No description available.

Methods for the remotely triggered release of biologically active molecules has been an area of intense research in recent years, as it would allow hard-to-obtain biomolecules to be tested in cell-like environments.1 The removal of polar functional groups from hydrophilic structures upon the application of an external stimulus would generate unfunctionalised molecules, which could then participate in amphiphilic self-assembly. This could be used in the release of bioactive molecules and therefore in the in vitro investigation of drug activity. In this PhD project, diazene chemistry was identified as the optimal method for the generation of unfunctionalised compounds through the removal of polar groups since fragmentation takes place rapidly and without the formation of potentially toxic intermediates or by-products. The synthesis of a range of protected hydrazines is described in this thesis (Scheme 1), in addition to the investigation of the rates of decomposition of various simple sulfonyl hydrazides, which led to the isolation of the product of the decomposition of a sulfonyl hydrazide. The photolysis of NVOC- and NPPOC-protected hydrazine derivatives is discussed.

Magister Chirurgiae Dentium - MChD / To compare the efficacy of two fluoride containing materials, namely, FluorSure and Duraphat, in protecting the enamel around and underneath the orthodontic brackets against decalcification. / South Africa

<p>To compare the efficacy of two fluoride containing materials, namely, FluorSure and Duraphat, in protecting the enamel around and underneath the orthodontic brackets against decalcification.</p>

<p>To compare the efficacy of two fluoride containing materials, namely, FluorSure and Duraphat, in protecting the enamel around and underneath the orthodontic brackets against decalcification.</p>

This work deals with the use of methoxymethyl protecting group in chemistry of cyclodextrins, where this group has not been used very often so far. The work deals with development of optimal methods for introduction and for subsequent removal of the group and shows its usefulness in the preparation of new 6I -O-monosubstituted cyclodextrin derivatives, which are hard to get by standard methods. Key words: cyclodextrin derivatives, methoxymethyl group, protecting group

This diploma thesis deals with formation and activities of the Financial Guard of the Czechoslovak Republic. It was a paramilitary security authority whose primary purpose was to oversee and prevent smuggling in the border area of the Czechoslovak Republic, simultaneously the Financial Guard was tasked with protecting the state border from unauthorized crossing of foreign nationals. The Financial guard existed before the establishment of the independent Czechoslovak Republic, but as one of the many institutes of Austria-Hungary it was also taken over into a new political arrangement. The aim of this work was to get acquainted with the term of Financial Guard. Define its basic functions and activities, and separate it from purely military churches. This work, in its first part, briefly and clearly talks about the establishment and prehistory of the Financial Guard, and its subsequent development to a fully functioning state body of the Czechoslovak Republic. In relation to subordination to the Ministry of Finance of the Czechoslovak Republic, I also deal with the partial analysis of this ministry in this work. Next chapter of this work defines the construction of the Financial Guard. Describes the first moments of the Financial Guard in the Czechoslovak Republic and gives examples of equipment of the...

Carbohydrates play major roles in many biological processes. Therefore, the synthesis of oligosaccharides is of considerable interest for biological, medicinal, and pharmacological studies. Many approaches have been developed for the synthesis of oligosaccharides, in which the main focus is often the formation of the glycosidic bonds. Traditional approaches use protecting group strategies that can be time consuming and can result in poor overall yield. This thesis describes the protecting group-free synthesis of a series of glycosyl donors of a range of mono- and disaccharides. These donors can be used to synthesize unprotected glycosyl chlorides, observed in situ. Reaction of the glycosyl chlorides with a variety of nucleophiles afforded the expected displacement products, giving access to a range of O-, N-, and S-linked glycosides, without resorting to the use of protecting groups.

Carbohydrates play major roles in many biological processes. Therefore, the synthesis of oligosaccharides is of considerable interest for biological, medicinal, and pharmacological studies. Many approaches have been developed for the synthesis of oligosaccharides, in which the main focus is often the formation of the glycosidic bonds. Traditional approaches use protecting group strategies that can be time consuming and can result in poor overall yield. This thesis describes the protecting group-free synthesis of a series of glycosyl donors of a range of mono- and disaccharides. These donors can be used to synthesize unprotected glycosyl chlorides, observed in situ. Reaction of the glycosyl chlorides with a variety of nucleophiles afforded the expected displacement products, giving access to a range of O-, N-, and S-linked glycosides, without resorting to the use of protecting groups.

The use of 4-acetoxy-2,2-dimethylbutanoyl protecting group for the C2-hydroxyl allows the selective formation of β-glycosides without producing α-glycosides. This very bulky protecting group can be removed under mild conditions.