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Estimation of mutation and switching rates in Plasmodium falciparum genes /Paget-McNicol, Sarah Melanie. January 2000 (has links) (PDF)
Thesis (Ph. D.)--University of Queensland, 2001. / Includes bibliographical references.
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Die biochemische Analyse des Plasmodium-falciparum-Zytoadhärenz-Moleküls PfEmp1 zeigt einen potentiell neuen Mechanismus für die Insertion von Oberflächenproteinen in MembranenPapakrivos, Janni. January 2004 (has links) (PDF)
Marburg, Universiẗat, Diss., 2004.
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Klonierung und Charakterisierung einer Adenylatcyclase aus Plasmodium falciparumWeber, Jost Holger. January 2003 (has links) (PDF)
Tübingen, Universiẗat, Diss., 2003.
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Rate, spectrum and genome-wide distribution of spontaneous mutation in the malaria parasite Plasmodium falciparumHamilton, William Lyle January 2015 (has links)
No description available.
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Development of a flux-balance model of Plasmodium falciparumBlackshaw, James Alan January 2016 (has links)
No description available.
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Functional and structural characterization of the unique bifunctional enzyme complex involved in regulation of polyamine metabolism in Plasmodium falciparumBirkholtz, Lyn-Marie. January 2005 (has links)
Thesis (Ph.D.)(Biochemistry)--University of Pretoria, 2002. / Includes bibliographical references.
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Genetic profiling of drug resistance in Plasmodium falciparum /Certain, Laura K. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 173-196).
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Functional genomics analysis of the effects of co-inhibition of the malarial S-adenosylmethionine decarboxylase/ornithine decarboxylaseVan Brummelen, Anna Catharina. January 2009 (has links)
Thesis (Ph.D.)(Biochemistry))--University of Pretoria, 2008. / Includes summary. Includes bibliographical references. Available on the Internet via the World Wide Web.
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In Silico analysis of malaria parasite databanks for specific genes and motifs associated with immune evasionDe Ridder, Jaco 09 February 2006 (has links)
In Silica analysis of available biological data is a powerful tool for not only the identification of new genes, but also to study evolutionary relationships and regulatory mechanisms. In this study, a number of bioinformatic tools and techniques were applied on the available sequence data of the malaria parasite, Plasmodium falciparum. In Silica techniques were used for the identification of a genomic sequence tag (GST) matching the facilitated glucose transporter family as assessed by BLAST. The open reading frame encoding the fUll-length glucose transporter gene was subsequently assembled from contig sequences of chromosome 2 of the malaria parasite. The frequency of occurrence of di-, tri- and tetranucleotide sequences in both the coding and non-coding regions of chromosome 2 of P. falciparum was also exhaustively analysed. The relative abundance (observed, compared to expected values) of these oligonucleotide sequences, normalised for the nucleotide base composition, was calculated as an odds ratio and compared to those of other organisms. These relative abundancies are referred to as the organism's genomic signature. The CC•GG and CG-dinucleotides exhibited the highest and the lowest odds ratios, respectively. These genome signatures were shown to be constrained by the codon preference and amino acid abundancies. A number of genes with genomic signatures differing significantly from the average signature were also identified and were deduced to be acquired by lateral transfer from unidentified sources. A definite association between interspaced TGCA tetranucleotides and polymorphic traits of the FC27 allele of merozoite surface antigen 2 (MSA-2) was shown. The observed switching and deletion of a limited number of identical nucleotide sequences of several alleles interspersed between direct repeats, provided clues to potential mechanisms employed by the parasite to affect antigenic polymorphism. The identification of a number of motifs for intragenic (homologous) recombination led us to propose a mechanism by which the parasite achieves antigenic variation in single copy genes. These results have profound implications for the design of candidate anti-malarial vaccines, microsatellite typing and characterisation of proteins mediating these recombination events. / Dissertation (MSc (Biochemistry))--University of Pretoria, 2001. / Biochemistry / unrestricted
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Synthesis of bisbenzylisoquinoline alkaloids as novel antimalarial agentsBennett, Stephen January 2001 (has links)
No description available.
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