[pt] Este trabalho procura contribuir para o debate sobre as relações entre escolas públicas, famílias de origem popular e vizinhança escolar, tendo como referência territórios pobres da cidade, notadamente o conjunto de favelas da Maré. A pesquisa aborda, especificamente,as relações no âmbito do Programa Escolas do Amanhã/ Bairro Educador (PEA/BE), política que se coloca na perspectiva, tanto das novas formas de educação prioritária e compensatória para escolas em territórios vulneráveis, como da reconfiguração dos espaços e tempos escolares e de uma visão ampliada dos espaços educacionais. Do ponto de vista metodológico, um estudo de abordagem qualitativa dessa experiência foi conduzido em escolas públicas municipais de Ensino Fundamental que se caracterizam por serem participantes e não participantes do PEA/BE na Maré. Com o objetivo de indagar a possível existência de diferenças nas relações entre escola-família-vizinhança em escolas que se distinguem basicamente por serem ou não participantes do PEA/BE, foram realizadas entrevistas com diferentes agentes educacionais, escolares, familiares e sociais envolvidos direta ou indiretamente no programa, buscando conhecer a percepção deles acerca dessa política. Particularmente, o Projeto Bairro Educador foi desenvolvido no âmbito do Programa Escolas do Amanhã da Secretaria Municipal de Educação da cidade do Rio de Janeiro (SME-RJ), com a finalidade de aproximar as escolas públicas localizadas em territórios marcados pela violência e que apresentam resultados abaixo da média da sua respectiva rede de ensino, das famílias e de suas vizinhanças, através do uso do território como ferramenta educativa e pedagógica. Os principais resultados da pesquisa permitem afirmar que o Programa Escolas de Amanhã/Bairro Educador não deixou um legado suficientemente consistente a ponto de marcar uma diferença substancial nas relações escolas-família-vizinhança entre as escolas que dele participaram. Uma das possíveis explicações para isso diz respeito à falta de alinhamento entre as orientações do PEA/BE e sua implementação, bem como aos problemas de externalidade, fragmentação e segmentação da coordenação político-pedagógica do BE e à falta de uma orientação mais enfática da SME-RJ acerca dos caminhos a percorrer para atingir os objetivos propostos. O trabalho se encerra com a apresentação de recomendações que pretendem contribuir para a orientação de políticas públicas que tenham como objetivo a aproximação entre escolas-famílias-vizinhança. / [en] This study aims on discussing the relations among public schools, low-income families, and the schools neighborhood, considering poor areas in Rio de Janeiro, specially a community called Maré. The research focuses on the relations within Escolas do Amanhã / Educator Neighborhood (PEA/BE in Portuguese), which considers the perspective of new priority and compensatory ways of education driven to vulnerable areas, as well as school space and time adjustments. A qualitative study of this experience has been conducted in order to analyze elementary and middle public schools in Maré that participate or not in PEA/BE. The objective has been to question if there are differences in the relations among school, family and neighborhood, considering schools which participate in the program and schools which do not. Different educational, school, family and social agents have been interviewed in order to comprehend the way they see this policy. Educator Neighborhood project, in particular, has been developed within Escolas do Amanhã program by the Education Municipal Office (SME-RJ in Portuguese), with the goal of integrating public schools placed in violent areas and with low results in relation to their education network, families and neighborhood, considering territory as an educational and pedagogical tool. The main results of the research show that Escolas do Amanhã / Educator Neighborhood program did not leave a consistent result in building better school, family and neighborhood relations among the schools that participated in the program. One of the possible reasons for it may be the lack of a guideline between PEA/BE and its implementation, as well as problems referring to its political-pedagogical coordination, such as its fragmentation and segmentation. This guideline could come from the Education Municipal Office, pointing to a path that leads to the program s objectives. Therefore, this thesis ends up with some recommendation about public policies that may contribute to closer relations among school, family and neighborhood.

Grâce à la présence et à l’instrumentalisation de la Mare de Déu, l’abbaye et le massif de Montserrat sont devenus, au fil des siècles, un symbole religieux et un bastion du christianisme, puis les gardiens des traditions, de la culture et de l’identité catalanes. Le mythe fondateur religieux, lié à la Vierge de Montserrat, est associé au mythe fondateur de la Catalogne, lié au comte de Barcelone Guifré le Velu, de sorte que religion et identité nationale sont étroitement imbriquées dès la fin du Moyen Âge. Beaucoup d’autres légendes sont élaborées à cette époque, mais la relation entre les Catalans et la Mare de Déu de Montserrat prend une orientation particulière et s’exerce dans un cadre à part.L’universalité de la pensée mythique permet une instrumentalisation politico-religieuse de l’image mariale tout au long de l'histoire de la Catalogne, jusqu’à aujourd’hui. Le XIXe siècle marque une étape majeure dans l’instrumentalisation de la Moreneta et sa liaison avec le sentiment identitaire. Le massif de Montserrat devient le symbole de la patrie catalane et la Vierge de Montserrat se transforme en Vierge de la Patrie. Le régime franquiste signifie une rupture profonde. La Moreneta, dans un premier temps, protège l’action de suppléance intellectuelle et culturelle accomplie par les Bénédictins de Montserrat, puis l’engagement politique devient total. Avec l’arrivée de la démocratie, la Catalogne se réapproprie son passé, et un nouveau rôle se dessine pour la Mare de Déu de Montserrat. / Thanks to the presence and implementation of the Mare de Déu, the abbey and the mountain of Montserrat became, in the course of the centuries, a religious symbol and a bastion of christianity, and, later on, the guardians of the catalan traditions, culture and identity. The religious founding myth, linked to Montserrat Virgin, is associated with Barcelona Count Guifré le Velu, so that religion and national identity have remained closely interlinked since the end of the Middle Ages. Numerous other legends were created at the same time, but the relationship between Catalan people and the Mare de Déu of Montserrat takes a special orientation and grows in a specific place.The universality of the myths enables a political and religious implementation of the marian image throughout the history of Catalonia, until nowadays. The XIXe century marks a major step in the implementation of the Moreneta and Her connection with the sense of identity. The Montserrat mountain becomes the symbol of the Catalan mother country and the Virgin of Montserrat is transformed into the Virgin of the mother country. The pro-Franco regime meant a deep change. At first, the Moreneta protectd the intellectual and cultural substitution carried out by the Montserrat Benedictines, then their political commitment became total. With the arrival of democracy, Catalonia has been recovering its past, and a new role has been emerging for the Mare de Déu of Montserrat.

Grâce à la présence et à l'instrumentalisation de la Mare de Déu, l'abbaye et le massif de Montserrat sont devenus, au fil des siècles, un symbole religieux et un bastion du christianisme, puis les gardiens des traditions, de la culture et de l'identité catalanes. Le mythe fondateur religieux, lié à la Vierge de Montserrat, est associé au mythe fondateur de la Catalogne, lié au comte de Barcelone Guifré le Velu, de sorte que religion et identité nationale sont étroitement imbriquées dès la fin du Moyen Âge. Beaucoup d'autres légendes sont élaborées à cette époque, mais la relation entre les Catalans et la Mare de Déu de Montserrat prend une orientation particulière et s'exerce dans un cadre à part.L'universalité de la pensée mythique permet une instrumentalisation politico-religieuse de l'image mariale tout au long de l'histoire de la Catalogne, jusqu'à aujourd'hui. Le XIXe siècle marque une étape majeure dans l'instrumentalisation de la Moreneta et sa liaison avec le sentiment identitaire. Le massif de Montserrat devient le symbole de la patrie catalane et la Vierge de Montserrat se transforme en Vierge de la Patrie. Le régime franquiste signifie une rupture profonde. La Moreneta, dans un premier temps, protège l'action de suppléance intellectuelle et culturelle accomplie par les Bénédictins de Montserrat, puis l'engagement politique devient total. Avec l'arrivée de la démocratie, la Catalogne se réapproprie son passé, et un nouveau rôle se dessine pour la Mare de Déu de Montserrat.

Cette thèse porte sur la pertinence du concept historiographique d’ « antithomisme » appliqué à l’histoire intellectuelle de la fin du XIIIe siècle et du début du XIV. Elle se compose d’une première partie sur le contexte historique de la période 1274-1323 et sur l’émergence de débats dans de nombreux centres intellectuels consacrés à l’héritage de la doctrine de Thomas d'Aquin. Elle s’attache pour cela à mettre en avant les différentes discussions qui apparaissent lors de la première réception des œuvres de Thomas d'Aquin : censures, polémiques entre dominicains et franciscains, apparition de législation sur la lecture des ses œuvres, etc. Le travail se poursuit, dans une seconde partie, avec l’étude plus approfondie de deux auteurs de la fin du XIIIe siècle ayant été qualifiés d’ « antithomistes » par l’historiographie contemporaine : Roger Marston, OFM, et Dietrich de Freiberg, OP. Leur rejet de la noétique thomasienne est ici étudié dans son aspect doctrinal et textuel. / The purpose of this PhD is to examine the accuracy of the concept of « antithomism » when applied to late XIIIth and early XIV th intellectual history. I firstly adress the historical context, from 1274 to 1324, and the arguments involving the theaching of Aquinas in various intellectual domains. In doing so I underline the various debates that occur about how to understand Aquinas(work looking specifically at censorship, the controversies between Franciscans and Dominicans and first rules about the various readings of Aquinas’works. The second part goes into further depth about the work of two scholars of the late XIIIthe century, who have been frequently labelled « antithomists » in today’s historiography : Roger Marston, OFM, and Dietrich of Freiberg, OP. I intend to examine how they refuse Thomas’noetic, from both a doctrinal and textual point of view.

La formation de méthylmercure, la forme la plus toxique du mercure, est due à l’activité bactérienne anaérobie. Afin de connaître la contribution des compartiments microbiens (biofilms, eaux brutes, sédiments) dans la méthylation du mercure, nous avons évalué les vitesses de méthylation d’échantillons de mares de région tempérée (Lorraine) et subarctique (Québec, Canada). Si les bactéries des biofilms ne semblent pas plus méthylantes que d’autres, le sédiment apparait comme le compartiment le plus méthylant en lien avec la concentration en nutriments ainsi qu’avec la température. Ainsi, les changements climatiques actuels, en augmentant la température de l’eau et en favorisant l’activité biologique, peuvent faire de ces mares des sites préférentiels de la méthylation du mercure en milieu subarctique. Enfin, l’activité des biofilms a mené à la formation de rouille verte, un minéral capable de réduire HgII en mercure élémentaire, concurrençant ainsi la méthylation bactérienne / Monomethylmercury formation, the neurotoxic form of mercury, is mainly linked to anaerobic microbial activity. In order to assess the relative contribution of several microbial compartments (biofilms, raw water and sediment) we evaluated methylation of samples from ponds of temperate area (Lorraine, France) and from subarctic ponds (Nunavik, Quebec). Biofilms were not found to specifically promote mercury methylation, whereas sediment emerges as the main compartment involved in mercury methylation. The formation of methylmercury is positively linked to the temperature and to nutrients. Thus, by increasing the open water period, the water temperature and of the microbial activity, current climate changes may turn these ponds in preferential location for mercury methylation in the subarctic ecosystem. Finally, the reactivity of green rust, a mineral which can be produced by bacterial activity of environmental biofilms, may compete with mercury methylation by reducing HgII into Hg0

[pt] A pesquisa entrelaça memória, espaços educativos não formais e identidade. O objetivo central é analisar a dimensão educativa do Museu da Maré no Rio de Janeiro e suas possibilidades de contribuição para o fortalecimento identitário de grupos populares através da valorização e ressignificação da história e da construção das memórias locais. Abordo o conceito, os pressupostos teóricos e desafios dos museus comunitários como espaços educativos não formais, enfocando como estudo de caso o Museu da Maré. Os museus comunitários e ecomuseus emergem no Rio de Janeiro com o Ecomuseu de Santa Cruz em 1983, porém ganham visibilidade com o Museu da Maré a partir de 2006, por ser este o primeiro museu de favela no Brasil criado pela própria comunidade. O quadro teórico baseou-se para o conceito de memória, principalmente em Paul Ricoeur, Jacques Le Goff e Beatriz Sarlo. Para o de identidade utilizamos Stuart Hall, Manuel Castells, Vera Maria Candau e Tomaz Tadeu da Silva. Para espaços educativos não formais privilegiei Maria Glória Gohn, Jaume Trilla e Elie Ganem. Por fim, para os conceitos da Nova Museologia, museu comunitário e ecomuseu me apoiei basicamente em Mário Chagas e Hugue de Varine. De inspiração etnográfica, meu caminho metodológico baseou-se na história oral. Na pesquisa de campo utilizou-se três tipos de aproximações ao objeto de estudo: observação de diferentes atividades desenvolvidas no Museu e de diversos ambientes da comunidade em geral, entrevistas semiestruturadas feitas aos pescadores da Maré e aos diretores e funcionários do Museu da Maré e análise dos Livros institucionais do Museu, a saber: o Livro de Assinaturas e o Livro de Depoimentos dos visitantes. Como uma das principais conclusões de minha pesquisa sobre a dimensão educativa do Museu da Maré posso afirmar que me deparei de fato com um Museu que tem significado para a região da Maré e dialoga com a cidade, o país e outros lugares, embora não represente totalmente todas as suas comunidades. No entanto, ele se fez comunitário, na medida em que foi criado e tem a participação cotidiana do movimento social e da comunidade local de seu entorno. Além disso, o fato do Museu da Maré apresentar uma linguagem museográfica que suscita referências da história local e permite que seus visitantes reflitam sobre as mesmas, se emocionem e construam memórias locais possibilitando através das mesmas um fortalecimento identitário, torna especialmente evidente e significativa sua dimensão educativa. Por fim, o Museu da Maré gera visões de nós e dos outros estabelecendo um jogo sutil e constante entre identidades e alteridades em suas memórias construídas e histórias narradas. / [en] The research intertwines memory, non-formal educational spaces and identity. The main objective is to analyze the educational dimension of the Maré Museum in Rio de Janeiro and its possible contributions to the strengthening of the group identity related to popular groups through appreciation and reinterpretation of the history and construction of local memories. I approach the concept, the theoretical assumptions and challenges of community museums as non-formal educative spaces, by using the Maré Museum as a case study . The community museums and ecomuseums emerge in Rio de Janeiro with the Eco-museum of Santa Cruz in 1983, but became more visible with the Maré Museum as of 2006, since this is the first museum in Brazil s slums created by the community itself. The theoretical framework related to the concept of memory was essentially based on work of Paul Ricoeur, Jacques Le Goff and Beatriz Sarlo. For the theoretical framework associated with identity development, I have chosen the studies performed by Stuart Hall, Manuel Castells, Vera Maria Candau and Tomaz Tadeu da Silva. For the non-formal educational spaces theoretical basis I have privileged Maria Gloria Gohn, Jaume Trilla and Elie Ganem. Finally, for the concepts of New Museology, community museum and ecomuseum I rely primarily on Mario Chagas and Hugue de Varine. My methodological approach of ethnographic inspiration was based on oral history. In the field research I used three types of approaches to the object of study: observation of different activities in the Museum and of the community at large, semi-structured interviews to fishermen of the Maré and to the directors and staff of the Museum of the Maré and analysis of the institutional books of the Museum, namely the Book of Signatures and the Book of Testimonies from visitors. As one of the main conclusions of my research on the educational dimension of the Mare Museum I can state that this museum does have meaning for the region of Maré and dialogues with the city, the country and elsewhere, although it does not fully represent all its communities. However, this museum has been able to develop a community related feature , as it was created by and has the daily involvement of the social movement and the local community of their surroundings. Moreover, the fact that the Mare Museum display a museographic language which raises references of local history and allows visitors to reflect on them and build local memories enabling a strengthening of identity, makes its educative dimension particularly evident and significant. Finally, the Maré Museum generates visions of ourselves and others by establishing a more subtle and constant dynamic between individuals identities and their constructed memories and narrated stories.

Screening of cattle sera: distribution of vesiviruses in terrestrial domestic animals. To broaden the knowledge of vesivirus occurrence and distribution dynamics in domestic livestock, we attempted the first extensive study in cattle to assess the distribution of vesiviruses by examining the seroprevalence. Cattle were chosen to be studied here, because this livestock is well characterized, they are suffering diseases with high percentages of unknown aetiologies and extensive animal data are available. Furthermore, several case reports exist on the isolation of vesiviruses from cattle. The objective was to evaluate the distribution of vesiviruses in cattle, correlate vesivirus infection with disease manifestations and estimate the possible impact on other animals and humans. Roughly seven hundred bovine sera from nine States within the United States were acquired and were tested for antibodies against vesiviruses. The sera tested were drawn from a total population of about 9 million cattle in nine States with a geographical distribution ranging from northern Alaska to tropical Hawaii. Screening of horse sera and tissue: correlation of vesivirus prevalence and mare reproductive loss syndrome (MRLS)? A newly emerged disease in horses was analyzed in the second half of this research project. Since all tests for the common toxic abortogenic agents had failed, a further nationwide investigation was initiated for uncommon and unknown infectious agent(s). Caliciviruses, and vesiviruses in particular, are a well established cause of abortion in swine and seals. Nevertheless, these viruses are not routinely tested for or diagnosed. When the Laboratory for Calicivirus Studies at Oregon State University was asked for specific help in this investigation, pertinent seroepidemiological studies were entrusted to me under the guidance of Professor Dr. Alvin W. Smith. After the first serological examination of equine blood samples from mares that had aborted in 2001 and an equal number of sera from unaffected animals from 2000 were examined, tissue samples from aborted fetuses and two other sets of blood samples from ETC-exposed mares from two experiments were acquired. These have been tested for vesivirus-antibodies and antigen. Furthermore, additional samples of ETC were tested for vesiviruses by RT-PCR.

Tot i que es coneix l’involucrament de les cèl·lules pancreàtiques acinars en patologies exocrines (pancreatitis i càncer de pàncrees), la manca de models normals basats en cèl·lules ha limitat l’estudi de les alteracions que succeeixen en el programa de diferenciació pancreàtica. Hem demostrat prèviament que les cèl·lules mare embrionàries murines, que són pluripotents, poden adquirir un fenotip acinar in vitro. Això es va aconseguir, en part, amb una combinació de senyals que provenien del cultiu de pàncrees fetals que no era, però, específic del llinatge pancreàtic. L’objectiu d’aquest treball ha estat el de desenvolupar un protocol selectiu pel llinatge acinar basat en l’activació seqüencial de vies de senyalització que recapitulin el desenvolupament pancreàtic in vivo, a través de la formació definitiva de l’endoderm, l’especificació pancreàtica i acinar i l’expansió/diferenciació de progenitors acinars. El tractament de cossos embrionaris amb Activina A va promoure l’expressió de gens d’endoderm com està prèviament descrit. El tractament subsegüent amb àcid Retinoic, FGF10 i Ciclopamina, un inhibidor de la via de Hedgehog, va resutar en la inducció dels marcadors de progenitors pancreàtics Pdx1, Ptf1a i Cpa1 però també d’aquells expressats en el llinatge pancreàtic, que van ser reduïts amb la inhibició de BMPs. Les cèl·lules van ser a continuació cultivades en Matrigel utilitzant un sistema de cultiu en 3D en presència de fol·listatina, dexametasona i KGF comportant una inducció significativa dels nivells de mRNA i proteïna de marcadors acinars i una disminució de l’expressió dels de marcadors acinars. A més, es va veure que Amyl es secretava en el medi. Aquestes dades indiquen que l’activació selectiva del programa de diferenciació acinar en cèl·lules mare embrionàries es pot dur a terme mitjançant una inducció esgraonada de vies de senyalització involucrades en el desenvolupament pancreàtic exocrí proporcionant una eina potencial per estudiar la diferenciació pancreàtica i malalties relacionades amb el pàncrees. / Despite known involvement of pancreatic acinar cells in exocrine pathologies (pancreatitis and pancreatic cancer), the lack of normal cell-based models has limited the study of the alterations that occur in the acinar differentiation program. We have previously shown that mESC (murine embryonic stem cells), which are pluripotent, can acquire an acinar phenotype in vitro. This was achieved, in part, by a combination of signals provided by the culture of foetal pancreases which was, however, no specific for the acinar lineage. The aim of this work was to develop a protocol selective for the acinar lineage based on the sequential activation of signaling pathways that recapitulate pancreatic development in vivo, through the definitive endoderm formation, the pancreatic and acinar specification and the expansion/differentiation of acinar progenitors. Treatment of embryoid bodies with Activin A enhanced the expression of endodermal genes as previously described. Subsequent treatment with Retinoic acid, FGF10 and Cyclopamine, an inhibitor of the Hedgehog pathway, resulted in the enhancement of pancreatic progenitor markers Pdx1, Ptf1a and Cpa1 but also of those expressed in the hepatic lineage, which were reduced by BMPs inhibition. Cells were further cultured in Matrigel using a 3D culture system in the presence of follistatin, dexamethasone, and KGF leading to a significant enhancement of the mRNA and protein levels of acinar markers while decreasing the expression of endocrine ones. Moreover, active Amyl was released into the medium. These data indicate that the selective activation of the acinar differentiation program in ES cells can be achieved by stepwise induction of signaling pathways involved in pancreatic exocrine development providing a potential tool for studying pancreatic differentiation and pancreas-related diseases.

Ce travail s’intéresse au traitement des effluents issus d’un petit bassin versant résidentiel urbain drainé par un réseau d’assainissement séparatif pluvial. Le traitement est effectué à l’aide d’une mare de sédimentation suivi d’un filtre planté de roseaux. L’instrumentation et les prélèvements permettent un suivi hydrodynamique et physico-chimique. Les résultats montrent que le système contribue fortement à la réduction de la pollution avant rejet au milieu récepteur. Les charges polluantes sont réduites de 70 à 100% pour tous les polluants (sauf la DBO5 et les nutriments, entre 4 et 100%). La mare de sédimentation a un rôle primordial dans l’élimination des polluants présents en phase particulaire, et plus particulièrement des HAPs (100%). Le filtre planté de roseaux intervient au niveau des polluants en phase particulaire non retenus par la mare, mais aussi au niveau des polluants en phase dissoute (nutriments, matière organique, micropolluants métalliques et pesticides). / This work deals with the treatment of effluents from a small urban residential catchment area drained by a separate sewer network. The treatment is made with a sedimentation pond and a constructed wetland. Instrumentation and samplings enable hydrodynamic and physic-chemical monitoring. Results show that the system deeply contributes to reduction of pollution before discharge into receiving water. The pollutant loads are reduced between 70 and 100% for all pollutants (except BOD5 and nutrients, between 4 and 100%). The sedimentation pond plays an essential role in eliminating pollutants in particulate phase, more specifically PAHs (100%). The constructed wetland treat pollutants in particulate phase that are not retained by the pond, but also pollutants in dissolved phase (nutrients, organic matter, metals and pesticides).

La Fièvre de la Vallée du Rift (FVR) est une zoonose observée pour la première fois au Kenya en 1930 qui s'est peu à peu propagée à la plupart des pays d'Afrique. La FVR est une maladie à transmission vectorielle dont le virus appartient au genre Phlebovirus de la famille des Bunyaviridæ. En Afrique de l'Est, l'émergence de foyers est prédite par des modèles statistiques, ce qui n'est pas le cas en Afrique de l'Ouest où les facteurs et les mécanismes en jeu sont encore mal définis. L'objectif de cette thèse est d'identifier les facteurs et les processus épidémiologiques expliquant l'émergence de foyers de FVR au Sénégal, en mettant en œuvre une approche éco-épidémiologique centrée sur les principaux moustiques vecteurs du virus. Par l'étude de variables environnementales et climatiques et par leur exploitation dans des modèles mathématiques, nous avons tenté de répondre à deux questions épidémiologiques majeures : (1) quelles sont les zones potentiellement à risque, et (2) quelles sont les périodes favorables à l'apparition de foyers. L'étude a été menée à l'échelle locale, dans une zone d'environ 10 km2 autour du village de Barkedji situé dans la région sylvo-pastorale du Ferlo.Pour localiser les zones à risque de transmission du virus, nous utilisons la télédétection et l'analyse paysagère afin de caractériser l'environnement favorable aux deux principaux candidats vecteurs du virus, Aedes vexans et Culex poicilipes. Pour identifier les périodes à risque, nous avons développé un modèle d'abondance de populations de moustique des deux espèces vectrices prenant en compte la dynamique des gîtes larvaires (les mares), et dont les simulations ont été validées avec des données de terrain de capture de moustiques. Pour se faire, nous avons dû préalablement développé un modèle dynamique de hauteur d'eau des mares temporaires, modèle calibré et validé à partir de données de terrain et de données d'observation de la Terre.Les résultats de l'analyse paysagère ont confirmé que les milieux favorables aux vecteurs de la maladie pouvaient être caractérisés par télédétection. Ils ont aussi mis en évidence l'importance des mares et de la densité de végétation environnante, et ont abouti à une cartographie de l'hétérogénéité spatiale du risque de circulation de la FVR. Les résultats de l'analyse temporelle ont montré que les années de circulation active du virus coïncidaient avec les années pour lesquelles les deux espèces de moustiques étaient présentes en forte quantité. On observe ainsi deux années à très forte densité des deux moustiques vecteurs, en 1987 et en 2003, correspondant aux années d'épidémie/épizootie les plus importantes dans la région. / The Rift Valley fever (RVF) is an arboviral zoonosis, first identified in Kenya in 1930, which has spread over many African countries. The RVF virus (RVFV) is a mosquito-borne virus member of the family Bunyaviridae, genus Phlebovirus. Statistical models that are used for predicting RVF outbreaks in East Africa do not work in West Africa where the factors and processes involved are still not well described. The aim of this thesis is to identify the factors and epidemiological processes that explain the emergence of RFV outbreaks in Senegal. To achieve that, we have chosen an eco-epidemiological approach targeted on the main candidate mosquito vectors of the RFV virus. By using the environmental and climatic variables and by their exploitation in mathematical models, we tried to answer two major epidemiological questions: (1) where are the potential zones at risk? And, (2) when are the periods favourable to RFV outbreaks?The study has been carried out at a local scale, in an area of about 10 km2 centred on the village of Barkedji in the pastoral Ferlo region in northern Senegal.When identifying risk areas for virus transmission, we used remote sensing and landscape analysis to characterize favourable environments fot the two main candidate vectors, Aedes vexans and Culex poicilipes (Diptera: Culicidae). For predicting risk of RVF outbreaks, we developed a mosquito population model for the two vector species taking into account the dynamics of the ponds as breeding sites. The results of the simulation have been validated with captured mosquito field data. This required the prior development of a temporary pond dynamics model that was calibrated and validated with field and remote sensing data.The results of the landscape analysis confirmed that favourable environments for the mosquito vectors of the RVF could be characterised by remote sensing. The importance of the ponds and the surrounding vegetation density was also highlighted, allowing to map the spatial heterogeneity of RVF circulation risk. The results of the mosquito model simulations showed that years of active virus circulation matched the years when both vector species were densely present. Indeed, the simulations showed high mosquito densities in 1987 and 2003, which correspond to the most important epidemic and epizootic events in that region.