571 |
Generation and application of x-rays from excimer laser produced plasmasTurcu, Ion Cristian Edmond January 1997 (has links)
No description available.
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572 |
Studies on the synthesis of biologically active steroids containing fluorine and/or sulphurLister-James, J. January 1981 (has links)
No description available.
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573 |
A study of some anastigmat lens systems of up to five lens elements using optimization techniquesSharma, K. D. January 1980 (has links)
No description available.
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574 |
Investigations of furo and thienopyronesClark, B. P. January 1982 (has links)
No description available.
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575 |
Photosensitive effects in optical fibresMcStay, Daniel January 1989 (has links)
No description available.
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576 |
The role of Bâ†1 and Bâ†2 kinin receptors in the modulation of inflammatory hyperalgesia in the rat knee jointDavis, Andrew John January 1998 (has links)
No description available.
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577 |
Generated surface area and related characteristics of compressed tabletsWells, J. I. January 1980 (has links)
No description available.
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578 |
Studies on the biochemical and pharmacological classification of vascular 5-HTâ†1-like receptorsSumner, Michael January 1991 (has links)
No description available.
|
579 |
Studies on the synthesis and antibacterial activities of 5- and 6-substituted quinazolinesHarris, N. V. January 1985 (has links)
No description available.
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580 |
Alpha-adrenoceptor subtypes in the cardiovascular system of the pithed ratPaciorek, P. M. January 1986 (has links)
The selectivity of a series of benzoquinolizines has been evaluated for pre and postjunctional α2-adrenoceptors in the pithed rat. Wy 25309, Wy 26392 and Wy 26703 exhibited a similar selectivity for, and potency at α2-adrenoceptors, to those of the α2-adrenoceptor antagonists yohimbine and idazoxan. The α2-adrenoceptor antagonists employed in this study did not reveal a difference between pre and postjunctional α2-adrenoceptors. The α2-adrenoceptor antagonist potencies of Wy 26392, Wy 26703 and yohimbine varied depending on the α2-adrenoceptor agonists employed. In addition to their α2-adrenoceptor agonist properties, B-HT 933, UK-14,304, clonidine, guanabenz and α-methylnoradrenaline were demonstrated to possess α1- or β-adrenoceptor agonist properties, or to be subjected to neuronal uptake. These other pharmacological properties of the α2-adrenoceptor agonists contributed to the varying α2-adrenoceptor antagonist potencies obtained. Under certain experimental conditions, blockade of prejunctional α2-adrenoceptors with Wy 26392 or yohimbine, potentiated the peak tachycardia to cardiac sympathetic nerve stimulation, and prolonged the duration of responses following cessation of stimulation, independently of the peak tachycardia obtained. Under the same experimental conditions, blockade of α1-adrenoceptors with prazosin resulted in a prolongation of the duration of responses following cardiac nerve stimulation without potentiating the peak tachycardia obtained. It is proposed that under these experimental conditions, α1-adrenoceptors participate in an endogenous negative feedback mechanism. Further examination of α1-adrenoceptors modulating responses in the heart revealed that under certain experimental conditions, the α1-adrenoceptor agonist methoxamine inhibited the tachycardia evoked by cardiac sympathetic nerve stimulation, or by isoprenaline, via a prazosin sensitive mechanism. The inhibitory effects of methoxamine on an isoprenaline tachycardia could still be demonstrated in 6-hydroxydopamine treated rats. In addition, the inhibitory effects of methoxamine on an isoprenaline tachycardia were partially blocked with indomethacin. It is proposed that there are two separate inhibitory α1-adrenoceptors in the pithed rat heart.
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