Made available in DSpace on 2016-04-28T14:16:25Z (GMT). No. of bitstreams: 1 CARLOS A LOIOLA DE SOUZA.pdf: 415449 bytes, checksum: d861caf6da8174df5e70f24cd0bc6748 (MD5) Previous issue date: 2006-05-29 / Sci - fi books depending on how they are structured by their authors, might be in our case, the astronomer Carl Sagan, be used as reference texts in Science History by his indisciplinity. The specific case of interplanetary trips, theorized and thought scientificaly and advertised under a sci - fi language in books of Carl Sagan, is what this dissertation talks about.The authors of fiction texts, such as Sagan Arthur Charles Clarke and Issac Asimov, try to found their extrpolate in careful notes of trends that happen in society and science, and develop the ( narration, in Asmov and Clarke´s case ) implication or advertising with rigidity and consistency.On the other hand, part of the futuristic literature would be an important History of Science analysis instrument, for it to be possible of thinking in alternative proposals for a scientific policy and taught which may have a social reach. A kind of experiment or imaginary exercise. In other words, what is studied here, is the relation between sci - fi and science, which talks about interplanetary trips, and how they are explained in Sagan´s books. However, the dissertation, delimitates, in the first instance, must be considered about interplanetary trips, its dissimilation from the 30´s to the 60´s and the adverstising through two of the best sci - fi writers of the twentieth century, whose work was to advertise scientific ideas or Astronautic for a better understanding of the science, its role and the impact of science and technology, in a society which moves really fast, but without many details. After all, as it was a relevant realization of some of these realized fantasies by Carl Sagan´s commitment, initially, with the American industial military complexduring the Cold War against USSR, and after that by NASA.And what we have learned scientifically from the exploration of the Solar Sistem and the nearest planets, in a way that the results of this spacial exploration could be advertised with the help from literature and fiction, in a type of alert about the problems that we will have to face in a near future. At last, the mankind destiny, imagined by Sagan in a kind of manifest advertised by himself in his main books and analysed here for it to be possible to keep its parallelism of contents and trends between sci - fi books and the academic literatureabout the development of science and technology and the destiny of mankind and the individuals that make itself. This is a conclusion that History students having a beginning or complementary graduation in humanities, will be able to find on the shelves of science history, a worthy manifest for an unexpective reflection or for a militancy / Obras de ficção científica podem, dependendo de como estiverem estruturadas por seus autores, em nosso caso, o astrônomo Carl Sagan, ser usadas como textos de referência em História da Ciência por sua interdisciplinaridade. O caso específico das viagens interplanetárias, pensadas e teorizadas cientificamente e divulgadas sob a linguagem da ficção científica nos livros de Carl Sagan, é o de que se ocupa esta dissertação. Os autores de textos de ficção, como os colegas de Sagan Arthur Charles Clarke e Isaac Asimov, procuram, como acontece com textos teóricos acadêmicos, assim como também eram alguns dos textos de Sagan, fundamentar suas extrapolações em observações cuidadosas de tendências em ação na sociedade e na ciência e desenvolver sua (narração, no caso de Asimov e Clarke) implementação ou divulgação com rigor e consistência. Ou seja, parte da literatura futurística seria um instrumento importante de análise de História da Ciência para que esta possa pensar em propostas alternativas para uma política científica e de ensino científico que tenha um alcance social. Uma espécie de experimento ou exercício imaginário. Em outras palavras, o que aqui se estuda é a relação entre ficção científica e ciência que fale das viagens interplanetárias e como elas estão expressas nas obras de Sagan. Portanto, a dissertação delimita o que, em primeiro lugar, deve-se considerar sobre as viagens interplanetárias, sua disseminação nos anos de 1930 a 1960 e sua divulgação através de dois dos melhores escritores de ficção científica do século XX, que se empenharam em divulgar idéias científicas ou de Astronáutica para uma melhor compreensão da ciência, do papel da ciência e do impacto da ciência e tecnologia numa sociedade com uma velocidade em movimento rápido, mas sem muitos detalhes. Depois, como foi a realização primordial de algumas dessas fantasias realizadas pelo envolvimento de Carl Sagan, inicialmente, com o complexo militar industrial dos Estados Unidos da América durante a Guerra Fria com a URSS e depois pela NASA. E o que se aprendeu, cientificamente, com a exploração de nosso sistema solar e de nossos planetas mais próximos, de maneira que esses resultados da exploração espacial pudessem ser divulgados com a ajuda da literatura de ficção em forma de alerta sobre os problemas que teremos de enfrentar num futuro bem próximo. E, por último, o destino da humanidade imaginado por Sagan numa espécie de manifesto divulgado por ele mesmo em seus principais livros e aqui analisado para que se pudesse manter o paralelismo de conteúdo e tendências entre as obras de ficção e a literatura acadêmica sobre o desenvolvimento da ciência e da tecnologia e o destino da humanidade e dos indivíduos que a compõem. Isto nos leva a concluir que o estudante de História da Ciência, tendo uma formação inicial ou complementar em humanidades, poderá encontrar na estante de História da Ciência um valioso manifesto para uma reflexão despretensiosa ou para a militância

This diploma thesis is concerned with possibilities of patient data transfer from a pacemaker or implantable cardioverter-defibrillator to physician over GSM. Theoretical part describes options of data transfer in GSM networks, data appropriate for sending and a structure of message is proposed. A device, that is able to send medical data in a form of SMS messages is designed and constructed. The device uses a Freescale MC68HC908GP32 microcontroller, character display with a Hitachi HD44780 controller and a cell phone Sony CMD-J70. The program for microcontroller is written in assembler for HC08. For tabular view of received messages, an application software for PC was created.

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Neurological disorders affect more than 14% of the population worldwide and together with traumatic brain and spinal cord injuries represent major health, public and economic burden of the society. Incidence of inherited and idiopathic neurodegenerative disorders and acute CNS injuries is growing globally while neuroscience society is being challenged by numerous unanswered questions. Therefore, research of the CNS disorders is essential. Since animal models of the CNS diseases and injuries represent the key step in the conversion of the basic research to the clinics, we focused our work on generation of new animal models and on their use in pre-clinical research. We generated and characterized transgenic minipig model of Huntington's disease (HD) which represents the only successful establishment of a transgenic model of HD in minipig which should be valuable for testing of long term safety of HD therapeutics. Next, we crossed the well characterized R6/2 mouse HD model with the gad mouse model which lacks the expression of UCHL1 which led to results that support the theory of "protective" role of mutant huntingtin aggregates and suggest that UCHL1 function(s) may be affected in HD disturbing certain branches of Ubiquitin Proteasome System. Traumatic spinal cord injury and Amyotrophic Lateral...

Die Studie wird in fünf Teile unterteilt: Das erste Kapitel beschäftigt sich mit Patentanmeldungen und geförderten Patenten im USPTO, WIPO, und EPO. In diesem Kapitel wird die Korrelation zwischen dem BIP und der länderspezifischen Patentanzahl analysiert. Das zweite Kapitel gibt einen Überblick über die Literatur über Patente in MEDLINE. In diesem Kapitel wird eine szientometrische Analyse durchgeführt, damit die Entwicklung der Patentliteratur in MEDLINE über den Zeitraum von 1965 bis 2005 quantitativ gemessen werden kann. Das dritte Kapitel befasst sich mit der Literatur über Patente im SCI. In diesem Kapitel werden alle Dokumente, die vom SCI über den Zeitraum 1965 bis 2005 als “Patents“ indexiert wurden, unter die Lupe genommen. Das vierte Kapitel analysiert die Patenten, die im SCI zitiert werden. Das fünfte Kapitel analysiert die Anzahl der Literaturhinweise (Referenzen) pro Veröffentlichung im SCI über den Zeitraum 1970-2005. In diesem Hinblick wurde eine Gesamtzahl von 10,000 Dokumenten pro Jahr ausgesucht sowie der Bedeutungswert von Nennungen pro Zeitschrift berechnet. Die Analyse der Daten ergab: Die USA sind das führende Land bezüglich der Erstellung und der Zulassung von Patenten, gleichermaßen gefolgt von Japan und Deutschland. Die Halbwertszeit der Zitierung von Patenten beträgt seit 1994 konstant 8,1 Jahre. Das ist eine 41% längere Zitierungsrate gegenüber den allgemeinen wissenschaftlichen Dokumenten im SCI. Es gibt eine lineare Korrelation zwischen der Zahl von Literaturhinweisen (Referenzen) in einem Journal, wie sie im SCI erfasst sind, und der Wahrscheinlichkeit zitiert zu werden. Die Anzahl der Literaturhinweise (Referenzen) pro Veröffentlichung zwischen 1970 und 2005 im SCI ist ständig angestiegen. Die Selbstzitation von Zeitschriften bei einer steigenden Zahl von Verweisen beeinflusst die Steigerung des Impact Factor im SCI. Die Leitartikelpolitik der Sprachen wurde in der MEDLINE und im SCI geändert. / This study is divided into five sections. The first section consists of patent applications and granted patents issued by USPTO, WIPO), and EPO. In this section the relationship between the GDP and country’s patent quantity is analysed. The second section analysis the patent literature in MEDLINE. In this section a scientometric analysis is performed to assess the quantitative trend of patent literature in MEDLINE throughout 1965-2005. The third section analysis the patent literature in the SCI. In this section all documents indexed as a topic of “patents” in the SCI throughout 1965-2005 are analysed. The fourth section analysis the citations to the patent documents indexed in the SCI, and illustrate the average number of cited references per paper for patent citing documents. The fifth section analysis the references per paper in the SCI through 1970-2005. The Analyses of data showed: The USA is the leading country filing and granting patents followed by Japan and Germany respectively. The half-life of citations to the patent-documents is 41% higher than the half-life of citations to the general scientific documents in the SCI. The number of references per paper from 1970 to 2005 has steadily increased. The rough constant percentage of self-citation of journals and the growing increase of references per paper led to the absolute growing number of self-citations and to the increase of the Impact Factor of the citing journals in the SCI. The editorial policy of languages is being changed in MEDLINE and in the SCI. The consideration of policy makers in these databases have been focused on the literature of science in English. There was a tendency in the last decades towards collaboration in scientific publishing with American authors that can be observed in the SCI with authors from different countries.

The study was undertaken to deepen understanding of living with a spinal cord injury (SCI) in the rural communities of the Eastern Cape Province, South Africa (RSA). The OR Tambo District Municipality, which was selected for its accessibility to the researcher, is virtually rural, the infrastructure is poorly developed and there is low socio-economic activity in the rural areas of the old Transkei. In the RSA services for management and rehabilitation of SCIs varies from province to province. A Heideggerian phenomenological approach was used to interpret the meaning of living with SCI persons in a rural community. The purpose was to describe and interpret what being-in the-world as a spinal cord injured person meant to the particpants. A key assumption in phenomenology is that understanding human beings and their actions is best achieved through examination of human experiences. Experience, including experience with living with SCI, offers itself as a record of human encounters, the interface between persons and their world, and experience can only be understood in terms of background and the social context of the experience (Pateman & Johnson 2000: 51). Phenomenological interviews with ten people living with SCI explored their experience. The overall goal was to increase awareness of their experiences of living with SCI, and to encourage incorporation of knowledge gained into nursing practice. The central question in the study was `What is it like to live with a spinal cord injury in a rural community? Data were analysed according to Heideggerian hermeneutic phenomenology. Two main themes were identified, namely reconceptualising being-in-the-world as a person with a disability; and being-with-each-other: experiencing being excluded, objectified and marginalized. The participants engaged in a process of reconstructing their identities following the traumatic loss of sensory and motor functioning. Data reflect the social and economic context in which living with SCI is experienced. The respondents' life experiences were influenced by socio-political, economic and historical factors, namely geographic location, poor infrastructure, poverty, low educational status, and unemployment and the community at large. It was noted that participants experienced difficulties in several areas in their daily life realm; naming, coping with health and disability problems, family interactions and relationships, and non-accessibility of amenities, including their own dwellings. In addition, being a person living with an SCI in the rural communities of the OR Tambo District Municipality carries a high physical and social risk due to lack of resources. The inability to live up to generally expected social roles led to role dissatisfaction. There is an urgent need for social support to overcome the negative societal attitudes experienced. They are forced into isolation with a limited social life and are poorly integrated into the communities in which they live. Most of what the participants raised pointed towards inadequate preparation for the outside world. Therefore, a holistic approach to rehabilitation is recommended, as holism means addressing the physical, social, emotional and cognitive needs. Accordingly, the researcher developed guidelines for facilitating community integration. In conclusion, understanding how people experience living with SCI in a rural community is an essential prerequisite to the development of appropriate strategies to facilitate community integration. / Health Studies / D. Litt et Phil (Health Studies)

The study was undertaken to deepen understanding of living with a spinal cord injury (SCI) in the rural communities of the Eastern Cape Province, South Africa (RSA). The OR Tambo District Municipality, which was selected for its accessibility to the researcher, is virtually rural, the infrastructure is poorly developed and there is low socio-economic activity in the rural areas of the old Transkei. In the RSA services for management and rehabilitation of SCIs varies from province to province. A Heideggerian phenomenological approach was used to interpret the meaning of living with SCI persons in a rural community. The purpose was to describe and interpret what being-in the-world as a spinal cord injured person meant to the particpants. A key assumption in phenomenology is that understanding human beings and their actions is best achieved through examination of human experiences. Experience, including experience with living with SCI, offers itself as a record of human encounters, the interface between persons and their world, and experience can only be understood in terms of background and the social context of the experience (Pateman & Johnson 2000: 51). Phenomenological interviews with ten people living with SCI explored their experience. The overall goal was to increase awareness of their experiences of living with SCI, and to encourage incorporation of knowledge gained into nursing practice. The central question in the study was `What is it like to live with a spinal cord injury in a rural community? Data were analysed according to Heideggerian hermeneutic phenomenology. Two main themes were identified, namely reconceptualising being-in-the-world as a person with a disability; and being-with-each-other: experiencing being excluded, objectified and marginalized. The participants engaged in a process of reconstructing their identities following the traumatic loss of sensory and motor functioning. Data reflect the social and economic context in which living with SCI is experienced. The respondents' life experiences were influenced by socio-political, economic and historical factors, namely geographic location, poor infrastructure, poverty, low educational status, and unemployment and the community at large. It was noted that participants experienced difficulties in several areas in their daily life realm; naming, coping with health and disability problems, family interactions and relationships, and non-accessibility of amenities, including their own dwellings. In addition, being a person living with an SCI in the rural communities of the OR Tambo District Municipality carries a high physical and social risk due to lack of resources. The inability to live up to generally expected social roles led to role dissatisfaction. There is an urgent need for social support to overcome the negative societal attitudes experienced. They are forced into isolation with a limited social life and are poorly integrated into the communities in which they live. Most of what the participants raised pointed towards inadequate preparation for the outside world. Therefore, a holistic approach to rehabilitation is recommended, as holism means addressing the physical, social, emotional and cognitive needs. Accordingly, the researcher developed guidelines for facilitating community integration. In conclusion, understanding how people experience living with SCI in a rural community is an essential prerequisite to the development of appropriate strategies to facilitate community integration. / Health Studies / D. Litt et Phil (Health Studies)