Thesis (Ph. D.)--California Institute of Technology, 1987. UM #87-19,702. / Advisor names found in the Acknowledgements pages of the thesis. Title from home page. Viewed 01/15/2010. Includes bibliographical references.

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A Dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Master of Science. / The addition of cyclohexyl substituents to existing ligands was investigated for its potential use as a factor in ligand design for achieving high specificity for particular metal ions, (Abbreviation abstract) / AC 2018

Thesis (Ph. D.)--State University of New York at Binghamton, Chemistry Dept., 2006. / Includes bibliographical references.

Bibliography: leaves 143-153. Studies the complexation of metal ions with the macrocyclic ligand, 1, 4, 8, 11-tetrakis (2-hydroxyethyl)-1, 4, 8, 11-tetraazacyclotetradecane (THEC)

The hairpin ribozyme is a small catalytic RNA that cleaves a phosphodiester bond. In order for cleavage to occur, the hairpin ribozyme must properly fold into its docked conformation, in which the two loops interact to form the active site. Metal ions and the four-way junction play critical roles in the stabilization of the docked conformation. The work presented in this thesis attempts to investigate the metal-ion dependence of the docking of the four-way junction construct of the hairpin ribozyme. In addition, the activity of the hairpin ribozyme in the presence of Mn2+ was observed. Initially, a four-stranded four-way junction construct of the hairpin ribozyme and a loopless mutant were characterized by native gel electrophoresis and thermal denaturation to verify ribozyme formation. A novel interaction between the sulfur of a phosphorothioate-substituted mononucleotide, such as adenosine thiomonophosphate (AMPS) or adenosine thiotrisphoshate (ATPgS), and Cd2+ has been characterized by UV-vis spectroscopy. A feature at 208 nm was identified to be a result of sulfur-to-Cd2+ transfer. The apparent binding affinities, the apparent extinction coefficients, and the binding ratios were determined for each complex.

Thesis (PhD) - Faculty of Life and Social Sciences, Swinburne University of Technology, 2008, [ie, 2009] / Submitted in fulfillment of the requirements for the degree of Doctor of Philosophy, Faculty of Life and Social Sciences, Swinburne University of Technology - 2008, [ie, 2009]. Typescript. Includes bibliographical references (p. 294-323)

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