Advanced Driver Assistance Systems (ADAS) and semi-autonomous driving systems are intended to enhance driver performance and improve transportation safety. The potential benefits of these technologies, such as reduction in number of crashes, enhancing driver comfort or convenience, decreasing environmental impact, etc., are well accepted and endorsed by transportation safety researchers and federal transportation agencies. Even though these systems afford safety advantages, they challenge the traditional role of drivers in operating vehicles. Driver acceptance, therefore, is essential for the implementation of ADAS and semi-autonomous driving systems into the transportation system. These technologies will not achieve their potential if drivers do not accept them and use them in a sustainable and appropriate manner. The potential benefits of these in-vehicle assistive systems presents a strong need for research. A comprehensive review of current literature on the definitions of acceptance, acceptance modelling approaches, and assessment techniques was carried out to explore and summarize the different approaches adopted by previous researchers. The review identified three major research needs: a comprehensive evaluation of general technology acceptance models in the context of ADAS, development of an acceptance model specifically for ADAS and similar technologies, and development of an acceptance assessment questionnaire. Two studies were conducted to address these needs. In the first study, data collection was done using two approaches: a driving simulator approach and an online survey approach. In both approaches, participants were exposed to an ADAS and, based on their experience, responded to several survey questions to indicate their attitude toward using the ADAS and their perception of its usefulness, usability, reliability, etc. The results of the first study showed the utility of the general technology acceptance theories to model driver acceptance. A Unified Model of Driver Acceptance (UMDA) and two versions (a long version with 21 items and a short version with 13 items) of an acceptance assessment questionnaire were also developed, based on the results of the first study. The second was conducted to validate the findings of first study. The results of the second study found statistical evidence validating UMDA and the two versions of the acceptance assessment questionnaire.