In this dissertation we investigate the applicability of different adaptive techniques to improve the effectiveness and efficiency of the regression testing. Initially, we introduce the concept of regression testing. We then perform a literature review of current practices and state-of-the-art regression testing techniques. Finally, we advance the regression testing techniques by performing four empirical studies in which we use different types of information (e.g. user session, source code, code commit, etc.) to investigate the effectiveness of each software metric on fault detection capability for different software environments. In our first empirical study, we show the effectiveness of applying user session information for test case prioritization. In our next study, we apply learning from the previous study, and implement a collaborative filtering recommender system for test case prioritization, which uses user sessions and change history information as input parameter, and return the risk score associated with each component. Results of this study show that our recommender system improves the effectiveness of test prioritization; the performance of our approach was particularly noteworthy when we were under time constraints. We then investigate the merits of multi-objective testing over single objective techniques with a graph-based testing framework. Results of this study indicate that the use of the graph-based technique reduces the algorithm execution time considerably, while being just as effective as the greedy algorithms in terms of fault detection rate. Finally, we apply the knowledge from the previous studies and implement a query answering framework for regression test selection. This framework is built based on a graph database and uses fault history information and test diversity in attempt to select the most effective set of test cases in term of fault detection capability. Our empirical evaluation of this study with four open source programs shows that our approach can be effective and efficient by selecting a far smaller subset of tests compared to the existing techniques.