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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 10 of 735 (0.017 seconds)
1

Semisynthetische Ras-Lipoproteine Studium der intrazellulären Lokalisation, biologischen Aktivität und Membranassoziation /

Wagner, Melanie. January 2003 (has links) (PDF)
Bochum, Universiẗat, Diss., 2003.
Ras-Proteine Ras-Proteine Ras-Proteine
2

Involvement of DNA methylation in ras-induced down-regulation of the metastasis suppressor RECK

Cho, Chun-yu 21 July 2006 (has links)
Many tumor suppressor genes are known to be inactivated by epigenetic modifications including DNA methylation and histone deacetylation. RECK is a membrane-anchored glycoprotein that may negatively regulate matrix metalloproteinase (MMP) activity and inhibit tumor metastasis. Our previous study demonstrated that oncogenic ras inhibited RECK expression via Sp1 binding site in the RECK promoter by histone deacetylation mechanism. In this study, we tried to characterize the molecular pathway that mediates the inhibitory effect of ras on RECK. Methylation specific PCR (MSP) indicated that RECK gene promoter is hypermethylated in ras-activated 2-12 cells. We also tested whether ras activation induced the binding of DNA methyltransferases (DNMTs) to Sp1 to repress RECK expression. Our data showed Sp1-associated DNMT3b in cells was increased after ras induction. By using DNA affinity precipitation assay (DAPA) and chromatin immunoprecipitation (ChIP) , we found that induction of oncogenic ras enhanced the binding of DNMT3b to the Sp1 site in the RECK promoter in vitro and in vivo. Additionally, treatment of DNMT inhibitor 5'-azacytidine led to the re-expression of RECK in ras-activated 2-12 cells. The signaling pathway by which ras suppresses RECK was also addressed. Chemical inhibitor of ERK signaling pathway U0126 reversed the methylation of RECK promoter and up-regulated RECK expression in ras-activated 2-12 cells. More importantly, 5'-azacytidine and DNMT3b siRNA may suppress the invasive ability of 2-12 cells. Taken together, our results suggest that oncogenic ras inhibit the metastasis suppressor gene RECK via a DNA methylation mechanism and provide valuable insights for the understanding of the mechanisms by which ras promotes tumor invasion and metastasis
Ras
RECK
3

Untersuchung des intrinsischen GTPase-Mechanismus von Ras p21 mit Mitteln der Molekulardynamik-Simulation und QM/MM-Kraftfeld

Klähn, Marco. January 2003 (has links) (PDF)
Bochum, Univ., Diss., 2003. / Computerdatei im Fernzugriff.
Ras-Proteine
4

Die Isoprenfunktion von Ras - Erkennungssignal bei der Interaktion mit Guaninnukleotid-Austauschfaktoren, Translokationsfaktoren und modifizierenden Enzymen

Popkirova, Boriana. January 2004 (has links) (PDF)
Bochum, Univ., Diss., 2005. / Computerdatei im Fernzugriff.
Ras-Proteine
5

A de-,reacylation cycle controls the localisation and compartmentalised activity of palmitoylated ras

Rocks, Oliver. January 2004 (has links) (PDF)
Bochum, Univ., Diss., 2005. / Computerdatei im Fernzugriff.
Ras-Proteine
6

Analyse von Struktur-Funktionsbeziehungen bei der Ras-abhängigen Raf-Aktivierung

Quack, Thomas. January 2002 (has links) (PDF)
Düsseldorf, Univ., Diss., 2002. / Das Oeffnen des Links kann einige Minuten dauern, da es sich um eine grosse Datei handelt (130,3 MB). Computerdatei im Fernzugriff.
Ras-Proteine
7

Analyse von Struktur-Funktionsbeziehungen bei der Ras-abhängigen Raf-Aktivierung

Quack, Thomas. January 2002 (has links) (PDF)
Düsseldorf, Univ., Diss., 2002. / Das Oeffnen des Links kann einige Minuten dauern, da es sich um eine grosse Datei handelt (130,3 MB). Computerdatei im Fernzugriff.
Ras-Proteine
8

Funktionelle und strukturelle Charakterisierung von Ras-Effektoren Eigenschaften des kleinen Ras-Effektors Novel Ras Effector 1 (Nore1) /

Schwarz, Daniel. January 2002 (has links) (PDF)
Bochum, Univ., Diss., 2003. / Computerdatei im Fernzugriff.
Ras-Proteine
9

Funktionelle und strukturelle Charakterisierung von Ras-Effektoren Eigenschaften des kleinen Ras-Effektors Novel Ras Effector 1 (Nore1) /

Schwarz, Daniel. January 2002 (has links) (PDF)
Bochum, Univ., Diss., 2003. / Computerdatei im Fernzugriff.
Ras-Proteine
10

FT-IR-spektroskopische Untersuchungen des Mechanismus der H-ras-p21-katalysierten GTPase

Blessenohl, Marco. January 2003 (has links) (PDF)
Bochum, Univ., Diss., 2003. / Computerdatei im Fernzugriff.
Ras-Proteine

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