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The effect of novel compounds on cell survival and apoptosis in colon cancer cell linesDahan-Farkas, Nurit January 2013 (has links)
A dissertation submitted to the Faculty of Health Sciences, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree
of Masters of Science in Medicine (Pharmacology)
Johannesburg, 2013 / Colon cancer is the third most common cancer worldwide and the second most common in
the western world. More than 40 % of colon cancer sufferers develop metastases and
chemotherapy is often used alone or in combination with radiotherapy as adjunctive therapy
for the advanced disease. A major effort has been made in the past decade to develop anticancer
agents through both empiric screening and rational design of new compounds. These
attempts are made to improve the survival rate, reduce the severe adverse effects associated
with existing cancer chemotherapeutic agents as well as to reduce the development of drug
resistance. In the present study, two colon cancer cell lines were exposed to novel
imidazo[1,2-a]pyridines and novel nucleoside analogues, aiming to investigate the cytotoxic
efficacy on the cells, the mode of cell death, and to explore the pathways by which cell death
was induced.
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Different genetic pathways involved in colorectal cancer /Salahshor, Sima, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.
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Colon cancer : disease related proteins in tumor tissue and serum /Roblick, Uwe Johannes, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 6 uppsatser.
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Hormone replacement therapy and colon cancer among members of a health maintenance organization /Jacobs, Eric J. January 1996 (has links)
Thesis (Ph. D.)--University of Washington, 1996. / Includes bibliographical references (leaves [62]-68).
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Colorectal cancer cost-effectiveness of screening and chemoprevention in average risk males /Coffindaffer, Jarrett W. January 2006 (has links)
Thesis (M.S.)--West Virginia University, 2006. / Title from document title page. Document formatted into pages; contains ix, 98 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 92-98).
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Uroguanylin and cGMP signaling : a pathway for regulating epithelial cell renewal in the intestine /Wang, Yuan, January 2001 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2001. / "December 2001." Typescript. Vita. Includes bibliographical references (leaves 95-113). Also available on the Internet.
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Laparoscopic and open surgery for colon cancer : studies on costs and health related quality of life /Janson, Martin, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.
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Enzymology and molecular biology of bile acid 7 [alpha]- and 7[beta]- dehydroxylation by the intestinal bacteria clostridium scindens and clostridium hylemonaeRidlon, Jason Michael, January 1900 (has links)
Thesis (Ph.D.)--Virginia Commonwealth University, 2008. / Title from title-page of electronic thesis. Prepared for: Dept. of Microbiology & Immunology. Bibliography: leaves 289-332.
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Enzymology and molecular biology of bile acid 7 [alpha]- and 7[beta]- dehydroxylation by the intestinal bacteria clostridium scindens and clostridium hylemonae /Ridlon, Jason Michael, January 2008 (has links)
Thesis (Ph.D.)--Virginia Commonwealth University, 2008. / Prepared for: Dept. of Microbiology and Immunology. Bibliography: leaves 289-332. Also available online via the Internet.
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Biomarkers for colon cancer : applications in human and rat studies /Karlsson, Pernilla C., January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 5 uppsatser.
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