Indiana University-Purdue University Indianapolis (IUPUI) / Development rate is a quantitative trait that displays significant variation within many species, including Cochliomyia macellaria Meigen (Diptera: Calliphoridae). Calliphorids are a family of dipterans known as blow flies and are commonly used in forensic entomology to estimate the minimum postmortem interval (PMIMIN), given some assumptions are made. In order to dissect the genetic underpinnings of development rate variation in this species, artificial selection for fast and slow development with population-based resequencing was used. The objective of this study is to isolate and characterize genomic regions that are correlated to development rate variation in blow flies. The first approach used known regulatory development genes from Drosophila melanogaster Meigen (Diptera: Drosophilidae) and isolated variants that were associated with development time changes in artificially selected fast and slow development C. macellaria strains. Three variants located in Ras and Eip74EF were associated with fast or slow development in selection strains with a significant change in allele frequency. The second approach involved the comparison of pooled artificially selected fast and slow C. macellaria genomes to investigate the genetic basis of development rate variation. When comparing the fast and slow genomes, 699 sequences were identified that contained 7290 variants with consistent changes in allele frequency. The variants indicated that the genomic regions that are associated with development rate were associated with developmental processes, including regulation of RNA polymerase II activity, and transporter activity, such as protein dimerization. Of the 699 sequences, 69 sequences were related to Achaete-scute complex and 14 were related to Cyp12A7. The identification of the genomic regions that associated with development rates from this study provides an important resource for future studies in identifying potential genetic markers to increase the effectiveness of PMIMIN estimates. By using significantly associated variants as a priori candidates for future studies, the data increases the understanding of natural development variation in blow flies.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / Currently, businesses implementing electrical projects lack the theoretical knowledge of ways to correctly develop the projects given that they are based on empirical knowledge. Consequently, a need has developed to implement lean philosophy and project management as distinctive and renowned pillars to ensure high competitiveness in the market of the sector under study. Through case studies, the literature on the subject demonstrated the importance of proper planning based on cost and time pillars. These pillars were analyzed using Ishikawa tools and a problem tree. The following lean tools were chosen: 5S, visual management, and quality circles. These tools and the project management guidelines, specifically the 47 processes published in the 5th edition of the Project Management Body of Knowledge, were applied as a model proposal at a pilot company in which the results of how this combination of solutions reduces delivery times for that organization were compared.

Syftet med studien var att få en bättre förståelse för hur sjukhusen använder sig av data och information i samband med Business Intelligence (BI). Det gjordes genom att undersöka ett fall som var ett BI- system och det var uppbyggt av människor och teknologier i PMI funktionen inom Karolinska universitetssjukhus. Forskningsfrågorna som skulle besvaras inkluderade vad det är som utmärker användandet av beslutsstöd för de medicinska processerna inom Perioperativ medicin och intensivvård. Dessutom skulle det undersökas hur framtiden ser ut med BI användningen inom PMI. De avdelningar som undersöktes inkluderade perioperativ vård, intensivvårdsavdelningen (IVA) och en translationell forskningsplattform. Detta gjordes som en kvalitativ fallstudie där relevanta personer med olika roller inom PMI intervjuades. Dessa roller inkluderade en BI arkitekt, anestesiläkare och enhetschefer. Empirin som samlades in inkluderade semi strukturerade intervjuer vilket var den främsta datakällan. Interna dokument med fakta kring verksamheten användes som komplement. Den teoretiska utgångspunkten som användes var ett BI ramverk och ett ramverk för arbetssystem, men andra teorier angående BI-förmågor användes också. Det resultat som genererades av studien var att samtliga delar av BI-systemet behöver fungera väl tillsammans för att ett beslutstöd ska på den högsta graden kunna erbjudas. Det visade sig att organisationsminnet och informationsintegreringen byggde upp det första steget i beslutstödet, därefter så är det insiktsskpandet som skapar uppfattningar av tidigare händelser. Sist är det presentation/kommunikation som erbjuder slutanvändaren informationen i form av dashboards. En annan slutsats var att den ökade mängden data inte egentligen hade en påverkan på BI-system och beslutsfattandet. / The purpose of this study was to get a better understanding of how hospitals use data and information in conjunction with Business intelligence (BI). That was done by examining a case that was a BI-system which people and technologies of the PMI department in Karolinska university hospital were a part of. The research questions that were supposed to be answered included what distinguished the usage of decision support in the medical processes in PMI. In addition to this the effect the increasing access of data had on the aforementioned processes were also to be examined. The departments that were examined included preoperative care, intensive care unit (ICU) and a translational research platform. This was conducted as a qualitative case study where relevant people who worked in PMI with different roles were to be interviewed. This included a BI architect, anaesthesiologist and unit managers. The empirical data that was created included several semi structured interviews which were the main data source and internal documents that had useful information regarding the departments. The main theoretical framework that was used to analyse the data was a BI framework and work system theories, but other theories regarding BI capabilities were also used. The result that was generated by the study was that all the different parts of the analysed BI-system have to work together in order for the decision support to be as good as possible. The results also showed that the BI capabilities organizational memory and information integration builds the first step towards decision support. Then it is insight creation and presentation/communication that creates the understanding of previous events. Another conclusion was that the increasing amounts of data did not have a major effect on the BI-system or decision support as a whole.

International Telemetering Conference Proceedings / October 20-23, 2003 / Riviera Hotel and Convention Center, Las Vegas, Nevada / While healthcare industry is striving to achieve e-health systems for improvements in healthcare quality, cost, and access, privacy and security about medical records should be considered carefully. This paper makes a deep study of Public Key Infrastructures (PKIs) and Privilege Management Infrastructures (PMIs) and how they can secure e-health systems. To access resources, e.g. patient records, both authentication and authorization are needed, so public key certificates and attribute certificates are both required to protect healthcare information. From a typical medical scenario, we see not only static but also dynamic permissions are required. Dynamic authorization maybe the most complex problem in e-health systems.

Durante el 2011 y 2012, en el consorcio de las empresas StraconGyM y Mota-Engil Perú, en el proyecto CC-02 “Construcción de Presa de Relave y Facilidades”, se implementó la gestión de control de costos, bajo el enfoque del PMI-PMBOK (Projetc Management Institute-Projetc Management Body of Knowledge). La investigación tuvo el objetivo de determinar en qué medida la implementación del modelo de gestión de control de costos bajo el enfoque del PMI-PMBOK, permite mejorar la eficiencia del costo del proyecto CC-02. La demostración de la mejora de la eficiencia del proyecto se sustentó en; la mejora de la satisfacción de la gestión de control de costos, la mejora del desempeño del costo, y en la mejora del desempeño del trabajo por completar. Para el cual se utilizó el un diseño cuasi-experimental de serie de tiempos. Como resultado de la investigación se obtuvo un incremento de 47.82% en la satisfacción de la gestión de costos, quiere decir que pasó de 33.34% a un 81.16%, un incremento del índice desempeño del costos (eficiencia) de 111 % a 145%, y un incremento del índice desempeño del trabajo por completar de 111% a 114%. La investigación concluye, que la implementación del modelo de gestión de control de costos bajo el enfoque del PMI-PMBOK, en el proyecto CC-02, ha contribuido en la mejora de la eficiencia del costos del proyecto CC-02. During 2011 and 2012, the consortium of companies StraconGyM and Mota-Engil Peru in the CC-02 "Construction of Tailings Dam and Facilities" project management cost control was implemented under the focus of PMI- PMBOK (Project directed Management Institute-Project directed Management Body of Knowledge). The research aimed to determine to what extent the implementation of the management model of cost control under the PMI-PMBOK approach, improves the efficiency of the cost of the CC-02 project. The demonstration of the improved efficiency of the project was based on; improving the satisfaction of the management cost control, improved cost performance, and improving the performance of work to complete. Which it was used for the quasi-experimental time series design. As a result of the investigation, a 47.82% increase in satisfying cost management was obtained, means that went from 33.34% to 81.16%, an increase of cost performance (efficiency) ratio of 111% to 145% and increased job performance complete index of 111% to 114%. The research concludes that the implementation of the management model of cost control under the PMI-PMBOK approach in the CC-02 project has contributed to improving the cost efficiency of the CC-02 project.

El presente trabajo de investigación contempla el proyecto de un nuevo sistema integral de fajas y cadenas transportadoras y se encuentra ubicado en un terminal portuario, Con fecha 01 de diciembre del 2014. Pagroin S.A se adjudicó el contrato de parte de Terminales Portuarios S.A. para la construcción del nuevo sistema integral de fajas y cadenas transportadoras. El proyecto, consta de cuatro etapas: Dirección de Proyectos, Procura, Construcción y Pruebas. El proyecto, empezó el 05 de diciembre de 2014 y finalizó el 09 de enero de 2016. El presupuesto de costos del proyecto es de $ 3, 441,733.63. Pagroin S.A. desarrollará el proyecto como la constructora responsable y su estrategia estará enfocado en la alta especialización y la disponibilidad de recursos, en general en las disciplinas mecánica, electricidad & automatización y obras civiles. La construcción del proyecto, en lo referido a la disciplina mecánica estará a cargo de Pagroin S.A., mientras que los contratistas de servicio se encargarán de todo lo referido a las disciplinas electricidad & automatización y obras civiles. El cliente Terminales Portuarios S.A. solicita a Pagroin S.A. que utilice las buenas prácticas de la guía del PMBOK® Quinta edición. Pagroin S.A considera este proyecto como una oportunidad para aumentar sus ingresos en orden del 20% anual, incrementar en 5% el retorno en la inversión (ROI) y la mejora de procesos internos entre otros. El proyecto fue exitoso en el cumplimiento de los objetivos relacionado al alcance, tiempo, costo y calidad. El cliente aprobó la conformidad del proyecto y Pagroin S.A consiguió los resultados esperados en cuanto al retorno en la inversión (ROI) y el aumento de los ingresos. Los indicadores financieros obtenidos fueron: TIR = 1.74%, VAN = $ 850,511 y un payback de 15 meses. / The present research work contemplates the project of a new integral system of conveyor belts and chains and is located in a port terminal. On December 1, 2014. Pagroin S.A was awarded the contract by Terminales Portuarios S.A. for the construction of the new integral system of conveyor belts and chains. The project consists of four stages: Project Management, Procurement, Construction and Testing. The project started on December 5, 2014 and ended on January 9, 2016. The project's cost budget is $ 3, 441,733.63. Pagroin S.A. will develop the project as the responsible constructor and its strategy will be focused on the high specialization and the availability of resources, in general in the disciplines of mechanics, electricity & automation and civil works. The construction of the project, with regard to mechanical discipline will be in charge of Pagroin S.A., while the service contractors will be responsible for everything related to the disciplines of electricity & automation and civil works. The Port Terminals client S.A. requests Pagroin S.A. use the good practices of the PMBOK® Fifth Edition guide. Pagroin S.A considers this project as an opportunity to increase its income in order of 20% per year, increase in 5% the return on investment (ROI) and the improvement of internal processes among others. The project was successful in meeting the objectives related to scope, time, cost and quality. The client approved the compliance of the project and Pagroin S.A achieved the expected results in terms of return on investment (ROI) and increased revenues. The financial indicators obtained were TIR = 1.74%, VAN = $ 850,511 and a 15-month payback / Trabajo de Investigación

Made available in DSpace on 2016-04-25T16:44:55Z (GMT). No. of bitstreams: 1 Dissertacao Mestrado PUC.pdf: 629205 bytes, checksum: c6c883b3f57af0cd553e521d11ab32b6 (MD5) Previous issue date: 2005-06-28 / Este trabalho, fruto da experiência profissional voltada para gerenciamento de projetos na área de TI, foi idealizado como instrumento de compreensão e reflexão sobre as práticas de gerenciamento de projetos de TI nas organizações no Brasil, utilizando-se das melhores práticas do PMI e as teorias de Cultura Organizacional. O objetivo, então, dessa pesquisa foi traçar um perfil das organizações que implementaram as práticas de gerenciamento de projetos do PMI no Brasil, baseado na tipologia cultural de Quinn ou CVM, identificando os tipos culturais mais e menos favoráveis à metodologia, levando a um entendimento maior sobre os fatores culturais para as práticas do PMI no Brasil. Palavras-chave: gerenciamento de projetos; cultura organizacional; melhores práticas de gerenciamento de projetos do PMI

There is increasing interest in the role of peers in facilitating the social interaction of pupils with ASD through Peer-mediated Interventions (PMI). A systematic literature review was conducted to provide an overview of methods used to evaluate the impact of PMI and provide examples of innovative practice. Four databases were searched. Following application of inclusion and exclusion criteria and coding of studies, 10 were included in the final review. The review found that measuring the outcome of PMI at the level of target pupils has been a focus, with less attention given to exploring experiences of participants; impact on peers and implementation of PMI within an educational context. An innovative PMI was implemented within a mainstream primary school to promote the social inclusion of a Year 3 male pupil with ASD, with his class and five peers. Key elements of the PMI included development of the programme with school staff, whole class awareness raising and a small group peer network. The intervention was evaluated through structured playground observations of pupil-peer interaction, interviews with the target pupil and school staff and a peer focus group. Findings indicated that this small-scale PMI had a positive impact at the level of the target pupil and peers. Key factors facilitating the implementation of this intervention within a school context were also identified. A structured dissemination strategy that involved consultation activities with key stakeholders explored the refinement of an ecologically valid and feasible model for delivery in mainstream schools. Future considerations in developing the intervention framework include; refining elements of the programme based on feedback from key stakeholders and trialling the delivery of the intervention by school staff trained in the programme. Implications for Educational Psychologists (EPs) in the development and delivery of the intervention are discussed.

El presente proyecto busca aprovechar la oportunidad que se origina por la demanda insatisfecha de profesionales técnicos con una formación de calidad en el mercado de Lima, necesidad que se satisface mediante la estrategia de diferenciación al crear valor en el servicio de formación técnica profesional e incluir los atributos valorados e identificados por nuestro público objetivo en el estudio de mercado respecto a las áreas de Enfermería Técnica, Administración de Empresas y Computación e Informática. Conforme al estudio de mercado, la demanda estimada de alumnos de NSE C y D interesados en seguir estudios técnicos superiores al 2019 dentro de nuestro mercado objetivo ascienden a 35,243 alumnos, iniciando la actividad educativa con un promedio de 264 alumnos nuevos en cada turno, alcanzando al término del primer año un total de 528 alumnos. La inversión inicial requerida es de S/. 4,616,442.00 soles, de los cuales el 65% será aportado por los socios de la empresa y el 35% restante será obtenido a través de financiamiento bancario. El punto de equilibrio de la demanda (alumnos por salón) es de 22, por lo que se estima que durante los primeros 5 años se obtendría un VANE de S/. 1,615,286.00 soles, con una TIRE de 32.67% y un periodo de recupero de 4 años y 4 meses, lo que demuestra la viabilidad, factibilidad y rentabilidad del Proyecto propuesto. La utilización del estándar del PMI permitirá asegurar los resultados obtenidos, reduciendo las probabilidades de pérdidas para Ciencitec en la inversión del proyecto propuesto. / The present project seeks to take advantage of the opportunity that arises from the unmet demand of technical professionals with quality training in the Lima market, a need that is satisfied through the differentiation strategy to create value in the professional technical training service and include the attributes valued and identified by our target audience in the market study regarding the areas of Technical Nursing, Business Administration and Computing and Information Technology. According to the market study, the estimated demand of NSE C and D students interested in pursuing higher technical studies in 2019 within our target market amounts to 35,243 students, initiating the educational activity with an average of 264 new students in each shift, reaching at the end of the first year a total of 528 students. The initial investment required is S /. 4,616,442.00 soles, of which 65% will be contributed by the partners of the company and the remaining 35% will be obtained through bank financing. The equilibrium point of demand (students per classroom) is 22, so it is estimated that during the first 5 years a VANE of S /. 1,615,286.00 soles, with a TIRE of 32.67% and a recovery period of 4 years and 4 months, which demonstrates the viability, feasibility and profitability of the proposed Project. The use of the PMI standard will ensure the results obtained, reducing the probability of losses for Ciencitec in the investment of the proposed project. / Tesis

This investigation explored the environmental and physiological factors affecting adult blow fly (Diptera: Calliphoridae) arrival and attendance at pig (Sus scrofa domesticus L.) carcasses in Brazos Co, TX in the summer and winter, and validated a new technique for estimating the pre-colonization interval. It also examined how the offspring of said blow flies compensate for adverse developmental conditions such as starvation or the presence of older competitors by determining the function of minimum viable weight, critical weight, and the terminal growth period in Cochliomyia macellaria (F.) (Diptera: Calliphoridae). Adult blow fly carcass attendance is poorly explained by temperature, wind speed, ambient light intensity, or body size for either winter or summer-active species. Time of day explained approximately 10% in carcass size variation for all four of the most common species. For summer flies, the degree of ovarian development changed significantly from 96%/98% fully developed on day 1 postmortem to 7%/2% fully developed on day 2 postmortem for C. macellaria and Chrysomya rufifacies (Macquart) iv respectively. Using the binomial distribution, the minimum postmortem interval was correctly estimated for 4/6 validation tests. Minimum viable weight for C. macellaria was found to be ~ 0.02 g, and was stable under conditions of starvation and simulated competition. Under starvation conditions, time to pupariation was not altered, whereas under simulated competition, growth rate was increased and terminal growth period shortened. Starved flies under simulated competition entered the pupal state ~12 h faster than starved flies without competition, but required ~12 longer to complete development. These effects should be considered when estimating post-colonization intervals.