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Effects of hindlimb unweighting on soleus muscle resistance artery endothelial function and eNOS expression /Schrage, William January 2001 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2001. / "May 2001." Typescript. Vita. Includes bibliographical references (leaves 141-150). Also available on the Internet.
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IGF-I Receptor Localization and Constant Infusion of a Supraphysiologic Dose of IGF-I in the Sprague-Dawley RatAlford, Timothy J. January 1993 (has links)
Indiana University-Purdue University Indianapolis (IUPUI) / Previous studies have shown an increased growth of the tibial growth plate in rats infused with supraphysiologic doses of IGF-I. However, no one has demonstrated this effect on the TMJ in vivo. To determine the effect of a constant infusion of IGF-1 on the TMJ, 20 Sprague-Dawley rats were divided into three groups: (1) control, (2) surgical control, and (3) IGF-1 and placebo infused. IGF-I was delivered at a rate of 1 μg/day over the TMJ via osmotic minipumps. lntravital bone labels were administered at two-week intervals to monitor growth rate. Following sacrifice, seven mandibular (Mn) dimensions were measured anthropometrically. The mandibles were then imbedded in acrylic and stained with tetrachrome to visualize the Mn cartilage. Fluorescence microscopy was utilized to measure the Mn growth between bone labels and calculate growth rates. In addition, the hypertrophic cartilage layer thickness was measured photomicrographically. ANOVA showed no significant difference (P<0.05) in growth rates or cartilage thicknesses between the groups. However, multiple t tests did show an increase in several Mn dimensions (increase in length from gonion to the mental foramen; increase in length from condylion to the mental foramen; and increase in condylar head anterior-posterior length) in the experimental animals comparing the IGF-I infused side with the placebo infused control side. Therefore, it was concluded that IGF-I, when infused at a constant supraphysiologic dose, may increase mandibular growth in certain directions. The present study is not able to definitively demonstrate that these increases are due to direct effects on Mn cartilage growth.
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Neurotoxicity and neurobehavioral effects of manganese phosphate/sulfate mixture in male sprague-dawley rats following subchronic inhalation exposureSalehi, Fariba January 2005 (has links)
Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.
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Effect of nitric oxide (NO) on orthodontic tooth movement in ratsVakani, Arvind Kenneth. January 2003 (has links)
Thesis (M.S.)--University of Florida, 2003. / Title from title page of source document. Includes vita. Includes bibliographical references.
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Effects of hindlimb unweighting on soleus muscle resistance artery endothelial function and eNOS expressionSchrage, William January 2001 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2001. / Typescript. Vita. Includes bibliographical references (leaves 141-150). Also available on the Internet.
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Region-selective effects of thiamine deficiency on cerebral metabolism in pyrithiamine-treated ratsNavarro, Darren. January 2008 (has links)
Pyrithiamine-induced thiamine deficiency in rats is a well-established animal model of Wernicke's Encephalopathy (WE). This thesis project, submitted as four articles, presents an examination of metabolic events that contribute to the selective neuronal lesions observed in the medial thalamus (MT) of thiamine-deficient (TD) rat. In addition, the phenomenon of glucose-precipitated worsening of neurological status in WE patients (Wallis et al., 1978; Watson et al., 1981) is explored. / Lactate accumulation is known to occur selectively in regions of the TD brain, which ultimately express neuronal cell death (McCandless, 1982; Munujos et al., 1996). In Article 1, the metabolic origin and cellular localization of region-selective lactate accumulation in the MT of TD rats was studied using combined 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. Parallel studies were performed to examine the effects of glucose loading on regional brain lactate synthesis in TD animals. Thiamine deficiency caused focal increases in the de novo synthesis of lactate via elevated glycolytic flux in the MT, while contribution via pyruvate recycling and the periphery remained nominal. Lactate levels remained unaltered in the frontal cortex (FC), a brain region that is spared in thiamine deficiency. Administration of a glucose load intensified the selective increases in lactate de novo synthesis and accumulation in the MT of TD rats, positing a role for lactic acidosis in the glucose-precipitated worsening of neurological status in TD patients. Accordingly, Article 2 addresses the effect of glucose loading on local cerebral pH in the vulnerable MT, compared to the FC, of TD rats. Administration of a glucose load resulted in detrimental decreases in regional pH selectively in the MT, implying that alterations of brain pH contribute to the pathogenesis of thalamic neuronal damage and consequent cerebral dysfunction in WE. / Region-specific alterations in the steady state levels of cerebral amino acid neurotransmitters have been well-documented in experimental animal models of thiamine deficiency (Butterworth et al., 1979; Butterworth & Heroux, 1989; Gaitonde et al., 1975; Plaitakis et al., 1979); however, the dynamics of these changes have never been systematically explored. In Article 3, we examined the metabolic fluxes through thiamine-dependent pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) using multinuclear NMR spectroscopy. Furthermore the cellular localization of the metabolic changes in relation to regional vulnerability to thiamine deficiency was addressed. Our studies clearly demonstrate that early decreases m metabolic flux through alpha-KGDH result in commensurate declines in aspartate concentrations in the MT of TD rats. Impairments to PDH flux manifest secondarily to the metabolic block at alpha-KGDH, likely due to depleted oxaloacetate pools. As a result of impaired pyruvate oxidation, declines in the de novo synthesis of glutamate and GABA ensue. The present findings also suggest that inhibition of flux through alpha-KGDH in TD brain occurs primarily in the neurons, while astrocytes possess compensatory mechanisms, i.e. the anaplerotic pathway, to replenish oxaloacetate concentrations via metabolic pathways that do not involve thiamine-dependent enzymes. / In Article 4, we investigated the regional effects of thiamine deficiency on the activity of thiamine-dependent branched-chain alpha-ketoacid dehydrogenase (BCKDH) and the resultant effects on regional cerebral branched-chain amino acid (BCAA) oxidation. Thiamine deficiency resulted in significant impairments in BCKDH activity; while parallel studies on enzyme distribution confirmed a lower oxidative capacity for BCAAs in the MT compared with the Fe. / The data presented in these four articles confirm and extend findings for the region-selective impairments in thiamine-dependent metabolic processes as the foundation of vulnerability of the MT to thiamine deficiency. In addition, glucose loading of TD rats exacerbates both lactic acidosis and impaired pyruvate oxidation in this vulnerable brain region, positing a role for these processes in the glucose-precipitated worsening of neurological status in TD patients. Impaired oxidative metabolism of glucose and BCAAs in the MT leads to the accumulation of potentially harmful metabolic intermediates, contributing to the mitochondrial dysfunction, cellular energy failure and ultimately neuronal cell death observed in thiamine deficiency.
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Changes in the spinal cord and peripheral innervation in an animal model of arthritisAlmarestani, Lina M. G. January 1900 (has links)
Thesis (Ph.D.). / Written for the Dept. of Pharmacology and Therapeutics. Title from title page of PDF (viewed 2009/06/05). Includes bibliographical references.
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Inhibition of the calcium plateau following in vitro status epilepticus prevents the development of spontaneous recurrent epileptiform dischargesNagarkatti, Nisha. January 1900 (has links)
Thesis (Ph.D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Pharmacology and Toxicology. Title from resource description page. Includes bibliographical references.
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The effects of environmental conditions on activity, feeding, and body weight in male and female adolescent rats /Tomchesson, Joshua L January 2006 (has links) (PDF)
Thesis (Ph.D.)--Uniformed Services University of the Health Sciences, 2006 / Typescript (photocopy)
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Behavioral and biological effects of housing conditions and stress in male rats -- relevance to heart disease /Shafer, Sarah T January 2006 (has links) (PDF)
Thesis (M.S.)--Uniformed Services University of the Health Sciences, 2006 / Typescript (photocopy)
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