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Inducible and constitutive modes of gene regulation by the dioxin receptor and Arnt /Antonsson, Camilla, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 4 uppsatser.
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The Optimum Design of a Broad-band Helix for Use in Electron Spin ResonanceGarlow, John R. 06 1900 (has links)
This thesis examines optimum designs for broad-band helix to be used in electron spin resonance.
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Cloning and characterization of genes encoding basic helix loop helix (bHLH) proteins in Arabidopsis /Zhang, Fan, January 2000 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2000. / Vita. Includes bibliographical references (leaves 151-164). Available also in a digital version from Dissertation Abstracts.
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Cloning and characterisation of gripe, a novel interacting partner of e12 during brain developmentHeng, Julian Ik Tsen Unknown Date (has links)
The mammalian cerebral cortex is a remarkable product of brain evolution, and is the structure that most distinctively delineates the human species from others (Northcutt and Kaas, 1995; Rakic, 1988). Neurons in the adult brain are organised into cytoarchitectonic areas, defined by distinct biochemical, morphological and physiological characteristics (Rakic 1988). Remarkably, this complex structure is generated from a simple neuroepithelium. (For complete abstract open document)
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Oncogenic function of TWIST in the development and progression of prostate cancerKwok, Wai-kei. January 2007 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
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Part 1 Synthesis of a potent histone deacetylase inhibitor; Part 2 Studies towards a stabilized helix-turn-helix peptideLiu, Tao 24 February 2007 (has links)
The first part of this work describes the synthesis of a new histone deacetylase (HDAC) inhibitor (HDI). HDAC enzymes modify core histones, influence nucleosome structure and change gene transcription by removing the acetyl groups from lysine residues on proteins. HDIs are showing exciting potential as a new class of drugs for cancer and a variety of other diseases. A new HDAC inhibitor based on the hydroxamic acid motif has been synthesized. Two characteristic structural features were incorporated into the design of the novel inhibitor. A cyclic peptide mimetic of known structure was fused to a hydroxamic acid moiety through an aliphatic chain. The HDAC inhibitor provided significant inhibitory activity against HDACs with an IC50 value of 46 ± 15 nM, and against HDAC8 with an IC50 value of 208 ± 20 nM. The potent HDAC inhibitory activity of the HDAC inhibitor demonstrates the importance of the rim recognition region in the design of HDIs. The hydrophobic cyclic turn mimic allows the formation of a tight complex between HDI and HDAC enzymes.
The second part of this work is to synthesize secondary structure mimics and incorporate them into the helix-turn-helix (HTH) motif. One of the important methods to study the conformation of the biologically active peptides is to incorporate the rigid peptidomimetics into the relevant peptides. Important information can be obtained from the study of conformationally constrained peptides. HTH proteins are well characterized and found in many organisms from prokaryotes to eukaryotes. The relatively small size, simple structure, and significance in stabilizing tertiary structures make the HTH peptide an attractive target to mimic. Both a Gly HTH turn mimic and a Ser HTH turn mimic were synthesized using stereoselective hydrogenation and macrocyclization starting from unnatural amino acids in a yield of 33% and 14%, respectively. The synthesis of Fmoc protected HTH turn mimics allowed incorporation into HTH peptides using Fmoc chemistry on solid phase. The incorporation of the HTH turn mimics into the peptides proved to be challenging, either by sequential elongation or by segment condensation. Alternative peptide synthesis strategies were employed in attempts to solve the problems. / Ph. D.
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Estudio técnico económico para la instalación de un criadero de caracoles comestibles terrestresSonoda Fujimoto, Guillermo January 2006 (has links)
El presente proyecto determina la viabilidad técnica económica para la instalación de un criadero de caracoles comestibles terrestres de la especie HELIX ASPERSA, para su comercialización en el extranjero en su forma precocida y congelada sin concha. El mercado objetivo se conforma por las casas importadoras de Madrid, las cuales adquieren caracoles precocidos y congelados para destinarlos a compradores que exigen carne de caracol de calidad y un abastecimiento constante y creciente. El criadero de caracoles comestibles terrestres se establecerá en el Departamento de Lima, en la Provincia de Lima y en el Distrito de Punta Negra, principalmente por las facilidad de acceso y cercanía a puertos e insumos. El proyecto tiene una vida útil de siete años y planea la producción de 26 TM por año de carne de caracol precocida congelada, para ello durante el primer año de operaciones se alcanzará 15.7 TM cantidad con la que abastecerá el 5.5% del mercado meta y desde el segundo año hasta el año siete 26 TM promedio por año con un 8% en promedio de participación en el mercado. La inversión total asciende a 180369 dólares, los inversionistas aportarán el 65% de la inversión total, alcanzando una suma de 117240 dólares. El 35% restante de la inversión total es 63129 dólares y se obtendrá mediante un préstamo solicitado a la banca comercial. Para el desarrollo del proyecto se utiliza una tasa de descuento de 12%, con dicha tasa de descuento se tiene un VANE = 244801 dólares y un VANF = 243026 dólares; una TIRE = 38% y una TIRF = 45%; se presenta el fenómeno del apalancamiento financiero; y el PRI es 3 años; estos indicadores de rentabilidad permiten concluir que la realización del proyecto es viable desde el punto de vista económico y financiero. Se concluye que dadas las condiciones esenciales para el desarrollo del presente proyecto, la ejecución del proyecto es viable tecnológica y económicamente.
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Mise au point et validation sur sites contaminés (ETM-HAP) d'un test de biosurveillance en microcosme croissance et bioaccumulation par gastéropode terrestre Helix Aspersa Aspersa /Viard-La Rocca, Bénédicte. Pihan, Jean-Claude. January 2008 (has links) (PDF)
Reproduction de : Thèse de doctorat : Sciences de la vie : Toxicologie de l'environnement : Metz : 2004. / Titre provenant de l'écran-titre. Notes bibliographiques.
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Computer simulation and advanced visualisation of DNASfyrakis, Konstantinos January 2001 (has links)
No description available.
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Structure and function of hemocyaninKonings, Wilhelmus Nicolaas. January 1969 (has links)
Proefschrift--Groningen. / "Stellingen": leaf inserted. Bibliography: p. 59-64.
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