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The DNA-damaging effect of bile acids and the protective effect of cellulose.Cheah, Peh Yean. January 1989 (has links)
Colon cancer is the second most common type of cancer in the United States. Its incidence is linked epidemiologically to high levels of bile acids in the feces. Bile acids have been implicated as promotors and cocarcinogens in the etiology of colon cancer and as comutagens and mutagens in bacteria. These observations suggest the hypothesis that bile acids may interact directly with DNA. Using agarose gel electrophoresis we showed that bile acids convert covalently closed circular plasmid DNA to the open circular form, indicating strand breakage. We next treated the single stranded circular DNA of phage M13 with bile acids and found that the transfection efficiency of this DNA declined up to a thousand-fold. The concentrations of bile acids used were of the same magnitude as the fecal bile acid concentrations found in colorectal cancer patients. This inactivation was largely prevented when the bile acids were pretreated with cellulose fiber.
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An investigation into different responses of a Pakistani biotype of Callosobruchus maculatus (Bruchidae: Coleoptera) to four new varieties of pulses from PakistanSulehrie, Mohammad Abid Qaiyum January 2000 (has links)
No description available.
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A study of graphoepitaxially grown Al and Cu interconnectsWeaver, David John January 1998 (has links)
No description available.
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Abiotic stress effects in potato (Solanum tuberosum L.) and sweet potato (Ipomoea batatas [L.] Lam.)Richardson, Kenneth Vincent Austin January 2000 (has links)
No description available.
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Analysis of gene regulation by mycobacterium tuberculosis LexADullaghan, Edith Mary January 2000 (has links)
No description available.
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Inducible tolerance and sensitivity to stress responses in 'Escherichia coli' with particular reference to copper and pHHussain, Noor Hana January 1996 (has links)
No description available.
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Characterisation of the RuvB branch migration motorGeorge, Helen Marion January 2000 (has links)
No description available.
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The mechanism by which hyperammonaemia may cause hepatic encephalopathySmart, Kevin Arthur January 1997 (has links)
No description available.
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Mechanisms of regulation of liver metabolism and growthMarker, Alison Jean January 1998 (has links)
No description available.
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The evaluation of p53 function in cells from members of cancer prone familiesLomax, Martine Elizabeth January 1998 (has links)
No description available.
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