Global ETD Search

1	Single-channel kinetic analysis of the allosteric transition of rod cyclic nucleotide-gated channels / Sunderman, Elizabeth R. January 1998 (has links) Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [114]-128).
2	Structural rearrangements during gating in cyclic nucleotide-modulated channels / Craven, Kimberley Beth. January 2006 (has links) Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 121-137).
3	Voltage sensor movements in shaker and HCN channels / Männikkö, Roope, January 2003 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
4	Cysteine-scanning mutagenesis of the ligand-binding domain of cyclic nucleotide-gated channels / Matulef, Kimberly Irene. January 2002 (has links) Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 103-117).
5	Modulation of Kir3 by lipids and tyrosine phosphorylation / Rogalski, Sherri Lynn. January 2000 (has links) Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 108-119).
6	Characterization of A-kinase anchoring proteins associated with the type IIA sodium channel / Tibbs, Victoria Celestine. January 2001 (has links) Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 68-82).
7	Characterization of histidine-tagged NaChBac ion channels Khatchadourian, Rafael Aharon. January 2008 (has links) Imaging tools in cellular and molecular biology have long relied on organic fluorophores to observe microorganisms or various cell constituents. The advent of semiconductor nanoparticles known as quantum dots (QDs) has offered the possibility to use this new class of fluorescent probes with very advantageous optical properties in cell biology. The imaging of transmembrane potential and ionic currents is of significant importance for monitoring the activity of the cell. It remains possible with relatively complicated instruments and methods such as patch clamping. A complementary approach to view the dynamics of ion channels with modern and efficient fluorophores is therefore of great interest to the field of biology in general. / We developed a construct based on the FRET signal between QDs and organic fluorescent dyes to monitor the conformational changes of voltage gated sodium channels. The amino acid histidine was used as a "landing platform" for QDs and the bacterial sodium channel NaChBac was chosen for testing. This study focused on the preliminary steps of the project and aimed to characterize the electrophysiological behavior of the histidine-tagged channel. The whole-cell configuration of patch clamping was the tool we used to understand the differences between the wild-type and the histidine-tagged variants of the channels. We also explore the possibility to land QDs on the histidine tag. Ion Channel Gating. Sodium Channels -- metabolism. Histidine. Quantum Dots. Fluorescent Dyes.
8	Sialic acid modulation of cardiac voltage-gated sodium channel gating throughout the developing myocardium / Stocker, Patrick J. January 2005 (has links) Dissertation (Ph.D.)--University of South Florida, 2005. / Includes vita. Includes bibliographical references. Also available online as a PDF document.
9	Gating of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by nucleoside triphosphates / Zeltwanger, Shawn January 1998 (has links) Thesis (Ph. D.)--University of Missouri--Columbia, 1998. / "December 1998" Typescript. Vita. Includes bibliographical references (l. 140-148). Also available on the Internet.
10	Developmental expression and functions of voltage-gated potassium channels in normal and mutant mice / Hallows, Janice Lynn, January 1999 (has links) Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (leaves 68-82).

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