<p>Göran Tunströms roman Juloratoriet har fängslat många läsare och man har forskat om boken inom många olika områden, men lämnat far och son perspektivet orört. Det fick bli mitt området som jag koncentrerade mig på och jag undersöker Aron och Sinders relation och Sidners och Viktors relation till varandra. Jag går även kort in på Torin och Garys relation. Jag använder mig av manlighetsperspektivet för att få ut så mycket som möjligt av min analys.</p>

Göran Tunströms roman Juloratoriet har fängslat många läsare och man har forskat om boken inom många olika områden, men lämnat far och son perspektivet orört. Det fick bli mitt området som jag koncentrerade mig på och jag undersöker Aron och Sinders relation och Sidners och Viktors relation till varandra. Jag går även kort in på Torin och Garys relation. Jag använder mig av manlighetsperspektivet för att få ut så mycket som möjligt av min analys.

Thesis--Göttingen. / Lebenslauf. Bibliography: p. xiii-xix.

Thesis--Göttingen. / Lebenslauf. Bibliography: p. xiii-xix.

Le projet principal a consisté à étudier le rôle d'ATAD3 dans un modèle de différenciation cellulaire en culture, les cellules adipocytaires 3T3-L1 induites par l'insuline. L'induction de ces cellules provoque la mise en route du programme d'adipogenèse qui précède la synthèse de gouttelettes de triglycérides (lipogenèse). Nous avons observé qu'au cours de la différenciation, une synthèse et un remodelage du réseau mitochondrial ont lieu. ATAD3, exprimée dans les pré-adipocytes, s'accumule avant la synthèse et le remodelage du réseau mitochondrial et est maintenue élevée tout au long de la différenciation. Nous avons réalisé des lignées invalidées constitutivement pour ATAD3 (siRNA) et étudié la différenciation de ces cellules. Nous avons montré que l'invalidation d'ATAD3 inhibe la lipogenèse et le remodelage du réseau mitochondrial sans affecter la signalisation par l'insuline ni la synthèse des protéines mitochondriales. Le phénotype a été récupéré par transfection d'ATAD3 et une complémentation par Drp1 a été mise en évidence. Ces résultats montrent qu'ATAD3 est nécessaire et limitant dans la différenciation adipocytaire. Trois projets annexes ont complétés ce travail de thèse : Le premier a consisté à contribuer à la purification d'ATAD3 humaine, produite chez la levure. Ces expériences n'ont pas permis de révéler l'activité ATPasique d'ATAD3 mais ont permis d'obtenir une quantité significative de protéine recombinante qui pourra servir à la production d'anticorps ainsi qu'à d'autres applications. Le second a consisté à étudier les isoformes d'ATAD3 chez l'homme et les rongeurs. Ces expériences ont permis de révéler l'existence de plusieurs isoformes tissulaires. Un troisième projet a consisté à identifier des partenaires protéiques d'ATAD3 afin de tenter de comprendre la fonction de cette protéine. A l'aide de sondes protéiques d'ATAD3 radiomarquées (transcription/traduction in vitro), nous avons réalisé des tests d'interaction de type Far Western. Ces expériences ont aboutis à quelques candidats potentiels interagissant avec les parties N- ou C-terminale d'ATAD3. / ATAD3 is a vital inner membrane mitochondrial ATPase with unknown function but widely expressed in animals and plants. The main project was to study the role of ATAD3 in a cellular model of differentiation, the one used being adipocyte-like 3T3-L1 cells induced by insuline. Induction of these cells provokes the start of the adipogenesis program which precedes lipid droplets synthesis (lipogenesis). We observed that along differentiation, a synthesis and a remodelling of mitochondria occur. ATAD3, which is expressed in pre-adipocytes, is increased before lipid droplets accumulation and before mitochondrial synthesis and remodelling and is maintained all along differntiation. We have generated cell lines with constitutive invalidation of ATAD3 (siRNA) and studied the differentiation of these cells. We have shown that ATAD3 invalidation inhibits lipogenesis and mitochondrial remodelling without any inhibition of insulin transduction signal neither inhibition of mitochondrial protein synthesis. The phenotype was rescued by ATAD3 transfection and complemented by over-expression of Drp1. These results show that ATAD3 is a necessary and limiting factor in adypocyte differentiation and lipogenesis. Three parallel projects completed this thesis work: The first was to contribute to purification of recombinant human ATAD3 produced in yeast. These experiments didn't allow us to reveal the ATPase activity of ATAD3 but allowed us to obtain a significant quantity of purified protein that will be useful to generate antibodies and also for others applications. The second was to study ATAD3 isoforms expression profiles in human and rodent samples. These experiments allowed the description of several isoforms of ATAD3 with tissue-specific expression. A third project was the identification of ATAD3 protein partners in order to try to understand its function. Using labelled ATAD3 protein probes (in vitro transcription/traduction), we performed interaction tests by Far Western. These experiments led to the identification of seve

Spatial dependency is commonly measured and tested with Moran's I statistic. The question to be answered is, whether far-off objects affect this statistic and influence the test. Far-off objects are observations that are far apart from all other objects in the dataset, i.e. they do not have spatial links to other design points. In the paper different possibilities of treating such objects are discussed, and their influence on Moran's I and the corresponding spatial autocorrelation test is analysed. (author's abstract) / Series: Research Report Series / Department of Statistics and Mathematics

The Project on Government Oversight listed 632 reported acts of government contractor misconduct since 2007 that resulted in settlements or fines totaling $41.95 billion in the government contracting industry. Government contracting officials changed the Federal Acquisition Regulation (FAR) in 2009 to reduce acts of misconduct. The purpose of this causal-comparative study was to discover if the change to the FAR in 2009 significantly reduced the rate of reported contractor misconduct and to investigate the impact of the change on government contractor ethics business processes. Deterrence theory guided this study of how the change to the FAR in 2009 impacted the rate of reported government contractor misconduct (dependent variable) and government contractor ethics business processes (dependent variable). Data were collected on the top 100 government contractors over 2 separate 3-year time periods (independent variable), 2006 through 2008 and 2010 through 2012, before and after the change to the FAR. Data extracted from official government databases and government oversight organizations included annual contract awards (n = 600), contractor misconduct reports (n = 600), and contractor ethics business process records (n = 600). A Wilcoxon Signed-Ranks test resulted in 2 findings. First, the rate of reported government contractor misconduct was not significantly reduced by the change to the FAR in 2009, z = -0.949, p = .34, r = -.072. Second, government contractor ethics business processes were significantly impacted by the change to the FAR in 2009, z = -12.263, p < .001, r = -.763. This study may contribute to positive social change by informing federal contracting authorities and corporate executives that implementing ethics business processes did not reduce misconduct. These findings call for further action to improve corporate ethical behavior.

Federal agencies spend over $400 billion annually on contracts for goods and services to support the mission and vision of their organizations. The purpose of this multiple case study was to determine what strategies federal government contract managers use to prepare effective contract proposals to help ensure business viability. The conceptual framework for this study was the objective theory of contracts. The population for this study was 9 federal contract managers employed by a contracting office located in Alabama, South Carolina, and Georgia. Data were collected from interviews, observation, and document review. Data were analyzed using a cross-case study to explore themes, similarities, and differences across cases. Data analyses revealed 4 key themes: market research, statement of work, independent government cost estimate, and price reasonableness. The findings from this study may help improve government procurement processes by identifying strategies used to prepare efficient contract proposals to increase competition among various contractors and reduce contract disputes. Results may be used by contracting officers and contracting industry to create positive social change by improving corporate social responsibility through accountability and transparent processes that could reduce protests and save taxpayer money.

Thesis (Ph. D.)--Princeton University.

Thesis (Ph. D.)--Princeton University, 1923. / Published also without thesis note.