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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
321

Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy

Al Wabel, Naser Ali January 2003 (has links)
No description available.
322

Bone Remodeling Surrounding Primary Teeth in the Maxilla and Mandible of Skeletally Immature Dogs

Randall, Letitia E. 23 August 2010 (has links)
No description available.
323

Evaluation of Computed Tomography Osteoabsorptiometry in Detection of Hip Dysplasia in Labrador Retrievers

Grimm, Patrick Joseph 25 August 2010 (has links)
No description available.
324

Diurnal Differences in Common Electrocardiographic Indices of Arrhythmic Liability in Normal Telemetered Dogs and Telemetered Dogs with Failing Hearts: Implications for Safety Pharmacology and Veterinary Cardiology

Pedraza-Toscano, Adriana Maria January 2011 (has links)
No description available.
325

HEMOGLOBIN SYNTHESIS, FUNCTION AND METABOLISM IN GREYHOUNDS

Zaldivar-Lopez, Sara 26 June 2012 (has links)
No description available.
326

The Delivery of Microencapsulated Non-Autologous Cells to the Central Nervous System of Dogs / Delivery of Microencapsulated Cells to the CNS of Dogs

Barsoum, Susan 09 1900 (has links)
Treatment for neurological diseases has been limited by the presence of the protective blood-brain barrier. Recent studies from our laboratory have shown that direct intraventricular implantation of microcapsules containing genetically modified cells can effectively deliver the transgene product to the mouse brain, thereby circumventing the blood-brain barrier. In this thesis, the experiments were aimed at scaling up the murine experiments to determine if direct implantation of alginate-poly-L-lysine-alginate microcapsules to the central nervous system of dogs was a feasible means of treating the large animal brain. In the first two experiments reported here, microcapsules containing cells genetically modified to secrete human growth hormone were injected into the central nervous system of dogs. Two routes of delivery were examined, intraventricular brain surgery and injection into the spinal intrathecal space (cisterna magna). While empty capsules within the central nervous system were benign, microcapsules containing cells induced an acute inflammatory response in the brain and spinal cord tissue, irrespective of the route of delivery. Human growth hormone was detected transiently in four of six dogs, but the data were interpreted with caution due to extraneous variables such as compromised microcapsules in two of the dogs and previous systemic treatment in six of the other dogs. In the last experiment, microcapsules containing cells genetically modified to secrete the lysosomal enzyme a-L-iduronidase were implanted into the lateral ventricles of a dog with Mucopolysaccharidosis type I in an attempt to correct the characteristic neuronal pathology. An immune response ensued and appeared to abolish any possible effect of the microcapsule treatment. The experiments presented here demonstrate the challenges and obstacles that need to be overcome to effectively scale up therapies from rodent experiments to large animals. The data also shed light on the immunological complications that may arise with invasive and repeated treatment in the central nervous system of large animals. / Thesis / Master of Science (MS)
327

Characterization of Canine Leishmaniasis in the United States: Pathogenesis, Immunological Responses, and Transmission of an American Isolate of Leishmania infantum

Rosypal, Alexa C. 15 April 2005 (has links)
Leishmania infantum, an etiologic agent of zoonotic visceral leishmaniasis, has recently emerged in the foxhound population in the United States and parts of Canada. Leishmania infections are usually spread to mammals by infected sand flies, however epidemiological data do not support a role for sand fly transmission in North America. The purpose of this work was to isolate and characterize L. infantum from a naturally infected foxhound from Virginia (LIVT-1 isolate). A mouse model of North American leishmaniasis was developed using immunocompetent and genetically immunodeficient mouse strains infected with LIVT-1 promastigotes by different inoculation routes. The intravenous route of infection was superior to the subcutaneous route for inducing consistent experimental infections and mice lacking interferon gamma, inducible nitric oxide synthase, or B-cells were resistant to clinical disease. Experimental infections in dogs were performed to examine the infectivity, immune responses, and pathogenicity of LIVT-1. Experimentally infected dogs developed parasitologically proven infections and a range of clinical manifestations that were similar to those observed in naturally occurring disease. Diagnostic tests including culture and cytologic evaluation of bone marrow and lymph node aspirates, polymerase chain reaction, and serology by indirect fluorescent antibody test, and recombinant K39 (rK39) immunoassay were evaluated. Kappa statistics revealed that PCR had the highest level of agreement with culture and cytology results although the rK39 dipstick assay consistently identified more experimentally infected dogs. Flow cytometry revealed no significant differences (p>0.05) in CD4+ or CD8+ expression on peripheral blood lymphocytes. Alternate transmission mechanisms in experimentally inoculated mice and dogs were investigated. PCR revealed a low level of vertical and direct transmission of LIVT-1 in inoculated BALB/c mice. Leishmania DNA was detectable by PCR in tissues from puppies from a LIVT-1 infected beagle. Although the strain of L. infantum infecting foxhounds in North America appears to predominantly use a non-vector transmission mode, the disease it produces is similar to canine leishmaniasis in other parts of the world. Non-sand fly transmission may be responsible for maintaining infections in the foxhound population. Results from this work will lead to improvement in diagnosis, clinical management, and control of canine leishmaniasis in North America. / Ph. D.
328

Designing outdoor spaces to support older adult dog walkers: A multi-method approach to identify and prioritize features in the built environment

Shealy, Elizabeth Carlisle 02 April 2021 (has links)
Associations between the built environment and walking are well understood among the general population, but far less is known about how features of the built environment influence walking in older adults. As compared to other age groups, older adults, defined as those 65 years of age and older, are more likely to experience declines in physical activity, social interaction, and loss of community connectivity. Animal companionship can provide older adults the motivation to stay physically active and help them mitigate the feelings of isolation. Built environments that align with the needs and abilities of older adults and their animal companions, like dogs, can encourage and help sustain walking habits. The aim of this study was to identify and prioritize features within the built environment pertinent to older adult dog walkers. Existing literature served as the basis for identifying neighborhood design features associated with general walking and dog walking. Through the use of a three round Delphi study, 25 experts from urban planning and design, management of outdoor spaces, public health, gerontology, and human-animal relationships modified and rated the importance of the identified features as it pertains to older adult dog walkers. Following the Delphi study, 12 older adult dog owners from the Warm Hearth Village participated in a guided walk and interview using the Photovoice technique. The goal was to gather their perceptions of the outdoor walking environment. Among expert panelists, safety from motorized traffic, crime, unleashed dogs, and personal injury was paramount (mean (M)= 93.20, standard deviation (SD) = 11.54). Experts also saw the value and agreed upon the importance of dog supportive features within the built environment, like dog waste stations dog waste stations (desirable; M = 87.95, SD = 11.37), and dog policy signage (desirable; M = 79.91, SD = 11.22). Older adults also believed safety was important. They saw their dog as a protective safety factor against walking deterrents like aggressive or unleashed dogs. However, the feature that resonated most with older adult dog walkers in this study was their interaction with nature. They described the pleasure of observing seasons change and the connection with nature that came from the tree canopy cocooning the walking path. Path design is also a necessary consideration. Older adults emphasized the importance of having options between paved and unpaved walking paths. The panelists stressed the need for creating lines of sight (desirable; M = 66.46, SD = 20.71) and lighting (desirable; M = 77.92, SD =19.77). Those who plan, develop, and maintain spaces that support older adults can prioritize the features I identified in my research. Incorporating these features into the design of spaces for older adults has the potential to translate into increased walking and opportunities to socialize, contributing to mental and physical health. / Doctor of Philosophy / Associations between the built environment and walking are well understood among the general population, but less is known about how features in the built environment influence older adults. As compared to other age groups, older adults are more likely to experience declines in physical activity and social interaction. Animal companionship can provide motivation to stay physically active and help them mitigate feelings of isolation. Built environments that align with the needs of older adults and their animal companions, like dogs, can encourage and help sustain walking habits. My research identified and prioritized features within the built environment pertinent to older adult dog walkers. I implemented an iterative three round study to gain consensus among expert panelists and guided walks and interviews with older adult dog walkers. Among expert panelists, safety from motorized traffic, crime, unleashed dogs, and personal injury was paramount. Experts also saw the value of dog supportive features within the built environment, like dog waste stations. Older adults also believed safety was important. They saw their dog as a protective safety factor against walking deterrents like aggressive dogs. The feature that resonated most with older adult in this study was nature. They described the pleasure of observing seasons change and the connection with nature that came from the tree canopy cocooning the walking path. Path design is also a necessary consideration. Older adults emphasized the importance of having options between paved and unpaved walking paths. Those who plan, develop, and maintain spaces that support older adults can prioritize the features I identified in my research. Incorporating these features into outdoor spaces has the potential to translate into increased walking and opportunities to socialize, contributing to mental and physical health.
329

The Effect of Hypothyroidism on Glucose Tolerance in Dogs

Inteeworn, Natalie 30 May 2008 (has links)
Background: Canine hypothyroidism is thought to cause abnormalities in glucose homeostasis, but the effect on glucose tolerance and insulin sensitivity has not been determined to date. Hypothesis/Objectives: The purpose of the study was to investigate whether hypothyroidism has an effect on glucose tolerance and insulin sensitivity in dogs. We hypothesized that hypothyroidism causes insulin resistance. Animals: Sixteen euthyroid bitches were randomly selected and allocated into two groups. In 8 dogs, hypothyroidism was induced by administration of 1 mCi/kg I-131. Experiments were performed on non-anesthetized, fasted dogs in anestrous approximately 12 months after hypothyroidism was induced. Methods: The insulin-modified frequently sampled intravenous glucose tolerance test (FSIGT) and minimal model analysis were used to determine basal insulin and glucose concentrations, acute insulin response to glucose (AIRg), insulin sensitivity (SI), glucose effectiveness (SG) and the disposition index (DI). Results: In the hypothyroid group, basal glucose concentrations were mildly decreased (P = 0.0079), whereas basal insulin was increased (P = 0.019). Insulin sensitivity was reduced in the hypothyroid group (P<0.001), whereas AIRg was higher (P=0.01). Other parameters were not different between groups. Conclusions/Clinical Importance: Hypothyroidism negatively affects glucose homeostasis by inducing insulin resistance. In hypothyroid dogs, the disposition index (insulin sensitivity x insulin secretion) remained unchanged due to a compensatory increase in insulin secretion, thereby maintaining glucose tolerance. In cases with impaired insulin secretion, such as canine diabetes mellitus, concurrent hypothyroidism can have important clinical implications in the successful management of the disease. / Master of Science
330

Biochemical and Immunocytochemical Characterization of Canine Corneal Cells Cultured in Two Different Media

Schorling, Jamie J. 06 June 2007 (has links)
The study purpose was to determine whether canine corneal cultures demonstrate superior growth when cultured in a fully defined epithelial selective medium, Epilife®, compared to Dulbecco's modification of Eagle's medium (DMEM) with fetal bovine serum (FBS), and to characterize cultured canine corneal cells. Superficial keratectomies were performed on three dogs. Samples were trypsinized to separate cell layers. Post-trypsinization, immunohistochemistry confirmed that epithelial cells had been released from the stroma. Both cell populations (presumed epithelial cells and stromal tissues) were cultured in DMEM with FBS or Epilife®. First passage cells were fixed for immunocytochemistry and prepared for PCR. Immunocytochemical staining for pancytokeratin, vimentin, and E-cadherin was evaluated, and immunofluorescence for zonula occludens-1 was attempted. Amplification of cytokeratin 5 (CK5) mRNA was assessed by PCR. Primary presumed epithelial cells grew faster when cultured in DMEM with FBS compared to Epilife®. Stromal tissue segments in Epilife® medium failed to adhere to culture plates, indicating that this medium may inhibit attachment and growth of non-epithelial tissues. Staining of corneal tissue segments confirmed that epithelial layers were pancytokeratin and E-cadherin positive, while stromal cells were vimentin positive. Immunocytochemistry of cultured cells revealed that epithelial cells stained positively for pancytokeratin, vimentin, and E-cadherin, while stromal cells remained only vimentin positive. Greater amplification of CK5 mRNA occurred from epithelial cells grown in Epilife® compared to epithelial cells in DMEM with FBS or the stromal cells. Based on PCR results, Epilife® medium may support retention of the epithelial characteristic of CK5 mRNA expression better than DMEM with FBS. / Master of Science

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