No description available.

No description available.

Software maintenance is an important activity in software engineering. Over the decades, software maintenance costs have been continually reported to account for a large majority of software costs [Zelkowitz 1979, Boehm 1981, McKee 1984, Boehm 1988, Erlikh 2000]. This fact is not surprising. On the one hand, software environments and requirements are constantly changing, which lead to new software system upgrades to keep pace with the changes. On the other hand, the economic benefits of software reuse have encouraged the software industry to reuse and enhance the existing systems rather than to build new ones [Boehm 1981, 1999]. Thus, it is crucial for project managers to estimate and manage the software maintenance costs effectively. / Accurate cost estimation of software projects is one of the most desired capabilities in software development Process. Accurate cost estimates not only help the customer make successful investments but also assist the software project manager in coming up with appropriate plans for the project and making reasonable decisions during the project execution. Although there have been reports that software maintenance accounts for the majority of the software total cost, the software estimation research has focused considerably on new development and much less on maintenance. Now if we talk about real time software system(RTSS) development cost estimation and maintenance cost estimation is not much differ from simple software but some critical factor are considered for RTSS development and maintenance like response time of software for input and processing time to give correct output. As like simple software maintenance cost estimation existing models (i.e. Modified COCOMO-II) can be used but after inclusion of some critical parameters related to RTSS. A Hypothetical Expert input and an industry data set of eighty completed software maintenance projects were used to build the model for RTSS maintenance cost. The full model, which was derived through the Bayesian analysis, yields effort estimates within 30% of the actual 51% of the time,outperforming the original COCOMO II model when it was used to estimate theseprojects by 34%. Further performance improvement was obtained when calibrating the full model to each individual program, generating effort estimates within 30% of the actual 80% of the time.

No description available.

No description available.

No description available.

No description available.

No description available.

In these experiments, we primarily investigate the role and source of nerve growth factor (NGF) in peripheral tissues undergoing chronic inflammation. It has been previously determined that there is a significant increase in the levels of NGF following prolonged inflammation of the urinary bladder or the colon, and the first of two projects discussed here mimics this increase with transgenic mice which ectopically produce NGF under control of the smooth muscle alpha-actin promoter. It was determined by this increase that a p75-sensitive increase in sympathetic innervation occurs when an abundance of NGF is produced locally in the descending colon. Sensory innervation in the colon was found to come from two unique populations, one of which increased following heightened NGF levels. The urinary bladders of NGF overexpressing mice were determined to have an increase in sensory axonal density. The second project described here features chemically induced colonic inflammation and observes the nervous and growth factor changes as a response. Transgenic reporter mice are used to observe the cellular source of NGF in the descending colon, which unexpectedly was determined to be Dogiel type II (DgII neurons) based on morphological and chemical characteristics. We report the increase in NGF mRNA and protein observed following a brief 5-day colonic inflammation, and note that there is no increase in axonal density observed. The chemical inflammation did, however, induce an increase in axonal varicosities, used as a measure of axon damage. Finally, a heterozygous null-mutation of NGF was made in a line of transgenic mice to observe changes in local sensory neurons, sympathetic innervation or NGF protein production, but no differences between the heterozygous null mutants and age-matched wild-type siblings were observed. / Thesis (Master, Neuroscience Studies) -- Queen's University, 2013-09-05 12:08:44.326

This thesis has explored the Historiography on William Hohenzollern from the viewpoint of eminent American, British and German historians. Specific phases or incidents have been taken out of William's life and have been analyzed with respect to the historian's viewpoint. The five main books that this study is mostly concerned with are:The Kaiser and His Times,, by Michael Balfour The Kaiser,, by Virginia Cowles The Kaiser, by Joachim von Kirenberg Wilhelm Hohenzollern, by Emil Ludwig The Kaiser on Trial, by George ViereckFive supporting books are used for more specific William's life:Kaiser and Chancellor, by Karl NowakThe Kaiser and His English Relations,, by Edward Benson The Fall of The Kaiser, by Maurice Baumont The Fall of The Dynasties., by Edmond TaylorHistory of The German General Staff, by Walter GoerlitzThis thesis traces the birth of William in 1888 to his abdication as Kaiser in November, 1918. Particular attention is paid to William's personality as seen by his biographers and the reasons for each biographer's study of William is explored.