Trace quantities of pharmaceuticals (including carbamazepine and sertraline) are continuously discharged into the environment, which causes concern among scientists and regulators regarding their potential long-term impacts on aquatic ecosystems. These compounds and their metabolites are continuously interacting with the orgranisms in various life stages, and may differentially influence development of embryo, larvae, juvenile, and adult stages. To fully understand the potential ecological risks of two candidate pharmaceutical chemicals (carbamazepine (CBZ) and sertraline (SERT)) exposure on survival, growth and reproduction of Ceriodaphnia dubia in three sucessive generations under static renewal toxicity test, a multigenerational approach was taken. Results indicate that SERT exposure showed higher sensitivity to chronic exposure to C. dubia growth and reproduction than CBZ exposure. The lowest concentration to affect fecundity and growth was at 50 µg L-1 SERT in the first two generations. These parameters become more sensitive during the third generation where the LOEC was 4.8 µg L-1. The effective concentrations (EC50) for the number of offspring per female, offspring body size, and dry weight were 17.2, 21.2, and 26.2 µg SERT L-1, respectively. Endpoints measured in this study demonstrate that chronic exposure of C. dubia to SERT leads to effects that occur at concentrations an order of magnitude higher than predicted environmental concentrations indicating potential transgenerationals effects. Additionally, a process-based dynamic energy budget (DEB) model is implemented to predict the simulated effects of chronic toxicity of SERT and CBZ to C. dubia individual behavior at laboratory condition. The model‘s output indicates the ecotoxicological mode of action of SERT exposure, which acts on feeding or assimilation with an effect that rapidly saturates at higher concentrations. Offspring size decreases with the toxic effects on feeding, and offspring number is thus less affected than total investment in reproduction. Consequently, CBZ affects direclty in reproduction which are captured by DEBtox model as increased embryonic hazard and reproduction cost as well as growth and maintenance costs. Furthermore, stress factor linearly increased not only with increasing chemical concentrations but also with exposure time. The DEBtox model establishes a cumulative life history consequence of multigenerational exposure to CBZ and SERT. This approach provides a tool to which to understand the effect of chemical to the individual organism and predict the population level effects in ecological risk assessment of the emerging contaminants.

In order to prevent the onset of several chronic diseases, populations that exhibit poor dietary practices must be identified and educated on proper nutritional habits. This study used the pre-validated Rapid Eating Assessment for Participants – Shortened version (REAP-S) survey and a four-question demographic questionnaire to identify these populations among undergraduate students at the University of Central Florida. The participants were 171 students of at least 18 years of age who completed the 17-question online survey. The data collected indicated that significant differences in diet quality regarding consumption of fats and saturated fats exist between ages, class standings, and sexes within an undergraduate population. Additionally, significant differences in diet quality regarding whole grain consumption were observed between sexes within an undergraduate population. More extensive dietary surveys and thorough demographic questionnaires should be utilized in future research to verify the existence and extent of these variations in diet quality to determine the groups of undergraduate students most at risk for chronic diseases.

Chronic pain remains a prevalent problem across the United States. Chronic pain does not seem to have a function and relief of this symptom remains elusive for many sufferers. Virtual reality has been used as an adjunct therapy to decrease acute pain with promising results, but there is little research on whether virtual reality could be used as a successful intervention for those with chronic pain. Virtual reality has few side effects, so it warrants consideration for the treatment of chronic pain. There is growing evidence that there is potential for virtual reality to produce desired results with patients having chronic pain, but without more research this intervention cannot be confidently recommended (Garrett, Taverner, & McDade 2017). This thesis reviewed published research on the use of virtual reality in those with chronic pain. A total of seven studies that addressed virtual reality and chronic pain were analyzed and integrated into this literature review. All studies used virtual reality as a distraction to improve chronic pain. Three studies included patients with chronic back pain, one study included patients with chronic neck pain, and the remaining three studies addressed other types of chronic pain including chronic postoperative breast cancer pain, chronic neuropathic pain, and chronic generalized pain. All studies reviewed reported improvement of chronic pain symptoms. This literature review provides evidence to support the use of virtual reality for those with chronic pain. More rigorous research with larger sample sizes is needed to increase the generalizability of results to help people suffering with chronic pain from a variety of causes. This literature review used the search terms "chronic pain" and "virtual reality" and the following databases: EBSCOhost, Medline, CINAHL Plus with Full Text, PsycINFO, Academic Search Premiere, and Applied Science & Technology Source.

No description available.

No description available.

No description available.

No description available.

No description available.

No description available.

No description available.