Orientador: Fausto Bérzin / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-21T07:47:29Z (GMT). No. of bitstreams: 1 Marques_CristhyanoPimenta_M.pdf: 1436980 bytes, checksum: e41a9812f77cbf93a7e9225b7fd352c6 (MD5) Previous issue date: 2012 / Resumo: O objetivo deste trabalho foi analisar a atividade eletromiográfica da parte descendente do músculo trapézio, submetidos à aplicação da acupuntura sistêmica nos pontos o LI4 (Hegu), LI11 (Quchi), ST36 (Zusanli), LR3 (Taichong), no repouso e durante a contração isométrica voluntária máxima (CIVM), antes e imediatamente após a aplicação da acupuntura. Amostra foi composta por 26 voluntários (10 do gênero masculino e 16 do gênero feminino) assintomáticos (obtido através de um questionário e exame físico) com idade entre 18 e 30 anos, divididos em três grupos: G1MS que recebeu acupuntura nos pontos o LI4 (Hegu), LI11 (Quchi), composta de 8 voluntários, G2MI recebeu acupuntura nos pontos ST36 (Zusanli), LR3 (Taichong), composta por 8 voluntários e o G3MSI que recebeu acupuntura nos pontos o LI4 (Hegu), LI11 (Quchi), ST36 (Zusanli ), LR3 (Taichong), com 10 voluntários. Este estudo foi aprovado pelo Comitê de Ética e Pesquisa (CEP) da Faculdade Atenas com protocolo 004/2011. A coleta de dados foi realizada utilizando-se eletrodo de superfície diferencial simples com ganho de 20 vezes e registrada através de um eletromiógrafo. O sinal eletromiográfico bruto foi quantificado pela Raiz Quadrada da Média (Root Mean Square - RMS) e a FMED (Frequência Mediana). Os sinais eletromiográficos foram submetidos a um filtro passa-alta de 20 Hz e passa-baixa de 500 Hz e a frequência de amostragem utilizada foi de 2000 Hz por canal. Os dados foram submetidos a análise estatística não paramétrica, empregando-se teste Wilcoxon. Comparando os valores médios de RMS bruto do músculo trapézio parte descendente foram observadas reduções significativas (p<0,05) entre situações de repouso para o trapézio parte descendente direito (TD) do G1MS e para o trapézio parte descendente esquerdo (TE) do G2MI, para a CIVM no trapézio parte descendente direito (TD) do G1MS. A FMED se mostrou significativa para o repouso do (TE) do G2MI apresentando -se aumentada e para a CIVM do (TE) como uma redução, não houve diferenças significativas (p>0,05) entre as demais variáveis estudadas. De acordo com a metodologia empregada e análise dos resultados deste estudo, conclui-se que a acupuntura sistêmica é capaz de provocar alterações da atividade eletromiográfica do músculo trapézio parte descendente na condição de repouso e CIMV para as combinações de pontos investigados neste estudo / Abstract: The objective of this study was to analyze the electromyographic activity of the descending part of the trapezius muscle undergoing systemic application of acupuncture points in the LI4 (Hegu), LI11 (Quchi), ST36 (Zusanli), LR3 (Taichong), at rest and during voluntary isometric contraction (MVIC) before and immediately after application of acupuncture. Sample consisted of 26 volunteers (10 males and 16 females) were asymptomatic (obtained through a questionnaire and physical examination) aged between 18 and 30 years, divided into three groups: G1MS the acupuncture points in the LI4 (Hegu), LI11 (Quchi), composed of eight volunteers, G2MI acupuncture points ST36 (Zusanli), LR3 (Taichong), composed of eight volunteers and G3MSI the acupuncture points in the LI4 (Hegu), LI11 (Quchi) ST36 (Zusanli), LR3 (Taichong), with 10 volunteers. This study was approved by the Ethics and Research (CER), School Athens Protocol 004/2011. Data collection was performed using a single differential surface electrode with a gain of 20 times and recorded by an electromyograph. The raw electromyographic signal was quantified by the Root Mean Square (Root Mean Square - RMS) and MF (median frequency). The signals were subjected to a high-pass filter of 20 Hz and low-pass and 500 Hz sampling frequency used was 2000 Hz per channel. The data were analyzed using nonparametric statistics, using the Wilcoxon test. Comparing the mean values of RMS rough descending part of the trapezius muscle were significant reductions (p <0.05) both at rest for the descending part of the right trapezius (TD) of G1MS and the descending part of the left trapezius (TE) of G2MI to the trapeze MVIC right descending part (TD) G1MS. The MF was significant for the home (TE) of G2MI presenting increased and the MVIC (TE) as a reduction, no significant differences (p> 0.05) among other variables. According to the methodology and analysis of the results of this study, it is concluded that acupuncture is capable of causing systemic changes electromyographic activity of the descending part of trapezius muscle at rest and CIMV for combinations of points investigated in this study / Mestrado / Anatomia / Mestre em Biologia Buco-Dental

Shoulder injuries are a focus of work related musculoskeletal disorder (WMSD) research due to rising healthcare costs, an aging workforce, and long recovery times. Substantial research has been performed in the area of shoulder WMSDs and a number of risk factors have been implicated in their development; including static loads, repetition, and deviated posture. However, knowledge of underlying pathophysiological mechanisms is limited. Thermography provides a non-invasive technique that may offer clues to unknown physiological markers associated with injury development during job task performance. The objective of this study was to quantify anterior deltoid surface temperature changes as function of changing task demands. Skin surface temperature changes of the anterior deltoid, modified Borg CR-10 ratings, and endurance time during overhead static exertions until exhaustion for two work loads (15 and 30% MVC) and shoulder angles (90o and 115o) were quantified. Ten participants (5 males and 5 females) participated in the study and were free of confounding conditions (such as chronic or acute shoulder injury) and were required to meet body fat percentile requirements. Thermography showed that the higher shoulder angle had a reduced blood flow while there were no differences in temperature for exertion. Modified Borg ratings were not found to be well correlated with temperature values. The findings suggest that workers performing overhead work should minimize their deviated posture when available to prevent a high risk of developing a shoulder WMSD. / Master of Science

Title: Effect of two active recovery methods on repeated bout of finger flexors isometric performance. Goals: Compare two methods of active recovery - global and local, during repeated isometric performance and learn the difference between active and passive recovery. Method: Ten recreational athletes in average age 30,4 ± 5,9 years performed in a random cross-over desing 3 sessions with 3 repeated isometric intermittent contraction. The effect of active global recovery, active local recovery and passive recovery between repetions was monitored. Results: More effective type of recovery was active recovery. There was no difference between both active recovery methods. Performed decrease in active global recovery was activleast effective method of recovery was passive recovery. Decrease in the time in active global recovery was 21,7s (29,77%) and in active local recovery 20,8s (30,1%). The least effective was passive recovery. There was decrease 24,6s (35,34%). Key words: recovery, active recovery, local recovery, finger flexors, interrmitent, isometric contraction.

by Choi Man. / Year shown on spine: 1997. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 146-153). / Abstract --- p.1 / Chapter 1 --- Introduction --- p.3 / Chapter 1.1 --- Anatomy --- p.4 / Chapter 1.2 --- Kinematics of the overhead sports --- p.6 / Chapter 1.3 --- Isokinetics assessment of the shoulder rotators --- p.8 / Chapter 1.4 --- Objectives of the study --- p.10 / Chapter 1.5 --- Method of investigation --- p.11 / Chapter 1.5.1 --- Subject --- p.12 / Chapter 1.5.2 --- Equipment --- p.13 / Chapter 1.5.3 --- Protocol --- p.14 / Chapter 1.6 --- Data Management --- p.17 / Chapter 1.7 --- Clinical application --- p.18 / Chapter 1.8 --- Definition of terms --- p.18 / Chapter 2 --- Literture Review --- p.20 / Chapter 2.1 --- Anatomy --- p.20 / Chapter 2.1.1 --- Ligament --- p.21 / Chapter 2.1.2 --- Muscles --- p.24 / Chapter 2.2 --- Biomechanics of the overhead movement --- p.30 / Chapter 2.2.1 --- Wind up Phase --- p.32 / Chapter 2.2.2 --- Cocking Phase --- p.33 / Chapter 2.2.3 --- Acceleration Phase --- p.36 / Chapter 2.2.4 --- Deceleration Phase --- p.38 / Chapter 2.3 --- Eccentric contraction --- p.40 / Chapter 2.3.1 --- Physiology of eccentric contraction --- p.40 / Chapter 2.3.2 --- Mechanical trauma in eccentric contraction & DOMS --- p.41 / Chapter 2.3.3 --- Eccentric contraction in Plyometric --- p.43 / Chapter 2.3.4 --- Role of eccentric contraction in overhead sports --- p.44 / Chapter 2.3.5 --- Comparison with concentric contraction --- p.45 / Chapter 2.4 --- Isokinetics --- p.46 / Chapter 2.4.1 --- Introduction to isokinetics --- p.46 / Chapter 2.4.2 --- Reliability of isokinetic assessment on Shoulder rotator --- p.48 / Chapter 2.4.3 --- Agonist / Antagonist Ratio --- p.51 / Chapter 2.4.4 --- Variation of torques with testing protocols --- p.52 / Chapter 2.4.5 --- Comparison of muscle torques in different groups --- p.56 / Chapter 2.4.6 --- Isokinetic eccentric contraction of shoulder Rotators --- p.62 / Chapter 3 --- Method of Investigation --- p.63 / Chapter 3.1 --- Subject --- p.64 / Chapter 3.1.1 --- Part One --- p.64 / Chapter 3.1.2 --- Part Two --- p.65 / Chapter 3.1.3 --- Criteria of subject recruitment --- p.65 / Chapter 3.2 --- Equipment --- p.66 / Chapter 3.2.1 --- Collection of medical history and general informations --- p.66 / Chapter 3.2.2 --- Test for general laxity --- p.66 / Chapter 3.2.3 --- Test for shoulder impingement --- p.72 / Chapter 3.2.4 --- Test for shoulder instability --- p.73 / Chapter 3.2.5 --- Joint range measurement --- p.76 / Chapter 3.2.6 --- Isokinetic strength of shoulder rotators --- p.78 / Chapter 3.3 --- Calibration --- p.79 / Chapter 3.4 --- Testing procedure --- p.79 / Chapter 3.4.1 --- "Explanation,warning & consent" --- p.79 / Chapter 3.4.2 --- Warming up --- p.80 / Chapter 3.4.3 --- Screening --- p.81 / Chapter 3.4.4 --- Isokinetic testing of the rotational strength of both shoulders --- p.81 / Chapter 3.5 --- Operator --- p.87 / Chapter 3.6 --- Data Management --- p.88 / Chapter 3.6.1 --- Part One --- p.88 / Chapter 3.6.2 --- Part Two --- p.89 / Chapter 4 --- Result --- p.91 / Chapter 4.1 --- Part One --- p.89 / Chapter 4.1.1 --- Intra-class correlation coefficient --- p.90 / Chapter 4.1.2 --- Correlation between the PTR & the ASMSTR --- p.92 / Chapter 4.2 --- Part Two --- p.94 / Chapter 4.2.1 --- Comparison between the Members in the Hong Kong Badminton Team with the Non-athlete Subjects --- p.94 / Chapter 4.2.2 --- Comparison between the Badminton Players in the Hong Kong Team and the Hong Kong National Junior Team --- p.105 / Chapter 5 --- Discussion --- p.111 / Chapter 5.1 --- General discussion of the design of the study --- p.111 / Chapter 5.1.1 --- Subject --- p.111 / Chapter 5.1.2 --- Specific test --- p.112 / Chapter 5.1.3 --- Warming up --- p.112 / Chapter 5.1.4 --- Testing protocol --- p.113 / Chapter 5.2 --- Part One --- p.116 / Chapter 5.2.1 --- Test-retest reliability --- p.117 / Chapter 5.2.2 --- Correlation between the PTR and the ASMSTR --- p.120 / Chapter 5.3 --- Part two --- p.122 / Chapter 5.3.1 --- Comparison between the HKT and the non- athletes --- p.123 / Chapter 5.3.2 --- Presentation of torque ratio in the HKJ --- p.133 / Chapter 5.3.3 --- Performance in those with history of shoulder problem --- p.134 / Chapter 5.4 --- Clinical application and suggestion for further study --- p.139 / Chapter 6 --- Conclusion --- p.144 / Chapter 7 --- Reference --- p.146 / Chapter 8 --- Appendix

Thesis (Ph. D.)--University of Missouri--Columbia, 2002. / "December 2002." Typescript. Vita. Includes bibliographical references (leaves 141-160). Also issued on the Internet.

Diss. (sammanfattning) Stockholm : Karol. Inst., 2002. / Härtill 4 uppsatser.

Made available in DSpace on 2014-06-11T19:22:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-10Bitstream added on 2014-06-13T20:09:54Z : No. of bitstreams: 1 silva_cr_me_prud.pdf: 377360 bytes, checksum: 38ec03183b67a69d80d817be978919e6 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / São encontradas na literatura várias propostas de processamento do sinal eletromiográfico (EMG) com o objetivo de determinar índices aplicados à monitoração do processo de fadiga muscular localizada. Em comum, todos os índices são baseados na análise de algum parâmetro do sinal monitorado durante o exercício. A avaliação conjunta do comportamento das variáveis extraídas no domínio do tempo e da frequência do sinal eletromiográfico (EMG) não é uma tarefa trivial. Diante disso, os objetivos do estudo foram: i) identificar por meio do comportamento da frequência mediana (Fmed) e da raiz quadrada da média (RMS) do sinal EMG o momento de instalação da fadiga muscular localizada (MF); ii) determinar a reprodutibilidade entre dias da Fmed, RMS, e bandas de baixa (20-45 Hz), média (46-95 Hz) e alta (96-400 Hz) frequência do sinal EMG e iii) aplicar uma análise estatística multivariada nas variáveis extraídas do sinal EMG durante o início, MF e final do teste. Dezoito sujeitos saudáveis foram avaliados em dois dias diferentes, sendo registrados os sinais EMG dos músculos vasto medial (VM), reto femoral (RF) e vasto lateral (VL) durante contrações isométricas a 20% e 70% da contração voluntária isométrica máxima (CVIM), realizada até a exaustão. Por meio das análises realizadas no comportamento da Fmed e do RMS ao longo dos testes foi possível identificar o MF para o VM e VL em ambas as intensidades de carga... / Various proposals are found in the literature of electromiographic signal (EMG) processing with the purpose of determining indices applied to monitoring the localized muscle fatigue. In common, all indexes are based on analysis of some signal parameter monitored during the exercise. The joint evaluation of the behavior of variables extracted in the time and frequency domain of the EMG signal is not a trivial task. That said, the objectives of the study were: i) identify through the behavior of median frequency (MFreq) and the root mean square (RMS) of EMG signal in the moment of installation of localized muscle fatigue (MF); ii) determining the reproducibility between days of MFreq, RMS, and low bands (20-45 Hz), average (46-95 Hz) and high (96-400 Hz) frequency of EMG signal and iii) applying a multivariate statistical analysis in variables extracted from EMG signal during the beginning, MF and end of test. Eighteen healthy subjects were evaluated in two different days, being recorded the EMG muscle signals of vastus medialis (VM), rectus femoris (RF) and vastus lateralis (VL) during isometric contractions at 20% and 70% of maximum isometric voluntary contraction (MIVC), held until exhaustion. The analysis of MFreq and RMS behavior over the tests was possible to identify the MF for VM and VL in both load intensities. There were... (Complete abstract click electronic access below)

Orientador: Fábio Mícolis de Azevedo / Banca: Neri Alves / Banca: Fernando Henrique Magalhães / Resumo: São encontradas na literatura várias propostas de processamento do sinal eletromiográfico (EMG) com o objetivo de determinar índices aplicados à monitoração do processo de fadiga muscular localizada. Em comum, todos os índices são baseados na análise de algum parâmetro do sinal monitorado durante o exercício. A avaliação conjunta do comportamento das variáveis extraídas no domínio do tempo e da frequência do sinal eletromiográfico (EMG) não é uma tarefa trivial. Diante disso, os objetivos do estudo foram: i) identificar por meio do comportamento da frequência mediana (Fmed) e da raiz quadrada da média (RMS) do sinal EMG o momento de instalação da fadiga muscular localizada (MF); ii) determinar a reprodutibilidade entre dias da Fmed, RMS, e bandas de baixa (20-45 Hz), média (46-95 Hz) e alta (96-400 Hz) frequência do sinal EMG e iii) aplicar uma análise estatística multivariada nas variáveis extraídas do sinal EMG durante o início, MF e final do teste. Dezoito sujeitos saudáveis foram avaliados em dois dias diferentes, sendo registrados os sinais EMG dos músculos vasto medial (VM), reto femoral (RF) e vasto lateral (VL) durante contrações isométricas a 20% e 70% da contração voluntária isométrica máxima (CVIM), realizada até a exaustão. Por meio das análises realizadas no comportamento da Fmed e do RMS ao longo dos testes foi possível identificar o MF para o VM e VL em ambas as intensidades de carga... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Various proposals are found in the literature of electromiographic signal (EMG) processing with the purpose of determining indices applied to monitoring the localized muscle fatigue. In common, all indexes are based on analysis of some signal parameter monitored during the exercise. The joint evaluation of the behavior of variables extracted in the time and frequency domain of the EMG signal is not a trivial task. That said, the objectives of the study were: i) identify through the behavior of median frequency (MFreq) and the root mean square (RMS) of EMG signal in the moment of installation of localized muscle fatigue (MF); ii) determining the reproducibility between days of MFreq, RMS, and low bands (20-45 Hz), average (46-95 Hz) and high (96-400 Hz) frequency of EMG signal and iii) applying a multivariate statistical analysis in variables extracted from EMG signal during the beginning, MF and end of test. Eighteen healthy subjects were evaluated in two different days, being recorded the EMG muscle signals of vastus medialis (VM), rectus femoris (RF) and vastus lateralis (VL) during isometric contractions at 20% and 70% of maximum isometric voluntary contraction (MIVC), held until exhaustion. The analysis of MFreq and RMS behavior over the tests was possible to identify the MF for VM and VL in both load intensities. There were... (Complete abstract click electronic access below) / Mestre

Orientador: Maria Claudia Gonçalves de Oliveira Fusaro / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas / Made available in DSpace on 2018-08-25T13:04:54Z (GMT). No. of bitstreams: 1 Santos_DiogoFranciscodaSilvados_M.pdf: 1159978 bytes, checksum: d14c7c199ca0e75686645ae3ca6a131c (MD5) Previous issue date: 2014 / Resumo: De todas as dores que acometem o ser humano ao longo da sua existência, a dor muscular, especialmente a induzida por contração isométrica sustentada, é uma das mais prevalentes e possui um importante impacto sócio-econômico. Entretanto, apesar da sua relevância clínica, os mecanismos moleculares envolvidos no desenvolvimento da dor muscular induzida pela contração isométrica sustentada são pouco conhecidos. Isto se deve, principalmente, à ausência de um modelo experimental mais realístico e com bom grau de predição do controle farmacológico desta dor. Portanto, o objetivo deste trabalho foi desenvolver um novo modelo de hiperalgesia muscular induzido por contração isométrica sustentada em ratos. A contração isométrica sustentada foi realizada por estimulações elétricas aplicadas diretamente no ventre do músculo gastrocnêmio de ratos wistar e os parâmetros foram de 19 milissegundos de duração de pulso, frequência em 50 Hertz, intensidade de 1,6 Volts (V) por um período de 1 hora. A hiperalgesia muscular mecânica foi avaliada com o método Randall Selitto nos tempos de meia hora até 48 horas após o término da contração isométrica sustentada. A contração isométrica sustentada, obedecendo o parâmetros supracitados, induziu hiperalgesia muscular mecânica por 1 hora, regredindo com valores próximos ao basal 2 horas após o término da contração. As respostas com 1,6V por 1 hora, foram significativamente maiores do que as induzidas por estimulações de 1,6V por 15 e 30 minutos; 0,5 e 1,0V por 1h ou sham. Demonstramos ainda que a hiperalgesia muscular mecânica induzida pela contração isométrica sustentada foi bloqueada pela dexametasona, evidenciando o caráter inflamatório desse novo modelo, respaldado pela presença de células inflamatórias no tecido muscular, confirmadas pela análise histológica. Juntos, estes dados sugerem que esse novo modelo de hiperalgesia muscular se aproxima de uma condição mais próxima da real encontrada nas dores musculares decorrentes das atividades diárias, além de possuir um grande potencial científico para os estudos dos mecanismos fisiopatológicos envolvidos na dor muscular relacionada à contração isométrica sustentada / Abstract: Among the types of pain that affect people throughout their lives, muscle pain, specially the one induced by sustained isometric contraction, is one of the most prevalent and has an important socio-economic impact. However, despite their clinical relevance, the molecular mechanisms involved in the development of muscle pain induced by sustained isometric contraction are unknown. This is mainly due to the absence of a more realistic experimental model that has a good degree of prediction of pharmacological control of pain. Therefore, the aim of this study was to develop a new model of muscle hyperalgesia induced by sustained isometric contraction in Wistar rats. The sustained isometric contraction was performed by the electrical stimulation directly to the belly of the gastrocnemius muscle of rats and the parameters were 19 millisecond of pulse duration, frequency of 50Hz, and intensity of 1.6 volts (V) for a period of 1 hour. Randall Selitto method was used to measure muscular hyperalgesia 30 minutes until 48 hours after the finish of sustained isometric contraction. This protocol induced mechanical muscle hyperalgesia for one hour and, after two hours, the responses were similar to the baseline. These responses were significantly higher than those induced by stimulation 1.6V for 15 and 30 minutes, 0.5 and 1.0 V for 1h or sham. We also demonstrated that the mechanical muscle hyperalgesia induced by sustained isometric contraction was blocked by dexamethasone, indicating the inflammatory nature of this new model, supported by the presence of inflammatory cells in muscle tissue, confirmed by histological analysis. Together, these data suggest that this new model of muscle hyperalgesia approaching a condition closest to the actual found in muscle pain resulting from daily activities, besides having a great scientific potential for the study of pathophysiological mechanisms involved in muscle pain related to contraction sustained isometric / Mestrado / Metabolismo e Biologia Molecular / Mestre em Ciências da Nutrição e do Esporte e Metabolismo

Orientadores: Maria Cláudia Gonçalves de Oliveira Fusaro, Andrea Maculano Esteves / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas / Made available in DSpace on 2018-08-27T04:11:06Z (GMT). No. of bitstreams: 1 Jorge_CarolinaOcanha_M.pdf: 1325403 bytes, checksum: 6635807ae28ce8dbb49ec5d1bcc74a75 (MD5) Previous issue date: 2015 / Resumo: A dor musculoesquelética é um importante problema de saúde mundial. Dentre todos os tipos de dor, àquela induzida pela contração isométrica sustentada está relacionada com os movimentos corporais nas atividades da vida diárias e apresenta um alto impacto socioeconômico. Apesar da sua relevância clínica, os mecanismos moleculares envolvidos no desenvolvimento da dor muscular induzida pela contração isométrica sustentada são pouco conhecidos. Portanto, o objetivo deste estudo foi avaliar o envolvimento dos receptores TRPV1 e TRPA1 na hiperalgesia muscular mecânica induzida pela contração isométrica sustentada no músculo gastrocnêmio de ratos machos, da linhagem wistar. O antagonista seletivo do receptor TRPV1, AMG9810, reduziu significativamente a hiperalgesia muscular mecânica induzida pela contração isométrica sustentada quando administrado no músculo gastrocnêmio ipsilateral, mas não no contralateral. A administração intratecal de AMG9810 apresentou a mesma resposta. Similar ao TRPV1, a administração intramuscular e intratecal do antagonista seletivo do receptor TRPA1, HC030031, reduziu significativamente a hiperalgesia muscular induzida pela contração isométrica sustentada. No entanto, não foi observado modificação da expressão proteica dos receptores TRPV1 e TRPA1 no tecido muscular após a contração isométrica sustentada. Os dados sugerem que os receptores TRPV1 e TRPA1 expressos no músculo gastrocnêmio e corno dorsal da medula espinhal estão envolvidos na hiperalgesia muscular mecânica induzida pela contração isométrica sustentada em ratos. Sugerimos, portanto, que os receptores TRPV1 e TRPA1 co-expressos nas fibras aferentes primárias trabalhem juntos para ativar os nociceptores das fibras aferentes durante a contração isométrica sustentada. Além disso, nós sugerimos que os receptores TRPV1 e TRPA1 sejam potenciais alvos para o controle da dor muscular inflamatória / Abstract: Musculoskeletal pain is an important health issue in the world. Among the kinds of muscle pain, the one induced by sustained isometric contraction is associated with body movements of the daily life and has a high socio-economic impact. Despite its clinical relevance, the molecular mechanisms involved in the development of muscle pain induced by sustained isometric contraction are poorly understood. Therefore, the aim of this study was to evaluate the involvement of TRPV1 and TRPA1 receptors in the mechanical muscle hyperalgesia induced by sustained isometric contraction of the gastrocnemius muscle of rats. The selective TRPV1 receptor antagonist AMG 9810 reduced the mechanical muscle hyperalgesia induced by sustained isometric contraction when administered in the ipsilateral but not in the contralateral gastrocnemius muscle. Also, the intratecal administration of AMG9810 reduced the same response. Similar to TRPV1, intramuscular and intrathecal administration of selective TRPA1 receptor antagonist HC030031 reduced the mechanical muscle hyperalgesia induced by sustained isometric contraction. Finally, the sustained isometric contraction did not modify the protein expression of TRPV1 and TRPA1 receptors in muscle tissue. We concluded that TRPV1 and TRPA1 receptors expressed in gastrocnemius muscle and spinal cord dorsal horn are involved with the mechanical muscle hyperalgesia induced by sustained isometric contraction in rats. We suggest that TRPV1 and TRPA1 receptors co-expressed in primary afferent fibers work together to activate nociceptive afferent fibers during sustained isometric contraction. Also, we suggest that TRPV1 and TRPA1 receptors are potential target to control inflammatory muscle pain / Mestrado / Biodinâmica do Movimento Humano e Esporte / Mestra em Ciências da Nutrição e do Esporte e Metabolismo