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Negotiating the powers : everyday religion in Ghanaian societyGraveling, Elizabeth January 2008 (has links)
Engagement with religion has recently become an important issue to development theoreticians, donors and practitioners. It is recognised that religion plays a key role in shaping moral frameworks and social identities, but little attention is paid to how this is played out in everyday life: the focus remains on ‘faith communities’ and ‘faith-based organisations’ as unified bodies. This thesis uses ethnographic methods to examine how members of two churches in rural Ghana are influenced by and engage with religion. Rather than viewing religion simply as (potentially) instrumental to development, it seeks to approach it in its own right. It challenges the rigidity of categories such as ‘physical/spiritual’ and ‘religious/non-religious’, and the notion of ‘faith communities’ as discrete, unified entities with coherent religious cosmologies. Insights from witchcraft studies and medical anthropology indicate that spiritual discourses are drawn on to negotiate hybrid and continuously changing modernities, and people tend to act pragmatically, combining and moving between discourses rather than fully espousing a particular ideology. Residents of the village studied appear to inhabit a world of different but interconnecting powers, which they are both, to some extent, subject to and able to marshal. These include God, secondary deities, juju, witchcraft, family authorities, traditional leaders, biomedicine and churches. Relationships with both spirits and humans are ambivalent and each of these powers can bring both blessings and harm. Religious experience is fluid, eclectic and pragmatic as people continually enter and exit groups and marshal different powers simultaneously to protect themselves from harm and procure blessings. Approaches by the development world seeking to engage with religion and to take seriously local people’s interests and viewpoints should thus be wary of oversimplification according to traditional Western social science categories, and be underpinned by an understanding of how religious discourses are interpreted and enacted in people’s everyday lives.
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Detecção de beta-lactamase de espectro estendido em membros da família EnterobateriaceaeRodrigues, Lilian de Oliveira [UNESP] 15 August 2005 (has links) (PDF)
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rodrigues_lo_me_arafcf.pdf: 364674 bytes, checksum: 25ad80987f7d2eb4d8bf537154a09922 (MD5) / Universidade Estadual Paulista (UNESP) / A produção de beta-lactamase de espectro estendido (ESBL) em membros da família Enterobacteriaceae pode conferir resistência a cefalosporinas de amploespectro, aztreonam e penicilinas. Devido a esse fenômeno, a detecção exata dos produtores de ESBL é essencial para a seleção apropriada da antibioticoterapia. Para detectar a produção de beta-lactamase de espectro estendido (ESBL) em bacilos Gram-negativos, foi usado um teste de triagem com os discos de aztreonam (ATM), ceftazidima (CAZ), cefotaxima (CTX) e ceftriaxona (CRO) sobre 300 cepas, das quais trinta e cinco eram suspeitas da presença de ESBL. A produção de ESBL foi demonstrada por três métodos fenotípicos confirmatórios de fácil utilização. Os três testes fenotípicos para confirmar a produção de ESBL incluíram o teste do sinergismo (double disk), E-test? ESBL e disco combinado. Os discos utilizados no teste do sinergismo e do disco combinado foram: aztreonam (30?g-ATM), cefotaxima (30?g-CTX), ceftazidima (30?g-CAZ), cefpodoxima (10?g-CPD) ceftriaxone (30?g-CRO) e amoxicilina+ácido clavulânico(30?g-AMC), cefotaxima+ácido clavulânico (30?g-10?g), ceftazidima+ácido clavulânico (30?g- 10?g), cefpodoxima+ácido clavulânico (10?g-1? g). Para E-test foram utilizadas fitas contendo as cefalosporinas: ceftazidima versus ceftazidima/ácido clavulânico; cefotaxima versus cefotaxima/ácido clavulânico. Os testes fenotípicos confirmaram a presença de ESBL em cinco cepas de enterobactérias (1,66%). Todos os métodos são de fácil execução, contudo o método do Etest requer experiência para interpretar os resultados. Os três testes oferecem uma solução viável para confirmar a produção de ESBL no laboratório clínico. / The production of extended spectrum beta-lactamase (ESBL) in the members of the family Enterobacteriaceae can check resistance to cephalosporins of extended-spectrum, aztreonam and penicilins. Due to this phenomenon, the exact detection of the producers of ESBL are essential for the appropriate selection of antimicrobial therapy. To detect the production of extended spectrum beta-lactamase (ESBL) in Gram-negative bacilli, a test of screening was used with the discs of aztreonam (ATM), ceftazidime (CAZ), cefotaxime (CTX) e ceftriaxone (CRO) in 300 strains, of which thirty-five were suspicious of the presence of ESBL. The production of ESBL was demonstrated by three phenotypic methods confirmed of easy utilization. The three phenotypic tests to confirm the production of ESBL included the test of sinergy (double disk), E-test? ESBL and combination disk. The disks used on the test sinergy and the combination disk were: aztreonam (30?g-ATM), cefotaxime (30?g-CTX), ceftazidime (30?g-CAZ), cefpodoxime (10?g-CPD) ceftriaxone (30?g- CRO) e amoxicillin+clavulanic acid (30?g-AMC), cefotaxime+clavulanic acid (30?g- 10? g), ceftazidime+clavulanic acid (30?g-10? g), cefpodoxime+clavulanic acid (10?g- 1? g). For E-test, were utilized strips containing the cephalosporins: ceftazidime and ceftazidime/clavulanic acid; cefotaxime and cefotaxime/clavulanic acid. The phenotypic tests confirmed the presence of ESBL in five strains Enterobacteriaceae (1,66%). All of the methods are of easy execution; however, the method of Etest requires experiment to interpret the results. The three tests offer a viable solution to confirm the production of ESBL on a clinic laboratory.
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Tecnologia de aplicação aérea de fungicidas na cultura do arroz irrigado / Technology aerial application of fungicides in irrigated riceSilva, Tânia Maria Bayer da 16 March 2012 (has links)
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Previous issue date: 2012-03-16 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / Este trabalho teve por objetivo avaliar o efeito de equipamentos e taxas de
aplicação, via aérea, no controle de doenças foliares e patógenos de grãos do arroz
irrigado da cultivar Puitá Inta CL, com o fungicida Azoxistrobina 250g +
Difenoconazol 250, além de verificar a densidade e penetração de gotas no dossel
das plantas através de cartões hidrosensíveis. Avaliou-se a quantidade de fungicida
depositado nos estratos superior e inferior através de análise cromatográfica e
determinou-se a relação entre a área foliar e o peso dos estratos inferior e superior
das plantas. As pulverizações foram realizadas com bico defletor Stol, bico hidráulico
Travicar e atomizador rotativo de discos Turboaero, com volumes variando entre 10
e 30 L.ha-1
. A utilização de cartões hidronsensiveis possibilitou verificar que taxas de
aplicação maiores proporcionaram maior densidade de gotas no estrato superior do
dossel foliar e que todos os equipamentos, assim como as taxas de aplicação
promovem similar penetração de gotas no dossel. Conclui-se que para estudar a
distribuição de produtos químicos nos estratos inferior e superior das plantas via
cromatografia, devem ser feitas extrações de porções vegetais com área foliar
equivalente e não por quantidades com pesos iguais. Mesmo com pouca severidade
de doença, a aplicação de fungicida mostrou-se importante no controle de fungos
presentes nos grãos em pós-colheita, a exemplo de Fusarium sp. e Gerlachia sp.e dos
patógenos Bipolaris sp. e Gerlachia sp. em condições de campo. / This study aimed to evaluate the effect of equipment and application rates, for the
control of foliar diseases and pathogens of grains of rice cultivar Puitá CL Inta, with
the fungicide azoxystrobin + difenoconazole, and check the density and penetration
of drops in the canopy of plants with water sensitive papers. We evaluated the
amount of fungicide deposited in the canopy by chromatographic analysis and
determined the relationship between the leaf area and the weight of upper and lower
layers of the plants. The products were sprayed with Stol deflector nozzle, Travicar
hydraulic nozzle and rotative atomizer Turboaero, with volumes between 10 and 30
L.ha-1
. The use of water sensitive papers allowed to verify that higher application
rates provided a higher density of droplets in the upper stratum of the canopy of
leaves and that all equipment, as well as application rates similar to promote
penetration of droplets into the canopy. It follows that to study the distribution of
chemicals in the lower and upper layers of the plants via chromatography, can be
made with the extraction of plant leaf area portions and not by amounts equivalent
weight equal. Even with low disease severity, fungicide application was shown to be
important in controlling fungi present in grain post-harvest, such as Fusarium sp. and
Gerlachia sp., and the pathogens Bipolaris sp. and Gerlachia sp. at field conditions.
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Sistema intensivo de incubação e manejo de cria de Acará Disco, Symphysodon spp.MORAIS, Francisco Borges 07 July 2005 (has links)
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Previous issue date: 2005-07-07 / The stages of incubation during the phases of egg and larva are taken as the of most difficult phases in the production of several aquatic organisms. The production of the disco fish, Symphysodon spp, by natural method, with eggs and larvae together with their parents, present zootechnical difficulties that influence the productivity negatively. The intensive raising, in the parent isolated system, under broad control process including water quality, feeding and sanitary prophylaxis was assessed in accordance with the larval survival up to the fifteenth day after larvae were born. Seven pairs laid eggs forty one times during the period of 1.182 days, adding up a total of 12.906 eggs, 10.379 of them were born (80,42%). 8.543 of the born larvae (82,31%) survived until the fifteenth day of life. The average fecundity per spawning was 314,8 eggs with Variation coefficient (CV) = 48%, the average number of births per spawning was 253,1 larvae with CV=58% and the average number of living larvae fifteen days after birth was 208,4 with CV=65%. The average interval between spawnings in the same reproduction station was 12,14 days with CV=76% and medium deviation (DM) = 6,6 days. The average interval between spawnings in the sequence reproduction station was 193 days with CV=31% and DM = 45 days. The results concerning the reproductive biology can be applied in the planning and operational. The efficiency, in accordance larval survival, of incubation system was considerate satisfactory. The economical and larval growth rate analysis of the system utilized, with traditional method comparison, should rout one large evaluation of the efficacy of incubation system. / Etapas de incubação durante as fases de ovo e larva são tidas como gargalo à produção de diversos organismos aquáticos. A produção de acará disco, Symphysodon spp, pelo método natural, com ovos e larvas junto ao casal reprodutor, apresenta dificuldades zootécnicas que influenciam negativamente a produtividade. O cultivo intensivo, em sistema isolado dos reprodutores, sob processos de controle abrangente de qualidade de água, alimentação e profilaxia sanitária, foi avaliado em termos de sobrevivência larval até quinze dias pós-eclosão. Sete casais produziram quarenta e uma desovas em um período de 1182 dias, totalizando 12906 ovos, dos quais 10379 eclodiram (80,42%). Das larvas eclodidas, 8543 (82,31%) foram a termo até os quinze dias de vida. A fecundidade média por desova foi 314,8 ovos com coeficiente de variação (CV) de 48%; a eclosão média por desova de 253,1 larvas com CV de 58%, e a média de larvas vivas 15 dias póseclosão foi de 208,4 com CV de 65%. O intervalo médio entre desovas da mesma estação reprodutiva foi de 12,14 dias com CV de 76% e desvio médio (DM) de 6,66 dias, apresentando de 1 a 6 desovas em cada estação reprodutiva. O intervalo médio entre desovas de estações reprodutivas seqüentes foi de 193 dias, com CV de 31% e DM de 45 dias. Os resultados relativos à biologia reprodutiva têm aplicação prática no planejamento e operação de pisciculturas de Symphysodon spp. A eficiência, em termos de sobrevivência larval, do sistema de incubação foi considerada satisfatória. A análise econômica e da taxa de crescimento larval do sistema de larvicultura, em relação ao método natural de cria, balizariam uma avaliação ampla da eficiência do sistema de incubação.
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Efeitos da remoção do disco e cartilagem articular no crescimento e microarquitetura óssea da mandíbula de ratos: análise por microtomografia / Effects of articular disc and cartilage removal on mandible of growing rats: a micro-computed tomography studyEduardo Massaharu Aoki 17 February 2016 (has links)
Alterações na articulação emporomandibular (ATM) comumente geram desequilíbrios musculares que estão associados à alterações no tecido ósseo. Esta articulação pode sofrer a influência de traumas, fatores congênitos ou desordens de crescimento. Estudos sobre alterações de crescimento do complexo maxilomandibular decorrentes de problemas da ATM são escassos. O objetivo deste trabalho foi avaliar por meio da microtomografia os efeitos da remoção do disco articular e a remoção conjugada do disco e cartilagem articular no crescimento e na microarquitetura óssea da mandíbula de ratos. Trinta ratos da raça Wistar com um mês de idade foram divididos em três grupos: CTR (controle operado); RD (remoção de disco articular) e RDC (remoção conjugada do disco e cartilagem articular). Apenas o lado direito foi operado; o lado esquerdo permaneceu intacto. Após dois meses de acompanhamento, os ratos foram sacrificados e as hemimandíbulas escaneadas em microtomógrafo A remoção do disco articular e a remoção conjugada do disco e cartilagem articular alteram o volume e microestrutura do osso trabecular da mandíbula de ratos jovens. Estas duas intervenções provocaram uma queda na qualidade de parâmetros da microestrutura do trabeculado do processo angular e diminuição do crescimento da hemimandíbula do lado operado. / Changes in the temporomandibular joint (TMJ) lead to muscle dysfunctions that are associated with bone changes. This joint region can be influenced by trauma, congenital factors or growth disorders. Studies linking TMJ problems and growth alterations are scarce. The aim of this study was to evaluate the effects of the articular disc removal or articular disc and cartilage removal on the bone microarchitecture and mandibular growth of young rats. Thirty Wistar rats (one month old) were divided into three groups: CTR (sham operated); RD (disc removal) and RDC (disc and cartilage removal). Only the right side was operated, keeping the left side intact. After two months, the rats were sacrificed and the mandibles scanned on micro-CT for quantitative analysis. Some microstructural parameters were altered by the disc removal or disc and cartilage removal. The right side presented lower growth than the left side.
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O disco intervertebral humano nas regiões cervical e lombar: morfologia e envelhecimento. / The human intervertebral disc in the cervical and lumbar segments: morphology and aging.Ricardo Bragança de Vasconcellos Fontes 20 September 2011 (has links)
As alterações morfológicas do envelhecimento normal do disco intervertebral confundem-se com as patológicas. O objetivo deste estudo foi elaborar um perfil destas alterações. Discos intervertebrais cervicais e lombares foram coletados de 30 indivíduos assintomáticos: 15 jovens e 15 idosos. A morfologia foi analisada por macroscopia, ressonância magnética, histologia, microscopia eletrônica de varredura (MEV) e imuno-histoquímica para os colágenos de tipo I, II, III, IV, V, VI, IX e X. Alterações degenerativas foram mais acentuadas nos discos de idosos. O anel fibroso possui lamelas oblíquas que se adensam com o envelhecimento. A análise histológica não revela um núcleo distinto em nível cervical, porém a MEV o demonstra. As fibras colágenas sofreram intenso remodelamento e formam um padrão único para cada segmento. Alterações em nível cervical são semelhantes às lombares com algumas peculiaridades: substituição cartilagínea é comum. Muitas das técnicas rotineiras de avaliação não conseguem detectar as alterações discais ultraestruturais únicas de cada segmento. / The morphological alterations of normal aging in the intervertebral disc are frequently mistaken for those considered to be pathologic. Our aim is to elaborate a morphological profile of these alterations. Human cervical and lumbar intervertebral discs were harvested from 15 young (<35 years old) and 15 elderly (>65 years old) asymptomatic individuals. Their morphology was studied utilizing macroscopic technique, magnetic resonance, histology, scanning electron microscopy (SEM) and immunohistochemistry against types I, II, III, IV, V, Vi, IX and X collagens. Degenerative changes were more evident in discs of elderly individuals but even young discs displayed significant degeneration. The annulus is composed of oblique lamellae that get denser as they age. Histology frequently did not reveal a distinct nucleus in the cervical segment but SEM did. Collagen fibers form a pattern unique to each segment. Alterations in cervical discs are similar to those in lumbar specimens but include peculiarities. Several alterations could not be detected by MR or normal histology.
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Estudo da correlação entre posicionamento do disco articular, cabeça da mandíbula, estalo e dor à palpação em pacientes portadores de disfunção temporomandibular avaliados clinicamente e pela ressonância magnética / Study of correlation between articular disc position, condyle, clicking and pain on palpation in patients with temporomandibular disorders assessed clinically and by magnetic resonance imagingThaís Borguezan Nunes 11 March 2013 (has links)
A Disfunção Temporomandibular (DTM) se refere a várias doenças que envolvem os músculos da mastigação e/ou a articulação temporomandibular (ATM). Ao longo da história, o desenvolvimento de técnicas de imagem possibilitou a avaliação das disfunções intra-articulares. A Ressonância Magnética (RM) é considerada o melhor método de avaliação de imagem para diagnosticar doenças da ATM e o exame mais preciso para detectar a posição do disco articular e visualizar estruturas ósseas, como a cabeça da mandíbula e a fossa mandibular, complementando o exame clínico. A associação entre sinais e sintomas de DTM e achados na RM é controversa na literatura e a correlação entre a posição da cabeça da mandíbula dentro da fossa mandibular e a sintomatologia de pacientes diagnosticados com DTM foi pouco elucidada pelos autores. O objetivo do estudo foi analisar os achados imaginológicos da ressonância magnética quanto à posição da cabeça da mandíbula e quanto à posição do disco articular, verificando sua correlação com os sinais clínicos de estalo e de dor à palpação muscular e articular relatados pelo paciente. Foram analisados 163 prontuários contendo ficha clínica e exame de RM de pacientes com DTM. As fichas clínicas forneceram dados referentes a sinais e sintomas dos pacientes, como presença de estalo e de dor à palpação, e o exame de imagem possibilitou a classificação da posição do disco articular (em posição, deslocado com redução e deslocado sem redução) e da cabeça da mandíbula (concêntrica, posterior e anterior). As variáveis clínicas e imaginológicas foram avaliadas por meio de um método de classificação que proporcionou uma análise dos dados sob o ponto de vista holístico, levando em consideração a situação clínica das duas ATMs do mesmo paciente simultanamente. Os dados obtidos foram analisando usando o teste exato de Fischer. A classificação adotada dificultou a comparação com outros estudos, já que usualmente os autores fazem a somatória das articulações do lado direito e esquerdo, porém é válida por proporcionar uma análise das variáveis clínicas e imaginológicas dentro de um sistema, que é o indivíduo. No estudo, 20,2% dos pacientes eram homens e 79,8% eram mulheres com média de idade de aproximadamente 37 anos. Os pacientes se distribuíram em maior porcentagem quando houve a mesma posição dos discos articulares bilateralmente (65,0%), porém quanto à cabeça da mandíbula, combinações heterogêneas foram observadas em maior quantidade (60,7%). Apenas 19,1% da amostra não possuía estalo e 25,8% apresentavam dor posterior à cápsula articular. Os músculos mais álgicos foram pterigoideo lateral e masseter, já os menos álgicos foram temporal posterior e cervical. A média de dor total muscular e articular (10,56) se mostrou maior do que a média de dor muscular (9,60) nos pacientes. A dor total em pacientes com ausência de dor posterior à cápsula articular foi significativamente menor do que a dor total em pacientes que apresentam dor posterior à cápsula bilateral. Não houve correlação entre a posição do disco articular e da cabeça da mandíbula, nem entre as variáveis clínicas e imaginológicas. A nova metodologia proposta permitiu a observação de que a maioria dos pacientes apresenta discos bilateralmente concordantes quanto à posição e que a presença de artralgia está relacionada à maior quantidade de músculos álgicos à palpação. / Temporomandibular Disorder (TMD) refers to various diseases involving masticatory muscles and/or temporomandibular joint (TMJ). Throughout history, the development of imaging techniques enabled the evaluation of intra-articular disorders. Magnetic resonance imaging (MRI) is considered the best method for evaluating image to diagnose TMJ diseases and most accurate test to detect the position of the articular disc and display bone structures as the condyle and glenoid fossa, complementing the clinical examination. The association between signs and symptoms of TMD and MRI findings in the literature is controversial and the correlation between the position of the condyle within the fossa and symptoms of patients diagnosed with TMD was somewhat elucidated by the authors. The aim of the study was to analyze the findings of magnetic resonance imaging as the position of the condyle (posterior, anterior or concentric) and on the position of the articular disc (in position, displaced with or without reduction), verifying its correlation with clinical signs clicking and pain on palpation of muscle and joint reported by the patient. We analyzed 163 records containing medical records and MRI in patients with TMD. The medical records provided data for signs and symptoms of patients such as presence of clicking and pain on palpation, and imaging examination allowed the classification of the position of the articular disc (in position, displaced with reduction and displaced without reduction) and condyle (concentric, posterior and anterior). The clinical and imaging procedures were evaluated using a grading method that provided an analysis of the data under the holistic point of view, taking into account the clinical condition of the two TMJs of the same patient. Data were analyzed using the Fisher exact test. The classification adopted it was difficult to compare with other studies, since usually the authors make the sum of the joints of the right and left side, however it is valid for providing an analysis of clinical and imaging procedures within a system, that is the individual. In the study, 20.2% were men and 79.8% were women with a mean age of approximately 37 years. The patients were divided into greater percentage when there was the same position of the articular disc bilaterally (65.0%), but as condyle heterogeneous combinations were observed in greater amounts (60.7%). Only 19.1% of the sample had no clicking and 25.8% had joint pain. The muscles more algesic were lateral pterygoid and masseter muscles, the less pain conditions were already temporal posterior and cervical. The average overall muscle and joint pain (10.56) was larger than the average muscle pain (9.60) in patients. The total pain in patients with no joint pain was significantly lower than the total pain in patients with bilateral joint pain. There was no correlation between the position of the articular disc and the condyle, or between clinical and imaging procedures. The new methodology allowed the observation that the majority of patients have bilateral agreement discs considering the position and the presence of arthralgia is closely related to the amount of muscles on palpation pain conditions.
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Computational Modeling of the AT<sub>2</sub> Receptor and AT<sub>2</sub> Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound ModelsSköld, Christian January 2007 (has links)
<p>Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). An equally important objective was to gain an understanding of the requirements for ligand binding to the Ang II receptors, with a focus on interactions with the AT<sub>2</sub> receptor.</p><p>The bioactive conformation of a peptide can provide important guidance in peptidomimetic design. By designing and introducing well-defined secondary structure mimetics into Ang II the bioactive conformation can be addressed. In this work, both γ- and β-turn mimetic scaffolds have been designed and characterized for incorporation into Ang II. Using conformational analysis and the pharmacophore recognition method DISCO, a model was derived of the binding mode of the pseudopeptide Ang II analogues. This model indicated that the positioning of the Arg side chain was important for AT<sub>2</sub> receptor binding, which was also supported when the structure–activity relationship of Ang II was investigated by performing a glycine scan.</p><p>To further examine ligand binding, a 3D model of the AT<sub>2</sub> receptor was constructed employing homology modeling. Using this receptor model in a docking study of the ligands, binding modes were identified that were in agreement with data from point-mutation studies of the AT<sub>2</sub> receptor.</p><p>By investigating truncated Ang II analogues, small pseudopeptides were developed that were structurally similar to nonpeptide AT<sub>2</sub> receptor ligands. For further guidance in ligand design of nonpeptide compounds, three-dimensional quantitative structure–activity relationship models for AT<sub>1</sub> and AT<sub>2</sub> receptor affinity as well as selectivity were derived. </p>
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Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound ModelsSköld, Christian January 2007 (has links)
Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). An equally important objective was to gain an understanding of the requirements for ligand binding to the Ang II receptors, with a focus on interactions with the AT2 receptor. The bioactive conformation of a peptide can provide important guidance in peptidomimetic design. By designing and introducing well-defined secondary structure mimetics into Ang II the bioactive conformation can be addressed. In this work, both γ- and β-turn mimetic scaffolds have been designed and characterized for incorporation into Ang II. Using conformational analysis and the pharmacophore recognition method DISCO, a model was derived of the binding mode of the pseudopeptide Ang II analogues. This model indicated that the positioning of the Arg side chain was important for AT2 receptor binding, which was also supported when the structure–activity relationship of Ang II was investigated by performing a glycine scan. To further examine ligand binding, a 3D model of the AT2 receptor was constructed employing homology modeling. Using this receptor model in a docking study of the ligands, binding modes were identified that were in agreement with data from point-mutation studies of the AT2 receptor. By investigating truncated Ang II analogues, small pseudopeptides were developed that were structurally similar to nonpeptide AT2 receptor ligands. For further guidance in ligand design of nonpeptide compounds, three-dimensional quantitative structure–activity relationship models for AT1 and AT2 receptor affinity as well as selectivity were derived.
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La canzone pop e il cinema italiano (1958-1963. Forme, gene ri, processi di trasformazioneBUZZI, MAURO 26 June 2012 (has links)
La tesi si occupa di indagare il campo della popular music italiana durante il periodo del boom, così come della situazione cinematografica nazionale del periodo. In seguito si analizzano le forme di utilizzo della prima all'interno del secondo, soprattutto nei confronti di due oggetti che nel rapporto prendono corpo:
1 - Il musicarello, che si configura come vero e proprio genere e di cui si vedranno caratteri principali e genesi
2 - L'insieme di film che fanno della canzone un uso significativo, ma non per questo si costituiscono come genere, o come corpo coeso. In comune hanno però una particolare configurazione di stile, che si costituisce appunto attorno al loro uso della canzone, e che si confronta con la questione della presenza di un "film medio" nazionale. / In Italy, between the end of the Fifties and the first half of the Sixties, a phenomenon of deep economic growth changes the nation in many ways. In the same period the first generation of young people starts to be known as such. With it followed the consideration of consumption as an opportunity for an aggregate and generational claim, pushing film, record, magazine and clothing producers to think of objects conforming to this desire, or even making it stronger. Medial consumption is one of the key practices that permitted to express a social and individual identity. The Thesis try to find out how an important medium like popular music, match himself with cinema, and what kind of new linguistic solution, and social practice they build together.
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