The chemical and optical properties of particulate organic compounds remain unclear, which leaves large uncertainties in the estimation of global radiative transfer balance. Gas and find particle (PM2.5) phase formic acid concentrations were measured with online instrumentation during separate one-month studies in the summer of 2010 in Los Angeles (LA), CA, and Atlanta, GA, and the gas-particle partitioning behavior was investigated and compared with that of water-soluble organic compounds (WSOC). The diurnal profiles clearly indicated that the photochemistry production serves as a strong source for the formation of organics, while the correlation between the gas and particle phase suggested that another partitioning route, the aqueous reactions, is also very important. Later, the optical properties of light-absorbing organic compounds were examined. Little is known about the optical importance of light absorbing particulate organic compounds (brown carbon), especially its extent and absorption relative to black carbon throughout the tropospheric column. Mie theory was applied to size-resolved spectrophotometric absorption measurements of methanol and water-extracts from cascade impactor substrates collected at three surface sites around Atlanta, GA, including both urban and rural. These results were applied to similar measurements of brown carbon in extracts from aircraft bulk filter samples collected over central USA. At the surface sites predicted light absorption by brown carbon relative to total absorption (brown carbon plus pure black carbon) was about 10% and 30% at 350 nm, versus 1 and 11% at 450 nm, for water and methanol extracts, respectively. The relative contribution of brown carbon was greater in the free troposphere and significantly increased with altitude. Although this approach has limitations, it demonstrates the ubiquity and significant potential contribution of brown carbon.

ITC/USA 2009 Conference Proceedings / The Forty-Fifth Annual International Telemetering Conference and Technical Exhibition / October 26-29, 2009 / Riviera Hotel & Convention Center, Las Vegas, Nevada / Virtualization technologies have the potential to transform the telemetry post-processing environment. Significant efficiencies can be gained by migrating telemetry post processing activities to virtual computing platforms. However, while facilitating better server utilization, virtualization also presents several challenges; one of the most difficult of those challenges being security. In virtualization, server environments are replicated in software; unfortunately, the security individual servers provide is not replicated in a software stack implementation of a server environment. After reviewing virtualization fundamentals, security issues and their impact on telemetry post processing will be discussed.

Blasting is a critical part of most mining operations. The primary function of blasting is to fragment and move rock. For decades, attempts have been made at increasing the efficiency of blasting to reduce costs and increase production. Most of these attempts involve trial and error techniques that focus on changing a single output. These techniques are costly and time consuming and it has been shown that as one output is optimized other outputs move away from their optimum level. To truly optimize a blasting program, the transfer of explosive energy into individual components must be quantified. Explosive energy is broken down into five primary components: rock fragmentation, heave, ground vibration, air blast, and heat. Fragmentation and heave are considered beneficial components while the remaining are considered waste. Past energy partitioning research has been able to account for less than 30% of a blast’s total explosive energy. The purpose of this dissertation was to account for a greater percentage of the explosive energy available during a blast. These values were determined using measurement techniques not previously applied to energy partitioning research. Four small-scale test series were completed, each designed to isolate individual energy components. Specific energy components measured include borehole chambering, elastic deformation (ground vibration), translational and rotational kinetic energy (heave), and air overpressure (air blast). This research was able to account for 73% of the total explosive energy. Borehole chambering (13%), rotational kinetic energy (25%), translational kinetic energy (5%), and air overpressure (28%) were determined to be the largest components. Prior research efforts have largely ignored rotational kinetic energy and have only been able to offer predictions for the values of borehole chambering and air overpressure energies. This dissertation accounted for a significantly higher percentage of total available explosive energy than previous research efforts using novel measurement techniques. It was shown that borehole chambering, heave, and air blast are the largest energy components in a blast. In addition to quantifying specific energy partitions, a basic goal programming objective function was proposed, incorporating explosive energy partitioning and blasting parameters into a framework that can be used for future energy optimization.

Multi-view video is capable of presenting a full and accurate depth perception of a scene. The concept of multi-view video is becoming more useful especially in 3D display systems by enhancing the viewing of high resolution stereoscopic images from arbitrary viewpoints without the use of any special glasses. Like monoscopic video, the multi-view video is faced with different challenges such as: reliable compression, storage and bandwidth due to the increased number of views as well as the high sensitivity to transmission errors. All these may lead to a detrimental effect on the reconstructed views. The work in this thesis investigates the problems and challenges of transmission losses in a multi-view video bitstream over error prone wireless networks. Based on the network simulation results, the proposed technique is capable of addressing the problem of transmission losses. In practical wireless networks, transmission errors are inevitable and pose a serious challenge to the coded video data. The aim of this research effort is to examine the effect of these errors in a multi-view video bitstream when transmitted over a lossy channel. Moreover, this research work aims to develop a novel scheme that can make the multi-view coded videos more robust to transmission errors by minimizing the error effects and improving the perceptual quality. Multi-layer data partitioning as an error resilient technique is developed in JMVC 8.5 reference software in order to make the multi-view video bitstream more robust during transmission. In addition to that, we propose a simple decoding scheme that can support the decoding of the multi-layer data partitioning bitstream over channels with high error rate. The proposed technique is benchmarked with the already existing H.264/AVC data partitioning technique. The work in this thesis also employs the use of group of pictures as a coding parameter to investigate and reduce the effects of transmission errors in multi-view video transmitted over a very high error rate channel. The experiments are carried out with different error loss rates in order to evaluate the performance of these techniques in terms of perceptual quality when transmitted over a simulated erroneous channel. Errors are introduced using the Sirannon network simulator. The error performance of each technique is evaluated and analysed both objectively and subjectively after reconstruction. The results of the research investigation and simulation are presented and analysed in chapter six of the thesis.

With new treatments and novel technology available, personalized medicine has become a key topic in the new era of healthcare. Traditional statistical methods for personalized medicine and subgroup identification primarily focus on single treatment or two arm randomized control trials (RCTs). With restricted inclusion and exclusion criteria, data from RCTs may not reflect real world treatment effectiveness. However, electronic medical records (EMR) offers an alternative venue. In this paper, we propose a general framework to identify individualized treatment rule (ITR), which connects the subgroup identification methods and ITR. It is applicable to both RCT and EMR data. Given the large scale of EMR datasets, we develop a recursive partitioning algorithm to solve the problem (ITR-Tree). A variable importance measure is also developed for personalized medicine using random forest. We demonstrate our method through simulations, and apply ITR-Tree to datasets from diabetes studies using both RCT and EMR data. Software package is available at https://github.com/jinjinzhou/ITR.Tree.

H παρούσα εργασία ασχολείται με τεχνικές εξόρυξης δεδομένων από εικόνες. Παρουσιάζει κάποια βασικά θεωρητικά στοιχεία σχετικά με τις διάφορες μεθόδους, και στη συνέχεια εστιάζει στην υλοποίηση της τεχνικής dynamic recursive partitioning (DRP), που αναφέρεται ειδικά σε εξόρυξη δεδομένων σε σχέση με εικόνες. Η συγκεκριμένη τεχνική μελετήθηκε έτσι ώστε να καθοριστούν και να χαρακτηριστούν συγκεκριμένα μορφομετρικά χαρακτηριστικά ανάμεσα σε ανατομικές δομές / εικόνες εγκεφάλων, για ιατρικές εφαρμογές. Στόχος είναι να αποδειχτεί ότι η μέθοδος αυτή μειώνει τον απαιτούμενο αριθμό στατιστικών τεστ σε σχέση με άλλες αντίστοιχες μεθόδους, όπως για παράδειγμα σε σχέση με τη μέθοδο ανάλυσης κατά pixel. Όπως φάνηκε η μέθοδος DRP αποδίδει έχοντας εξίσου καλά και ικανοποιητικά αποτελέσματα με την μέθοδο ανάλυσης κατά pixel. Ταυτόχρονα όμως, η χρήση της DRP έχει ως αποτέλεσμα να χρησιμοποιείται σαφώς μικρότερος αριθμός στατιστικών τεστ, για την εξόρυξη των δεδομένων από τις εικόνες και την καταγραφή των περιοχών των εικόνων με τις σημαντικότερες μορφολογικές διαφοροποιήσεις, με την μείωση αυτή να φτάνει ως και το 50%. / This dissertation deals with methods of data mining from images. It presents a basic theoretical background regarding the several different methods, and then it focuses on a specific technique called dynamic recursive partitioning (DRP). The specific technique was examined in order to define some basic morphological characteristics between anatomical structures / images of brains for medical applications. The main target was to prove that this method reduces the necessary number of statistical tests with respect to other similar methods. As it was shown, DRP indeed performs at least the same as other methods. At the same time, its usage results in a significantly lower number of statistical tests, in order to perform data mining from the images and extract the areas of images with the most important morphological differences. This reduction of statistical tests reaches almost 50%.

Application profiling is an important step in the design and optimization of embedded systems. Accurately identifying and analyzing the execution of frequently executed computational kernels is needed to effectively optimize the system implementation, both at design time and runtime. In a traditional design process, it suffices to perform the profiling and optimization steps offline, during design time. The offline profiling guides the design space exploration, hardware software codesign, or power and performance optimizations. When the system implementation can be finalized at design time, this approach works well. However, dynamic optimization techniques, which adapt and reconfigure the system at runtime, require dynamic profiling with minimum runtime overheads. Existing profiling methods are usually software based and incur significant overheads that may be prohibitive or impractical for profiling embedded systems at runtime. In addition, these profiling methods typically focus on profiling the execution of specific tasks executing on a single processor core, but do not consider accurate and holistic profiling across multiple processor cores. Directly utilizing existing profiling approaches and naively combining isolated profiles from multiple processor cores can lead to significant profile inaccuracies of up to 35%. To address these challenges, a hardware-based dynamic application profiler for non-intrusively and accurately profiling software applications in multicore embedded systems is presented. The profiler provides a detailed execution profile for computational kernels and maintains profile accuracy across multiple processor cores. The hardware-based profiler achieves an average error of less than 0.5% for the percentage execution time of profiled applications while being area efficient.

Redundantly actuated manipulators have only recently aroused significant scientific interest. Their advantages in terms of enlarged workspace, higher payload ratio and better manipulability with respect to non-redundantly actuated systems explain the appearance of numerous applications in various fields: high-precision machining, fault-tolerant manipulators, transport and outer-space applications, surgical operation assistance, etc. The present Ph.D. research proposes a unified approach for modeling and actuation of redundantly actuated parallel manipulators. The approach takes advantage of the actuator redundancy principles and thus allows for following trajectories that contain parallel (force) singularities, and for eliminating the negative effect of the latter. As a first step of the approach, parallel manipulator kinematic and dynamic models are generated and treated in such a way that they do not suffer from kinematic loop closure numeric problems. Using symbolic models based on the multibody formalism and a Newton-Euler recursive computation scheme, faster-than-real-time computer simulations can thus be achieved. Further, an original piecewise actuation strategy is applied to the manipulators in order to eliminate singularity effects during their motion. Depending on the manipulator and the trajectories to be followed, this strategy results in non-redundant or redundant actuation solutions that satisfy actuator performance limits and additional optimality criteria. Finally, a validation of the theoretical results and the redundant actuation benefits is performed on the basis of well-known control algorithms applied on two parallel manipulators of different complexity. This is done both by means of computer simulations and experimental runs on a prototype designed at the Center for Research in Mechatronics of the UCL. The advantages of the actuator redundancy of parallel manipulators with respect to the elimination of singularity effects during motion and the actuator load optimization are thus confirmed (virtually and experimentally) and highlighted thanks to the proposed approach for modeling, simulation and control.

<p>Dans ce travail, les préférences alimentaires pour les espèces végétales consommées par les lombriciens peuplant certains îlots des pelouses de l’avenue Roosevelt ont été étudiées. L’analyse des contenus digestifs et des fèces des vers a montré que les plantes identifiées dans les pelouses ne sont pas toutes consommées.<br> Mesurée par l’indice d’Ivlev, la sélectivité des items végétaux est variable en fonction de l’espèce de ver, de la classe d’âge et de la saison. Lorsque les dicotylédones sont en plein développement au printemps et en été, les choix des vers sont surtout manifestés pour les monocotylédones. En automne et en hiver, les monocotylédones prédominent et, les dicotylédones se retrouvant dans la litière, font l’objet de préférences marquées qui induisent des rejets relatifs de monocotylédones. Bien que Lolium perenne soit la plante la plus consommée, Bellis perennis est la dicotylédone la plus appréciée, Trifolium repens et Poa trivialis étant les plantes généralement rejetées.<br> L’indice d’Ivlev n’ayant permis de connaître que les rangs de préférences des différentes espèces végétales, les analyses ont été complétées par des tests du χ² qui ont montré que la consommation des plantes par les vers ne se fait pas au hasard. <p>Les épigés Satchellius mammalis et Lumbricus rubellus sont les espèces qui présentent le taux le plus élevé de matière organique figurée (respectivement 27 % et 26 % [19 % chez les jeunes Lumbricus spp]) dans leurs contenus digestifs. Chez les anéciques Aporrectodea longa et Lumbricus terrestris, ces taux sont très faibles (respectivement 6 % [2 fois plus chez les jeunes vers] et 11 %). Les endogés (Aporrectodea caliginosa, A. icterica et A. rosea) présentent des taux variant respectivement de 21 % [9 % chez les jeunes vers] à 8 % et 11 %. <p>L’axe de la taille des particules consommées n’a pas permis une ségrégation des niches (d’après notre étude, la taille des vers n’affecte pas celle des particules ingérées), mais l’axe de la nature des particules consommées est plus discriminant. Dans la niche tridimensionnelle (taille et nature des particules ingérées, notre étude, et les cycles annuels d’activité [Tiho, 2001]), le seul recouvrement fort qui se maintienne est celui de la niche de L. rubellus sur celle de L. terrestris. Un recouvrement marginal (α = 0,66) est observé, celui de la niche de A. longa sur celle de L. terrestris. Ceci révèle une compétition interspécifique entre ces trois espèces ayant des régimes alimentaires très proches. <p> <p>In this study, preferences for plants consumed by earthworms inhabiting certain islets of the Roosevelt avenue lawns have been studied. Examination of gut contents and faeces showed that not all of the plants identified in the lawns are consumed.<br> Measured by the Ivlev’s electivity index, the selectivity of plants is variable according to the earthworm species, its size class and the season. When the dicotyledons are developing in spring and in summer, the choices of the earthworms are particularly observed for the monocotyledons. In autumn and winter, the monocotyledons are developing and the dicotyledons in the litter are highly chosen, leading the relative reject of the monocotyledons.<br> Although Lolium perenne is the most consumed plant, Bellis perennis is the most appreciated dicotyledon, Trifolium repens and Poa trivialis being generally rejected.<br> As the Ivlev’s index of preference has only permit to know the rank of preference of the different plants, the analysis was completed by the χ² tests which demonstrated that the consumption of plants by earthworms is not done randomly. <p>The epigées Satchellius mammalis and Lumbricus rubellus are the species which present the highest rate of organic matter (respectively 27 % and 26 % [19 % for the immatures Lumbricus spp] in their gut contents.<br> For the anéciques Aporrectodea longa and Lumbricus terrestris, these rates are very low (respectively 6 % [twice more for the immatures worms] and 11 %).<br> The endogées (Aporrectodea caliginosa, Aporrectodea icterica and Aporrectodea rosea) present rates varying respectively from 21 % [9 % for the young worms] to 8 % and 11 %. <p>The axis of the particles size ingested did not permit the niches segregation (in our study, the earthworms size does not affect the size of the particles ingested), but the axis of the nature of the particles ingested is more discriminant. In the three-dimensional niche (size and nature of particles ingested [our study] and the annuals cycles of activity [Tiho, 2001]), the young worms not being considered, only one high overlap is maintained, that of L. rubellus niche on that of L. terrestris. A marginal overlap (α = 0.66) is observed, that of A. longa niche on that of L. terrestris. Having a similar trophic resource (consumption of litter), an interspecific competition must exist between these three species for the access to the food.

Thesis (PhD (Genetics))--Stellenbosch University, 2010. / ENGLISH ABSTRACT: The current understanding of the regulation of carbohydrate accumulation is still under investigation despite the tremendous work done in this subject. Purine and pyrimidine nucleotides have been implicated in many biochemical processes in plants. Amongst others, they are building blocks for nucleic acid synthesis, an energy source, precursors for the synthesis of primary products such as sucrose, polysaccharides, phospholipids, as well as secondary products. With the aim of placing adenine and uridine nucleotides in the context of sucrose and starch metabolism and carbon partitioning in higher plant, we have investigated the transcripts, enzymes and metabolites in carbohydrate metabolism and both de novo and salvage of purine and pyrimidine nucleotides in both sugarcane and tobacco tissues. For that purpose, adenylate kinase (ADK) and UMP synthase were chosen for silencing and over expression as they are rate limiting steps of de novo adenine and uridine nucleotides biosynthesis, respectively. Sugarcane with repressed ADK activity showed significant increase in both the starch and adenylate pools. Increase in starch content was highly correlated with reduced ADK activity. As a result of decreased ADK activity, the salvage pathway was up regulated via the increased activity of both adenosine kinase (AK) and adenine phosphoribosyl transferase (APRTase) which positively correlated with increase in adenine nucleotide contents. In addition hexose phosphates and ADP glucose, the committed substrate for starch biosynthesis positively correlated with changes in starch content. A high ratio of ATP/ADP was observed in all transgenic lines compared with the untransformed wild type and suggested to favour starch synthesis. Over expression of cytosolic ADK in tobacco demonstrated an expression of the enzyme where 2/3 of the total activity was in the direction of ADP production. As a result of over expression of ADK, starch content increased in all transgenic plants and positively correlated with changes in the activity of ADK. Despite changes in adenine nucleotide content, the salvage pathway was not activated and no significant changes in both AK and APRTase acivities were found between the transgenic and the untransformed plants. Sucrose synthase (SuSy) activity in breakdown direction positively correlated with changes in starch content suggesting a contribution in the starch accumulation in tobacco plants. In addition the ratio of ATP/ADP was low in all transgenic lines compared with the untransformed wild type. This was in line with the higher content in ADP compare to ATP in all transgenic lines and was supported by the over expression of ADK, and predominantly in the direction of ADP production. Repressed UMP synthase in transgenic sugarcane resulted in increases in sucrose, starch and uridinylate. UDP-glucose, hexose phosphates and uridinylate content positively correlated with changes in sucrose content. Transgenic lines had increased sucrose phosphate synthase (SPS) activity and low activity in SuSy, which suggests alteration of carbon flux toward sucrose. As a result of decreased UMP synthase activity, an up regulation of the salvage pathway was observed and predominantly via increased activity of uridine kinase (UK) which positively correlated with changes in the uridinylate pool. In addition to repressed UMP synthase activity, starch content and adenine nucleotides increased in transgenic lines. Tobacco plants transformed with a cytosolic UMP synthase demonstrated an over expression of the enzyme in all transgenic lines. As a result of over expression of UMP synthase, key metabolites were up regulated, amongst them sucrose. Increase in sucrose content positively correlated with both hexoses and hexose phosphates but not the uridinylate pool. SPS activity positively correlated with increase in sucrose content, and accounted for most of the sucrose synthesized in transgenic lines. Despite the increase in the adenylate pool, no significant changes were observed in starch content. The depletion level of UDP-glucose in all transgenic lines was a mere reflection of the higher activity of UDP glucose pyrophosphorylase (UGPase) in the formation of glucose-1-phosphate. In addition, no salvage pathway was up regulated in transgenic lines. / AFRIKAANSE OPSOMMING: Die huidige beskikbare inligting in verband met die reguleering van koolhidraat akkumulasie word steeds ondersoek ten spyte van die groot hoeveelheid navorsing wat reeds in hierdie verband gedoen is. Purien en pirimidien nukleotide speel ‘n rol in baie biochemiese prosesse in plante. Onder andere is hulle boublokke vir nukleïensuur sintese, ‘n energie bron, voorlopers vir die sintese van primêre produkte soos byvoorbeeld sukrose, polisakkariede, fosfolipiede, asook sekondêre produkte. Met die vooruitsig om adenine- en uridiennukleotide in verband te plaas met sukrose en stysel metabolisme en koolstof afskorting in plante, ondersoek ons hier die transkripte, ensieme en metaboliete in koolhidraat metabolisme in beide de novo en berging van purien en pirimidien nukleotide in suikerriet asook tabak weefsel. Vir hierdie doel is adenilaatkinase (ADK) en UMP-sintase gekies vir uitskakeling en ooruitdrukking, juis omdat hulle tempo vermindering stappe van de novo adenine- en uridiennukleotide biosintese is. Suikerriet met onderdrukte ADK aktiwiteit wys betekenisvolle vermeerdering in beide die stysel en adenilaat poele. Verhoging in styselinhoud was hoogs gekorreleerd met verminderde ADK aktiwiteit. As gevolg van ‘n vermindering in ADK aktiwiteit, is die bergingspad opwaards gereguleer via die vermeerdering van beide adenosienkinase (AK) en adenien-fosforibosieltransferase (APRTase) aktiwiteit wat positief korreleer met die vermeerdering in adeniennukleotied-inhoud. Addisioneel word hexosefosfate en ADP-glukose, die toegewysde substraat vir stysel biosintese, positief gekorreleer met veranderinge in styselinhoud. ‘n Hoë verhouding van ATP/ADP was geobserveer in alle transgeniese lyne in vergelyking met die nie-getransformeerde wilde tipe en blyk stysel sintese te begunstig. Ooruitdrukking van sitologiese ADK in tabak demonstreer die uitdrukking van die ensiem waar 2/3 van die totale aktiwiteit in die rigting van ADP produksie was. As ‘n resultaat van ooruitdrukking van ADK, word stysel inhoud vermeerder in alle transgeniese plante en positief gekorreleer met die verandering in die aktiwiteit van ADK. Ten spyte van veranderinge in adeniennukleotide inhoud was die bergingspad nie geaktiveer nie en geen betekenisvolle veranderinge in beide AK en APRTase aktiwiteit was gevind tussen die transgeniese en nie-transgeniese plante nie. Sukrose sintese (SuSy) aktiwiteit tydens afbreking korreleer positief met die veranderinge in stysel inhoud en dui moontlik op ‘n bydrae in die stysel akkumulasie in tabak plante. Verder was die verhouding van ATP/ADP laag in alle transgeniese lyne in vergelyking met die nie-getransformeerde wilde tipe. Hierdie bevinding word ondersteun deur die hoër inhoud in ADP in vergelyking met ATP in alle transgeniese lyne en word verder ondersteun deur die ooruitdrukking van ADK, hoofsaaklik in die rigting van ADP produksie. Onderdrukte UMP-sintase in transgeniese suikerriet lei tot verhogings in sukrose, stysel en uridienilaat. UDP-glukose, hexose-fosfate en uridienilaat inhoud korreleer positief met die verandering in sukrose inhoud. Transgeniese lyne het verhoogde sukrose-fosfaatsintase (SPS) aktiwiteit en lae SuSy aktiwiteit wat dui op ‘n verandering in koolstof vloei in die rigting van sukrose. As gevolg van die afname in UMP-sintese aktiwiteit, word ‘n verhoogde reguleering van die bergingspad gesien, en dít hoofsaaklik via verhoogde aktiwiteit in uridienkinase (UK) wat positief korreleer met veranderinge in die uridienilaat poel. Addisioneel tot die onderdrukking van UMP-sintase was stysel inhoud en adenine- nucleotides in transgeniese lyne verhoog. Tabak plante wat getransformeer is met sitologiese UMP-sintase demonstreer verhoogde uitdrukking van die ensiem in al die transgeniese lyne. As ‘n resultaat van ooruitdrukking van UMP-sintase is sleutel metaboliete, onderandere sucrose, oorgereguleer. ‘n Verhoging in sukrose inhoud korreleer positief met beide hexose en hexose-fosfate maar nie met die uridienilaat poel nie. SPS aktiwiteit korreleer positief met die verhoging in sukrose inhoud en verklaar die meeste van die sukrose vervaardig in transgeniese lyne. Ten spyte van die verhoging in die adenilaat poel word geen noemenswaardige veranderinge gesien in die stysel inhoud nie. Die uitputtingsvlak van die UDP-glukose in alle transgeniese lyne was slegs ‘n aanduiding van die hoër aktiwiteit van UDP-glukose pirofosforilase (UGPase) in die formasie van glukose-1-fosfaat. Verder was geen bergingspad opgereguleer in die transgeniese lyne nie. / The South African Sugarcane Research Institute and the Gabonese Government who provided the financial support for this work