京都大学 / 新制・課程博士 / 博士(エネルギー科学) / 甲第23999号 / エネ博第435号 / 新制||エネ||82(附属図書館) / 京都大学大学院エネルギー科学研究科エネルギー基礎科学専攻 / (主査)教授 野平 俊之, 教授 萩原 理加, 教授 宇田 哲也 / 学位規則第4条第1項該当 / Doctor of Energy Science / Kyoto University / DFAM

This thesis presents data which support cochlear involvement in attentional listening. It has been previously proposed that the descending auditory pathways, in particular the medial olivocochlear system, play a role in reducing the cochlea's response to noise in a process known as antimasking. This hypothesis was investigated in human subjects for its potential impact on the detection of signals in noise following auditory cues. Three experimental chapters (Chapters 3, 4 and 5) are described in this thesis. Experiments in the first chapter measured the effect of acoustic cues on the detection of subsequent tones of equal or different frequency. Results show that changes in the ability to detect signals following auditory cues are the result of both enhanced detection for tones at the cued frequency, and suppressed detection for tones at non-cue frequencies. Both effects were measured to be in the order of ~3 dB. This thesis has argued that the enhancement of a cued tone is the implicit result of an auditory cue, while suppression of a probe tone results from the expectation of a specific frequency based on accumulated experience of a listening task. The properties of enhancement support the antimasking hypothesis, however, the physiological mechanism for suppression is uncertain. In the second experimental chapter, auditory cues were replaced with visual cues (representing musical notes) whose pitch corresponded to the target frequency, and were presented to musician subjects who possessed absolute or relative pitch. Results from these experiments showed that a visual cue produces the same magnitude of enhancement as that produced by an acoustic cue. This finding demonstrates a cognitive influence on the detection of tones in noise, and implicates the role of higher centres such as those involved in template-matching or top-down control of the efferent pathways. The final experimental chapter repeated several of the experiments from the first chapter on subjects with various forms of hearing loss. The results indicate that subjects with an outer hair cell deficit (concomitant with a sensorineural hearing loss) do not exhibit an enhancement of cued frequencies or a suppression of unexpected frequencies to the same extent as the normal-hearing subjects. In addition, one subject with a long-standing conductive hearing loss (with normal cochlear function) produced an enhancement equivalent to that of the normalhearing subjects. These findings also support the role of the medial olivocochlear system and the outer hair cells in antimasking. It is the conclusion of this thesis that enhancement most likely results from a combination of changes in receptive field characteristics, at various levels of the auditory system. The medial olivocochlear system is likely to be involved in unmasking a portion of the signal at the cochlear level, which may be influenced by both acoustic reflex pathways or higher centres of the brain.

No abstract.

One means by which inhibitory control in selective attention may be studied is with the negative priming (NP) procedure. It is widely assumed that children are characterised by reduced capacity for inhibition (Diamond, 2002) and that inhibitory dysfunction is a key characteristic of children and adolescents with ADHD (Barkley, 1997). This should translate into reduced NP effects for these populations. In this dissertation, four studies using the NP procedure find no evidence for reduced inhibitory function in typical children or in adolescents with ADHD. Study 1 examined the magnitude of NP in children compared with adults. An important line of support for the idea that children suffer an inhibitory decrement has been based an empirical report suggesting that conceptual (identity or semantic) NP effects, assumed to reflect the by-product of distractor inhibition, while consistently found in adults are lacking in children (Tipper, Bourque, Anderson, & Brehaut, 1989). In Study 1, the opposite result was found. Study 2 compared NP effects between 7-year-old children and adults while replicating the respective methodologies of the only two studies to explore conceptual NP effects in developmental populations to date (Pritchard & Neumann, 2004, vs. Tipper et al., 1989) to determine the nature of the divergent results between these studies. In Study 2, it was found that distractor inhibition effects are comparable between children and adults when a NP task contains trials in which the distractor stimulus is consistently incongruent with the target stimulus, but that children may be more susceptible than adults to divide attention between target and distractor when a NP task contains a number of trials in which target selection difficulty is reduced. These are critical new findings, highlighting that reduced NP may often relate to methodological artifacts, and when considered in the light of current theories of NP, are also problematic for anti-inhibitory accounts of NP. Having distinguished more definitively the role of inhibition in developmental NP effects, Studies 3 and 4 explored whether the inhibitory process underpinning NP was implicated in young persons with ADHD. To date, evidence for NP in ADHD populations is equivocal. Study 3 found no evidence for a reduced NP effect in ADHD devoid of a corresponding diagnosis. Study 4 found that conduct and oppositional defiant disorders had the potential to confound the evaluation of NP in ADHD. Taken together, results in Studies 1 - 4 parallel very recent results in the literature on NP in older adults and adult psychopathology where presumed reductions of NP in these populations may also be accounted for by methodological artifacts (Buchner & Mayr, in press). It is concluded that NP may reflect a primitive and robust form of inhibitory processing, one that develops early and one that is often the last to deteriorate.

Thesis (M.S.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 21, 2008) Includes bibliographical references.

Thesis (M.S.)--University of North Carolina Wilmington, 2007. / Includes bibliographical references (Leaves: 110-116)

Diss. (sammanfattning) Umeå : Sveriges lantbruksuniv., 2007. / Härtill 5 uppsatser.

Diss. (sammanfattning) Umeå : Sveriges lantbruksuniversitet, 2006. / Härtill 3 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.