Diploma thesis "The influence of the activities of non-profit sector on the quality of life of people with mental retardation" is concerned with the analysis of the area of social services for people with mental retardation. The thesis aims at characterising the current position of the non-profit sector in meeting the needs of people with mental retardation, identifying problem areas and proposing recommendations, which could support the activities of the non-profit sector in this area. Methods such as institutional framework analysis, stakeholder analysis, interview with experts and stakeholders and questionnaire survey in NGOs are used. The issue of mental retardation is based on the theory of needs, the quality of life concept and the concept of human rights. The role of the non-profit sector is analysed in a broader institutional and social context. The availability of social services provided by NGOs for people with mental retardation in the Czech Republic is investigated and the main spheres of activities of NGOs according to the services provided are indentified. The description of examples of good practice follows. In the next part the relations between non-profit sector and state are analysed. Recommendations leading to improving the system of social services for people with mental retardation are...

This thesis is focused on analysis of educational system during the process of integration of mental disabled pupils - especialy during basic education at primary schools in mainstreaming. Characteristics of the educational system and its opportunities, considering the specification of mental disability, is the main intention of this dissertation. Another accents are put on main problems in educational system for mentaly disabled people as well as designing the ways that lead to improvement of attainment of pupils with special needs.There are used methods of expert investigation - especially of interviews with principal actors and question-forms. Basis for this are: rights of everyone to recieve education, premise that everyone is educatable and theory of streel level-byrocracy. Detailed look is focused on terms 'integration' and 'inclusion' plus its explanation in terms of matters that is related to education of mental disabled pupils. Issue is incorporated to the wider international and juridical connection. Considering Czech Republic I joined a special characteristic of general problems in the field of professional preparation, financing and attitude. I have mentioned how good examples in foreign countries could be the true kind of inspiration that leads to improvement of actual educational statement for...

The Diploma Thesis "Utilization of art therapy methods and techniques in social services for mentally disabled people" deals with topic of art therapy and its elements which are used while working with mentally disabled people. The thesis defines the term art therapy and describes art therapy methods and techniques which are used in social services for mentally disabled people. Object of the thesis is to ascertain to what extent art therapy methods and techniques are utilized while working with mentally disabled people and whether these methods and techniques help to develop mentally disabled people. The theoretical part of the thesis defines the term art therapy and its position in a system of coordinated rehabilitation. It also describes the history of art therapy, its forms and possibilities of utilization of colors in art therapy. The other part of the theoretical part defines mental retardation and its classification and social services for mentally retarded people are described here as well. In the end, the theoretical part is devoted to art therapy methods and techniques. The practical part of the thesis deals with two researches. The quantitative one which was performed with mentally retarded people ascertains whether mentally retarded people like using art therapy methods and techniques...

No description available.

No description available.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24801号 / 医博第4993号 / 新制||医||1067(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 鈴木 実, 教授 溝脇 尚志, 教授 江木 盛時 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

The object of the research was the hardiness of adolescents with mental retardation. The subject of the research was the personal characteristics, manifestations of hardiness, as well as features of the coping-strategies choice of adolescents with mental retardation. The master's thesis consists of an introduction, two chapters, conclusion, list of references (153 sources) and an Appendix, including the test results forms for the subjects, as well as the results of mathematical data processing performed in the SPSS Statistic program. The volume of the master's thesis is 158 pages, which contains 4figures and 32 tables. In conclusion, the results of the theoretical and empirical parts of the work, as well as conclusions on the hypotheses put forward, the practical significance of the study and the possible prospects for further development of this problem are described in a generalized form. / Объектом исследования явилась жизнестойкость подростков с задержкой психического развития. Предметом исследования стали личностные характеристики, проявления жизнестойкости, а также особенности выбора стратегий совладающего поведения подростков с задержкой психического развития. Магистерская диссертация состоит из введения, двух глав, заключения, списка литературы (153 источника) и двух приложений, включающих в себя бланки с результатами тестирования для испытуемых, а также результаты математической обработки данных, выполненные в программе SPSS Statistic. Объем магистерской диссертации 158 страниц, на которых размещены 4 рисунка и 32 таблица. В заключении в обобщенном виде изложены результаты теоретической и эмпирической частей работы, а также выводы по выдвинутым гипотезам, обоснована практическая значимость исследования и описаны возможные перспективы дальнейшей разработки данной проблематики.

В диссертации рассмотрены особенности психического и физического развития, а также двигательные способности детей с умственной отсталостью. Разработана программа коррекции координационных способностей посредством игры в бочче. Предложенная программа может быть рекомендована преподавателям адаптивного физического воспитания, педагогам дополнительного образования, воспитателям группы продленного дня, работающим с детьми 12-15 лет с умственной отсталостью. / The dissertation examines the mental and physical development as well as motor abilities of children with intellectual disabilities. A programme for the correction of coordination abilities by playing bocce has been developed. The proposed programme can be recommended to teachers of adaptive physical education, teachers of additional education, educators of day-care groups, working with 12-15 years old children with mental retardation.

No description available.

Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. Both genetic and environmental factors contribute to the onset and progression of these diseases. However, despite intensive research, the underlying cause remains unclear. The role of viral infection as an environmental factor in the context of neurodegenerative diseases has not received much attention. The purpose of this study is to investigate the effects of Herpes Simplex Virus 1 (HSV-1) infection on nuclear amyloid aggregation in model cell lines of HD and SCA. The research process consists mainly of laboratory work which involved the use of several molecular techniques used in the field of biotechnology. The work comprises cultivating cells, infecting cells with HSV-1, Fluorescence microscopy, Western Blot and isolation and detection of amyloids. Western Blot is used for the analysis of specific proteins associated with protein aggregation in HD and SCA. The techniques used for detecting amyloids are Dot Blot and Antibody-staining of amyloids in cells. The results from Western Blot showed that aggregates changed in the presence of the virus. This pattern is observed for both HD and SCA1 cell lines. A big effort is done in this study to optimize Dot Blot as it is method that could be applied in every lab. Normalization of samples proved to be the most challenging part with Dot Blot. No definitive conclusions can be drawn from the Dot Blot results as reproducibility and sensitivity were lacking. This work addresses some of the difficulties encountered when working with detection of amyloids especially Dot Blot. Antibody-staining of amyloids showed that amyloids were formed in the presence of virus in comparison to non-infected. To conclude, aggregates changed, and amyloids were formed in the presence of virus. These results point to the fact that HSV-1 infection could be involved in the process of nuclear amyloid aggregation. The data presented in this thesis will need further investigation and characterization to identify the precise role of viral-induced amyloid formation in HD and SCA patient cells. / Huntingtons sjukdom (HD) och Spinocerebellära ataxier (SCA) är obotliga neurodegenerativa sjukdomar som påverkar det centrala nervsystemet. Amyloid, proteinaggregat som har en viss konformation är ett kännemärke för många neurodegenerativa sjukdomar. Ackumulering av dessa amyloider är toxiskt och är den främsta orsaken till att nervceller dör. Både genetiska faktorer och miljöfaktorer bidrar till uppkomsten och progressionen av dessa sjukdomar. Trots intensiv forskning är den bakomliggande orsaken emellertid fortfarande oklar. Virusinfektion som en potentiell miljöfaktor har i detta sammanhang inte fått mycket uppmärksamhet. Syftet med denna studie är att undersöka effekterna av Herpes Simplex Virus 1 (HSV-1) infektion på amyloid aggregering i modellcellinjer av HD och SCA. Forskningsarbetet bestod i huvudsakligen av experimentellt arbete med hjälp av flera molekylära tekniker inom bioteknikområdet som cell odling, infektering av celler med HSV-1, fluorescensmikroskopi, Western Blot och isolering och detektion av amyloider. Western Blot användes for att analysera specifika proteiner associerade med protein aggregering i HD och SCA. Amyloider detekterades med Dot Blot och med antikroppar specifika för amyloider. Resultat från Western Blot visade att amyloiderna förändras i virusinfekterade celler. Detta mönster observerades i både HD and SCA1 cellinjer. En stor bemöda görs i denna studie för att optimera Dot Blot eftersom det är en metod som kan användas i alla laboratorier. Normalisering visade sig vara det svåraste med detektion av amyloider. Inga definitiva slutsatser kan dras från dessa experiment, eftersom reproducerbarhet och känslighet var bristande. Detta arbete tar upp några av de svårigheter som uppstod vid arbetande med detektion av amyloider speciellt Dot Blot. Detektion av amyloider med antikropp visade att amyloider bildades till stor utsträckning i infekterade cellinjer i jämförelse med icke-infekterade. Sammanfattningsvis, amyloider förändrades och amyloider bildades i närvaro av virus. Dessa resultat indikerar på att HSV-1 infektion skulle kunna vara involverad i processen av amyloid aggregering. De presenterade uppgifter i detta examensarbete är preliminära och behöver följas upp med ytterligare studier för att identifiera virusens exakta roll i amyloid bildning i HD och SCA patient celler.