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The degradation of the stem-loop binding protein at the late 2-cell stage of mouse embryogenesis /Poirier, Luc January 2003 (has links)
The efficient processing of replication-dependent histone mRNA requires the Stem-Loop Binding Protein (SLBP). SLBP is also involved in regulating histone mRNA half-life, their nucleocytoplasmic transport, and their translation. Unlike somatic cells, where SLBP protein accumulates only in S-phase, SLBP protein is present throughout the first two embryonic cell cycles in mice. We report here that in late 2-cell mouse embryos there is a substantial, proteasome-dependent decrease in SLBP throughout the cell. Based on chromosome morphology, the degradation of SLBP protein in late 2-cell embryos is most likely a late G2-phase event. The degradation of SLBP protein is not simply a zygotic clock event, but requires development to the late 2-cell stage. Furthermore, SLBP protein degradation in 2-cell mouse embryos requires cyclin-dependent kinase (Cdk) activity, DNA replication, and zygotic genome activation. A model for SLBP protein degradation is proposed based on observations made in both early mouse embryos and somatic cells.
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The degradation of the stem-loop binding protein at the late 2-cell stage of mouse embryogenesis /Poirier, Luc January 2003 (has links)
No description available.
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Murine Mind bomb1 its role in Notch and ß-catenin signaling during embryonic development /Rajendra, Rashmi, January 1900 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2006. / Vita. Includes bibliographical references.
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Studies on the toxicity and teratogenicity of cadmium on mouse pre-embryos in vitro and in vivo with special reference to their subsequent development /Yu, Hing-Sing. January 1987 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1988.
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Investigating the role of Oct4 during lineage specification in the physiological context of mouse embryonic developmentChia, Gloryn Le Bin January 2013 (has links)
No description available.
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Effects of prostaglandins on peri-implantation development of mouse embryos /Chan, Siu-yuen. January 1989 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1990.
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A study on the embryotrophic action of the complement component-3 derivative (iC3b) in the preimplantation mouse embryo developmentCheong, Wan-yee, Ana., 張韻怡. January 2009 (has links)
published_or_final_version / Obstetrics and Gynaecology / Master / Master of Philosophy
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Elucidating the molecular mechanisms underlying cell movements during early embryogenesisJoyce, Bradley January 2011 (has links)
The anterior visceral endoderm (AVE) is a specialised subpopulation of the visceral endoderm (VE), a single layer simple epithelium that surrounds the extra-embryonic ectoderm and epiblast of the egg cylinder stage embryo. Initially induced at the distal tip of the egg cylinder, AVE cells undergo a stereotypic migration towards the prospective anterior, stopping at the interface between the underlying epiblast and extra-embryonic ectoderm (ExE). Previous research has shown that membrane enrichment of Dvl2 is present in the VE overlying the epiblast (Epi-VE). In this thesis I confirm the presence of planar cell polarity (pep) signalling in this region by assaying the subcellular localisation of additional core pep proteins Vangl2 and Daaml. I show that null embryos of the Nodal antagonist Lefty1 exhibit ectopic membrane enrichment of Dvl2 and a previously unreported AVE over-migration phenotype. Furthermore, using pharmacological inhibition of Nodal signalling I show that the TGF~ protein Nodal modulates pep signalling in the YE. Utilising DIe and confocal microscopy I perform detailed time-lapse analyses of the VE to quantify the dynamic cell behaviour and topology. Using this assay I show that wild-type embryos exhibit dynamic cell movement, which is regionally restricted to the Epi-VE. Analysis of Leftyl-/- and ROSA26lyn-Celsr-l mutants, both of which exhibit disrupted pep signalling and AVE over-migration phenotypes, indicates that normal VE dynamics and topology are disrupted. The results of this quantitation indicate that these mutants exhibit increased cell migration and neighbour exchange across the YE. These data show that regional restriction of movement is lost and results in the AVE over-migration phenotypes observed. Together these results show that regionally restricted pep signalling in the VE acts to modulate cell behaviour and topology, which in turn determines the regional restriction and normal end-point of AVE migration.
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Developmental regulation and molecular nature of an activity in murine oocytes that transfers histones onto sperm DNAMcLay, David W. January 2001 (has links)
No description available.
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A study of embryotrophic mechanism of human oviductal cells on mouse embryo development in vitroXu, Jiasen. January 2000 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 182-211).
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