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Meiotic events : recombination, DNA repair and the role of small RNA species /Marcon, Edyta. January 2007 (has links)
Thesis (Ph.D.)--York University, 2007. Graduate Programme in Biology. / Typescript. Includes bibliographical references (leaves 166-175). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:NR39036
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Nucleotide excision repair in mammalian cells /Zheng, Yi, January 1999 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1999. / Vita. Includes bibliographical references (leaves 202-222). Available also in a digital version from Dissertation Abstracts.
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Investigation of the mechanistic basis for the role of Rad50 in double-strand break repairBhaskara, Venugopal 28 August 2008 (has links)
Not available / text
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The role of dynamic intracellular protein mobility in mitosis and DNA repairMahen, Robert William John January 2012 (has links)
No description available.
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Molecular basis of TopBP1 BRCT domain interactions in the DNA damage responseLeung, Charles Unknown Date
No description available.
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Cloning of a DNA repair gene (uvsF) from AspergillusOza, Kalpesh January 1989 (has links)
In order to clone the DNA repair gene of Aspergillus nidulans, uvsF$ sp-$ pyrG$ sp-$ strains were transformed with a genomic library in a plasmid vector that carried the pyr-4 gene of Neurospora which complements pyrG mutants of Aspergillus. Out of the several transformants obtained, four were like wild type. For rescuing plasmids, transformant DNA was digested with Bg/II and self ligated, and used for transformation of E. coli. Two types of plasmids were obtained; these two had a region in common ($<$1.0 kb) that was not a simple overlap and gave evidence for rearrangements. Surprisingly, only the plasmids with the larger insert of Aspergillus DNA were able to complement uvsF$ sp-$ in the secondary transformation. Northerns of polyA$ sp+$-enriched mRNA, probed with this plasmid, showed three bands. However, its subclone which spans the shared region hybridized to only one of them (1.0 kb). Two cDNA and five genomic clones were identified. The two cDNA clones though not identical, cross-hybridized. Three out of five genomic clones were identical. The cDNA hybridized to a short segment (2.2 kb) of one of the three types of genomic clones, locating the putative uvsF gene sequence.
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A study of poly(ADP-ribosyl)ation in polyoma virus-transformed and untransformed BHK21/C13 cellsGordon, A. M. January 1986 (has links)
The activity of Adenosine diphosphoribosyl transferase (ADPRT), the chromatin-bound enzyme which specifically catalyses the cleavage of oxidized NAD<sup>+</sup> with the concomitant covalent attachment of the ADP-ribose moiety to acceptor proteins, was investigated in Polyoma Virus-Transformed (PyY) and Untransformed BHK21/C13 (BHK) cells. It was shown that ADPRT activity was consistently 2-4 fold higher in PyY cells than in BHK cells. The spectrum of (ADP-ribose)<sub>n</sub> residues synthesised by the two cell types was very similar when analysed by hydroxyapatite column chromatography. Poly (ADP-ribose) Glycohydrolase activity in the two cell types was identical with 25-30% degradation of the poly(ADP-ribose) over a period of 90 minutes. DNA damage resulting from incubation with Deoxyribonuclease was reflected by an immediate increase in ADPRT activity and an increase in (ADP-ribose)<sub>n</sub> chain length by both cell types. Polyamines which are present at high concentrations in rapidly dividing tissues were able to stimulate ADPRT activity both <i>in vitro</i> and <i>in vivo</i> in BHK and PyY cells. In general the average chain length of ADP-ribose residues synthesised remained unaltered. No significant increase in the level of DNA-strand breakage could be detected in the polyamine-treated cells. Depletion of the cellular polyamine levels resulted in stimulation of ADPRT activity, but there was no significant difference in the spectrum of (ADP-ribose)<sub>n</sub> residues synthesised. Again no significant increase in the level of DNA-strand breaks could be detected in the polyamine-depleted cells. These results suggest that DNA-damage may not be the only means of regulating ADPRT activity and that polyamines may have a role to play in this regard <i>in vivo</i>.
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Investigations into the feasibility of single-stranded oligonucleotide-mediated targeted gene repair in mammalian cells /Lu, Linyu. January 2006 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Also available online.
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Phenotypic analysis of human MLH1 variants for DNA mismatch repair /Hippchen, Karen Jean. January 1900 (has links)
Thesis (M.S.)--Oregon State University, 2008. / Printout. Includes bibliographical references (leaves 75-76). Also available on the World Wide Web.
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Mismatch repair proteins and spermiogenesisShampeny, Katie Marie, January 2008 (has links) (PDF)
Thesis (M.S. in genetics and cell biology)--Washington State University, December 2008. / Title from PDF title page (viewed on Dec. 31, 2008). "School of Molecular Biosciences." Includes bibliographical references.
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