Dulcitol hexanitrate was prepared in 90% yield by nitrating dulcitol with nitric and sulphuric acid. The optically inactive hexanitrate crystallized from ethanol and water to give fine, colorless needles melting at 98-99°C. When the pure dulcitol hexanitrate was dissolved in anhydrous pyridine, an exothermic reaction occurred with the evolution of a gas. On dilution of the solution with water, a crystalline dulcitol pentanitrate separated in 65% yield. The pentanitrate was re-crystallized from ethanol and water as fine, colorless needles, which melted at 85-86°C; it was optically inactive and did not reduce Fehling's solution. The pentanitrate was methylated with silver oxide and methyl iodide, and then reduced with hydrogen over palladized charcoal to give an optically inactive monomethyl dulcitol. This product crystallized from ethanol as heavy, colorless crystals which melted at 149-150°C. Periodate oxidation of the monomethyl dulcitol indicated that it was a racemic mixture of 3- and 4-methyl D-dulcitol (D-galactitol). Hence the action of pyridine selectively removed a nitric acid ester group from the 3-(or chemically equivalent 4-) position in the D-dulcitol hexanitrate molecule leaving a hydroxyl group. / Science, Faculty of / Chemistry, Department of / Graduate

Mailey and Ocone1'2 treated pyridine-l-oxide with hexafluoropropene and obtained 2-(l, 2,2,2-tetrafluoroethyl)pyridine in 44 per cent yield; the mechanism they postulated involved the formation of an isoxazolidine intermediate. This thesis forms a natural extension of their work, since the reaction has been applied to various 2-, 3-, 4-, 2.6- and polysubstituted pyridine-l-oxides and extended also to other heterocyclic N-oxides, namely those of 5-methylpyrimidine and quinoline. The N-oxides used are as shown below. The objectives of the investigations were to throw light on the proposed mechanism, to examine the generality of the reaction, and to obtain a number of fluorinated pyridine-N-oxides for testing as agrochemicals. Throughout the research it was found that some reactions gave only 'Mailey-and-Ocone' isolable products; e. g. 4-nitropyridine-l-oxide gave one tractable nongaseous product (A), whilst other reactions were considerably more complex, e. g. 3-bromopyridine-l-oxide gave four products (B) - (E)i that could not all be explained by the proposed (B) mechanism. During the course of this work, therefore, many new fluoroalkyl heterocycles were isolated inculding some unexpected compounds, another example being tetrahydrofuro(3,2-b)pyridine (F) from 2-ethoxypyridine-l-oxide. Many fluoroalkylpyridines formed in the above reactions were subjected to N-oxidation with peracids, and samples of the products listed below were sent for screening as potential agrochemicals.

Typescript Includes bibliographical references Specific enzymic assays by direct spectrophotometry for both the oxidized and reduced forms of nicotinamide-adenine dinucleotide and of nicotinamide-adenine dinucleotide phosphate are described.

In this study, we used pyridine-2,6-dicarboxylic acid and 2,2¡¦:6¡¦,2¡¨ - terpyridine as ligands to form the neutral osmium complex. The metal center showed a reversible redox wave at E1/2 = 0.36 V, and there was also an irreversible redox wave at E1/2 = -1.50 V. The complex had a pseudo-octahedral structure, which contained a C2 axis and both a H2O and ether molecule were inside. There was a intermolecular £k-£k interaction between terpyridines, and H-bonding between H2O and the carbonyl group of pyridine-2,6-dicarboxylate ligand. Computer deconvolution of the MLCT band with three Gaussian lines and two lines of ligand-centered band was carried out.

Thesis (Ph.D)--University of Adelaide, Dept. of Agricultural Chemistry, 1964. / Typescript. Includes bibliographical references.

Thesis (M.S.)--Villanova University, 2009 / Chemistry Dept. Includes bibliographical references.

Inaug.-Diss.--Zürich. / Curriculum vitae. "Literaturverzeichnis": p. [36]-38.

Thesis (Ph. D.)--Johns Hopkins University, 1923. / Biography. Imprint date on cover changed in manuscript to 1924.

Th.--Sci. phys.--Grenoble 1, 1982. N°: 51.

No description available.