of some aspects of contemporary social policy and consumer culture. A distinction is made between human relationships as transactions and as gifts. Insights from the theology of gift relationships are offered. The question is raised whether it is appropriate to consider gift relationships as a form of capital and Churches as a form of social capital. Liturgy is considered as a form of liberative praxis.

This dissertation argues that a major factor in Pentecostalism's rapid world-wide growth was the emergence of a strong literary, as distinct from oral, tradition. From its earliest days the movement gave birth to a plethora of publications and publishing houses, mostly operating by faith, that proved highly successful in disseminating the distinctive tenets of the movement across the globe. The first part of this work outlines the social, historical and religious background to the movement in the USA and Britain, and highlights the distinctive doctrines and practices of Pentecostalism. The second section examines the emergence of Pentecostal publishing movements and their products in the USA, especially the role played by the prototypical magazine of W. J. Seymour, The Apostolic Faith. The third and major part of this dissertation is a detailed case study of the earliest, and most influential, Pentecostal magazine published in Britain, Confidence. The crucial role that this journal and its editor, A. A. Boddy, played in formulating and propagating the beliefs and practices of the nascent movement is critically examined, together with an assessment of its contribution to wider issues of religious life and thought in Britain. Areas of subsequent influence in the development of historic Pentecostalism and its contemporary offshoots are also discussed

The aim of this thesis is to explore the “strange phenomenon” of the Intentional Christian Community Othona in Bradwell-on-Sea, Essex, Great Britain, founded in 1946 by Norman Motley, to cherish differences and diversity through reconciliation among nations that had been at war with each other. An old neglected chapel, St Peter-on-the-Wall, became the spiritual centre of this Community. A phenomenographic, auto-ethnographic and multi-dimensional research approach, designed to investigate and describe the Othona Community and its praxis and the researcher's involvement in it, is used for the empirical part of the thesis. The study seeks to discover a) the Lebenswelten ― or the world created by its life ― of the Othona Community, b) members'/participants' perception of the Community through interviews and Community literature, c) a way of understanding this “strange phenomenon” and its special charism with the help of an “endogenous theology”. This thesis shows that a two-fold encounter lies at the heart of the experience at Othona: encounter between a person and the “Other” (represented by the Stoep) and between a person and the “Wholly Other” (represented by the Chapel). Through examination of these encounters light is shed on the extraordinariness of Othona. The German term Heimat (a deeply spiritual home) is introduced here to encapsulate these “encounteral” experiences which induce a transformation of place and people alike. Theologically, the thesis claims that a combination of a Theology of Encounter and an understanding of Heimat can assist the appreciation of the Othona phenomenon as a Community of temporary withdrawal and restoration, where differences and a Kingdom model are experienced in narrative encounters on the margins by offering Heimat through belonging and significance.

The issues raised by the phenomenon of homosexuality among the Shona are so complex in their nature. The widely held assumptions are that firstly, there is no place for gays and lesbian within the Shona culture and secondly, God Forbids. To justify these claims they point to prevalent socio-cultural as well as ecclesiastical intermediary systems that serve as authorities to enforce and monitor specific rules of conduct and moral goals. The study explores these conventional notions and attempts to establish the reality in which these moral actions are carried out. It marks the beginning of the work of demystification and deconstruction of various existing theories and theologies of sexuality. By scanning through the intricate socio-cultural and ecclesiastical structures the study seeks to identify the place of homosexuality among the Shona and discuss the paradoxes and contradictions presented by the Church‟s approach. This study is an analysis of the underlying issues in regards to homosexuality among the Shona. Such an analysis helps in identifying and developing contextual sexual theological approaches.

This thesis uses a practical-theological methodology to explore the theology and spirituality of „spiritual warfare‟ that developed in the charismatic renewal from the 1960s. Beginning with a study of twelve charismatic Anglican pioneers, a detailed case study then explores spiritual warfare praxis in a charismatic Anglican congregation. The ensuing theological reflection focuses on the ontology of evil, through dialogue with Nigel Wright, Amos Yong, and Gregory Boyd, as well as Karl Barth and Walter Wink. The thesis argues for a positive ontology for evil powers, based on a charismatic hermeneutic of biblical texts; on the grounds that Jesus treated Satan and demons as real spiritual entities, the Pauline epistles refer to real evil spiritual powers in the heavenly realms, and charismatic experience supports this ontology. Such powers are in malevolent and wilful rebellion against God, deriving from a corrupted fallen angelic nature. A Trinitarian model of theological praxis is presented, focused on responding to the goodness of God in repentance; renewing faith in the believer‟s identity in Christ and His victory upon the cross; and resisting the devil in the power of the Spirit. This model emphasizes personal responsibility, helps bring freedom from fear, and re-connects with Anglican baptismal liturgy.

An experimental attempt to consider the history of the London Missionary Society (LMS) from the lens of the artefacts that accumulated at its London headquarters, which included a museum from 1814 until 1910. The movement of these things through space and over time offers a rich perspective for considering the impacts on Britain of its history of overseas missionary activity. Building on anthropological debates about exchange, material culture, and the agency of things, the biographies of particular objects are explored in relation to the processes involved in the assemblage, circulation and dispersal of the LMS collection. Methodologically, the research is an attempt to develop what Latour has called a symmetrical anthropology, with archaeological approaches to the material products of historical processes as an important dimension of this. Drawing on attempts to study ‘along the grain’ in historical anthropology, and to move beyond iconoclasm as a critical stance, it is argued that museums should be understood as ‘other places’ in which objects are made by techniques of inscription and confinement which have a significant ceremonial dimension. At the same time, certain charismatic objects are shown to have transcended these contexts of confinement, affecting those they encounter, and shaping history around themselves.

This Practical Theological thesis examines the uses, understandings, and attitudes toward the rite of Christian Initiation (variously known as 'baptism' or 'christening') in the Church of England, contrasting the experiences of churchgoers and clergy with non-regular churchgoers and demonstrating its pivotal role in ecclesiastical boundary drawing. It develops a critical conversation between ecclesiology, theology, and the assumptions of ordinary people, revealed in their language when discussing the rite. Corpus based methods are used to explore naturally-occurring language in various corpora from a variety of genres, from 1500 to the present day. It concludes that there are significant linguistic differences between clergy/regular churchgoers and non-regular churchgoers and that the roots of this split go back to before Reformation times. Non-regular churchgoers’ use of language to describe this rite is more varied than that of churchgoers, who rarely used the word 'christening' nor figurative uses of these words. Non-regular churchgoers attached great social importance to the rite, but this was little understood by clergy and regular churchgoers. The Church would benefit from understanding and appreciating these different perspectives, both to enrich their own experience of Christian Initiation, and to allow more sympathetic pastoral care for those requesting the rite for their children.