Lança-se aqui a hipótese de que é possível reproduzir o comportamento do protótipo a partir de modelos feitos de materiais diferentes dos utilizados na estrutura de referência. A influência de distorção de espessura, de diferentes densidades, tensões de escoamento, encruamento e viscoplasticidade são todas avaliadas através de equações analíticas e simulações das estruturas básicas como viga, placa e o impacto de uma estrutura de chapa dupla. Adicionalmente, são realizadas caracterizações quase-estáticas e dinâmicas de material e experimentos em placas circulares para três escalas diferentes (1/1, 2/3 e 1/3), quatro materiais (alumínio, titânio, aço inox e cobre) e duas condições de carregamento: impacto de uma massa a baixa velocidade (3,5m/s) e um projétil a alta velocidade (130m/s). Mostra-se que o uso da lei de Johnson-Cook para descrever o comportamento viscoplástico dos materiais permite obter boa aproximação para o cálculo da velocidade de impacto corrigida, sem que sejam necessárias informações adicionais do comportamento da estrutura. Além disso, os resultados revelam a importância de se manter a razão entre massa de impacto e massa da estrutura constante em modelo e protótipo, levando a desejável similaridade das distorções entre ambas. Assim, ao se confirmar a hipótese deste trabalho, mostra-se possível inferir o comportamento de um protótipo com uso de modelos em escala reduzida feitos a partir de materiais diferentes. / It is hypothesized that it is possible to reproduce the behaviour of the prototype by using models made of different materials. The influence of thickness, different densities, flow stresses, hardening and viscoplasticity are all evaluated through analytical equations and simulations of basic structures such as beam, plate and the impact of a double plate structure. In addition, quasi-static and dynamic materials characterization are conducted , with experiments being performed in circular plates for three different scales (1/1, 2/3 and 1/3), four materials (Aluminum, Titanium, Stainless Steel and Copper) and two conditions impact of a mass (3,5m/s) and a projectile at high speed (130m/s). It is shown that the use of Johnson-Cook\'s law to describe the viscoplastic behavior of the materials allows a satisfactory approximation to the calculation of the corrected impact velocity, without the need for additional information on the behavior of the structure. In addition, the results reveal the relevance of maintaining the ratio between impact mass and structure mass constant in model and prototype, leading to the desirable similarity of the distortions between the two. Thus, when confirming the hypothesis of this work, it is possible to infer the behavior of a prototype using small scale models made from different materials.

As leis usuais de redução de escala não produzem bons resultados em estruturas sujeitas a cargas de impacto, gerando uma semelhança imperfeita entre modelo e protótipo. Neste trabalho, utiliza-se a técnica de similaridade não direta através da alteração da velocidade inicial do corpo de impacto, gerando uma resposta do modelo idêntica ao do protótipo. Três fatores que contribuem para a resposta não similar da estrutura em escala são estudados nessa tese: taxa de deformação e modelo com parâmetros geométricos e de material distorcidos em relação ao protótipo. Além disso, mostra-se como a técnica proposta pode ser usada para correção das distorções através da mudança da massa de impacto. Considerando-se todos esses elementos, um procedimento abrangente e simples que gera um modelo com comportamento similar ao do protótipo é criado. Para corroborar as hipóteses levantadas durante a tese e estudar o método de correção, três problemas analíticos e dois problemas numéricos são explorados. Em todas as análises, os resultados mostram uma melhora significativa na semelhança entre modelo e protótipo após a aplicação do método de correção apresentado. Ao longo do trabalho, as vantagens e limitações das técnicas desenvolvidas e as principais diferenças em relação a trabalhos anteriores são detidamente discutidas. / Current scaling laws are not capable of predicting the structural impact response of prototypes from the behavior of the corresponding scaled models. Here, the nondirect similitude technique is employed by changing the initial impact velocity loading so that model and prototype behave the same. Three main factors that contribute to the non-similar response of a scaled structure are investigated: strain rate, model geometry and material parameters distorted in relation to the prototype. Moreover, it is shown how the proposed technique can be applied to alter the impact mass instead of its velocity. By considering all these aspects, it is then created a comprehensive and simple procedure that generates models similar to a given prototype. Three analytical and two numerical problems are used to present the main features of the technique. In all the cases analyzed, after the correction is applied, it was possible to accurately predict the behavior of the structure under analysis by the response of the model. Throughout this work, limitations and advantages of the method are emphasized bearing in mind other published works.

Barragens de rejeitos são estruturas que têm a finalidade de reter os resíduos sólidos e água dos processos de beneficiamento de minério. Seu planejamento inicia com a procura do local para implantação, etapa na qual se deve vincular todo tipo de variáveis que direta ou indiretamente influenciam a obra: características geológicas, hidrológicas, topográficas, geotécnicas, ambientais, sociais, avaliação de riscos, entre outras. Este trabalho apresenta um estudo sobre a utilização do método de analise hierárquica como apoio na tomada de decisões para seleção de locais para barragens de rejeitos. A revisão bibliográfica de fatores que influem nesta etapa de decisão resultou em indicadores claros de avaliação, que foram orientadores para a coleta de dados no estudo de caso. O estudo de caso consistiu na avaliação de três locais para a localização da nova barragem de rejeitos de beneficiamento de cobre a ser construída pela MINER S.A. no município de Carmen de Atrato, na Colômbia. Para a seleção do local entre três alternativas, foram considerados dois aspectos: custo inicial total e impacto ambiental. Na aplicação do método de análise hierárquica, o objetivo principal da hierarquia proposta foi o menor impacto ambiental, considerando-se as três causas consideradas mais importantes: implantação da barragem, ruptura da barragem e transporte de rejeitos da usina ao local de disposição. Foram analisados os impactos potenciais na água, solo, fauna, flora e ocupação humana. Os custos foram tratados separadamente. No final foi realizada uma análise conjunta dos custos iniciais totais e dos resultados do método de análise hierárquica, para servir como apoio ao tomador de decisão. Foi também realizada uma análise de sensibilidade, que mostra a influência significativa de um dos critérios nos pesos finais dos locais avaliados. / Tailings dams are structures designed to retain solid wastes and water generated in the processing of metal ore. The overall planning of these dams starts with site selection, step in which all directly or indirectly influential variables should be considered: geological, hydrological, topographic, geotechnical, environmental and social characteristics, risk evaluation etc. This work presents a study of the utilization of the hierarchy analysis process (AHP) as a tool for decision-making in the selection of sites for tailings dams. The bibliographic review of relevant factors resulted in the proposal of a list of indicators, which was very useful as an orientation for data collection in the study case, and is considered as an important contribution from this research. The study case consisted in the location of the new copper tailings dam of MINER Inc. in Carmen de Atrato, Colombia. Initially, a geochemical software was applied to the region to discard unsuitable areas. For the selection of a site among three resulting alternatives, two aspects were taken into account: total initial cost and environmental impact. In the application of AHP, the main objective of the proposed hierarchy was the lowest environmental impact. Three possible causes were considered as the most important concerning environmental impact: dam and reservoir occupancy, dam collapse and transportation of wastes from the plant to the disposal site. Potential impacts on water, soil, fauna, flora and human occupation were analyzed. Costs were treated separately. Finally, a joint analysis of total initial costs and results from the AHP application was carried out in order to convey a support for the decision maker. A sensilibtily analysis was also performed to show the influence of one of the subcriteria on the final alternatives weights.

Neste trabalho são feitas comparações entre os principais sinais horizontais de trânsito (Parada Obrigatória, Faixa de Pedestre e Lombada) padronizados pelo Código de Trânsito Brasileiro (CTB), com modelos alternativos que sofreram variações na forma e/ou cor, alguns deles já usados em algumas cidades brasileiras, com o objetivo de identificar se essas alterações melhoram ou não a percepção do sinal (impacto visual). Para isso são utilizados dois métodos da Psicofísica. Numa primeira etapa a análise é feita utilizando o Método de Comparação aos Pares, para um grupo de quatro estímulos para cada sinal estudado. Em seguida, aplicando o Método de Estimativa das Categorias, foi avaliado o impacto visual do sinal horizontal de Parada Obrigatória quanto à presença ou ausência de orla externa. Por fim, também pelo Método de Comparação aos Pares, foi avaliado o impacto visual causado pelo uso conjugado de sinais horizontais em cruzamentos não semaforizados. Foram estudadas as combinações entre os sinais de parada obrigatória, faixa de pedestres e faixa de retenção. Os resultados obtidos permitem inferir as seguintes conclusões: as alterações na forma e cor propostas para os sinais de parada obrigatória e faixa de pedestres causam maior impacto visual quando comparadas ao modelo padronizado pelo CTB mas, no caso das lombadas, a sinalização padrão mostrou-se ser mais perceptível; quanto a presença ou não da orla externa no sinal de parada obrigatória, esta demonstrou ser positiva; o uso conjugado dos sinais de parada obrigatória, faixa de pedestres e faixa de retenção é a combinação que mais desperta a atenção dos usuários. / This work compares the main horizontal traffic signs (Obligatory Stop, Zebra Crossing and Bump Mark) standardized by the Brazilian Traffic Code (CTB), with alternative models that suffered variations in the form and/or color, some of them already used in some Brazilians cities, with the objective of identifying those alterations get inpruve better or not the perception ofe the sign (visual impact). Two Psychophysics Methods are used in this comparisons. In a first stage the analysis is made using the Comparision in Pair Method, for a group of four stimulus for each studied sign. Afterwards, applying the Categories Estimative Method, the visual impact of Stop sign was evaluated considering the presence or absence of the border. Finally, also using the Comparison in pairs Method, the visual impact caused by the conjugated use of horizontal signs in intersections without traffic lights was evaluated. The combinations among the signs of Stop, Zebra Crossing and Retention Strip were studied. The obtained results allow to infer the following conclusions: the alterations in the form and color proposed for Stop and Zebra Crossing signs cause higher visual impact when compared to the standardized models by CTB, but in the case of the bumps marks, the standard sign has shown to be more perceptible; with the presence or not of the external border in the Stop sign, this was demonstrated to be positive; The conjugated use of the Stop, Zebra Crossing and Retention Strip signs is the combination that more attracts the users attention.

Resumo: Chorume é um líquido produzido durante a decomposição anaeróbia dos resíduos sólidos que tem potencial impacto ao ambiente devido a larga variedade de substâncias orgânicas e inorgânicas contidas nesta matriz. Dessa forma, o presente estudo apresenta a caracterização e estudo térmico de amostras de chorume de diferentes procedências as quais foram coletadas nos aterros de Araraquara (CA), São Carlos (CSC), Campinas (CC) e da usina de compostagem na Vila Leopoldina-SP (CSP). Adicionalmente foram estudados os extratos solúveis (ES) obtidos de composto maturado (CM) e o chorume de sistemas anaeróbios (SA1 e SA2) preenchidos com resíduos sólidos provenientes de restaurante universitário simulando as condições acidogênicas de decomposição anaeróbia de aterros. Os resultados obtidos da análise térmica (TG, DTA e DSC) evidenciaram que as amostras de chorume com características acidogênicas (CC, SA1, SA2) apresentaram-se menos estáveis termicamente quando comparadas as CA e CSP que estão em condições metanogênicas. O método isoconversional de Flynn-Wall permitiu a determinação dos parâmetros cinéticos (E e A) para reações de desidratação em intervalos fixos de temperatura. Os valores de E e lnA associados ao procedimento desenvolvido por Málek e Koga conduziu ao modelo mais aproximado para as reações em estudo. O modelo cinético SB (Sesták- Berggren) foi indicado para as reações de decomposição das amostras de extratos solúveis do composto maturado, chorume e derivados. Para a primeira e segunda reação de decomposição térmica do composto maturado os modelos cinéticos mais aproximados foram RO e JMA (n<1) respectivamente. A relação linear entre lnA versus E foi verificada para grupos de reações constatando o chamado efeito de compensação cinética (KCE) . Nas análises de metais pesados realizadas em algumas amostras... (Resumo completo, clicar aceso eletrônico abaixo) / Abstract: Leachate is a liquid produced during the anaerobic decomposition of solid waste that has a potential impact to the environment, due to a large variety of organic and inorganic substances contained in this matrix. Thus, this study presents the chemical characterization and thermal study of the leachate samples from different backgrounds which were collected in landfills of Araraquara (CA), São Carlos (CSC), Campinas (CC) and composting usine from Vila Leopoldina-SP (CSP). Additionally it was also studied the soluble extract (ES) obtained from matured compound (CM), and leachate from anaerobic systems (SA1 and SA2) filled with solid residues from the university restaurant simulating the acidogenic conditions of anaerobic decomposition of the landfills. The obtained results of the TG, DTA and DSC curves showed that, leachate samples with acidogenic characteristics (CC, SA1 and SA2) presented less thermal stability when compared with CA and CSP, which are in metanogenic conditions. Flynn-Wall isoconversional method allowed the determination of the kinetic parameters (E and A) to dehydration reactions in fixed range of temperature. The E and lnA values associated to the procedures of Málek and Koga lead to the most appropriate model to the reaction in study. SB kinetic model was indicated to the decomposition reactions to soluble extract of matured compound, leachate and derivates. To the first and second reaction of thermal decomposition of matured compound, RO and JMA (n<1) were the more approximate kinetic models, respectively. The linear relationship between lnA vs. E was verified for groups of reactions, noting the so-called kinetic compensation effect (KCE). In the analysis of heavy metals, held in some leachate samples were detected concentrations of Mn, that exceed the maximum values allowed. Phenols, phthalates, bisphenol A... (Complete abstract click electronic access below) / Orientador: Marisa Spirandeli Crespi / Coorientador: Clóvis Augusto Ribeiro / Banca: Fernando Luis Fertonani / Banca: Eny Maria Vieira / Banca: Ana Maria de Guzzi Plepis / Banca: Valdir Schalch / Doutor

A Fibropapilomatose (FP) é uma neoplasia reportada em todas as espécies de tartarugas-marinhas. Dentre as espécies, a tartaruga-verde apresenta a maior prevalência da doença, sendo assim considerada uma doença panzoótica emergente. A associação do Chelonid alphaherpesvirus 5 (ChHV5) à tecidos tumorais, demonstrada por inúmeros estudos moleculares, descreve como agente etiológico da FP o ChHV5. Entretanto, há um consenso de que a doença possui caráter multifatorial e sua patogênese não é elucidada. A detecção de ChHV5 em diferentes tecidos permite o monitoramento do vírus na região e contribui para a compreensão da epidemiologia e patogênese deste agente, auxiliando na gestão e conservação da espécie. Dessa forma, o presente estudo teve por objetivo a detecção de ChHV5 em amostras de Chelonia mydas (tartaruga-verde), acometidas e não acometidas pela FP, provenientes do Litoral Norte do Estado de São Paulo, através de técnicas moleculares e avaliação histopatológica. Foram avaliadas amostras de tumores (42 externos e um interno), pele (n=50) e pulmões (n=27) procedentes de 53 espécimes. A prevalência de ChHV5 nos indivíduos foi de 94,33% (50/53), observando a presença do vírus em todos os tipos de tecidos avaliados, e em indivíduos acometidos e não acometidos pela doença. A avaliação histopatológica demonstrou uma maior frequência de tecidos tumorais caracterizados como fibropapilomas, seguido por papilomas, fibromas e papiloma/fibropapiloma, e observou-se corpúsculos de inclusão intranucleares e degeneração balonosa em 5,26% (2/38) das amostras. Os resultados permitiram a formulação de hipóteses que podem contribuir para a compreensão de aspectos relacionados à patogênese da doença, forneceram dados de prevalência, auxiliando no monitoramento do agente na região estudada, e demonstraram a presença do vírus em pulmões de indivíduos não acometidos pela FP, não descrita em literature. / Fibropapillomatosis (FP) is a neoplastic disease reported in all marine turtle species. However, green sea turtles (Chelonia mydas) present the highest prevalence of FP, which is considered an emergent panzootic disease. The association between Chelonid alphaherpesvirus 5 (ChHV5) and FP tumors, demonstrated by several studies, describes this virus as the primary etiological agent. However, there is a consensus that FP has multifactorial cause, and its pathogenesis is still unclear. The detection of ChHV5, in different types of samples, allows its monitoring in the environment, and contributes to knowledge about its epidemiology and pathogenesis providing skills for sea turtle conservation issues. The aims of this study were to characterize the FP tumors and detect ChHV5 in samples of C. mydas specimens with and without FP, from north coast of São Paulo State, through histopathological and molecular analyzes. Samples of FP tumor (42 external and one internal), skin (n = 50) and lung (n = 27) were obtained from 53 specimens. The prevalence of ChHV5 was 94.33% (50/53), and this virus was detected in all types of analyzed samples from tumored and non-tumored individuals. According to histopathological analysis, the most FP tumors was characterized as fibropapillomas, followed by papillomas, fibromas, and papilloma/fibropapilloma. Ballooning degeneration with intranuclear inclusion bodies were observed in 5.26% (2/38) of the samples. The data generated in this study allow the elaboration of hypothesis that can contribute to elucidate the pathogenesis of FP and provide prevalence information helping in the monitoring of this etiological agent in the studied area. In addition, the results revealed the presence of ChHV5 in lung samples from specimens without FP, findings not yet reported in previous studies.

L'objectif du projet de thèse est d'étudier et d'analyser le comportement mécanique à l'impact et en post impact de composites à fibres végétales. Le déroulement de cette thèse nécessite : L'élaboration et la caractérisation des matériaux de l'étude : Les matériaux de l'étude seront constitués de tissus à fibres végétales (lin et/ou chanvre) imprégnées de résine thermodurcissable (de type époxyde) ou thermoplastique (de type PP ou PLA). Ceux-ci seront fabriqués sous forme de plaque par la technique d'infusion sous vide ou la technique de la thermocompression, en fonction du type de résine. La caractérisation mécanique sera effectuée à partir d'essais mécaniques statiques et d'essais d'impact avec une tour de chute (à plusieurs niveaux d'énergie). Celle-ci sera d'abord menée sur des éprouvettes modèles (non impactées et non vieillis, sans et avec renfort fibreux) puis sur des éprouvettes dégradées (impactées à chaque niveau d'énergie et vieillis en humidité et température). La caractérisation de l'endommagement : Elle permettra, à partir des analyses d'images associées aux techniques de l'émission acoustique, de localiser et d'identifier les différents mécanismes d'endommagement intervenant dans ces matériaux au cours des diverses sollicitations choisies. Cette étude conduira à définir le degré de nocivité de ces endommagements tout en associant à la démarche l'influence des paramètres microstructuraux tels que la nature du renfort fibreux et des constituants (résine et fibres). L'identification de modèles de comportement : Il s'agit de proposer une méthode d'identification des paramètres matériaux de modèles de comportement tenant compte de l'endommagement au niveau de la microstructure du matériau (résine et torons de fibres). Cette étude conduira à la mise en œuvre d'une méthode de type recalage de modèles éléments finis en utilisant les bases de données expérimentales constituées notamment des mesures de champs cinématiques. L'objectif à terme est de disposer de modèles fiables et prédictifs pour le calcul de structures de ces matériaux dans l'industrie / The purpose of this PhD project is to study and analyze the mechanical behavior during the impact and post-impact of plant-fiber based composite materials. The conduct of this thesis requires: The manufacturing and characterization of the materials involved in the study : The materials are composed of plant-fiber fabrics (flax and/or hemp) impregnated with thermosetting resin (epoxy type) or thermoplastic resin (PP or PLA). These are manufactured using the vacuum infusion process or using thermocompression, depending on the resin. The materials are plate-shaped. The mechanical characterization will be performed using static mechanical testing and impact testing with a drop tower (over several energy levels). This will be first conducted on unmodified specimens (unimpacted and unaged, with and without fiber reinforcement) then on degraded specimens (impacted with a known energy and/or aged in humidity and temperature). The characterization of damage: It will, from the analysis of the images associated to the techniques of the acoustic emission, locate and identify the various damage mechanisms that intervene in these materials during different stresses. This study will lead to define the degree of harmfulness of such damage while associating to the approach the influence of microstructural parameters such as the nature of the fiber reinforcement and the components (resin and fibers). The identification of behavioral patterns: It consists in suggesting a method to identify the material parameters of behavioral patterns while taking into account the damage level of the material's microstructure (resin and fiber strands). This study will lead to the implementation of a finite element model updating-like method using experimental databases such as kinematic field measurements. The ultimate purpose is to have reliable and predictive models in order to calculate the structures of such materials in the industry

Rotavirus is the most common cause of severe gastroenteritis among children <5 years of age worldwide and is responsible for 453,000 deaths among children in this age group. More than half of these deaths occur in sub-Saharan Africa. Because of the tremendous global burden of rotavirus, vaccine development and introduction has been a high priority for several international agencies, including the World Health Organization (WHO) and GAVI. Two live, attenuated, orally administered rotavirus vaccines, a pentavalent bovine-human reassortant vaccine (RV5; RotaTeq® (Merck and Co, Inc, Pennsylvania)) and a monovalent vaccine (RV1; Rotarix™ (GSK Biologicals, Rixensart, Belgium)) based on a human rotavirus strain, are licensed and available for use in many countries worldwide. Pre-licensure clinical trials of each of these vaccines in high and middle-income countries demonstrated high efficacy (85-98%) against severe rotavirus disease. Further studies conducted in low-income countries of Asia and Africa found modest efficacy (50%-70%) of these vaccines against severe rotavirus disease. However, the public health impact of vaccination (in terms of burden of severe rotavirus disease prevented by vaccinating a given number of children) is greater in developing countries because of the substantially higher baseline rotavirus disease burden in these settings. In 2009, the World Health Organization recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries globally and particularly in those countries with high child mortality due to diarrhea. Of the 16 countries recently approved by GAVI for rotavirus vaccine introduction, 12 countries are located in Africa. As rotavirus vaccines are introduced into national immunization programs, monitoring their impact is a high priority for several reasons. There is a need to assess the effectiveness of these vaccines in routine use to ensure it parallels that of pre-licensure trials, particularly when used in developing countries. Assessing the impact of vaccination on disease burden in countries such as Rwanda will be vital to understanding the full public health benefit of the vaccine. The primary purpose of this program evaluation is to determine the impact of pentavalent rotavirus vaccine on rotavirus and all-cause diarrhea morbidity following introduction into the national immunization program in Rwanda in May 2012. Additionally, this evaluation will document changes in circulating strains over time pre- and post-vaccine introduction. It will also strengthen support for economic evaluation of treating diarrhea versus introduction of new vaccine in routine immunization. Methodology Various studies have been implemented since 2011 in the health sector in Rwanda to reach the goal of this thesis. First, we analyzed data for all-cause, non-bloody diarrheal disease among children <5 years of age from the routine health management information system (HMIS) in Rwanda from January 2008 through December 2011, The objective of this analysis was to determine whether routinely collected health information on national diarrhea hospitalizations, in-hospital deaths, and outpatient visits can be used to monitor the impact of rotavirus vaccine. We used data from the health management information system (HMIS) in Rwanda to describe trends in all-cause, non-bloody diarrhea hospitalizations and outpatient visits among children <5 years of age from 2008 to 2011 prior to vaccine introduction. Second, we evaluated the economic burden attributable to hospitalization for diarrhea among children aged less than 5 years in Rwanda. This was a prospective costing study where medical records and hospital bills for children admitted with diarrhea at 3 hospitals were collected to estimate costs. Interviews with the child’s caregivers provided medical costs incurred before and after hospitalization and the household costs. Third, we analyzed and tried to understand the introduction and delivery cost per dose or per child of the three new vaccines in Rwanda including the rotavirus vaccine for domestic and external financial resource mobilization. Fourth, we determined the rotavirus prevalence rates and circulating genotypes directly pre- and post-introduction of the RotaTeq rotavirus vaccine in May 2012. Stool samples were collected from 1,847 children <5 admitted to 8 surveillance sites for acute gastroenteritis (AGE) and tested for rotavirus antigens by enzyme immunoassay. Fifth, to monitor the effect of rotavirus vaccine in Rwanda, we studied trends in the number of hospital admissions for diarrhea and rotavirus before and after the introduction of the rotavirus vaccine. We conducted a time-series analysis to examine trends in admissions to hospital for non-bloody diarrhea in children younger than 5 years in Rwanda between Jan 1, 2009, and Dec 31, 2014, using monthly discharge data from the HMIS.Result All-cause, non bloody diarrheal hospitalizations and outpatient visits among children <5 years of age in Rwanda from 2008 to 2011 peaked during the June to August dry season, coinciding with the rotavirus season. The bulk of the diarrheal disease burden occurred in children <1 year of age. Average medical costs for each child for the hospitalization were $44.22 ± $23.74 and the total economic burden per hospitalization was $101, of which 65% was borne by the household. The unit cost of introducing rotavirus vaccines 2012 was 22.69 US. Among the 397 stool samples that were genotyped, 5 G types (G1, G4, G8, G9, and G12) and 3 P types (P[4], P[6], and P[8]) were identified. G8 (30.3%), G9 (28.0%), and G1 (19.7%) were the most prevalent G types, while P[8] (52.0%) and P[4] (32.6%) were the most prevalent P types. There was a significant amount of mixed G genotypes (12.1%), while mixed P types were less common (5.1%). G8P[4], G9P[8], and G1P[8] were the most prevalent strains, accounting for 27.8%, 24.3%, and 15.3% of all specimens, respectively.Compared with the 2009–11 pre vaccine baseline, hospital admissions for non-bloody diarrhea captured by the HMIS fell by 17–29% from a pre-vaccine median of 4051 to 2881 in 2013 and 3371 in 2014, admissions for AGE captured in pediatric ward registries decreased by 48–49%, and admissions specific to rotavirus captured by active surveillance fell by 61–70%. The greatest effect was recorded in children age-eligible to be vaccinated, but we noted a decrease in the proportion of children with diarrhea testing positive for rotavirus in almost every age group.ConclusionGiven the stable and consistent trends and the prominent seasonality consistent with that of rotavirus, HMIS data should provide a useful baseline to monitor rotavirus vaccine impact on the overall diarrheal disease burden in Rwanda. Active, sentinel surveillance for rotavirus diarrhea will help interpret changes in diarrheal disease trends following vaccine introduction. Other countries planning rotavirus vaccine introduction should explore the availability and quality of their HMIS data.Households often bear the largest share of the economic burden attributable to diarrhea hospitalization and the burden can be substantial, especially for households in the lowest income quintile.The cost of introduction of new vaccines (rotavirus) is less than the cost of treating the diarrhea diseases. The number of admissions to hospital for diarrhea and rotavirus in Rwanda fell substantially after rotavirus vaccine implementation, including among older children age-ineligible for vaccination, suggesting indirect protection through reduced transmission of rotavirus. These data highlight the benefits of routine vaccination against rotavirus in low-income settings. / Doctorat en Santé Publique / info:eu-repo/semantics/nonPublished

O presente estudo analisa a água da bacia do alto Tietê, tanto como insumo na forma de água potável produzido em oito Estações de Tratamento de Água (ETA), quanto insumo na forma de energia hidráulica, ou ainda, como água residuária gerada por diferentes atividades de origem antrópica. O maior problema desta bacia é a água residuária que é lançada nos rio Tietê e Pinheiros devido ao déficit de 32,41 m3/s (2008) no tratamento de esgoto da Região Metropolitana de São Paulo (RMSP) o qual produz uma carga poluidora de 920 mil kg de DBO/dia. As águas urbanas que passam pelo canal do rio Pinheiros no período de cheias e de seca têm o mesmo destino que é o reservatório Billings. No entanto, os atos institucionais que permitem a operação de bombeamento da água para o reservatório são distintos. O primeiro caso ocorre pela ação de controle de cheia da RMSP e está apoiada na Resolução Conjunta de Secretarias de Estado de São Paulo (SEE- SMASRHSO em 13/03/96) que permite o bombeamento das águas nas seguintes situações de emergência: (1) previsão de vazão do rio Tietê no ponto de sua confluência com o rio Pinheiros, acima de 160 m3/s. (2) sobrelevação superior a 30 cm de nível d´água na confluência com o rio Pinheiros. No segundo caso, a Empresa Metropolitana de Águas e Energia (EMAE) propôs o Projeto Flotação à Secretaria de Estado do Meio Ambiente (SMA, 2004) para tratar 10 m3/s de águas originárias do canal de Pinheiros (set/2007 a set/2008) por meio da tecnologia de Flotação em Fluxo. Usando-se como base em informações do Plano de Tratamento de Esgoto para a grande São Paulo (SANEGRAN) e dados da operação do protótipo de flotação do Sistema Pinheiros-Billings (Projeto QAPB), concluiu-se que o impacto ambiental causado no reservatório Billings pela carga de poluentes (massa por segundo) bombeada após a flotação da água do rio Pinheiros foi sempre menor do que aquela observada na operação controle de cheias. O tratamento por flotação apresentou remoção de 91% para o fósforo total, 90% para o E.coli, 53% para a matéria orgânica e 14% para o nitrogênio amoniacal. Observou-se um aumento de 34% para o oxigênio e uma diminuição de 46% na turbidez. A análise da viabilidade técnica da operação do Sistema Elevatório Tietê-Billings realizada pelo Método AHP-Analitic Hierarchy Process, demonstrou que 65,62% da água que entra no reservatório Billings pode ser utilizada para gerar energia elétrica, enquanto que 34,38% desta água pode ser utilizada no abastecimento da RMSP. O estudo da viabilidade econômica comparou o custo do processo flotação com o custo de aporte de água proveniente de outros mananciais e demonstrou que o custo da operação de flotação das águas do rio Pinheiros para servir ao abastecimento da RMSP é economicamente viável. / This study examines the characteristics of the water from the upper Tietê, as an input in the form of drinking water produced in eight stations, water treatment plant (WTP), an input for hydropower generation and wastewater generated by different anthropogenic activities. The most important problem of this basin is the wastewater that is released in the Pinheiros river and due to the deficit of 32.41 m3/s (2008) in the treatment of sewage in the metropolitan region of São Paulo (RMSP) which produces one pollutant load of 920 thousand kilograms of BOD per day. The Pinheiros rivers flow during the floods and drought has the same destination, the Billings reservoir. However, the legislation for floods and drought periods are different. The first case - floods occurs by the action of full control of the metropolitan region and is supported by the Joint Resolution of Secretaries of State of Sao Paulo (SEE-SMA-SRHSO on 13/03/96) that allows the pumping of water in the following emergencies: (1) estimates of flow of the Tietê river at the point of its confluence with the river Pinheiros, above 160 m3/ s; (2) raised level above 30 cm water level at the confluence with the river Pinheiros. The second case - drought, the Metropolitan Company for Water and Energy (EMAE) Project proposed flotation of the Secretary of State for the Environment (SMA, 2004) to treat 10 m3/ s water originating channel Pinheiros (set/2007 the set / 2008) by means of flotation technology in flow. Using information based on Environmental Sanitation Great São Paulo (SANEGRAN) and data from the operation of the prototype flotation system Pinheiros-Billings (Project QAPB), concluded that the environmental impact of the reservoir Billings for the load of pollutants (mass per second) pumped after the flotation of the Pinheiros river water was always lower than that observed in the flood control operation. The treatment presented by flotation removal of 91% for total phosphorus, 90% for E. coli, 53% for organic matter and 14% for ammonia nitrogen. There was an increase of 34% for oxygen and a decrease of 46% in turbidity. The analysis of the technical operation of the lift system Tietê-Billings, held in the AHP-Analytic Hierarchy Process, showed that 65.62% of the water entering the reservoir Billings can be used to generate electricity, while 34.38% this water can be used to supply the ´´RMSP´´. The feasibility study compared the economic cost of the flotation process with the cost of input of water from other sources and concluded that the cost of the flotation of the waters of the Pinheiros river to serve the supply of the metropolitan region is economically viable.

Local and global loadings, which may cause the local damage and/or global failure and collapse of offshore structures and ships, are experimentally investigated in this study. The big research question is how the aeration of water and the elasticity of the structural section affect loading during severe environmental conditions. A further question is how the scattered waves from ships and offshore structures, the mooring line force and the structural response, which are known to affect local load and contribute to global load, will be affected by wave-structure interaction of a ship or offshore structure under non-breaking wave conditions. Three different experiments were undertaken in this study to try to answer these questions: (i) slamming impacts of a square flat rigid/elastic plate, which represents a plate section of the bottom or bow of ship structure, onto pure and aerated water surface with zero degree deadrise angle; (ii) wave impacts on a truncated vertical rigid/elastic wall in pure and aerated water, where the wall represents a plate section of a hull; and (iii) wave-structure interactions of different FPSO-shaped models, where the models were fixed or taut moored. The experiments were carried out at Plymouth University’s COAST Laboratory. Spatial impact pressure distributions on the square plate have been characterised under different impact velocities. It was found that the impact pressures and force in pure water were proportional to the square of impact velocity. There was a significant reduction in both the maximum impact pressure and force for slamming in aerated water compared to that in pure water. An exponential relationship of the maximum force and the void fraction is proposed and its coefficients are found from drop test in this study. There was also a significant reduction in the first phase of the pressure and force impulse for slamming into aerated water compared with pure water. On the truncated wall, aeration also significantly reduced peak wave loads (both pressure and force) but impulses were not reduced by very much. For the case considered here, elasticity of the impact plate has a significant effect on the impact loads, though only at high impact velocities; here the impact loads were considerably reduced with increasing elasticity. Wave loading on the truncated wall was found to reduce with increasing elasticity of the wall for all investigated breaking wave types: high aeration, flip-through and slightly breaking wave impacts. In particular, impact pressure decreases with increasing elasticity of the wall under flip-through wave impact. As elasticity increases, the impulse of the first positive phase of pressure and force decreases significantly. This significant effect of hydroelasticity is also found for the total force impulse on the vertical wall under wave impacts. Scattered waves were generated from the interaction of focused wave groups with an FPSO model. The results show that close to the bow of the FPSO model, the highest amplitude scattered waves are observed with the most compact model, and the third- and fourth-harmonics are significantly larger than the incident bound harmonic components. At the locations close to the stern, the linear harmonic was found to increase as the model length was decreased, although the nonlinear harmonics were similar for all three tested lengths, and the second- and third-harmonics were strongest with the medium length model. The nonlinear scattered waves increased with increasing wave steepness and a second pulse was evident in the higher-order scattered wave fields for the fixed and free floating models. In addition, the higher harmonics of the mooring line force, and the heave and pitch motions all increased with increasing wave steepness. Incident wave angles of 0 (head-on), 10 and 20 degrees were experimentally investigated in this study. As the incident wave angle between the waves and the long axis of the vessel was increased from 0 to 20 degrees, the third- and fourth-harmonic scattered waves reduced on the upstream side. These third- and fourth-harmonic diffracted waves are important in assessing wave run-up and loading for offshore structure design and ringing-type structural response in fixed and taut moored structures. The second-, third- and fourth-harmonics of the mooring line force, and the heave and pitch motions decreased as the incident wave angle increased from 0 to 20 degrees.