Global ETD Search

1	Development of a Distal Tip Extension Mechanism for Endoscopes Kadhim, Ibrahim F. 25 August 2015 (has links) No description available. Mechanical Engineering Extension Mechanism Colonoscopy Distal Tip Loops in Colon Extension Knob Telescoping Shaft Extension Process
2	smig-1(ev809) is a Novel Suppressor of Distal Tip Cell Migration Mutants in Caenorhabditis elegans Tran, Nhat 19 March 2014 (has links) smig-1(ev809) is a novel suppressor of multiple distal tip cell (DTC) migration mutants in the nematode Caenorhabditis elegans. In the C. elegans hermaphrodite, the two U-shaped gonad arms develop and form as a result of the migration of two DTCs. smig-1(ev809) suppresses DTC migration defects of mutants encoding components of intracellular glycosylation pathways as well as extracellular basement membrane glycoproteins. The smig-1(ev809) mutation bypasses the requirement for a fully functional chondroitin pathway and MIG-17 metalloprotease in DTC pathfinding. I found that i) suppression of the hypomorphic chondroitin mutant mig-22(k141) is not completely dependent on MIG-17 activity; ii) the smig-1(ev809) mutant is likely to be a loss- of-function suppressor; and iii) SMIG-1 does not visibly affect the localization of poorly glycosylated MIG-17 on the gonad surface. Understanding SMIG-1 function will shed light on the role of glycosylation, the extracellular matrix and basement membranes in cell migration during development. cell migration developmental genetics ADAMTS metalloprotease chondroitin distal tip cell mig-6 ev809 mig-17 mig-22 glycosylation mig-23 tm4684 C50F2.4 basement membrane 0369
3	smig-1(ev809) is a Novel Suppressor of Distal Tip Cell Migration Mutants in Caenorhabditis elegans Tran, Nhat 19 March 2014 (has links) smig-1(ev809) is a novel suppressor of multiple distal tip cell (DTC) migration mutants in the nematode Caenorhabditis elegans. In the C. elegans hermaphrodite, the two U-shaped gonad arms develop and form as a result of the migration of two DTCs. smig-1(ev809) suppresses DTC migration defects of mutants encoding components of intracellular glycosylation pathways as well as extracellular basement membrane glycoproteins. The smig-1(ev809) mutation bypasses the requirement for a fully functional chondroitin pathway and MIG-17 metalloprotease in DTC pathfinding. I found that i) suppression of the hypomorphic chondroitin mutant mig-22(k141) is not completely dependent on MIG-17 activity; ii) the smig-1(ev809) mutant is likely to be a loss- of-function suppressor; and iii) SMIG-1 does not visibly affect the localization of poorly glycosylated MIG-17 on the gonad surface. Understanding SMIG-1 function will shed light on the role of glycosylation, the extracellular matrix and basement membranes in cell migration during development. cell migration developmental genetics ADAMTS metalloprotease chondroitin distal tip cell mig-6 ev809 mig-17 mig-22 glycosylation mig-23 tm4684 C50F2.4 basement membrane 0369

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