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Modeling of the human head/neck system using rigid body dynamics /Estep, Christina Renee, January 1992 (has links)
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1992. / Vita. Abstract. Includes bibliographical references (leaves 88-90). Also available via the Internet.
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Fine needle aspiration cytology in the study of neck massChen, Xiuyun. January 2003 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2003. / Includes bibliographical references (leaves 54-64). Also available in print.
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Optimum management of head and neck cancer /Coman, W. B. January 2006 (has links) (PDF)
Thesis (M.D.) - University of Queensland, 2006. / Includes bibliography.
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Application of p63 4A4 antibody in detection of cervical cancer and precursors in cytology samplesNg, Kin-man. January 2009 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 67-77).
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Head and neck lymph node region delineation with automatic segmentation and image registration /Teng, Chia-Chi, January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 89-97).
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Neurovascular lesions and mechanisms in suicidal hanging: an anatomical, physiological and pathological studyMoar, Jacob Joseph 25 April 2013 (has links)
Thesis (Ph.D.)--University of the Witwatersrand, Faculty of Health Sciences, 2012 / Background and Purposes
Suicide by hanging is a relatively common occurrence. The actual cause of death in
suicidal hanging is, however, controversial, having been attributed variously to
asphyxia, carotid artery compression and vagal nerve stimulation.
The aim of this Ph.D thesis was to determine the possible neurovascular
cause of death in suicides by hanging by careful study of the anatomy and
physiology of the neck region in relation to the ensuing pathology. The study was,
therefore, approached from an anatomical, physiological, histological and
pathological pespective. It therefore comprised a detailed exploration of the anatomy
and physiology of the neck structures to match these with the underlying traumatised
neurovascular structures, the latter trauma being brought about by the suicidal
hanging process.
Methods
The methods used in the study included an investigation of the ligature and position
of the ligature in relation to the level of the neck and the physical effects of the
ligature on the skin and underlying anatomical structures. A careful and detailed
dissection of the neck was undertaken and samples of the vessels and nerves were
processed for histological study. Fifty consecutive cases of suicidal hanging and five
“non-hanging” cases which served as controls were used in the study. In addition, ten
cases of suicidal hanging not included in the study were subjected to occlusion
studies by means of probe exploration. This technique and procedure was not carried
out or applied to the cases included in the study for fear that the probe itself might
produce artefactual damage to the delicate endothelium lining the inner layer of the
vessel wall.
The study was classified into various components such as:
1. Examination of the type and structure of the ligature material;
2. The position of the ligature on the neck, i.e. whether involving upper, middle,
or lower third of neck and to correlate this position with the underlying
anatomical structures subjected to the accompanying tensile, compressive and
haemodynamic forces;
3. The physical effects of the ligature upon the skin and the underlying deeper
neurovascular structures of the neck;
4. Meticulous “bloodless” dissection of the neck structures to corroborate any
pathology noted with the above three criteria. Currently, all putative causes of
death remain speculative;
5. Particular attention was paid to those structures most vulnerable to the
compressive forces, tensile forces and haemodynamic forces operative in
hanging. These comprise the neurovascular structures contained within the
fibrous carotid sheath and the phrenic nerves in the neck, in particular with
regard to the anatomical relationship of these structures to the positioning of
the ligature. As far as analysing the forces involved, the engineering
principles pertaining to these were interpreted in consultation with the
Faculty of Engineering at the University of the Witwatersrand. Results
The main findings of the study showed damage to vascular, neural (including
phrenic nerve), carotid bodies and accessory glomal bodies. The vascular
findings emerged following an examination of the total number of arteries in the
study, namely, 300, the figure derived as follows: six arteries in each of the fifty
hanging subjects, viz., the left common carotid artery, the right common
carotid artery, the left internal carotid artery, the right internal carotid
artery, the left external carotid artery and the right external carotid artery (6
x 50 = 300). The damage shown was particularly the case with regard to the
finding of tears in the various layers of the vessel wall. These extended from the
intima through to the adventitia or outermost layer of the vessel wall and these
were further subdivided into being either single or multiple.
The tears found ranged from those involving the intima alone (single tears
being found in 17 (5.6%) of the 300 arteries examined and multiple tears in 37
(12.3%) of the 300 arteries examined., the intima extending to the internal
elastic lamina (single tears being found in 20 (6.6%) of the 300 arteries
examined and multiple tears in 8 (2.6%) of the 300 arteries examined), tears
involving the intima and extending through to involve the media, i.e. intimomedial
tears and whether these latter tears involved the inner-, middle-, or
outer-thirds of the media (single or multiple). Single intimo-medial tears
extending through the intima to involve the inner-third of the media comprised
6 (2.0%) of the arteries examined, those extending from the intima to involve the
middle-third of the media comprised 3 (1.0%) of the 300 arteries examined and
single intimo-medial tears extending through the intima to involve the outeriv
third of the media similarly comprised 3 (1%) of the arteries examined. Multiple
intimo-medial tears extending through from intima to inner-, middle-, and outerthirds
of the media respectively, comprised 3 (1.0%), 5 (1.6%) and 1 (0.3%) of
the arteries examined.
Single tears involving the inner-third of the media alone comrised 6
(2.0%) of the 300 arteries examined, single tears involving the middle-third of
the media comprised 9 (3.0%) of the arteries examined and single tears
involving the outer-third of the media alone comprised 8 (2.6%) of the arteries
examined. Multiple tears involving the inner-, middle and outer-thirds of the
media respectively comprised 6 (2.0%), 13 (4.3%) and 16 (5.3%) of the arteries
examined.
Single tears involving both adventitia and media, i.e. adventitio-medial
tears extending through the inner-, middle-, or outer-thirds of the media to
involve the adventitia comprised 1 (0.3%), 2 (0.6%) and 6 (2.0%) respectively
of the 300 arteries examined. Multiple adventitio-medial tears of the inner-,
middle-, and outer-thirds of the media, respectively, comprised 0 (0.0%), 3
(1.0%) and 2 (0.6%) of the 300 arteries examined.
Single tears of the adventitia alone comprised 21 (7.0%) of the arteries
examined while multiple tears comprised 7 (2.3%). Complete circumferential
transverse rupture of the vessel wall was found in 3 (1.0%) of the arteries
examined while adventitial haemorrhage was found in 103 (34.3%) of the 300
arteries examined.
The vascular findings were represented numerically in tabular form in the 50
hanging subjects in Table III and were further analysed and compared with
regard to either unilateral or bilateral vessel involvement in the fifty (50) suicidal
hanging subjects and the findings represented in Tables IIIa (unilateral
involvement) and IIIb (bilateral involvement).
Additional vascular findings comprised endothelial elevation/avulsion,
internal elastic lamina dehiscence, subendothelial clefts, multiple medial
fenestrations, adventitio-medial separation, vascular congestion and a
vascular plane of cleavage. These were similarly represented in Table IV and
analysed with regard to unilateral or bilateral involvement in Tables IVa and IVb.
Endothelial elevation/avulsion was found in 295 (98.3%) of the 300 arteries
examined, internal elastic lamina dehiscence in 290 (96.6%) of the arteries
examined, subendothelial clefts in 289 (96.3%) of the arteries examined,
multiple medial fenestrations in 17 (5.6%) of the arteries examined, adventitiomedial
separation in 273 (91.0%) of the arteries examined, vascular congestion
in 224 (74.6%) of the arteries examined and a vascular plane of cleavage in 98
(32.6%) of the arteries examined. These findings, unexpected, showed the
extreme fragility and vulnerability of the intima and adventitia to the
compressive and tensile forces acting on the vessel wall during hanging, being
explicable not only on the basis of the various complex forces interacting
simultaneously during hanging but on the magnitude of forces applied. A
mathematical analysis, found at the end of the Discussion chapter, conducted in
order to estimate the minimum peak pressure applied and exerted on the vessel
wall during hanging, in collaboration with the School of Mechanical, Industrial
and Aeronautical Engineering at the University of the Witwatersrand, confirmed
the magnitude of these forces.
The neural findings (Table V) were divided into neural congestion, neural
haemorrhage, neural internal dehiscence, neural tearing and perineural
separation and these were similarly analysed with regard to either unilateral or
bilateral involvement in the fifty hanging subjects (Tables Va and Vb). Neural
congestion was found in association with 20 (6.6%) of the 300 arteries
examined, neural haemorrhage in14 (4.6%), neural internal dehiscence in 54
(18.0%), neural tearing in 35 (11.6%) and perineural separation in 112
(37.3%). Neural ganglionic findings were similarly divided into ganglionic
congestion, ganglionic haemorrhage, ganglionic internal dehiscence and
ganglionic tearing. Ganglionic congestion, in association with the 300 arteries
examined, was found in 20 (6.6%), ganglionic haemorrhage in 8 (2.6%),
ganglionic internal dehiscence in 15 (5.0%) and ganglionic tearing in 6
(2.0%).
The findings in the carotid bodies were divided into carotid body
congestion, carotid body haemorrhage, carotid body internal dehiscence and
carotid body tearing. Carotid body congestion, in association with the 300
arteries examined, was found in 8 (2.6%), carotid body haemorrhage in 2
(0.6%), carotid body internal dehiscence in 4 (1.3%) and carotid body tearing
in 2 (0.6%).
Accessory glomal body findings were, once again, divided into accessory
glomal congestion, accessory glomal haemorrhage, accessory glomal internal
dehiscence and accessory glomal tearing. However, in view of the close
anatomical association between the accessory glomal bodies and the adventitia
of the arterial walls, an additional pathological finding of accessory glomal
adventitial separation emerged. Accessory glomal congestion, in association
with the 300 arteries examined, was found in 20 (6.6%), accessory glomal
haemorrhage in 7 (2.3%), accessory glomal internal dehiscence in 50 (16.6%),
accessory glomal tearing in 18 (6.0%) and accessory glomal adventitial
separation in 124 (41.3%). This latter finding once again demonstrated the
vulnerability of the adventitial layer of the vessel wall to tensile forces,
separating it from its associated structures.
Damage to the phrenic nerves and surrounding muscles, underlying the site
of ligature application, was similarly found, suggesting a role for phrenic nerve
stimulation with consequent diaphragmatic paralysis in contributing to death in
the hanging process.
Discussion and Conclusion
In this Ph.D thesis the principles of dimensional analysis i.e., the breaking down
of a complex phenomenon into its component parts, have been applied. However,
in view of the complexity and proximity of structures to one another in the neck,
consisting not only of the rigid hyoid-larynx complex and vertebral column but
also the integrated vascular and neural structures, it appears that not one single
biological mechanism can be ascribed and attributed to the cause of death in
suicidal hanging. Rather, it appears that unconsciousness and death causation
appears to be multifactorial. Both the sympathetic and parasympathetic arms of
the autonomic nervous system are involved, often with antagonistic and therefore
paradoxical effects. In a ddition, pressure to the phrenic nerve, not previously
considered in playing a role in death causation in hanging, may, it is suggested,
be a major contributory factor in death causation. This nerve, the innervation to
the major muscle of respiration, i.e. the diaphragm, in a neural response to the
compressive and tensile forces in hanging, fixes the diaphragm in a state of
inspiratory paralysis. This latter effect would be further augmented by neural
stimulation of the accessory muscles of respiration, i.e. the sternocleidomastoid
and scaleni muscles, similarly lying deep to the site of ligature application,
contributing to the thoracic cage becoming fixed in a state of inspiratory
paralysis. This latter effect, as described in that section of the Discussion chapter
dealing with an analysis of the physiological functions at play, is brought about
by initiation of the dynamic and static stretch reflexes occurring in these
muscles on application of a compressive or tensile stimulus.
Compression of the carotid arteries, on the other hand, results, as shown, not
only in major damage to these vessels and their accompanying veins, but, in
addition, must produce a dramatic element of cerebral ischaemia with ensuing
loss of consciousness. It thus appears that loss of consciousness is the critical
factor for it is the state when the victim is no longer able to save himself or
herself. Without loss of consciousness survival may occur, but with it, death
becomes inevitable.
The question then arises :- what is the cause of unconsciousness? In
physiological terms, carotid artery occlusion induces rapid unconsciousness, i.e.
within 11 to 12 seconds, resulting ultimately in death. In other words, the sudden
application and unremitting pressure of the ligature must inevitably result in
death. On the other hand, the sudden application of a ligature with consequent
vagal nerve compression may produce instantaneous cardiac arrest with cessation
of blood flow to the brain and resultant loss of consciousness. This event would
produce unconsciousness in less than the time period of 11 seconds of carotid
artery occlusion (although the brain continues to survive for several minutes
thereafter despite cessation of heart beat). If, however, unconsciousness is
contributed to by phrenic nerve compression, it would not be instantaneous as
shown by the fact that one can normally hold one’s breath for several minutes (as
underwater swimmers do) and unconsciousness does not supervene either
instantaneously or within 11 seconds. In short, unconsciousness would not occur
within 11 seconds in the case of compression of the phrenic nerve unless a more
critical factor supervenes.Thus, the rapidity of onset of unconsciousness appears
to be the critical factor in determining the progression to ultimate (and inevitable)
death. Moreover, as pointed out in the Materials and Methods chapter, the
carotid arteries in several tested cases would not allow the passage of a probe
through the obstructed arteries beneath a tightly applied ligature. This obstruction
would, therefore, appear to be the initiator of the deadly unconsciousness factor,
although respiratory arrest would be compounded by neural and muscular
factors.
While in this thesis the principles of dimensional analysis i.e., the breaking
down of a complex phenomenon into its component parts have been applied, the
principles of integrated analysis i.e., the combining and synthesis of separate
parts into a whole have also been attempted. In essence, while it is suggested that
the neural elements play a pivotal role in the hanging process due to the neural
effect on both brain and heart as a result of autonomic nervous system
stimulation and the function of the phrenic nerve in respiration, it appears that
multiple factors, acting in concert, simultaneously or in rapid sequence to one
another, all play a role in contributing to death causation in the hanging process.
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Neck pain : analysis of prognostic factors and treatment effects /Kjellman, Görel, January 1900 (has links) (PDF)
Diss. (sammanfattning) Linköping : Univ., 2001. / Härtill 4 uppsatser.
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Prognostic factors in squamous cell carcinoma of the head and neck with emphasis on 11q13 rearrangments and Cyclin D1 overexpression /Åkervall, Jan. January 1998 (has links)
Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted.
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Prognostic factors in squamous cell carcinoma of the head and neck with emphasis on 11q13 rearrangments and Cyclin D1 overexpression /Åkervall, Jan. January 1998 (has links)
Thesis (doctoral)--Lund University, 1998. / Added t.p. with thesis statement inserted.
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The effect of manual cervical traction versus mechanical cervical traction in the treatment of chronic neck painRinke, Marike 02 April 2014 (has links)
M.Tech. (Chiropractic) / Introduction: The most common chronic pain condition in modern society is neck pain (Jensen and Harms-Ringdahl, 2007). Chronic neck pain is a common complaint for many, from young patients to older patients with stressful work situations. According to Graham, Gross and Goldsmith (2006) neck disorders are common, disabling to various degrees and costly. Various structures in the cervical spine capable of transmitting pain include facet joints, intervertebral discs, nerve root dura, ligaments, and muscles (Manchikanti, Singh, Rivera and Pampati, 2002). According to Rochester (2009) chiropractors treat patients with chronic neck pain by using spinal manipulative therapy (SMT) to address a segmental joint hypomobility within the cervical spine as determined by joint motion palpation and endplay assessment. Traction is commonly used for the treatment of the spine by various physical therapists. It may be included as part of a chiropractic treatment protocol. According to Hooper (1996) traction involves the application of both manual and mechanical forces to draw adjacent body parts away from each other resulting in decompressed irritated tissues, realign parts, and relaxing tight structures. There are several types of cervical traction. The short and medium term improvement for chronic neck pain as well as the comparative effect of manual cervical traction versus mechanical cervical traction in combination with spinal manipulative therapy has not yet been established. Aim: This particular research study aimed to compare the short to medium term efficacy of manual cervical traction with mechanical cervical traction combined with spinal manipulative therapy with regards to decreased pain and improvement of cervical spine ranges of motion in patients with chronic neck pain. Methodology: Participants who met the inclusion and exclusion criteria were eligible to participate in this study. Advertisements were placed on notice boards around the campus of the University of Johannesburg and participants were recruited from the use of advertisements as well as word of mouth to partake in this research study. Thirty participants who suffered from chronic neck pain, volunteered for this comparative research study. This study was a randomized comparative study, where participants were randomly selected to be either in Group 1 or in Group 2. Group 1 received manual cervical traction whereas Group 2 received mechanical cervical traction. Both groups received spinal manipulative therapy to the restricted motion segments found in the cervical spine. Participants received seven trial sessions, with six treatments, over a period of two weeks. At the final 7th visit, one month after the sixth visit, no treatment was performed. Subjective and objective measurements were recorded at each visit. The subjective measurements of this particular study consisted of the Numerical Pain Rating Scale (NPRS) and the Vernon-Mior Neck Disability Index to evaluate the participants’ sensitivity to pain and disability. The objective measurements of this study included the Cervical Spine Range of Motion instrument to assess the participants’ cervical spine movement. Results: Both groups demonstrated a statistically significant improvement over time with regards to pain and disability, as well as increased range of motion to the cervical spine. The greatest percentage improvement with regards to range of motion was in lateral flexion and rotation of the cervical spine. Conclusion: According to the results of this study, it could be concluded that either manual cervical traction or mechanical cervical traction in combination with spinal manipulative therapy can be used effectively in the treatment of chronic neck pain as part of a chiropractic treatment protocol. Both groups proved to have a statistically significant improvement with regards to pain and disability as well as increased cervical spine range of motion...
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