Thesis (Ph. D.)--Princeton University, 1925.

Thesis (M.S.) in Chemistry--University of Maine, 2007. / Includes vita. Includes bibliographical references (leaves 37-39).

Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references.

Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1958. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references. Also available on the Internet.

No description available.

A B S T R A C T V2O5/SnO2 solid acid catalysts have been employed for the vapour-phase Beckmann rearrangement of cyclohexanone oxime to e-caprolactam. Catalysts with different vanadia loading (3–15 wt%) were prepared by impregnation method and characterized by XRD, BET surface area, FTIR and 51V NMR techniques. The surface acidic properties were determined by temperature programmed desorption and cumene cracking reaction. Under optimized reaction conditions, catalyst with 9 wt% V2O5 gives the maximum amount of desired product (yield 78.8%). However, the catalysts are susceptible for deactivation due to the basic nature of the reaction products (50% deactivation in 5 h). A good correlation was obtained among the rearrangement activities of V2O5/SnO2 catalysts, their weak plus medium acidities (usually of the Bro¨ nsted type) and structural properties.

The first section of this work describes the synthesis of a library of novel rhein analogues that are potential anticancer agents. The design of these compounds takes advantage of the ability for rhein to intercalate into DNA and as the incorporation of an alkylating agent, which serves to covalently modify DNA. In three cell lines, these compounds showed potent cytotoxicity with IC50 in the low to mid-μM range. The second project was focused on the development of an efficient synthesis of 6H-Isoindolo[2,1-α]indol-6-one (24), a core structure for a number of biologically active compounds. The approach is metal-free and uses a Beckmann rearrangement followed by an intramolecular cyclization.

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 211-219).