In Nigeria, manufacturing businesses play a vital role in the industrial growth of the nation and have many dynamic benefits crucial for the growth of a sustainable economy. The manufacturing sector has added substantially to the gross domestic products of many countries. Nonetheless, 50% of manufacturing firms in Nigeria experience a decline in production capacity utilization and profitability because of inefficient production processes. The purpose of this qualitative multiple case study was to explore strategies leaders of manufacturing firms in Nigeria use to support efficient manufacturing operations. The theory of constraints served as the conceptual framework for this study. Eight participants from two manufacturing firms in Nigeria who had strategies to support efficient manufacturing operations participated in this study. Data sources included semistructured interviews and the review of organizational documents consisting of corporate quality policy, quality objectives, and mission statements. Analysis involved data compilation, data coding by breaking it down into categories, and reassembling the data into emergent themes. Member checking and methodological triangulation strengthened the credibility of the findings. Four major themes emerged: strategic planning, continuous process improvement, strategic equipment maintenance, and strategic capacity expansion. The findings from this research might provide the basis for developing an advanced manufacturing practice for some Nigerian manufacturing firms that could contribute to social change by improving production efficiency, local consumption, and sustainable economic growth.