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Regulation of SMC/MUC4 Expression in the AirwayTheodore, George 18 February 2010 (has links)
MUC4 is a heterodimeric mucin glycoprotein expressed in the epithelia of tissues. Previous studies in our laboratory demonstrated that MUC4 protein expression is regulated by exogenous growth factors and that MUC4 is found in complex with the receptor tyrosine kinase ErbB2. MUC4 protein expression in airway epithelia was evaluated using molecular biology techniques. The impact of the protein on ErbB2 activation was evaluated post mechanical wounding of airway epithelia, and upon MUC4 RNA silencing. MUC4 levels were increased with exposure to the differentiating agent retinoic acid and decreased upon exposure to epidermal growth factor, a proliferative agent. In the absence of MUC4, ErbB2 phosphorylation was diminished. These results support the hypothesis that MUC4 expression is enhanced during differentiation of epithelia. Furthermore these findings provide evidence for an additional level of ErbB regulation in airway injury and subsequent epithelial wound healing.
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Studies of the SH2- and SH3- containing adaptor, Nck /Chen, Min. January 1999 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Biochemistry and Molecular Biology, June 1999. / Includes bibliographical references. Also available on the Internet.
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Regulation of 1,25D(3)-MARRS expression by TGFB1 in a rat intestinal epithelial cell lineRohe, Benjamin G. January 2006 (has links)
Thesis (M.S.)--University of Delaware, 2006. / Principal faculty advisor: Mary C. Farach-Carson, Dept. of Biological Sciences. Includes bibliographical references.
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Role of cytokines in reduced implantation following excessive ovarian stimulationMakkar, Guneet. January 2005 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.
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Studies in cranial suture biologyPremaraj, Sundaralingam. January 2006 (has links)
Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 137-153).
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Spatial and temporal distribution of growth factors receptors in the callus: Implications for improvement of distraction osteogenesisIshiguro, Naoki, Kawasumi, Motoaki, Kitoh, Hiroshi, Siwicka, Karolina A 08 1900 (has links)
No description available.
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Study the therapeutic potential of targeting Granulin-Epithelin Precursor (GEP) in hepatocellular carcinomaTsui, Tsz-wai, Germaine. January 2009 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 78-84). Also available in print.
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Study the therapeutic potential of targeting Granulin-Epithelin Precursor (GEP) in hepatocellular carcinoma /Tsui, Tsz-wai, Germaine. January 2009 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 78-84). Also available online.
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A novel role for activin in wound healing and psoriasis induction of a sensory neuropeptide /Cruise, Bethany Ann. January 2004 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2004. / [School of Medicine] Department of Neurosciences. Includes bibliographical references. Available online via OhioLINK's ETD Center.
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Ex vivo expansion, microRNA expression and immortalization of CD34⁺ cells derived from human umbilical cord bloodKwok, Ka-yin, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 248-277). Also available in print.
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