No description available.

No description available.

No description available.

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A lesão do nervo alveolar inferior (NAI) está relacionada à prática odontológica. Estudos demonstram que a laserterapia promove a regeneração do nervo e analgesia. Usando o modelo de esmagamento do NAI associado à laserterapia avaliamos a reparação nervosa e a nocicepção dos animais antes da lesão, e após o tratamento. Vimos que o laser reverteu o comportamento hipernociceptivo e que a modulação de receptores para glutamato, de neurotrofinas, do receptor de potencial transiente vanilóide do subtipo 1, da substância p e do peptídeo relacionado ao gene da calcitonina atuam neste processo. Adicionalmente, o laser alterou o microambiente da lesão modulando proteínas, como laminina, proteína mielínica zero e neurofilamentos, promovendo a regeneração do nervo; por microscopia eletrônica mostramos esta regeneração, evidenciada pelo aumento no número de fibras nervosas e da espessura da bainha de mielina no nervo do grupo tratado em relação ao grupo operado. Em conjunto, os resultados obtidos contribuem para reforçar o uso terapêutico do laser. / The inferior alveolar nerve injury (IAN) is related to dental practice. Studies have shown that LLLT promotes nerve regeneration and analgesia. Using IAN crush model associated with laser therapy we evaluated nerve repair and nociception of animals before injury and after treatment. We have seen that the laser reversed hipernociceptive behavior and modulation of glutamate receptors, neurotrophins, the transient potential vanilloid receptor subtype 1, substance P and calcitonin gene-related peptide act in this process. Additionally, the laser alter the microenvironment of the lesion modulating proteins such as laminin, myelin protein zero and neurofilaments, promoting nerve regeneration; electron microscopy showed this regeneration, evidenced by the increase in the number of nerve fibers and the thickness of the myelin sheath in nerve treated group compared to the surgery group. Together, these results contribute to enhance the therapeutic use of the laser.

A lesão do nervo alveolar inferior (NAI) está relacionada à prática odontológica. Estudos demonstram que a laserterapia promove a regeneração do nervo e analgesia. Usando o modelo de esmagamento do NAI associado à laserterapia avaliamos a reparação nervosa e a nocicepção dos animais antes da lesão, e após o tratamento. Vimos que o laser reverteu o comportamento hipernociceptivo e que a modulação de receptores para glutamato, de neurotrofinas, do receptor de potencial transiente vanilóide do subtipo 1, da substância p e do peptídeo relacionado ao gene da calcitonina atuam neste processo. Adicionalmente, o laser alterou o microambiente da lesão modulando proteínas, como laminina, proteína mielínica zero e neurofilamentos, promovendo a regeneração do nervo; por microscopia eletrônica mostramos esta regeneração, evidenciada pelo aumento no número de fibras nervosas e da espessura da bainha de mielina no nervo do grupo tratado em relação ao grupo operado. Em conjunto, os resultados obtidos contribuem para reforçar o uso terapêutico do laser. / The inferior alveolar nerve injury (IAN) is related to dental practice. Studies have shown that LLLT promotes nerve regeneration and analgesia. Using IAN crush model associated with laser therapy we evaluated nerve repair and nociception of animals before injury and after treatment. We have seen that the laser reversed hipernociceptive behavior and modulation of glutamate receptors, neurotrophins, the transient potential vanilloid receptor subtype 1, substance P and calcitonin gene-related peptide act in this process. Additionally, the laser alter the microenvironment of the lesion modulating proteins such as laminin, myelin protein zero and neurofilaments, promoting nerve regeneration; electron microscopy showed this regeneration, evidenced by the increase in the number of nerve fibers and the thickness of the myelin sheath in nerve treated group compared to the surgery group. Together, these results contribute to enhance the therapeutic use of the laser.

No description available.

Syftet med denna randomiserade kliniska studie var att jämföra anestesieffekten mellan 2 % lidocain med 1:200,000 adrenalin och 3 % prilocain med 0,03 i.u./ml felypressin vid en blockad av Nervus alveolaris inferior för behandling av patienter med symtomatisk pulpit i en underkäksmolar eller –premolar.Materialet utgjordes av 5 patienter som uppsökt Tandvårdshögskolans jourmottagning för akuta besvär. Patienterna fick upp till 3,6 ml av antingen 2% lidocain (n=4) eller 3% prilocain (n=1). Det valda medlet var okänt för både patient och behandlare under hela behandlingen. Behandling (pulpotomi) påbörjades först när patienten erhållit bedövad läpp. Information om smärta före och under behandling, intag av analgetika och oro inför behandling noterades. Lyckad anestesi ansågs vara ingen eller endast mild smärta under behandling (<54 mm av 170 mm på en visuell analog skala).Lyckandefrekvensen för lidocain var 50 % och för prilocain 100 %. Det insamlade materialet var för litet för möjliggöra statistisk analys.De patienter som inkluderades i denna pilotstudie var för få för att visa eventuella skillnader i anestesieffekt mellan lidocain och prilocain vid en blockad av Nervus alveolaris inferior för behandling av patienter med symtomatisk pulpit i en underkäksmolar eller –premolar. Ett större underlag krävs för att kunna dra slutsatser om något av de testade bedövningsmedlen är överlägset. Ett stickprov på 57 deltagare i varje grupp krävs för att upptäcka en skillnad i lyckandefrekvens på 25 % (power 80 %). Protokollet har nu testats och visat sig vara lämpligt att använda i en större studie. / The aim of this randomized clinical trial was to compare the anesthetic efficacy of 2% lidocaine with 1:200,000 epinephrine and 3% prilocaine with 0,03 i.u./ml felypressin used for the inferior alveolar nerve block (IANB) in endodontic treatment of adult patients with symptomatic pulpitis in posterior mandibular teeth.5 patients visiting the emergency clinic of the Faculty of Odontology, Malmö University participated in the study. They randomly received, in a double-blind manner, up to 3,6 ml of either 2% lidocaine (n=4) or 3% prilocaine (n=1) in a conventional IANB. Treatment (pulpotomy) was only initiated after profound lip numbness was obtained. Pre- and perioperative pain, intake of analgesics and anxiety was recorded. Anesthetic success was defined as no or only mild pain (a rating of <54mm on a 170mm Visual Analogue Scale) during treatment.The success rate for IANB using lidocaine was 50% and for prilocaine 100%. The material size was insufficient to enable statistical analysis.The few patients selected for this pilot study were insufficient to assess any difference in anesthetic efficacy between lidocaine and prilocaine for IANB in endodontic treatment of adult patients with symptomatic pulpitis in a posterior mandibular tooth. Further data collection is needed to make conclusions about possible superiority of any of the tested substances. A sample size of 57 test subjects in each group would give a power of 80% to detect a difference of 25% in success rate. The protocol appears to be suitable for use in a larger-scale study.