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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The relationship of zinc and copper with stage in non-small cell cancer of the lung

Chetty, Dinoshan Namasivayan 23 November 2011 (has links)
Objective Several studies have shown that serum copper concentrations are higher in various carcinomas when compared to a healthy population; owing to their role as an inflammatory marker. Zinc acts as a cellular growth protector and it has been demonstrated that its deficiency is involved in several stages of malignant cell transformation. However, the usefulness of the serum zinc and copper determinations in cancer prevention, detection, treatment monitoring and prognosis require further investigation. The aim of this study is to demonstrate the diagnostic and prognostic significance of serum zinc levels (SZL) and serum copper levels (SCL), and the copper/zinc (Cu/Zn) ratio, in non-small cell lung cancer (NSCLC). Materials and Methods Thirty-four patients with NSCLC were prospectively identified, prior to treatment, over a period of one calendar year (February 2003 - January 2004) at the Department of Radiation Oncology, Johannesburg General Hospital (now Charlotte Maxeke Johannesburg Academic Hospital) and the University of the Witwatersrand. SCL and SZL were measured using atomic absorption spectroscopy (AAS) and the Cu/Zn ratio was calculated. Results SCL shows an increase (mean SCL were 0.66mg/L, 0.74mg/L and 0.76mg/L for stage II, III and IV respectively) (P=0.0897); and SZL shows a decrease (0.70mg/L,0.63mg/L and 0.62mg/L for stage II, III and IV respectively) (P=0.199) with advancing stage. The levels of both these trace elements are much lower than the reference range for a normal population. The Cu/Zn ratio increases with stage (0.995, 1.308 and 1.441 for stage II, III and IV respectively). The results were not statistically significant, but a definite trend could be observed. In addition, marked differences were noted between early stages (II) and advanced stages (III and IV) of the disease. Conclusion The lower levels of both trace elements, when compared to a reference range, are an indication of the low levels of immunity and poor general condition of patients with NSCLC (with particular reference to the author‟s institution). A clear trend could be demonstrated of increasing SCLs and decreasing SZLs with progressive stages in NSCLC. The Cu/Zn ratio also reflects similar findings in relation to stages of the disease. The results were not statistically significant, although this can be attributed to a small sample size. While trace element levels and the Cu/Zn ratio cannot be advocated as a tumour marker and prognostic variable for NSCLC at present, they do merit further study, especially in a resource constrained environment, as a simple and inexpensive diagnostic and prognostic test.
2

Angiogenesis related markers in non-small cell lung cancer /

Brattström, Daniel, January 2003 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2003. / Härtill 4 uppsatser.
3

Breast cancer metastasis to the lungs : from genes to mechanisms /

Gupta, Gaorav January 2007 (has links)
Thesis (Ph. D.)--Cornell University, May, 2007. / Vita. Includes bibliographical references.
4

The impact of dosimetric optimization using respiratory gating and inhomogeneity corrections on potential therapeutic gain in patients with lung cancer a dissertation /

De La Fuente Herman, Tania. January 2008 (has links)
Dissertation (Ph.D.).--University of Texas Graduate School of Biomedical Sciences at San Antonio, 2008. / Vita. Includes bibliographical references.
5

Keuhkosyövän sädehoito

Ojala, Antti. January 1978 (has links)
Thesis (doctoral)--Turun, 1978.
6

Quantitative analysis of tobacco specific nitrosamine in human urine using molecularly imprinted polymers as a potential tool for cancer risk assessment

Shah, Kumar Arvind, January 1900 (has links)
Thesis (Ph.D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Pharmaceutics. Title from title-page of electronic thesis. Bibliography: leaves 207-235.
7

The epidemiology of lung cancer in metropolitan Detroit racial differences in men : a dissertation submitted in partial fulfillment ... for the degree of Doctor of Public Health (Epidemiology) ... /

Iwamoto, Kumiko. January 1994 (has links)
Thesis (D.P.H.)--University of Michigan, 1994.
8

The health status of the primary caregiver of the lung cancer client in the home setting a research report submitted in partial fulfillment ... Master of Science (Community Health Nursing) /

Parker, Peggy S. January 1990 (has links)
Thesis (M.S.)--University of Michigan, 1990.
9

The epidemiology of lung cancer in metropolitan Detroit racial differences in men : a dissertation submitted in partial fulfillment ... for the degree of Doctor of Public Health (Epidemiology) ... /

Iwamoto, Kumiko. January 1994 (has links)
Thesis (D.P.H.)--University of Michigan, 1994.
10

Cytogenetic studies of lung tumors

Johansson Soller, Maria. January 1994 (has links)
Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

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