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Aspects of hypertension in endocrine diseaseRitchie, Catherine Marian January 1986 (has links)
No description available.
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102 |
Molecular consequences of protein misfolding mutations in FBN1Suk, Ji Young January 2003 (has links)
No description available.
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103 |
Expression and functional characterization of carbohydrate recognition domains of bovine conglutinin and human lung surfactant protein DWang, Jiu-Yao January 1996 (has links)
No description available.
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Metabolic studies on the uraemic ratKlim, R. A. January 1984 (has links)
No description available.
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Molecular consequences of mutations in FBNIMcGettrick, Aileen Jane January 2002 (has links)
No description available.
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106 |
Identification and Verification of Candidate Biomarkers for Down Syndrome and Discovery of Dysregulated Molecular Pathways in Amniocytes by Proteomics ApproachesCho, Chan-Kyung Jane 06 December 2012 (has links)
Down syndrome (DS), caused by an extra chromosome 21, affects 1 in 750 live births, and is characterized by cognitive impairment as well as several congenital defects. Currently, little is known about the molecular pathogenesis of DS and no direct genotype-phenotype relationship has yet been confirmed. The current screening test for DS subjects many women to undergo invasive procedures such as amniocentesis due to suboptimal sensitivity and specificity. Therefore, this study aimed to discover novel biomarkers to improve screening tests, and to discovery dysregulated molecular pathways in DS-affected fetus to better understand pathogenesis. To achieve this objective, proteomic analyses of amniotic fluid (AF) and amniotic fluid cells (amniocytes) were performed using mass spectrometry (MS), which allows discovery of a large number of proteins in complex biological samples. Since AF contains the most information of the developing fetus, we first generated the most comprehensive list of proteins present in AF by using high resolution MS. We then performed quantitative analyses of proteins from AF as well as amniocytes to reveal novel biomarkers and clues to altered molecular mechanisms of DS. Comparison between the proteome of AF from unaffected and DS-affected pregnancies allowed selection of 60 candidate biomarkers based on spectral counting. Two candidates, APP and TNC-C, were verified by immunoassays to show two-fold increase in AF from DS-pregnancies. Additionally, CPA4, MUC13, CEL, DPP4 and MMP2 were verified to be differentially expressed in trisomy 21-AF via selected reaction monitoring assays using triple-quadruple mass spectrometer. Amniocytes from DS-affected and unaffected fetuses were also quantitatively analyzed by using Stable Isotope Labelling of Amino acids in Cell culture technique. Over 4900 proteins were identified from amniocyte lysate and supernatant by LTQ-Orbitrap mass spectrometer, and 85% of these proteins were quantified based on MS/MS spectra ratios of peptides containing isotope-labelled amino acids. Proteins that consistently showed aberrant expression from affected amniocytes have been selected for further verification and molecular network analyses since they may play a role in DS pathogenesis.
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Collagen genes in osteogenesis imperfectaBaigrie, Carolyn Frances January 1990 (has links)
No description available.
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108 |
Developing a cognitive intervention programme to help people with autism learn about beliefMcGregor, Evelyn January 1999 (has links)
No description available.
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109 |
A comparison of sacroiliac joint manipulation versus piriformis muscle ice-and-stretch combined with sacroiliac joint manipulation on post-partum females suffering from sacroiliac syndrome17 June 2009 (has links)
M.Tech.
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Psychotherapeutic assistance to adolescent siblings in families with a Down syndrome member15 October 2015 (has links)
M.A. (Counselling Psychology) / Sibling interaction is often an overlooked aspect of family functioning. For many years there has been an overemphasis on the importance of parental influences on children, yet common sense dictates that brothers and sisters must have some effect on each other even though this effect may not always be obvious. The sibling relationship is a life-long process, and is therefore highly influential throughout the life cycle ...
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