This thesis examines the arguments of the Great Debate over the Iroquois Influence Thesis. The author researches the history of the thesis origin and its historiography, plus historical facts, which contribute to the Iroquois Influence Thesis existence. Related statements by the Founding Fathers, an examination of the Cornell Conference on the issue, and points of contention debated by scholars are also conducted. The author used on-line sources, books and scholarly articles fundamental to the Iroquois Influence Thesis to launch the study, then procured sources, documented therein, plus documents and letters to proceed. Findings show cause for the Iroquois Influence Thesis to exist; however, the author's conclusion is that the nature of much evidence is circumstantial, thus, facilitating to the debate. The reader will learn novel details of U.S. Colonial History, and the political and sociological views of the Founding Fathers regarding Indian governments and customs.