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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Bronchiectasis; radiological diagnosis and prognosis after operative treatment.

Gudbjerg, Carl Einer. January 1957 (has links)
Afhandling--Københavns universitet. / Summary in Danish. "Previously published papers b̈y the author]": p. [5] Bibliography: p. 113-[115].
2

Bronchiectasis radiological diagnosis and prognosis after operative treatment.

Gudbjerg, Carl Einer. January 1957 (has links)
Afhandling--Københavns universitet. / Summary in Danish. "Previously published papers b̈y the author]": p. [5] Bibliography: p. 113-[115].
3

Control of syndecan-1 shedding to limit smoking-related neutrophilic inflammation

Wu, Lap-kei, 胡立基 January 2015 (has links)
abstract / Biochemistry / Doctoral / Doctor of Philosophy
4

The effect of antimicrobial therapy on lung secretions in bronchiectasis

Hill, S. L. January 1988 (has links)
No description available.
5

Lectin pathway of complement and bacterial colonisation in bronchiectasis

Chalmers, James Duncan January 2014 (has links)
Bronchiectasis is a chronic inflammatory lung disease associated with failure of the normal mucociliary escalator, chronic bacterial colonisation of the airways, neutrophil mediated inflammation and a resulting clinical syndrome of respiratory infections, lung damage and symptoms such as cough, sputum production and shortness of breath. These are few effective treatments and the cause of bronchiectasis is unknown in the majority of patients. It is hypothesised that unrecognised immune defects may predispose to bronchiectasis or affect the severity of lung disease. Ficolin-2 is a circulating innate immune protein able to activate the lectin pathway of complement through interaction with mannose binding lectin associated serine protease-2. Through its structural and functional similarity to complement component C1q and mannose binding lectin, it is hypothesised that ficolin-2 may be involved in opsonophagocytosis of pathogens. A number of single nucleotide polymorphisms in the ficolin-2 gene have been described causing considerable variation in human ficolin-2 serum concentrations in healthy individuals. In this thesis, the role of the key lectin pathway components ficolin-2 and mannose binding lectin, are investigated in patients with bronchiectasis. We demonstrate a significant association between single nucleotide polymorphisms in the FCN2 gene and disease severity in bronchiectasis. Specifically, patients with low expressing FCN2 haplotypes have a higher frequency of chronic colonisation, colonisation with P. aeruginosa, more frequent exacerbations and worse health related quality of life. An association between MBL deficient genotypes and disease severity is also demonstrated suggesting an important role for the lectin pathway of complement in modifying disease severity in bronchiectasis. In-vitro studies identify that ficolin-2 is the major lectin pathway component responsible for complement activation on P. aeruginosa and that ficolin-2 binds to a wide range of clinically relevant pathogens. Neutrophils isolated from the sputum of patients with bronchiectasis showed significant alterations in surface receptor expression and function compared to peripheral blood neutrophils, with a novel effect of neutrophil elastase cleavage of CD88 contributing to reduced phagocytosis by airway neutrophils. Despite loss of phagocytic receptors from sputum neutrophils, opsonisation by ficolin-2/MASP-2 complexes still enhanced phagocytosis of P. aeruginosa by sputum neutrophils, suggesting that ficolin-2 may be relevant in the clearance of P. aeruginosa in the airway. In summary, ficolin-2 was found to be an important modifier of disease severity in bronchiectasis.
6

Quality of life questionnaires in respiratory disease

Chan, Lai-yee. January 2000 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 45-47).
7

A pathophysiologic study of airway inflammation in bronchiectasis

葉秀文, Ip, Sau-man, Mary. January 1991 (has links)
published_or_final_version / Medicine / Master / Doctor of Medicine
8

A HRCT and immunohistochemistry study on bronchiectasis

Lam, Sing-chi., 藍承志. January 2004 (has links)
published_or_final_version / abstract / toc / Diagnostic Radiology / Master / Master of Research in Medicine
9

A pathophysiologic study of airway inflammation in bronchiectasis /

Ip, Sau-man, Mary. January 1991 (has links)
Thesis (M.D.)--University of Hong Kong, 1992. / Includes bibliographical references (leaves 186-206).
10

Quality of life questionnaires in respiratory disease

Chan, Lai-yee. January 2000 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 45-47). Also available in print.

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